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Pregled bibliografske jedinice broj: 711534

The rational use of animal models in the evaluation of novel bone regenerative therapies

Perić, Mihaela; Dumić-Čule, Ivo; Grčević, Danka; Matijašić, Mario; Verbanac, Donatella; Paul, Ruth; Grgurević, Lovorka; Trkulja, Vladimir; Bagi, Cedo M; Vukicevic, Slobodan
The rational use of animal models in the evaluation of novel bone regenerative therapies // Bone (New York, N.Y.), 70 (2015), 73-86 doi:10.1016/j.bone.2014.07.010 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 711534 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The rational use of animal models in the evaluation of novel bone regenerative therapies

Autori
Perić, Mihaela ; Dumić-Čule, Ivo ; Grčević, Danka ; Matijašić, Mario ; Verbanac, Donatella ; Paul, Ruth ; Grgurević, Lovorka ; Trkulja, Vladimir ; Bagi, Cedo M ; Vukicevic, Slobodan

Izvornik
Bone (New York, N.Y.) (8756-3282) 70 (2015); 73-86

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
bone fracture; bone healing; animal model; regenerative therapy; tools for scoring; healing parameters
(bone fracture; bBone healing; animal model; regenerative therapy; tools for scoring; healing parameters)

Sažetak
Bone has a high potential for endogenous self-repair. However, due to population aging, human diseases with impaired bone regeneration are on the rise. Current strategies to facilitate bone healing include various biomolecules, cellular therapies, biomaterials and different combinations of these. Animal models for testing novel regenerative therapies remain the gold standard in pre-clinical phases of drug discovery and development. Despite improvements in animal experimentation, excessive poorly designed animal studies with inappropriate endpoints and inaccurate conclusions are being conducted. In this review, we discuss animal models, procedures, methods and technologies used in bone repair studies with the aim to assist investigators in planning and performing scientifically sound experiments that respect the wellbeing of animals. In the process of designing an animal study for bone repair investigators should consider: skeletal characteristics of the selected animal species ; a suitable animal model that mimics the intended clinical indication ; an appropriate assessment plan with validated methods, markers, timing, endpoints and scoring systems ; relevant dosing and statistically pre-justified sample sizes and evaluation methods ; synchronization of the study with regulatory requirements and additional evaluations specific to cell-based approaches.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
108-1080229-0142 - Molekularni mehanizmi učinaka imunosnih poremećaja na kost (Grčević, Danka, MZOS ) ( CroRIS)
108-1080327-0320 - Uloga TSH u modelu osteoporoze i u bolesnica sa smanjenom koštanom masom (Vukičević, Slobodan, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Donatella Verbanac (autor)

Avatar Url Danka Grčević (autor)

Avatar Url Slobodan Vukičević (autor)

Avatar Url Mihaela Perić (autor)

Avatar Url Mario Matijašić (autor)

Avatar Url Ivo Dumić-Čule (autor)

Avatar Url Lovorka Grgurević (autor)

Avatar Url Vladimir Trkulja (autor)

Poveznice na cjeloviti tekst rada:

doi www.ncbi.nlm.nih.gov

Citiraj ovu publikaciju:

Perić, Mihaela; Dumić-Čule, Ivo; Grčević, Danka; Matijašić, Mario; Verbanac, Donatella; Paul, Ruth; Grgurević, Lovorka; Trkulja, Vladimir; Bagi, Cedo M; Vukicevic, Slobodan
The rational use of animal models in the evaluation of novel bone regenerative therapies // Bone (New York, N.Y.), 70 (2015), 73-86 doi:10.1016/j.bone.2014.07.010 (međunarodna recenzija, članak, znanstveni)
Perić, M., Dumić-Čule, I., Grčević, D., Matijašić, M., Verbanac, D., Paul, R., Grgurević, L., Trkulja, V., Bagi, C. & Vukicevic, S. (2015) The rational use of animal models in the evaluation of novel bone regenerative therapies. Bone (New York, N.Y.), 70, 73-86 doi:10.1016/j.bone.2014.07.010.
@article{article, author = {Peri\'{c}, Mihaela and Dumi\'{c}-\v{C}ule, Ivo and Gr\v{c}evi\'{c}, Danka and Matija\v{s}i\'{c}, Mario and Verbanac, Donatella and Paul, Ruth and Grgurevi\'{c}, Lovorka and Trkulja, Vladimir and Bagi, Cedo M and Vukicevic, Slobodan}, year = {2015}, pages = {73-86}, DOI = {10.1016/j.bone.2014.07.010}, keywords = {bone fracture, bone healing, animal model, regenerative therapy, tools for scoring, healing parameters}, journal = {Bone (New York, N.Y.)}, doi = {10.1016/j.bone.2014.07.010}, volume = {70}, issn = {8756-3282}, title = {The rational use of animal models in the evaluation of novel bone regenerative therapies}, keyword = {bone fracture, bone healing, animal model, regenerative therapy, tools for scoring, healing parameters} }
@article{article, author = {Peri\'{c}, Mihaela and Dumi\'{c}-\v{C}ule, Ivo and Gr\v{c}evi\'{c}, Danka and Matija\v{s}i\'{c}, Mario and Verbanac, Donatella and Paul, Ruth and Grgurevi\'{c}, Lovorka and Trkulja, Vladimir and Bagi, Cedo M and Vukicevic, Slobodan}, year = {2015}, pages = {73-86}, DOI = {10.1016/j.bone.2014.07.010}, keywords = {bone fracture, bBone healing, animal model, regenerative therapy, tools for scoring, healing parameters}, journal = {Bone (New York, N.Y.)}, doi = {10.1016/j.bone.2014.07.010}, volume = {70}, issn = {8756-3282}, title = {The rational use of animal models in the evaluation of novel bone regenerative therapies}, keyword = {bone fracture, bBone healing, animal model, regenerative therapy, tools for scoring, healing parameters} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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