Naslov
Peptidomimetics derived from ferrocene mono- and diamines

Autori
Kovačević, Monika ; Čakić Semenčić, Mojca ; Kodrin, Ivan ; Roca, Sunčica ; Meden, Anton ; Barišić, Lidija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
7th International Symposium on Bioorganometallic Chemistry / Keppler, Bernhard ; Hartinger, Christian ; Kandioller, Wolfgang - Beč, 2014, P02-P02

Skup
7th International Symposium on Bioorganometallic Chemistry

Mjesto i datum
Beč, Austrija, 22.07.2014. - 25.07.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Ferrocene ; Proline ; Peptidomimetic ; Intramolecular hydrogen bond ; Conformational analysis

Sažetak
Ferrocene-peptide conjugates present useful and efficient bioorganometallic constraint designed to induce chirally organized structures through intramolecular hydrogen bonding as a prerequisite for 3D structure formation and function of biological systems. As opposed to well-documented peptides derived from ferrocene-1, 1’-dicarboxylic acid (Fcda) and 1’-aminoferrocene-1-carboxylic acid (Fca) [1], only two representatives of peptides I derived from ferrocene-1, 1’-diamine were reported [2]. We have established a facile and efficient synthetic route for preparation of peptides I which does not include unstable Fcda synthon. Recently, we have showed that introduction of minimum-sized peptide chain on aminoferrocene II led to the formation of a β-turn-like structure originating from intrachain hydrogen- bonding. Herein, we present the synthesis of peptides I and II bearing homo- and heterochiral Ala-Pro sequences followed by extensive studies of their conformational preferences in solution as well as in solid state.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA