Naslov
Dynein, microtubule and cargo: a ménage à trois

Autori
Pavin, Nenad ; Tolić‑Nørrelykke, Iva M.

Izvornik
Biochemical Society transactions (0300-5127) 41 (2013), 6; 1731-1735

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
cargo ; cortical anchor ; dynein ; microtubule ; motor protein ; targeting

Sažetak
To exert forces, motor proteins bind with one end to cytoskeletal filaments, such as microtubules and actin, and with the other end to the cell cortex, a vesicle or another motor. A general question is how motors search for sites in the cell where both motor ends can bind to their respective binding partners. In the present review, we focus on cytoplasmic dynein, which is required for a myriad of cellular functions in interphase, mitosis and meiosis, ranging from transport of organelles and functioning of the mitotic spindle to chromosome movements in meiotic prophase. We discuss how dynein targets sites where it can exert a pulling force on the microtubule to transport cargo inside the cell.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA