Naslov
High-dose-rate Brachytherapy and Concurrent Chemoradiotherapy Followed by Surgery for Stage Ib-IIb Cervical Cancer: Single Institution Experience

Autori
Frobe, Ana ; Jones, Glenn ; Bokulić, Tomislav ; Mrčela, Iva ; Budanec, Mirjana ; Murgić, Jure ; Jakšić, Blanka ; Prpić, Marin ; Bolanča, Ante ; Kusić, Zvonko

Izvornik
Anticancer research (0250-7005) 34 (2014), 7; 3861-3866

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cervical cancer; high dose rate brachytherapy; concomitant chemoradiotherapy; surgery

Sažetak
There are still controversies about the benefit of surgery after concurrent radiochemotherapy (CRT) for locally advanced cervical cancer. The aim of this study was to evaluate toxicity, local tumor control and overall survival of surgery after CRT in stage IB-IIB cervical cancer. Between 2002 and 2008, 24 patients with stage IB-IIB cervical cancer were treated with external-beam radiotherapy concomitantly with chemotherapy. High-dose rate brachytherapy fractions were given once weekly. Radical hysterectomy was undertaken after a median of 42 days. Overall survival at five years was estimated at 75% (95% confidence interval=52-88%) and sustained thereafter through to 8.9 years. No patient experienced local failure in the surgical bed. Postoperative complications were recorded in two patients. Surgery after CRT in stage IB-IIB cervical cancer is safe and leads to better local control of the disease and overall survival.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA