Naslov
Bone Densitometry in Premenopausal Women With High Risk of Secondary Osteoporosis

Autori
Šijanović, Siniša ; Karner, Ivan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
International Journal of Gynecology and Obstetrics / Sciarra, J. - Chicago (IL) : FIGO, 2000, 31-32

Skup
XVI FIGO World Congress of Gynecology and Obstetrics

Mjesto i datum
Washington D.C., Sjedinjene Američke Države, 03.09.2000. - 08.09.2000

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
premenopausal women; thyroxine suppressive therapy; bone densitometry; osteopenia

Sažetak
BACKGROUND: It is controversial if the long-term treatment with thyroid hormone given at suppressive doses has a negative effect on bone metabolism. The AIM this study was to determine whether the long-term thyroxine therapy in premenopausal period is a risk for development of secondary osteoporosis, and whether those women have increased loss of bone mass during premenopausal period. PATIENTS AND METODS: There was a selected group of women in premenopausal period (N=19) aging 39,0ą8,0 suffering from differentiated thyroid gland carcinoma. To all, of them, the total thyreoidectomy was done and the thyroxine suppressive therapy was introduced. The duration of the suppressive therapy from the beginning of the research, amounted 9,4ą6,4 years. Laboratory results have excluded other possible factors for secondary osteoporosis. The prospective study of the bone densitometry was done to all of the examinees using the method of dual photon x-ray absorptoimetry(DXA) of the spine and the femoral neck, and also by the method of single-photon absorptiometry (SPA) of the distal radius. RESULTS: In the beginning of this study, while the patients were treated for 10 years osteopeny was found in the spine and femoral neck in two examinees for every region. On the distal radius osteopeny was found in 4 examinees. The total was 8 out of 19 with osteopeni. One year later, after the second measurment no statisticaly significant loss of bone mass was in any region of sceleton. However, looking at the individual scores, osteopeny was found in 6 examinees on the distal radius but on the spine and the femoral neck there where bone loss in several women not to the point that would create osteopeny. But, after the 4 years of measurement t-test had shown some significant bone loss. CONCLUSION: And finaly, we can come to the decision that women who begin with long-term thyroxine therapy (about 10 years) in premenopausal period can develop osteopeny in the beginning of menopause. In that case, those women should complete mamography test and bone densitometry before hormon replacement therapy used.

Izvorni jezik
Engleski

POVEZANOST RADA