Naslov
Application of carbon nanotubes in analysis of ropinirole

Autori
Sadiković, Mirela ; Nigović, Biljana ; Jurić, Sandra ; Mornar, Ana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
15th Ružička days Today science - tomorrow industry : book of abstracts / Šubarić, D. - Osijek : Prehrambeno tehnološki fakultet Sveučilišta Josipa Jurja Strossmayera u Osijeku ; Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2014, 110-110

ISBN
978-953-7005-34-4

Skup
Ružička days Today science - tomorrow industry (15 ; 2014)

Mjesto i datum
Vukovar, Hrvatska, 11.09.2014. - 12.09.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Ropinirole; Carbon nanotubes; Electrochemical sensor; Electroanalytical tecnique

Sažetak
Ropinirole (ROP) is a novel nonergoline dopamine agonist indicated for the treatment of early and advanced Parkinson's disease and also for the treatment of primary restless legs syndrom. Due to noticeable shortage of analytical methods for ROP determination, there is a constant demand for developing reliable methods to evaluate the quality of its pharmaceutical formulations and to quantify drug in biological samples. Electroanalytical tecniques are particularly suitable for quantification of many drugs. Since the discovery, carbon nanotubes (CNTs) have been attracted enormous attention for the preparation of electrochemical sensors due to their unique structure and extraordinary electronic properties. A remarkable enhancement effect on the electrochemical response has been observed after dispersing CNTs in Nafion, a perflourosulfonated polymer. A simple and sensitive sensor was developed and electrochemical behaviour of ROP was investigated on the multi-walled carbon nanotubes/Nafion composite film modified glassy carbon electrode (MWCNTs- Nafion/GCE). Under optimized conditions, the response peak currents had linear relationship with drug concentration in the range of 1.0 x 10-7 – 1.0 x 10-5 M. A new electroanalytical method with good precision and accuracy was developed for direct quantification of ROP in tablets. The results were satisfactory in comparison with those obtained using high- performance liquid chromatographic method.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

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