Naslov
Imipenem consumption and gram-negative pathogen resistance to imipenem at Sestre milosrdnice University Hospital

Autori
Jajić Benčić, Ines ; Benčić, IVan ; Vukičević-Baudoin, Dina.

Izvornik
Acta clinica Croatica (0353-9466) 40 (2001); 185-189

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
gram-negative bacterial infections; cross infections; drug resistance; imipenem; therapeutic use; imipenem; pharmacology

Sažetak
The study was performed to determine the consumption of imipenem and resistance of gram-negative pathogens (Pseudomonas aeruginosa, Acinetobacter sp., Klebsiella sp., Escherichia coli, Proteus mirabilis, Serratia marcescens, Enterobacter sp.) to imipenem. Gram-negative pathogens were isolated at the Sestre milosrdnice University Hospital from Zagreb in 1999 and 2000. The imipenem sensitivity testing was performed by disk diffusion and E-test methods. The consumption of imipenem was expressed in DDD/100 hospital days in the same periods. Imipenem resistance of Acinetobacter sp. decreased significantly in the year 2000 (p=0.0052), especially in the first six months (p=0.021) when the lowest consumption of imipenem was recorded. Imipenem resistance of other gram negative pathogens did not decrease significantly. Results suggest that the consumption of imipenem might lead to changes in resistance to imipenem among Acinetobacter strains.

Izvorni jezik
Engleski

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