Naslov
Patterns of genomic inbreeding in worldwide sheep populations

Autori
Curik, Ino ; Ferenčaković, Maja ; Šalamon, Dragica ; Sölkner, Johann ; Lenstra, A. Johannes ; International Sheep Genomic Consortium

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
Livestock Genomic Resources in a Changing World Conference

Mjesto i datum
Cardiff, Ujedinjeno Kraljevstvo, 17.06.2014. - 19.06.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Inbreeding; ROH pattern; Worldwide sheep populations

Sažetak
Inbreeding is a fundamental parameter in conservation genetics of any small population as its increase results in the reduction of effective population size, increase in frequency of deleterious alleles and the concomitant inbreeding depression of fitness and fertility. We have inferred levels of inbreeding in 77 sheep populations (2938 individuals) from different continents, using individual runs of homozygosity (ROH) estimates of 4, 8 and 16 Mb in 47502 autosomal SNPs and expressed as the coefficients FROH>4Mb, FROH>8Mb and FROH>16Mb. Inbreeding level estimates ranged from 0.005 (Rasa Aragonesa) to 0.309 (MacArthur Merino) for FROH>4Mb (average 0.07) as maximal values, from 0.002 (Rasa Aragonesa) to 0.202 (MacArthur Merino) for FROH>8Mb (average 0.047) and from 0.001 (Rasa Aragonesa) to 0.090 (Wiltshire) for FROH>16Mb, ( average 0.025). Pearson correlations among inbreeding levels ranged from 0.877 (FROH>4Mb : FROH>16Mb) to 0.974 (FROH>4Mb : FROH>8Mb). Negative Pearson correlations between allele richness/ (observed heterozygosity) were decreasing with ROH lengths from -0.746/ (-0.823) for FROH>4Mb, but lower for longer ROHs to (-0.533/ (-0.688) for FROH>16Mb). In addition, uUsing linear statistical modeling, we have analyzed the impact of crossbreeding, geographic location of a breed, use of artificial insemination and main type of production as well as the effect of chromosome location, chromosome length and recombination rates on the ROH-derived inbreeding levels.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Poljoprivreda (agronomija), Biotehnologija

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