Pregled bibliografske jedinice broj: 712216
Human Hair Follicle: An Update on Biology and Perspectives in Hair Growth Disorders Treatment
Human Hair Follicle: An Update on Biology and Perspectives in Hair Growth Disorders Treatment // Hair therapy & transplantation, 4 (2014), 3-6 doi:10.4172/2167-0951.1000115 (podatak o recenziji nije dostupan, članak, stručni)
CROSBI ID: 712216 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Human Hair Follicle: An Update on Biology and Perspectives in Hair Growth Disorders Treatment
Autori
Brajac, Ines ; Vičić, Marijana ; Periša, Darinka ; Kaštelan, Marija
Izvornik
Hair therapy & transplantation (2167-0951) 4
(2014);
3-6
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni
Ključne riječi
Hair disorders; Hair follicle; Hair cycle; Alopecia areata
Sažetak
The Hair Follicle (HF) is a vital component of mammalian skin and represents a unique, highly regenerative system that undergoes phases of rapid growth, regression, and resting periods. The hair cycling is of profound clinical relevance since majority of the hair growth disorders occur as a result of cycle changes. The influence of many molecules governing the formation of HF has been investigated and many of important cycle mediators have been identified. Cellular and molecular events during cycling are controlled by a network of sequential activation of autocrine, paracrine and endocrine signaling pathways. This implies variations in the expression or activity of the Wnt family molecules, Fibroblast Growth Factor (FGF), Transforming Growth Factor β (TGF-β), Hedgehog pathway, β-Catenin pathway, noggin, transcription factor Stat3, Epidermal Growth Factor (EGF), Insulin Growth Factor-1 (IGF- 1), Vascular Endothelial Growth Factor (VEGF), Thyrotropin Releasing Hormone (TRH), Polyamine, Spermidine, Neurotrophins (NT3, NT4), prolactin, retinoids, Bone Morphogenetic Protein 4 (BMP4), cathepsin L, 17-β estradiol, dihydrotestosterone and many others. Despite considerable progress in this area, the key elements of cycle control have not been identified. Therefore, for the most common hair disorders several agents are available, even none of these is curative or preventive. The one of the prime challenges of hair research is a better understanding of the molecular controls of hair cycling and developing drug which would effectively manipulate the cycle. Future therapy strategies will be based on new and better knowledge about the HF biology. Until than, alopecia areata, telogen effluvium and androgenetic alopecia, will remain unsolved medical problems.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
062-0620239-0197 - Imunološki mehanizmi u patogenezi psorijaze (Kaštelan, Marija, MZOS ) ( CroRIS)
062-0620239-0199 - Uloga neurogene upale i psihičkih čimbenika u patogenezi psorijaze (Brajac, Ines, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka