Pregled bibliografske jedinice broj: 72683
Biochemical studies of oximes synthesized in Croatia over the past decades
Biochemical studies of oximes synthesized in Croatia over the past decades // World congress on chemical and biological terrorism, CBMTS-Industry II, Dubrovnik, Abstracts
Zagreb, 2001. (predavanje, međunarodna recenzija, sažetak, pregledni)
CROSBI ID: 72683 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Biochemical studies of oximes synthesized in Croatia over the past decades
Autori
Simeon, Vera ; Reiner, Elsa
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, pregledni
Izvornik
World congress on chemical and biological terrorism, CBMTS-Industry II, Dubrovnik, Abstracts
/ - Zagreb, 2001
Skup
World congress on chemical and biological terrorism, CBMTS-Industry II, Dubrovnik
Mjesto i datum
Dubrovnik, Hrvatska, 22.04.2001. - 27.04.2001
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
cholinesterases; nerve warfare agents; oximes; synthesis; protection; reactivation
Sažetak
A review of the biochemical research of oximes sythesized in Croatia over the past decades was presented. The synthesised compounds contained one or two oxime groups at various positions on pyridinium, imidazolium, or quinuclidinium rings. Aromatic rings of some compounds were substituted with aliphatic or aromatic radicals. Biochemical studies of the oximes focused on the mechanism of reversible binding of oximes to cholinesterases, reactivation of phosphorylated cholinesterases, protection of the enzyme against inhibition by the organophosphates (Soman, Sarin, Tabun, VX or DDVP), and interaction of oximes with thiocholine substrates.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
00220104
Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb
