Naslov
Shift in arachidonic acid metabolites production underlies cerebrovascular reactivity to changes in pO2 and hyperoxygenation

Autori
Drenjancevic, Ines ; Unfirer, Sanela ; Hegeduš, Ivana ; Mišir, Mihael

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
65th SIF National Congress / - , 2014, 72-72

ISBN
978-88-940105-0-3

Skup
65th SIF National Congress

Mjesto i datum
Anacapri, Italija, 28.09.2014. - 30.09.2014

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
arachidonic acid; 20-HETE; EETs; microcirculation

Sažetak
Arachidonic acid (AA) metabolites (prostaglandins, thromboxanes, 20-HETE and EETs) are significant mediators of cerebrovascular reactivity in responses to various stimuli, and primary mediators of vascular reactivity to changes in oxygen level. While direct stimulation by increased pO2 results in vasoconstriction, and hypoxia results in vasodilation in healthy tissues (except pulmonary), in conditions such as diabetes, hypertension and stroke it can result in paradoxical vascular responses. In addition, temporal conditioning by hyperoxygenation (HBO2) (by subsequently exposing organism to very high pO2) can significantly affect vascular relaxation mechanisms, including responses to changes in pO2 per se. For example, our recent studies on the effect of HBO2 in diabetic rats demonstrated restored vascular relaxation responses to reduced pO2 in hyperoxygenated rats as well as shift in AA metabolites production/sensitivity in these responses, which included metabolites of AA epoxygenation, EETs. Similar shift was observed in healthy rats undergoing HBO2. Diabetic rats had reduced brain infarct size after HBO2. Complementary to animal studies, we subjected stroke patients with/without diabetes to acute hyperoxygenation via facial mask which led to significant increase in mean blood flow velocity in correlation with decrease in thromoboxane A2 plasma levels in both groups, adding the evidence to importance of AA metabolites in cerebrovascular reactivity to O2.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA