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Pregled bibliografske jedinice broj: 702866

Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1

Crouse, Josh; Bedeniković, Gregor; Wiesel, Melanie; Ibberson, Mark; Xenarios, Ioannis; Von Laer, Dorothee; Kalinke, Ulrich; Vivier, Eric; Jonjić, Stipan; Oxenius, Annette
Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1 // Immunity, 40 (2014), 6; 961-73 doi:10.1016/j.immuni.2014.05.003 (međunarodna recenzija, članak, znanstveni)

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Naslov
Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1

Autori
Crouse, Josh ; Bedeniković, Gregor ; Wiesel, Melanie ; Ibberson, Mark ; Xenarios, Ioannis ; Von Laer, Dorothee ; Kalinke, Ulrich ; Vivier, Eric ; Jonjić, Stipan ; Oxenius, Annette

Izvornik
Immunity (1074-7613) 40 (2014), 6; 961-73

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
IFN ; T cells ; NCR1

Sažetak
Direct type I interferon (IFN) signaling on T cells is necessary for the proper expansion, differentiation, and survival of responding T cells following infection with viruses prominently inducing type I IFN. The reasons for the abortive response of T cells lacking the type I IFN receptor (Ifnar1(-/-)) remain unclear. We report here that Ifnar1(-/-) T cells were highly susceptible to natural killer (NK) cell-mediated killing in a perforin-dependent manner. Depletion of NK cells prior to lymphocytic choriomeningitis virus (LCMV) infection completely restored the early expansion of Ifnar1(-/-) T cells. Ifnar1(-/-) T cells had elevated expression of natural cytotoxicity triggering receptor 1 (NCR1) ligands upon infection, rendering them targets for NCR1 mediated NK cell attack. Thus, direct sensing of type I IFNs by T cells protects them from NK cell killing by regulating the expression of NCR1 ligands, thereby revealing a mechanism by which T cells can evade the potent cytotoxic activity of NK cells.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
062-0621261-1263 - Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru (Jonjić, Stipan, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Rijeka

Profili:

Avatar Url Stipan Jonjić (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com www.sciencedirect.com

Citiraj ovu publikaciju:

Crouse, Josh; Bedeniković, Gregor; Wiesel, Melanie; Ibberson, Mark; Xenarios, Ioannis; Von Laer, Dorothee; Kalinke, Ulrich; Vivier, Eric; Jonjić, Stipan; Oxenius, Annette
Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1 // Immunity, 40 (2014), 6; 961-73 doi:10.1016/j.immuni.2014.05.003 (međunarodna recenzija, članak, znanstveni)
Crouse, J., Bedeniković, G., Wiesel, M., Ibberson, M., Xenarios, I., Von Laer, D., Kalinke, U., Vivier, E., Jonjić, S. & Oxenius, A. (2014) Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1. Immunity, 40 (6), 961-73 doi:10.1016/j.immuni.2014.05.003.
@article{article, author = {Crouse, Josh and Bedenikovi\'{c}, Gregor and Wiesel, Melanie and Ibberson, Mark and Xenarios, Ioannis and Von Laer, Dorothee and Kalinke, Ulrich and Vivier, Eric and Jonji\'{c}, Stipan and Oxenius, Annette}, year = {2014}, pages = {961-73}, DOI = {10.1016/j.immuni.2014.05.003}, keywords = {IFN, T cells, NCR1}, journal = {Immunity}, doi = {10.1016/j.immuni.2014.05.003}, volume = {40}, number = {6}, issn = {1074-7613}, title = {Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1}, keyword = {IFN, T cells, NCR1} }
@article{article, author = {Crouse, Josh and Bedenikovi\'{c}, Gregor and Wiesel, Melanie and Ibberson, Mark and Xenarios, Ioannis and Von Laer, Dorothee and Kalinke, Ulrich and Vivier, Eric and Jonji\'{c}, Stipan and Oxenius, Annette}, year = {2014}, pages = {961-73}, DOI = {10.1016/j.immuni.2014.05.003}, keywords = {IFN, T cells, NCR1}, journal = {Immunity}, doi = {10.1016/j.immuni.2014.05.003}, volume = {40}, number = {6}, issn = {1074-7613}, title = {Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1}, keyword = {IFN, T cells, NCR1} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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