Naslov
Effects of chronic DHEAS administration on seizure threshold, locomotor activity, motor coordination and body weight in male and female mice

Autori
Švob Štrac, Dubravka ; Vlainić, Josipa ; Krsnik, Željka ; Samardžić, Janko ; Erhardt, Julija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Knjiga sažetaka-Drugi simpozij Hrvatskog društva za znanost o laboratorijskim životinjama s međunarodnim sudjelovanjem “Pokusne životinje u znanstvenim istraživanjima” Zagreb, 10. listopad, 2014. / Bubić Špoljar, Jadranka ; Erhardt, Julija ; Lang Balija, Maja ; Smolić, Blanka ; Švob Štrac, Dubravka - Zagreb : Hrvatsko društvo za znanost o laboratorijskim životinjama (CroLASA), 2014, 104-105

Skup
Drugi simpozij Hrvatskog društva za znanost o laboratorijskim životinjama s međunarodnim sudjelovanjem “Pokusne životinje u znanstvenim istraživanjima

Mjesto i datum
Zagreb, Hrvatska, 10.10.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
dehydroepiandrosterone sulphate; mice; sex differences; seizure threshold; motor activity; body weight

Sažetak
Dehydroepiandrosterone sulphate (DHEAS) is a neurosteroid associated to various important brain functions, such as neuronal plasticity, cognition and emotions. It appears that the effects of DHEAS in the central nervous system are primarily mediated through its action on several neurotransmitter systems, including GABAergic and glutamatergic neurotransmission, which are also involved in regulating the balance between excitation and inhibition in the brain. It is possible that enhancement of brain excitability and seizures might limit DHEAS potential therapeutic applications. In order to investigate the effects of chronic neurosteroid treatment, DHEAS has been administered intraperitoneally to female and male mice once daily for 4 weeks in a dose of 10 mg/kg. The effects of long-term DHEAS administration on the picrotoxin-, pentylentetrazole- and NMDA-induced seizures, locomotor activity, motor coordination and body weight of the animals of both sexes have been studied. Chronic DHEAS has not modified the locomotor activity, motor coordination and body weight of both male and female mice. The results also failed to demonstrate significant effects of long-term DHEAS treatment on the doses of intravenously administered picrotoxin, pentylentetrazole and NMDA, needed to produce convulsant signs in male and in female mice. However, sex differences in the susceptibility to seizures became more prominent following chronic DHEAS administration to mice. Although our findings suggest that long-term DHEAS treatment might be safe for various potential therapeutic applications, they also support reported interaction of DHEAS with male and female hormonal status, which may underline observed sex differences in the relationship between DHEAS and various health outcomes.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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