Naslov
Determination of elemental impurities in active pharmaceuticals by single ICP-MS run after prior stabilisation of osmium

Autori
Bešić, Denis ; Raič, Irena ; Meštrović, Ernest ; Rončević, Sanda

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
20th International Mass Spectrometry Conference Program / - Ženeva, 2014, 111-111

Skup
IMSC 2014 20th International Mass Spectrometry Conference Program

Mjesto i datum
Ženeva, Švicarska, 24.08.2014. - 29.08.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
ICP-MS; Elemental impurities; osmium

Sažetak
The aim of this study is to develop method for the analysis of elemental impurities (Li, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Mo, Ru, Rh, Pd, Ag, Cd, Sn, Sb, Ba, Os, Ir, Pt, Au, Hg, Tl and Pb) in active pharmaceutical substances. Pharmaceutical active substance is considered to be a pharmaceutically active ingredient (API) or excipient. Elements which are covered by this method are typically used as process catalysts or reagents during the synthesis of pharmaceuticals but also we can find them in manufacturing equipment and piping, cleaning solvents and packaging. Their use can lead to residues in the final pharmaceutical active ingredients, and thus in the final product - a drug. Analysis of elemental impurities is performed at every stage of production process of API, including the analysis of intermediates and starting materials.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA