Naslov
Decreased serum monocytes and elevated neutrophils as additional markers of insulin resistance in type 1 diabetes

Autori
Bulum, Tomislav ; Kolarić, Branko ; Duvnjak, Lea

Izvornik
International Journal of Diabetes in Developing Countries (0973-3930) 34 (2014); 150-155

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
type 1 diabetes; insulin resistance; monocyte count; neutrophil count

Sažetak
Insulin resistance contributes to the high risk for cardiovascular diseases in subjects with type 1 diabetes. The differential white blood cell counts also predict the future incidence of coronary artery disease. The objective of this study was to evaluate the associations of differential white blood cell count with insulin resistance in type 1 diabetic patients. Study included 353 patients with type 1 diabetes. Insulin sensitivity was measured by estimated glucose disposal rate (eGDR) calculated with the equation: eGDR=24.31-(12.22xWHR)-(3.29xHT)- (0.57xHbA1c). The units were mgkg-1min-1 ; WHR=waist to hip ratio ; HT=hypertension. Monocyte count significantly correlated with insulin resistance measured by eGDR (r=0.10, P=0.04). Subjects in the upper quartile of the eGDR (>10.87 mgkg-1min-1) had significantly higher levels of monocyte count (median 6.2 vs 5.4%, P=0.02), compared to patients in the lowest quartile of eGDR (<7.82 mgkg-1min-1). In a multiple logistic regression models adjusted for age, sex, duration of diabetes and BMI, monocyte and neutrophil levels were significantly associated with risk of insulin resistance in our subjects (OR=0.79, and 1.03, P<0.05). The odd ratios for insulin resistance decreased across baseline monocyte quartiles: 1, 0.75, 0.69, and 0.34. In contrast, odd ratios for insulin resistance increased across baseline neutrophil quartiles: 1, 0.95, 1.60 and 1.99. The significant independent association of monocytes and neutrophils with insulin resistance suggests that activation of the immune system may play a role in the pathogenesis of insulin resistance in type 1 diabetes.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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