Naslov
BMPs and their antagonists in development and growth of human knee joint osteophytes

Autori
Zoričić Cvek, Sanja ; Đudarić, Luka ; , Cvijanović, Olga ; Marić, Ivana ; Šestan, Branko ; Šantić, Veljko ; Pilipović, Kristina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
6th International Symposium of Clinical and Applied Anatomy : abstracts ; u: Revista Argentina de Anatomía Clínica 6 (2014) (2) / Biasutto, Susana - Cordoba : Asociación Argentina de Anatomía Clínica, 2014, 134-135

Skup
International Symposium of Clinical and Applied Anatomy (6 ; 2014)

Mjesto i datum
Krk, Hrvatska; Rijeka, Hrvatska, 26.06.2014. - 29.06.2014

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
BMP; BMP antagonists; osteophyte

Sažetak
The osteophytes are bone spurs overgrowing the edge of the articular cartilage during the course of osteoarthritis (OA). Although the cellular mechanism of their development and growth is revealed and resemblin normal bone development, there is still debate concerning molecular mechanism of their growth. Since the role of bone morphogenetic proteins family members (BMPs) in bone development is well established and documented, the members of the BMPs as an important member of the local grpwth factor network and their extracellular inhibitors were recognized as an important factors that could modulate, even cease development and growth of osteophytes. The aim of our study was to analyse expression and localization of the most potent osteoinductive BMP-2, -4 and -7, and their extracellular inhibitors gremlin, chordin, follisatin and noggin. The study was performed on tissue collection of 25 osteophytes collected during total knee joint replacement surgery due to severe OA, and on 10 samples of normal knee joint tissues from individuals undergoing autopsy. The expression of molecular factors was analysed using immunohistochemistry and Western blot analysis. Our result demonstrate the significant differences in BMPs and their antagonists expression between normal and OA affected joint tissue and suggest the potent role of these molecular factors in pathogenesis and / or mechanism of growth and development of human knee joint osteophytes.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

Napomena
Sažetak ovog kongresnog priopćenja objavljen je u Knjizi sažetaka ; Zoričić Cvek, Sanja (ur.) ; Rijeka, 2014 ; str. 14-14.

POVEZANOST RADA