Naslov
Preparation and application of sulfaguanidine-imprinted polymer on solid-phase extraction of pharmaceuticals from water

Autori
Mutavdžić Pavlović, Dragana ; Nikšić, Korana ; Livazović, Sara ; Brnardić, Ivan ; Anžlovar, Alojz

Izvornik
Talanta (0039-9140) 131 (2015); 99-107

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
sulfaguanidine ; molecularly imprinted polymers ; pharmaceuticals ; production wastewater

Sažetak
The molecularly imprinted polymers (MIPs) with sulfaguanidine as a template, methacrylic acid, 4- vinylpyridine, and 2-hydroxyethyl methacrylate as a functional monomers, ethylene glycol dimethacrylate as a cross-linker and 2, 2´- azobis-isobutyronitrile as an initiator have been prepared through the cross-link reaction of polymerization. Solid-phase extraction (SPE) procedure for the extraction of sulfaguanidine from water samples using the prepared MIPs and non-imprinted (NIPs) was evaluated. The best MIP in combination with commercial sorbents was applied for simultaneous extraction of eight pharmaceuticals. New SPE cartridges were prepared by combination of optimal produced MIP and Oasis HLB in 6 mL of polypropilene SPE reservoir. Developed method which includes new SPE cartridge (MIPMAA-Oasis HLB, 400 mg/ 6 mL) and thin-layer chromatography was validated. The method provides a linear response over the concentration range of 0.5-150 μg/L, depending on the pharmaceutical with the correlation coefficients > 0.9843 in all cases except for norfloxacin (0.9770) and penicillin G procaine (0.9801). Also, the method has revealed low limits of detection (0.25–20 μg/L), good precision (intra and inter-day), a relative standard deviation below 15% and recoveries above 95% for all eight pharmaceuticals. The developed method by using newly prepared SPE cartridge has been successfully applied to the analysis of production wastewater samples from pharmaceutical industry.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Kemijsko inženjerstvo, Temeljne tehničke znanosti

Napomena
Glavni autori: Dragana Mutavdžić Pavlović

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