Naslov
Novel material for medical use based on Ag-zeolite/polyvinyl chloride composite

Autori
Milenković, Јelena ; Rajić, Nevenka ; Hrenović, Jasna ; Goić-Barišić, Ivana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Porous Systems: From Novel Materials to Sustainable Solutions / Krager, Jorg - Leipzig : Universitat Leipzig, 2014, 688-688

Skup
6th International FEZA Conference

Mjesto i datum
Leipzig, Njemačka, 08.09.2014. - 11.09.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
antibacterial activity; bacteria; biofilm; endotracheal tube; public health

Sažetak
Introduction Polyvinil chloride (PVC), frequently used in endotracheal tubes, usually acts as a reservoir for bacteria causing nosocomial infections with a high level of mortality. This work investigated the antibacterial activity of Ag-exchanged clinoptilolite/PVC composites (AgZ/PVC) toward clinical isolate of Acinetobacter baumannii. Experimental AgZ containing 44 mg Ag/g was added in a solution of PVC (1 g) in tetrahydrofuran (20 cm3) at different percentages (0, 5, 10 and 15 wt. %). The mixtures were left to dryness in a vacuum dryer and the obtained films were divided in two series: Tyr – the composites (AgZ/PVC) coated by D-Tyrosine and NTyr – uncoated. As a control PVC film without AgZ was used. Antibacterial activity of the composites were tested against clinical isolate of A. baumannii ST 145. Results and Conclusions For the both series of composites AgZ amount did not influence the number of immobilized cells of A. baumannii onto the composites. The percent of reduction of immobilized bacteria (in comparison to control) depends of the composite coating: 100% reduction was found for the Tyr series indicates its bactericidal effect towards A. baumannii whereas for NTyr the reduction was about 70%. The reduction of planktonic bacteria increases with the increase of AgZ in NTyr: 63% for composite with 5 wt.% of AgZ and 74% for composite with 15 wt.%. For the Tyr the reduction of planktonic bacteria does not change significantly with AgZ content (being about 65%). The results indicate that the AgZ/PVC coated by D-Tyrosine is a promising novel material for further clinical investigation and medical applications.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija

POVEZANOST RADA