Pretraga

Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 711035

Hepatoprotective effects of met-enkephalin on acetaminophen-induced liver lesions in male CBA mice

Martinić, Roko; Šošić, Hrvoje; Turčić, Petra; Konjevoda, Paško; Fučić, Aleksandra; Stojković, Ranko; Aralica, Gorana; Gabričević, Mario; Weitner, Tin; Štambuk, Nikola
Hepatoprotective effects of met-enkephalin on acetaminophen-induced liver lesions in male CBA mice // Molecules, 19 (2014), 8; 11833-11845 doi:10.3390/molecules190811833 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 711035 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Hepatoprotective effects of met-enkephalin on acetaminophen-induced liver lesions in male CBA mice

Autori
Martinić, Roko ; Šošić, Hrvoje ; Turčić, Petra ; Konjevoda, Paško ; Fučić, Aleksandra ; Stojković, Ranko ; Aralica, Gorana ; Gabričević, Mario ; Weitner, Tin ; Štambuk, Nikola

Izvornik
Molecules (1420-3049) 19 (2014), 8; 11833-11845

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
met-enkephalin; hepatoprotection; genotoxicity; antisense peptide; binding; spectroscopy

Sažetak
Recent histopathological investigations in patients with hepatitis suggested possible involvement of Met-enkephalin and its receptors in the pathophysiology of hepatitis. Consequently, we evaluated the potential hepatoprotective effects of this endogenous opioid pentapeptide in the experimental model of acetaminophen induced hepatotoxicity in male CBA mice. Met-enkephalin exhibited strong hepatoprotective effects in a dose of 7.5 mg/kg, which corresponds to the protective dose reported for several different animal disease models. In this group plasma alanine aminotransferase and aspartate aminotransferase enzyme activities, as well as liver necrosis score were significantly reduced in comparison to control animals treated with physiological saline (p > 0.01). The specificity of the peptide hepatoprotection was investigated from the standpoint of the receptor and peptide blockade. It was concluded that Met-enkephalin effects on the liver were mediated via δ and ζ opioid receptors. Genotoxic testing of Met- enkephalin confirmed the safety of the peptide.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA

Projekti:
098-0982929-2524 - Modeliranje bioaktivnih molekula i ispitivanje njihovih svojstava i učinka (Štambuk, Nikola, MZOS ) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
KBC Split,
Klinička bolnica "Dubrava",
Klinički bolnički centar Zagreb

Profili:

Avatar Url Roko Martinić (autor)

Avatar Url Aleksandra Fučić (autor)

Avatar Url Petra Turčić (autor)

Avatar Url Nikola Štambuk (autor)

Avatar Url Tin Weitner (autor)

Avatar Url Paško Konjevoda (autor)

Avatar Url Mario Gabričević (autor)

Avatar Url Gorana Aralica (autor)

Avatar Url Ranko Stojković (autor)

Avatar Url Hrvoje Šošić (autor)

Poveznice na cjeloviti tekst rada:

doi fulir.irb.hr www.mdpi.com

Citiraj ovu publikaciju:

Martinić, Roko; Šošić, Hrvoje; Turčić, Petra; Konjevoda, Paško; Fučić, Aleksandra; Stojković, Ranko; Aralica, Gorana; Gabričević, Mario; Weitner, Tin; Štambuk, Nikola
Hepatoprotective effects of met-enkephalin on acetaminophen-induced liver lesions in male CBA mice // Molecules, 19 (2014), 8; 11833-11845 doi:10.3390/molecules190811833 (međunarodna recenzija, članak, znanstveni)
Martinić, R., Šošić, H., Turčić, P., Konjevoda, P., Fučić, A., Stojković, R., Aralica, G., Gabričević, M., Weitner, T. & Štambuk, N. (2014) Hepatoprotective effects of met-enkephalin on acetaminophen-induced liver lesions in male CBA mice. Molecules, 19 (8), 11833-11845 doi:10.3390/molecules190811833.
@article{article, author = {Martini\'{c}, Roko and \v{S}o\v{s}i\'{c}, Hrvoje and Tur\v{c}i\'{c}, Petra and Konjevoda, Pa\v{s}ko and Fu\v{c}i\'{c}, Aleksandra and Stojkovi\'{c}, Ranko and Aralica, Gorana and Gabri\v{c}evi\'{c}, Mario and Weitner, Tin and \v{S}tambuk, Nikola}, year = {2014}, pages = {11833-11845}, DOI = {10.3390/molecules190811833}, keywords = {met-enkephalin, hepatoprotection, genotoxicity, antisense peptide, binding, spectroscopy}, journal = {Molecules}, doi = {10.3390/molecules190811833}, volume = {19}, number = {8}, issn = {1420-3049}, title = {Hepatoprotective effects of met-enkephalin on acetaminophen-induced liver lesions in male CBA mice}, keyword = {met-enkephalin, hepatoprotection, genotoxicity, antisense peptide, binding, spectroscopy} }
@article{article, author = {Martini\'{c}, Roko and \v{S}o\v{s}i\'{c}, Hrvoje and Tur\v{c}i\'{c}, Petra and Konjevoda, Pa\v{s}ko and Fu\v{c}i\'{c}, Aleksandra and Stojkovi\'{c}, Ranko and Aralica, Gorana and Gabri\v{c}evi\'{c}, Mario and Weitner, Tin and \v{S}tambuk, Nikola}, year = {2014}, pages = {11833-11845}, DOI = {10.3390/molecules190811833}, keywords = {met-enkephalin, hepatoprotection, genotoxicity, antisense peptide, binding, spectroscopy}, journal = {Molecules}, doi = {10.3390/molecules190811833}, volume = {19}, number = {8}, issn = {1420-3049}, title = {Hepatoprotective effects of met-enkephalin on acetaminophen-induced liver lesions in male CBA mice}, keyword = {met-enkephalin, hepatoprotection, genotoxicity, antisense peptide, binding, spectroscopy} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

Citati:

    Altmetrijski pokazatelji:


    Podijeli:





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font
    CROSBI koristi kolačiće (cookies) kako bi poboljšao funkcionalnost stranice.