Naslov
CD44 correlates with MMP-9 in prostate carcinoma

Autori
Đorđević, Gordana ; Štifter, Sanja ; Hadžisejdić, Ita ; Mozetič, Vladimir ; Oguić, Romano ; Mustać, Elvira

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
25th European Congress of Pathology, u Virchows Archiv / - : Springer, 2013

Skup
25th European Congress of Pathology

Mjesto i datum
Lisabon, Portugal, 31.08.2013. - 04.09.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
CD44; prostate cancer; prognosis

Sažetak
Objectives: CD 44 is the adhesion molecule shown to be a useful prognostic marker of aggressive prostate cancer. Also, CD44s accumulates metalloproteinase-9 (MMP-9) on the cell membrane which allows angiogenesis and invasion. The aim of this study was to investigate the expression of CD44 in prostate cancer specimens obtained by prostatectomy and to correlate it with MMP-9 expression. Methods:Tissue microarrays (TMA) of 120 archival, formalin fixed paraffin embedded prostate carcinoma were immunohistochemically evaluated for CD44s and MMP-9 expression Results: Median CD44 expression was 52.1713 ( SD±48.6701) with non significant correlation with clinicopathological parameters, stage, margin status or reccurence free survival. CD44 molecule shows loss of expression in tumor cells, discontinuous membrane staining and focal irregular distribution in tumors with higher Gleason score. CD44 and MMP9 showed inverse correlation (p=0.0198). Conclusion: Our results showed loss of expression of CD44 in poorly differentiated tumors, while correlation with MMP9 needs further evaluation.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA