Naslov
PRAĆENJE "SAMO-OKSIDACIJE" CISTEINA U PRISUTNOSTI Cu2+
(MONITORING OF "SELF-OXIDATION" OF CYSTEINE IN PRESENCE OF Cu2+ IN REAL-TIME)

Autori
Buzuk, Marijo ; Brinić, Slobodan ; Vladislavić, Nives ; Bralić, Marija ; Buljac, Maša

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
15th Ružička Days“TODAY SCIENCE - TOMORROW INDUSTRY” / Šubarić, Drago (ur.). - Osijek : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2014, 29-29

ISBN
978-953-6894-52-9

Skup
15th Ružička Days“TODAY SCIENCE - TOMORROW INDUSTRY”

Mjesto i datum
Vukovar, Hrvatska, 11.09.2014. - 12.09.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Oksidacija cisteina ; Cu-ISE ; EIS
(Oxidation of cysteine ; Cu-ISE ; EIS)

Sažetak
The thiol functional group of the amino acid cysteine is highly sensitive to redox state, mainly due to reactivity of anionic sulfur to various oxidized agents that can form multiple types of oxidized species and can perform a countless number of physiological functions. Copper is known to being the cofactor of enzymes involved in respiration processes or in removal of reactive oxygen species. Cooper ions influence on catalytic oxidation of biomolecules, thus on production of reactive oxygen species (ROS) and consequently on the level oxidative stress. Interactions of cysteine (thiols) with various transition metals have been received a considerable amount of attention, but available data are to contradictory or scarce to estimate the mechanism of the proposed reaction. These include dependence of the oxidation rate of thiol compounds on pH, inertness of thiol to oxygen in aqueous alkaline solution and oxidation of aminothiols in presence of various variable-valence metals [1-5]. In this work, a novel approach to investigation of a mechanism, kinetics and rate of oxidation of cysteine in real-time, with simple, low-cost and wide available commercial Cu-ISE, are presented. Behaviour and processes that take place near or at electrode surface are monitored and explained using electrochemical impedance spectroscopy (EIS).

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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