Pregled bibliografske jedinice broj: 704305
Enzyme-catalyzed cascade synthesis of hydroxyiminoacetamides
Enzyme-catalyzed cascade synthesis of hydroxyiminoacetamides // Tetrahedron letters, 55 (2014), 31; 4338-4341 doi:10.1016/j.tetlet.2014.06.027 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 704305 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Enzyme-catalyzed cascade synthesis of hydroxyiminoacetamides
Autori
Knežević, Anamarija ; Vinković, Vladimir ; Maraković, Nikola ; Šinko, Goran
Izvornik
Tetrahedron letters (0040-4039) 55
(2014), 31;
4338-4341
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
amide formation; chemoenzymatic synthesis; coupling reagents; enzyme catalysis; oxime protecting groups
Sažetak
In order to synthesize N-(3-azido-1- phenylpropyl)-2-hydroxyiminoacetamide, a key compound for the preparation of acetylcholinesterase (AChE) reactivators of the N- substituted 2-hydroxyiminoacetamide type, it was necessary to develop a method for forming an amide bond between an ethyl glyoxylate oxime and an amine. Using Candida antarctica lipase B (CAL-B) in a cascade enzyme-BOP catalyzed reaction, the efficient synthesis of the target hydroxyiminoacetamide was achieved.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
HRZZ-IP-2013-11-4307 - Dizajn, sinteza i evaluacija novih protuotrova kod trovanja živčanim bojnim otrovima i pesticidima (CHOLINESTERASE) (Kovarik, Zrinka, HRZZ - 2013-11) ( CroRIS)
098-0982904-2910 - Kiralni organski materijali – sintetska, strukturna i funkcionalna istraživanja (Vinković, Vladimir, MZOS ) ( CroRIS)
Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Institut "Ruđer Bošković", Zagreb
Profili:
Nikola Maraković
(autor)
Goran Šinko
(autor)
Vladimir Vinković
(autor)
Anamarija Knežević
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus