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Pregled bibliografske jedinice broj: 719103

Oral health, dental care and mouthwash associated with upper aerodigestive tract cancer risk in Europe: the ARCAGE study.

Ahrens, W.; Pohlabeln, H.; Foraita, R.; Nelis, M.; Lagiou, P.; Lagiou, A.; Bouchardy, C.; Slamova, A.; Schejbalova, M.; Merletti, F. et al.
Oral health, dental care and mouthwash associated with upper aerodigestive tract cancer risk in Europe: the ARCAGE study. // Oral Oncology, 50 (2014), 6; 616-625 doi:10.1016/j.oraloncology.2014.03.001 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 719103 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Oral health, dental care and mouthwash associated with upper aerodigestive tract cancer risk in Europe: the ARCAGE study.

Autori
Ahrens, W. ; Pohlabeln, H. ; Foraita, R. ; Nelis, M. ; Lagiou, P. ; Lagiou, A. ; Bouchardy, C. ; Slamova, A. ; Schejbalova, M. ; Merletti, F. ; Richiardi, L. ; Kjaerheim, K. ; Agudo, A. ; Castellsague, X. ; Macfarlane, TV ; Macfarlane, GJ ; Lee, YC ; Talamini, R. ; Barzan, L. ; Canova, C. ; Simonato, L. ; Thomson, P. ; McKinney, PA ; McMahon, AD ; Znaor, Ariana ; Healy, CM ; McCartan, BE ; Metspalu, A. ; Marron, M. ; Hashibe, M. ; Conway, DI ; Brennan, P.

Izvornik
Oral Oncology (1368-8375) 50 (2014), 6; 616-625

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Head and neck neoplasms ; Oral health ; Oral hygiene ; Genetic polymorphisms

Sažetak
OBJECTIVE: We aimed to assess the association of oral health (OH), dental care (DC) and mouthwash with upper-aerodigestive tract (UADT) cancer risk, and to examine the extent that enzymes involved in the metabolism of alcohol modify the effect of mouthwash. MATERIALS AND METHODS: The study included 1963 patients with incident cancer of the oral cavity, oropharynx, hypopharynx, larynx or esophagus and 1993 controls. Subjects were interviewed about their oral health and dental care behaviors (which were converted to scores of OH and DC respectively), as well as smoking, alcohol drinking, diet, occupations, medical conditions and socio-economic status. Blood samples were taken for genetic analyses. Mouthwash use was analyzed in relation to the presence of polymorphisms of alcohol-metabolizing genes known to be associated with UADT. Adjusted odds ratios (ORs) and 95%-confidence intervals [CI] were estimated with multiple logistic regression models adjusting for multiple confounders. RESULTS: Fully adjusted ORs of low versus high scores of DC and OH were 2.36[CI=1.51-3.67] and 2.22[CI=1.45-3.41], respectively, for all UADT sites combined. The OR for frequent use of mouthwash use (3 or more times/day) was 3.23[CI=1.68-6.19]. The OR for the rare variant ADH7 (coding for fast ethanol metabolism) was lower in mouthwash-users (OR=0.53[CI=0.35-0.81]) as compared to never-users (OR=0.97[CI=0.73-1.29]) indicating effect modification (pheterogeneity=0.065) while no relevant differences were observed between users and non-users for the variant alleles of ADH1B, ADH1C or ALDH2. CONCLUSIONS: Poor OH and DC seem to be independent risk factors for UADT because corresponding risk estimates remain substantially elevated after detailed adjustment for multiple confounders. Whether mouthwash use may entail some risk through the alcohol content in most formulations on the market remains to be fully clarified.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA

Projekti:
005-1080315-0294 - Odrednice multiplih primarnih sijela raka u populaciji (Znaor, Ariana, MZOS ) ( CroRIS)

Ustanove:
Hrvatski zavod za javno zdravstvo,
Medicinski fakultet, Zagreb

Profili:

Avatar Url Ariana Znaor (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Ahrens, W.; Pohlabeln, H.; Foraita, R.; Nelis, M.; Lagiou, P.; Lagiou, A.; Bouchardy, C.; Slamova, A.; Schejbalova, M.; Merletti, F. et al.
Oral health, dental care and mouthwash associated with upper aerodigestive tract cancer risk in Europe: the ARCAGE study. // Oral Oncology, 50 (2014), 6; 616-625 doi:10.1016/j.oraloncology.2014.03.001 (međunarodna recenzija, članak, znanstveni)
Ahrens, W., Pohlabeln, H., Foraita, R., Nelis, M., Lagiou, P., Lagiou, A., Bouchardy, C., Slamova, A., Schejbalova, M. & Merletti, F. (2014) Oral health, dental care and mouthwash associated with upper aerodigestive tract cancer risk in Europe: the ARCAGE study.. Oral Oncology, 50 (6), 616-625 doi:10.1016/j.oraloncology.2014.03.001.
@article{article, author = {Ahrens, W. and Pohlabeln, H. and Foraita, R. and Nelis, M. and Lagiou, P. and Lagiou, A. and Bouchardy, C. and Slamova, A. and Schejbalova, M. and Merletti, F. and Richiardi, L. and Kjaerheim, K. and Agudo, A. and Castellsague, X. and Macfarlane, TV and Macfarlane, GJ and Lee, YC and Talamini, R. and Barzan, L. and Canova, C. and Simonato, L. and Thomson, P. and McKinney, PA and McMahon, AD and Znaor, Ariana and Healy, CM and McCartan, BE and Metspalu, A. and Marron, M. and Hashibe, M. and Conway, DI and Brennan, P.}, year = {2014}, pages = {616-625}, DOI = {10.1016/j.oraloncology.2014.03.001}, keywords = {Head and neck neoplasms, Oral health, Oral hygiene, Genetic polymorphisms}, journal = {Oral Oncology}, doi = {10.1016/j.oraloncology.2014.03.001}, volume = {50}, number = {6}, issn = {1368-8375}, title = {Oral health, dental care and mouthwash associated with upper aerodigestive tract cancer risk in Europe: the ARCAGE study.}, keyword = {Head and neck neoplasms, Oral health, Oral hygiene, Genetic polymorphisms} }
@article{article, author = {Ahrens, W. and Pohlabeln, H. and Foraita, R. and Nelis, M. and Lagiou, P. and Lagiou, A. and Bouchardy, C. and Slamova, A. and Schejbalova, M. and Merletti, F. and Richiardi, L. and Kjaerheim, K. and Agudo, A. and Castellsague, X. and Macfarlane, TV and Macfarlane, GJ and Lee, YC and Talamini, R. and Barzan, L. and Canova, C. and Simonato, L. and Thomson, P. and McKinney, PA and McMahon, AD and Znaor, Ariana and Healy, CM and McCartan, BE and Metspalu, A. and Marron, M. and Hashibe, M. and Conway, DI and Brennan, P.}, year = {2014}, pages = {616-625}, DOI = {10.1016/j.oraloncology.2014.03.001}, keywords = {Head and neck neoplasms, Oral health, Oral hygiene, Genetic polymorphisms}, journal = {Oral Oncology}, doi = {10.1016/j.oraloncology.2014.03.001}, volume = {50}, number = {6}, issn = {1368-8375}, title = {Oral health, dental care and mouthwash associated with upper aerodigestive tract cancer risk in Europe: the ARCAGE study.}, keyword = {Head and neck neoplasms, Oral health, Oral hygiene, Genetic polymorphisms} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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