Naslov
Evaluation of brainstem involvement in multiple sclerosis

Autori
Krbot Skoric, Magdalena ; Adamec, Ivan, Nesek Madaric, Vesna ; Habek, Mario

Izvornik
Canadian journal of neurological sciences (0317-1671) 41 (2014); 346-349

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Clinical examination; MRI; Auditory evoked potentials; Vestibular evoked myogenic potentials; multiple sclerosis

Sažetak
Background/Aims: The aim of the present study was to determine the optimum method to detect brainstem lesions in patients with MS. Methods: 72 patients with the diagnosis of relapsing-remitting MS were prospectively included. Brainstem functional system score (BSFS) (part of the EDSS evaluating brainstem symptomatology) was calculated. MRI was performed on 1.5T and T1, T2, PD and FLAIR sequences were analyzed for presence of brainstem lesions. Auditory evoked potentials (AEP) and ocular and cervical vestibular evoked myogenic potentials (oVEMP and cVEMP) were performed according to the standardized protocol. Results: From 72 patients, 18 (25%) had clinical involvement of the brainstem. MRI showed brainstem involvement in 29 (40%) patients. Of the neurophysiological tests, AEP showed pathological result in 16 (22%) patients, oVEMP in 36 (50%) patients, cVEMP in 18 (25%) patients, and VEMP (combination of oVEMP and cVEMP) in 45 (63%) patients. VEMP detected brainstem lesions in higher percentage than clinical examination, MRI and AEP, which was statistically significant (< 0.0001, 0.012 and < 0.0001, respectively). Conclusions: Results of the present study have shown that VEMPs are the optimal method to detect brainstem lesions in multiple sclerosis and that they detect them significantly better than clinical examination, AEP or MRI.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA