Naslov
In vitro and in vivo antitumor activity of the halogenated boroxine dipotassium- trioxohydroxytetrafluorotriborate (K2[B3O3F4OH])

Autori
Ivanković, Siniša ; Stojković, Ranko ; Galić, Zoran ; Galić, Borivoj ; Ostojić, Jelena ; Marasović, Maja ; Miloš, Mladen

Izvornik
Journal of enzyme inhibition and medicinal chemistry (1475-6366) 30 (2015), 3; 354-359

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Antitumor activity; drug research; halogenated boroxine

Sažetak
Dipotassium-trioxohydroxytetrafluorotriborate K2[B3O3F4OH] was listed as a promising new therapeutic for cancer diseases. For in vitro and in vivo investigation of its antitumor effects 4T1 mammary adenocarcinoma, B16F10 melanoma and squamous cell carcinoma SCCVII were used. The detailed in vitro investigation undoubtedly showed that K2[B3O3F4OH] affects the growth of cancer cells. The proliferation of cells depends on the concentration so that aqueous solution of K2[B3O3F4OH], the concentrations of 104M and less, does not affect cell growth, but the concentrations of 103M or more, significantly slows cells growth. B16F10 and SCCVII cells show higher sensitivity to the cytotoxic effects of K2[B3O3F4OH] compared to 4T1 cells. Under in vivo conditions, K2[B3O3F4OH] slows the growth of all three tumors tested compared to the control, and the inhibitory effect was most pronounced during the application of the substance. There is almost no difference if K2[B3O3F4OH] was applied intraperitoneally, intratumor, peroral or as ointment. Addition of 5- FU did not further increase the antitumor efficacy of K2[B3O3F4OH].

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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