Naslov
An Efficient Synthesis of Pyridoxal Oxime Derivatives Under Microwave Irradiation

Autori
Gašo-Sokač, Dajana ; Bušić, Valentina ; Cetina, Mario ; Jukić, Marijana

Izvornik
Molecules (1420-3049) 19 (2014), 6; 7610-7620

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
eco-friendly quaternization; microwave synthesis; phenacyl bromides; pyridoxal oxime

Sažetak
Quaternary salts of pyridoxal oxime have been synthesized by the quaternization of pyridoxal oxime with substituted phenacyl bromides using microwave heating. Microwave-assisted rapid synthesis was done both in solvent (acetone) and under solvent-free conditions. Good to excellent yields (58%–94%) were obtained in acetone in very short reaction times (3–5 min) as well as in the solvent-free procedure (42%–78%) in very short reaction times (7–10 min) too. Effective metodologies for the preparation of pyridoxal oxime quaternary salts, having the advantagies of being eco-friendly, easy to handle, and performed in shorter reactions time are presented. The structure of compound 7, in which a 4-fluorophenacyl moiety is bonded to the pyridinium ring nitrogen atom, was unequivocally confirmed by the single-crystal X-ray diffraction method.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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