Pretraga

Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 717636

Glycans are a novel biomarker of chronological and biological age

Krištić, Jasminka; Vučković, Frano; Menni, Cristina; Klarić, Lucija; Keser, Toma; Beceheli, Ivona; Pučić-Baković, Maja; Novokmet, Mislav; Mangino, Massimo; Thaqi, Kujtim et al.
Glycans are a novel biomarker of chronological and biological age // Book of Abstracts of the Congress of the Croatian Society of Biochemistry and Molecular Biology "The Interplay of Biomolecules", HDBMB2014 / Katalinić, Maja ; Kovarnik, Zrinka (ur.).
Zagreb, Hrvatska; Zadar, Hrvatska: Hrvatsko Društvo za Biotehnologiju, 2014. str. 103-103 (poster, nije recenziran, sažetak, ostalo)

CROSBI ID: 717636 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Glycans are a novel biomarker of chronological and biological age

Autori
Krištić, Jasminka ; Vučković, Frano ; Menni, Cristina ; Klarić, Lucija ; Keser, Toma ; Beceheli, Ivona ; Pučić-Baković, Maja ; Novokmet, Mislav ; Mangino, Massimo ; Thaqi, Kujtim ; Rudan, Pavao ; Novokmet, Natalija ; Šarac, Jelena ; Missoni, Saša ; Kolčić, Ivana ; Polašek, Ozren ; Rudan, Igor ; Campbell, Harry ; Hayward, Caroline ; Aulchenko, Yurii ; Valdes, Ana ; Wilson, James F ; Gornik, Olga ; Primorac, Dragan ; Zoldoš, Vlatka ; Lauc, Gordan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Book of Abstracts of the Congress of the Croatian Society of Biochemistry and Molecular Biology "The Interplay of Biomolecules", HDBMB2014 / Katalinić, Maja ; Kovarnik, Zrinka - : Hrvatsko Društvo za Biotehnologiju, 2014, 103-103

ISBN
978-953-95551-5-1

Skup
The Interplay of Biomolecules, HDBMB2014

Mjesto i datum
Zagreb, Hrvatska; Zadar, Hrvatska, 24.09.2014. - 27.09.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Aging ; Glycome ; Glycosylation ; Immunoglobulin G ; Inflammation

Sažetak
Fine structural details of glycans attached to the conserved N-glycosylation site significantly affect function of individual IgG molecules, but also mediate inflammation at the systemic level. By analysing IgG glycosylation in 5117 individuals from four European populations we have revealed very complex patterns of changes of IgG glycosylation with age. Several IgG glycans (including FA2B, FA2G2, FA2BG2) changed considerably with age and the combination of these three glycans can explain up to 58% of variance in chronological age, significantly more than other markers of biological age like telomere lengths. The remaining variance in these glycans strongly correlated with physiological parameters associated with biological age. Thus IgG glycosylation appears to be closely linked with both chronological and biological age. Considering the important role of IgG glycans in inflammation, and since the observed changes with age promote inflammation, changes in IgG glycosylation also seem to represent a factor contributing to aging.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA

Profili:

Avatar Url Olga Gornik Kljaić (autor)

Avatar Url Vlatka Zoldoš (autor)

Avatar Url Igor Rudan (autor)

Avatar Url Jelena Šarac (autor)

Avatar Url Ivana Kolčić (autor)

Avatar Url Pavao Rudan (autor)

Avatar Url Dragan Primorac (autor)

Avatar Url Ivona Bečeheli (autor)

Avatar Url Jasminka Krištić (autor)

Avatar Url Ozren Polašek (autor)

Avatar Url Gordan Lauc (autor)

Avatar Url Mislav Novokmet (autor)

Avatar Url Toma Keser (autor)

Avatar Url Natalija Novokmet (autor)

Avatar Url Frano Vučković (autor)

Avatar Url Maja Pučić Baković (autor)

Avatar Url Saša Missoni (autor)

Citiraj ovu publikaciju:

Krištić, Jasminka; Vučković, Frano; Menni, Cristina; Klarić, Lucija; Keser, Toma; Beceheli, Ivona; Pučić-Baković, Maja; Novokmet, Mislav; Mangino, Massimo; Thaqi, Kujtim et al.
Glycans are a novel biomarker of chronological and biological age // Book of Abstracts of the Congress of the Croatian Society of Biochemistry and Molecular Biology "The Interplay of Biomolecules", HDBMB2014 / Katalinić, Maja ; Kovarnik, Zrinka (ur.).
Zagreb, Hrvatska; Zadar, Hrvatska: Hrvatsko Društvo za Biotehnologiju, 2014. str. 103-103 (poster, nije recenziran, sažetak, ostalo)
Krištić, J., Vučković, F., Menni, C., Klarić, L., Keser, T., Beceheli, I., Pučić-Baković, M., Novokmet, M., Mangino, M. & Thaqi, K. (2014) Glycans are a novel biomarker of chronological and biological age. U: Katalinić, M. & Kovarnik, Z. (ur.)Book of Abstracts of the Congress of the Croatian Society of Biochemistry and Molecular Biology "The Interplay of Biomolecules", HDBMB2014.
@article{article, author = {Kri\v{s}ti\'{c}, Jasminka and Vu\v{c}kovi\'{c}, Frano and Menni, Cristina and Klari\'{c}, Lucija and Keser, Toma and Beceheli, Ivona and Pu\v{c}i\'{c}-Bakovi\'{c}, Maja and Novokmet, Mislav and Mangino, Massimo and Thaqi, Kujtim and Rudan, Pavao and Novokmet, Natalija and \v{S}arac, Jelena and Missoni, Sa\v{s}a and Kol\v{c}i\'{c}, Ivana and Pola\v{s}ek, Ozren and Rudan, Igor and Campbell, Harry and Hayward, Caroline and Aulchenko, Yurii and Valdes, Ana and Wilson, James F and Gornik, Olga and Primorac, Dragan and Zoldo\v{s}, Vlatka and Lauc, Gordan}, year = {2014}, pages = {103-103}, keywords = {Aging, Glycome, Glycosylation, Immunoglobulin G, Inflammation}, isbn = {978-953-95551-5-1}, title = {Glycans are a novel biomarker of chronological and biological age}, keyword = {Aging, Glycome, Glycosylation, Immunoglobulin G, Inflammation}, publisher = {Hrvatsko Dru\v{s}tvo za Biotehnologiju}, publisherplace = {Zagreb, Hrvatska; Zadar, Hrvatska} }
@article{article, author = {Kri\v{s}ti\'{c}, Jasminka and Vu\v{c}kovi\'{c}, Frano and Menni, Cristina and Klari\'{c}, Lucija and Keser, Toma and Beceheli, Ivona and Pu\v{c}i\'{c}-Bakovi\'{c}, Maja and Novokmet, Mislav and Mangino, Massimo and Thaqi, Kujtim and Rudan, Pavao and Novokmet, Natalija and \v{S}arac, Jelena and Missoni, Sa\v{s}a and Kol\v{c}i\'{c}, Ivana and Pola\v{s}ek, Ozren and Rudan, Igor and Campbell, Harry and Hayward, Caroline and Aulchenko, Yurii and Valdes, Ana and Wilson, James F and Gornik, Olga and Primorac, Dragan and Zoldo\v{s}, Vlatka and Lauc, Gordan}, year = {2014}, pages = {103-103}, keywords = {Aging, Glycome, Glycosylation, Immunoglobulin G, Inflammation}, isbn = {978-953-95551-5-1}, title = {Glycans are a novel biomarker of chronological and biological age}, keyword = {Aging, Glycome, Glycosylation, Immunoglobulin G, Inflammation}, publisher = {Hrvatsko Dru\v{s}tvo za Biotehnologiju}, publisherplace = {Zagreb, Hrvatska; Zadar, Hrvatska} }

Podijeli:





Contrast
Increase Font
Decrease Font
Dyslexic Font
CROSBI koristi kolačiće (cookies) kako bi poboljšao funkcionalnost stranice.