Naslov
The regulation of programmed necrosis and intrinsic apoptotic pathway following DNA damage is FADD dependent

Autori
Josipović, Pavle ; Džinić, Tamara ; Štambuk, Jerko ; Matić, Igor ; Antunović, Maja ; Caput Mihalić, Katarina ; Marijanović, Inga

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
PERIODICUM BIOLOGORUM / Vitale, Branko - Zagreb, 2012, 52-52

Skup
HDIR-2 "From Bench to Clinic", Second Meeting of the Croatian Association for Cancer Research with International Participation

Mjesto i datum
Zagreb, Hrvatska, 08.11.2012. - 09.11.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
UVB irradiation; adaptor protein FADD; necroptosis; Bcl-2; Bax

Sažetak
Cell death can be morphologically described as apoptosis or necrosis. Apoptosis can be induced via activation of intrinsic or extrinsic apoptotic pathway. Necrosis can be regulated via RIP1-kinase signaling and then it is called necroptosis. Adaptor protein FADD (Fas- associated death domain) in lymphocytes acts as a positive regulator of apoptosis and negative regulator of necroptosis in signal transduction from cell death receptors to caspase 8 or RIP1 kinase. There were differences reported regarding the role of FADD in the regulation of necroptosis which were dependent of cell type and cell death inducer. As a cell death inducer we used UVB irradiation, a potential carcinogen.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

POVEZANOST RADA