Naslov
Konformacijska svojstva ferocenskih peptida s izmijenjenim slijedom konstituirajućih aminokiselina
(Conformational properties of ferrocene peptides containing exchanged sequence of constituent amino acids)

Autori
Barišić, Lidija ; Kovačević, Monika ; Mamić, Marija ; Kodrin, Ivan ; Mihalić, Zlatko ; Rapić, Vladimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Knjiga sažetaka XXIII. Hrvatski skup kemičara i kemijskih inženjera / Hadžiev, Andrea ; Blažeković, Zdenko - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2013, 169-169

Skup
XXIII. Hrvatski skup kemičara i kemijskih inženjera

Mjesto i datum
Osijek, Hrvatska, 21.04.2013. - 24.04.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Ferocen; peptid; konformacijska analiza
(Ferrocene; peptide; conformational analysis)

Sažetak
We explored the structural properties of ferrocene peptides II [Y-AA-Fca-OMe ; Y = Boc, Ac ; AA = L-Ala, D-Ala ; Fca = 1'-aminoferrocene-1-carboxylic acid] [1] with an exchanged sequence of constituent amino acids relative to previously described I (Y-Fca-AA-OMe ; Y = Boc, Ac ; AA = L-Ala, D-Ala) [2]. In order to examine their conformational properties, peptides II were subjected to spectroscopic analysis (IR, 1H NMR, CD) and molecular modeling (DFT). The alteration of peptides I into II significantly influenced their conformational properties. Conjugates I were stabilized through interchain hydrogen bonding, whereas inter- and intrachain hydrogen bonds were established in their constitutional isomers II. The replacement of the bulky Boc group with an Ac group did not cause major conformational changes, and the absolute configuration of the alanine chiral centers did not affect the conformational properties.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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