Naslov
Oral cadmium exsposure during pregnancy: Assessment of microelement distribution in mother rat and foetus at term

Autori
Mikolić, Anja ; Sulimanec Grgec, Antonija ; Piasek, Martina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Knjiga sažetaka/Book of Abstracts Drugi simpozij Hrvatskoga društva za znanost o laboratorijskim životinjama s međunarodnim sudjelovanjem „Pokusne životinje u znanstvenim istraživanjima“/2nd Symposium of Croatian Laboratory Animal Science Association with international participation “Experimental animals in scientific research” / - Zagreb, 2014, 72-73

Skup
Drugi simpozij Hrvatskoga društva za znanost o laboratorijskim životinjama s međunarodnim sudjelovanjem „Pokusne životinje u znanstvenim istraživanjima“/2nd Symposium of Croatian Laboratory Animal Science Association with international participation “Experimental animals in scientific research”

Mjesto i datum
Zagreb, Hrvatska, 10.10.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
cadmium; oral exposure; pregnancy; placenta; foetus; micronutrients

Sažetak
The effects of oral cadmium exposure on microelement distribution in Wistar rats orally exposed to 50 mg Cd/L of demineralised water (prepared from CdCl2xH2O) during 20 days of pregnancy were evaluated. Control rats received demineralised water. Non-pregnant rats were treated under the same experimental conditions. The rats were supplied standard pelleted feed (Mucedola, Italy). All rats were then euthanized in general anaesthesia and samples of blood, liver, kidney, placenta, and foetus were dissected and prepared for element analyses (by AAS). Cadmium body retention was higher in pregnant than in non- pregnant exposed rats as evidenced by higher cadmium blood levels and organ cadmium contents. Liver zinc increased in all of the exposed rats. Iron levels decreased in liver and kidney of exposed pregnant rats. Placental zinc and foetal iron decreased. In all of the pregnant vs. non- pregnant rats, copper levels were lower in liver and higher in kidney. In conclusion, cadmium accumulation and tissue perturbations of essential microelements were more pronounced in exposed pregnant than exposed non-pregnant rats. Maternally-mediated oral cadmium exposure disrupts transplacental passage of iron and zinc and thus may compromise perinatal growth and development.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

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