Naslov
Decreased platelet serotonin concentration in Alzheimer’s disease with involuntary emotional expression disorder

Autori
Prokšelj, Tatjana ; Jerin, Aleš ; Muck-Šeler, Dorotea ; Kogoj, Aleš

Izvornik
Neuroscience letters (0304-3940) 578 (2014); 71-74

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Alzheimer's disease ; affective symptoms ; aaggression ; blood platelets ; emotional disturbances ; serotonin

Sažetak
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder manifested by progressive decline in cognitive functions. A variety of behavioral disturbances appear very often in AD which might be associated with altered function of serotoninergic system. The aim of the study was to determine platelet serotonin (5-HT) concentrations in 49 patients with AD (NINCDS-ADRDA and DSM-IV-TR criteria) sub-divided in three groups: (a) patients with aggressive behavior, (b) patients with involuntary emotional expression disorder (IEED) and (c) patients without aggression or IEED (controls). Platelet 5-HT concentrations were measured using ELISA. Platelet 5-HT concentrations were significantly lower in patients with AD and co-existing IEED compared to AD patients with aggressive behavior or control patients. No significant difference in platelet 5-HT concentrations was found between patients expressing aggressive behavior and controls. Our results suggest disruptions in serotoninergic system in AD patients with comorbid IEED but not with aggressive behavior and support the presumption that platelet 5-HT concentration is a suitable and easy measured peripheral indicator of some behavioral and psychological symptoms of AD.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA