Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 715084

Synthesis and biological activity of novel 2, 5-diamino substituted benzimidazo[1, 2-a]quinolines


Perin, Nataša; Sović, Irena; Aleksić, Maja; Karminski-Zamola, Grace; Hranjec, Marijana; Martin-Kleiner, Irena; Kralj, Marijeta; Nhili, Raja; Laine, William; David-Cordonnier, Marie-Helene
Synthesis and biological activity of novel 2, 5-diamino substituted benzimidazo[1, 2-a]quinolines // EFMC International Symposium on Medicinal Chemistry, Book of Abstracts / Ortuzar, Natalia (ur.).
Weinheim: Wiley-VCH, 2014. str. 387-387 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 715084 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Synthesis and biological activity of novel 2, 5-diamino substituted benzimidazo[1, 2-a]quinolines

Autori
Perin, Nataša ; Sović, Irena ; Aleksić, Maja ; Karminski-Zamola, Grace ; Hranjec, Marijana ; Martin-Kleiner, Irena ; Kralj, Marijeta ; Nhili, Raja ; Laine, William ; David-Cordonnier, Marie-Helene

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
EFMC International Symposium on Medicinal Chemistry, Book of Abstracts / Ortuzar, Natalia - Weinheim : Wiley-VCH, 2014, 387-387

Skup
XXIII International Symposium on Medicinal Chemistry

Mjesto i datum
Lisabon, Portugal, 07.09.2014. - 11.09.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
benzimidazoles ; benzimidazo[1 ; 2-a]quinolines ; antiproliferative activity ; DNA binding ; topoisomerase I

Sažetak
Over the past few years substituted benzimidazoles, as a very important and fundamental building skeletons of various essential synthetic and natural pharmacological compounds, have been one of the most extensively studied classes of heterocycles compounds due to their well known biological activities. Because of the structural similarity with naturally occurring compounds such as purine, benzimidazole derivatives can easily interact with biomolecules of the living systems. High fluorescence intensity and possibility of interaction with important biomacromolecules of the living systems offer the potential use of azino fused benzimidazoles as fluorescent probes for detection of important molecules as DNA or different proteins in biomedical diagnostics. As a part of our continuing research in the field of medicinal chemistry, novel 2, 5-diamino substituted benzimidazo[1, 2-a]quinolines were synthesized by uncatalyzed microwave assisted amination. All compounds were characterized by 1H, 13C and NOESY NMR, UV/Vis and fluorimetric spectroscopy and mass spectrometry. Antitumor activity in vitro of prepared compounds was tested on breast, colon and lung carcinoma cell lines. All compounds showed differential activity towards all tested cell lines without the selectivity toward any cell line. To shed more light on the mechanisms of biological action, additional experiments regarded to DNA binding properties of most active compounds were performed.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
098-0982464-2514 - Uloga različitih mehanizama odgovora stanica na terapiju oštećenjem DNA (Kralj, Marijeta, MZOS ) ( CroRIS)
HRZZ-IP-2013-11-5596 - Sinteza i citostatska ispitivanja biblioteke novih dušikovih heterocikla (SCIENcENTRY) (Raić-Malić, Silvana, HRZZ - 2013-11) ( CroRIS)
125-0982464-1356 - Novi heterocikli kao antitumorski i antivirusni (pametni) lijekovi (Hranjec, Marijana, MZOS ) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada

Citiraj ovu publikaciju:

Perin, Nataša; Sović, Irena; Aleksić, Maja; Karminski-Zamola, Grace; Hranjec, Marijana; Martin-Kleiner, Irena; Kralj, Marijeta; Nhili, Raja; Laine, William; David-Cordonnier, Marie-Helene
Synthesis and biological activity of novel 2, 5-diamino substituted benzimidazo[1, 2-a]quinolines // EFMC International Symposium on Medicinal Chemistry, Book of Abstracts / Ortuzar, Natalia (ur.).
Weinheim: Wiley-VCH, 2014. str. 387-387 (poster, međunarodna recenzija, sažetak, znanstveni)
Perin, N., Sović, I., Aleksić, M., Karminski-Zamola, G., Hranjec, M., Martin-Kleiner, I., Kralj, M., Nhili, R., Laine, W. & David-Cordonnier, M. (2014) Synthesis and biological activity of novel 2, 5-diamino substituted benzimidazo[1, 2-a]quinolines. U: Ortuzar, N. (ur.)EFMC International Symposium on Medicinal Chemistry, Book of Abstracts.
@article{article, author = {Perin, Nata\v{s}a and Sovi\'{c}, Irena and Aleksi\'{c}, Maja and Karminski-Zamola, Grace and Hranjec, Marijana and Martin-Kleiner, Irena and Kralj, Marijeta and Nhili, Raja and Laine, William and David-Cordonnier, Marie-Helene}, editor = {Ortuzar, N.}, year = {2014}, pages = {387-387}, keywords = {benzimidazoles, benzimidazo[1, 2-a]quinolines, antiproliferative activity, DNA binding, topoisomerase I}, title = {Synthesis and biological activity of novel 2, 5-diamino substituted benzimidazo[1, 2-a]quinolines}, keyword = {benzimidazoles, benzimidazo[1, 2-a]quinolines, antiproliferative activity, DNA binding, topoisomerase I}, publisher = {Wiley-VCH}, publisherplace = {Lisabon, Portugal} }
@article{article, author = {Perin, Nata\v{s}a and Sovi\'{c}, Irena and Aleksi\'{c}, Maja and Karminski-Zamola, Grace and Hranjec, Marijana and Martin-Kleiner, Irena and Kralj, Marijeta and Nhili, Raja and Laine, William and David-Cordonnier, Marie-Helene}, editor = {Ortuzar, N.}, year = {2014}, pages = {387-387}, keywords = {benzimidazoles, benzimidazo[1, 2-a]quinolines, antiproliferative activity, DNA binding, topoisomerase I}, title = {Synthesis and biological activity of novel 2, 5-diamino substituted benzimidazo[1, 2-a]quinolines}, keyword = {benzimidazoles, benzimidazo[1, 2-a]quinolines, antiproliferative activity, DNA binding, topoisomerase I}, publisher = {Wiley-VCH}, publisherplace = {Lisabon, Portugal} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





Contrast
Increase Font
Decrease Font
Dyslexic Font