Naslov
Human mycotoxicoses caused by aflatoxins, ochratoxin A, fumonisin B1 and zearalenone

Autori
Peraica, Maja ; Rašić, Dubravka ; Glluščić, Valentina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
11th Serbian Congress of Toxicology "New frontiers and challenges in toxicology" / Matović, Vesna - Beograd : Serbian Society of Toxicology, 2014, 161-161

ISBN
978-86-917867-0-0

Skup
11th Serbian Congress of Toxicology

Mjesto i datum
Sremski Karlovci, Srbija, 24.06.2014. - 27.06.2014

Vrsta sudjelovanja
Plenarno

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
aflatoxin; aflatoxicosis; ochratoxin A; ochratoxicosis; fumonisin B1; zearalenone

Sažetak
Mycotoxicoses are acute and chronic diseases caused by exposure to mould toxins that contaminate food and feed across the world. In Croatia and other temperate zone countries, the most frequently found mycotoxins of toxicological concern are aflatoxins B1 and B2 (AFB1, AFB2), ochratoxin A (OTA), fumonisin B1 (FB1), and zearalenone (ZEA). Symptoms of a single mycotoxicosis depend on the intrinsic toxicological features of mycotoxins, such as toxicokinetics and target organs of toxicity that show high variability. For instance, the target organ of AFB1 and AFB2 is the liver and aflatoxins cause acute or chronic liver injury ; OTA is nephrotoxic and a possible causative agent of Balkan Endemic Nephropathy (BEN) ; FB1 impedes the closure of neural tubes during embryonic development causing brain and spinal cord malformations ; whereas ZEA interacts with estrogen receptors disturbing the reproductive system. The severity of symptoms depends on the dose and length of exposure. Acute mycotoxicoses, which result from exposure to high doses of mycotoxins, are yet to be recorded in Croatia, while chronic mycotoxicoses have been suspected of occurring. Among mycotoxins, only aflatoxins have been proven to be carcinogenic (cause primary liver carcinoma), while OTA and FB1 are carcinogen in experimental animals but have not been shown to present a threat to humans. However, OTA is suspected to be the causative agent of very frequent urinary tract tumors in the BEN-region, and FB1 to be the causative agent of esophageal tumors in some regions of Africa and Italy as well as the primary liver carcinoma in China.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

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