Naslov
Clinical features and therapeutic outcomes of patients with acromegaly: single-center experience

Autori
Dušek, Tina ; Kaštelan, Darko ; Melada, Ante ; Baretić, Maja ; Škorić Polovina, Tanja ; Perković, Zdravko ; Giljević, Zlatko ; Jelčić, Jozo ; Paladino, Josip ; Aganović, Izet ; Koršić, Mirko

Izvornik
Journal of endocrinological investigation (0391-4097) 34 (2011), 11; 382-385

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
acromegaly ; acromegaly treatment ; pituitary adenoma ; transsphenoidal surgery

Sažetak
The aim of this study was to review the outcome of acromegaly treatment, as well as co-morbidity and mortality in a series of patients with acromegaly attending a single center in the last 10 yr. In that period, 53 patients were treated for acromegaly. Transsphenoidal operation was applied as the first-line therapy in 94.3% of patients and it led to disease remission in 59.2% of them. The remission criteria included a nadir GH<1 μg/l after glucose load, and normal age-related IGF-I levels. The remission rate after transsphenoidal surgery was significantly higher in the group of patients with microadenoma (76.9%), than in the group of patients with macroadenoma (52.8%). Patients with invasive tumors had remission rate of 16.7% after transsphenoidal surgery. There were no perioperative deaths. As the second-line treatment somatostatin analogues, radiotherapy, and dopaminergic agonists were used. Hypertension and diabetes were the most frequent co-morbidities in the group of patients. After successful treatment, 30% of patients with diabetes or impaired glucose tolerance had significant improvement of glycemic control. Transsphenoidal surgery is the appropriate firstline therapy in patients with somatotropinoma. Medical and radio-therapy should be reserved as the second-line therapy after surgery failure.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA