Naslov
Comparison of the Impact of Four Generations of Progestins on Hemostatic Variables

Autori
Oslaković, Sandra ; Zadro, Renata

Izvornik
Clinical and applied thrombosis/hemostasis (1076-0296) 20 (2014), 4; 448-455

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
blood coagulation factors; clinical pharmacology; gynecology and obstetrics

Sažetak
This study was undertaken to evaluate the impact of progestins as part of low-estrogen (ethinyl estradiol [EE2] 35 mg) combined oral contraceptives (COCs) on hemostatic variables. One hundred ninety-five healthy women took oral contraceptives with following formulations: 35 EE2/norgestimate (NGM), 35 EE2/cyproterone acetate, 35 EE2/norethisterone, 30 EE2/levonorgestrel, 30 EE2/drospirenone (DRSP), 20 EE2/gestodene, and 20 EE2/DRSP, for 6 months. Hemostatic assays (prothrombin time, activated partial thromboplastin time, fibrinogen, resistance to activated protein C ratio, protein C, protein S, factor VIII [FVIII], antithrombin, plasminogen, a2-antiplasmin, inhibitor of plasminogen activator type 1 [PAI-1] and D-dimers) were performed in 3 time points: at baseline, after 3, and 6 cycles. For each formulation, results were compared according to baseline values, intergroup analysis, and the amount of estrogen or progestin component. Most of the variables were changed except FVIII. Significant difference between oral contraceptives was found in antithrombin, protein C, protein S activities, and PAI-1 values, but changes were mostly within reference range.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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