Pregled bibliografske jedinice broj: 714559
Axon extension occurs independently of centrosomal microtubule nucleation
Axon extension occurs independently of centrosomal microtubule nucleation // Science, 327 (2010), 5966; 704-707 doi:10.1126/science.1182179 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 714559 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Axon extension occurs independently of centrosomal
microtubule nucleation
Autori
Stiess, Michael ; Maghelli, Nicola ; Kapitein, Lukas C. ; Gomis-Rüth, Susana ; Wilsch-Bräuninger, Michaela ; Hoogenraad, Casper C. ; Tolić- Nørrelykke, Iva M. ; Bradke, Frank
Izvornik
Science (0036-8075) 327
(2010), 5966;
704-707
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
centrosome ; axon ; neuron ; microtubules ; laser ablation
Sažetak
Microtubules are polymeric protein structures and components of the cytoskeleton. Their dynamic polymerization is important for diverse cellular functions. The centrosome is the classical site of microtubule nucleation and is thought to be essential for axon growth and neuronal differentiation-- processes that require microtubule assembly. We found that the centrosome loses its function as a microtubule organizing center during development of rodent hippocampal neurons. Axons still extended and regenerated through acentrosomal microtubule nucleation, and axons continued to grow after laser ablation of the centrosome in early neuronal development. Thus, decentralized microtubule assembly enables axon extension and regeneration, and, after axon initiation, acentrosomal microtubule nucleation arranges the cytoskeleton, which is the source of the sophisticated morphology of neurons.
Izvorni jezik
Engleski
Znanstvena područja
Biologija
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
