Pregled bibliografske jedinice broj: 719952
Macromolecular oxidation in anisotonic suspensions of mouse spleen cells
Macromolecular oxidation in anisotonic suspensions of mouse spleen cells // Cell biochemistry and fuction, 24 (2006), 3; 201-207 doi:10.1002/cbf.1207 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 719952 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Macromolecular oxidation in anisotonic suspensions of mouse spleen cells
Autori
Bilić, Ivan ; Kovač Zdenko
Izvornik
Cell biochemistry and fuction (0263-6484) 24
(2006), 3;
201-207
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
oxidative stress; anisotonicity; osmotic stress; splenocytes; protein carbonylation; TBARS; lipid peroxidation
Sažetak
Macromolecular oxidative alterations have been analysed in vitro in anisotonic suspensions of mouse splenocytes. Both hypertonicity and hypotonicity induced the generation of thiobarbituric acid reactive species (TBARS) and carbonylation of the proteins, which took place along with cell death. Addition of antioxidants partially inhibited oxidative changes in isotonic and hypotonic suspensions. Anisotonic shock of mouse splenocytes proved to be an inducer of oxidative stress. The oxidative macromolecular alterations might contribute to pathogenesis of cell death caused by osmotic stress.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
