Pregled bibliografske jedinice broj: 699109
Clinical and metabolic predictors of nonproliferative and proliferative/laser treated retinopathy in normoalbuminuric type 1 diabetic patients with normal or mildly impaired renal function
Clinical and metabolic predictors of nonproliferative and proliferative/laser treated retinopathy in normoalbuminuric type 1 diabetic patients with normal or mildly impaired renal function // Nephrology Dialysis Transplantation 2014 ; 29 (Suppl. 3): iii426-iii427.
Amsterdam, Nizozemska, 2014. (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 699109 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Clinical and metabolic predictors of nonproliferative and proliferative/laser treated retinopathy in normoalbuminuric type 1 diabetic patients with normal or mildly impaired renal function
Autori
Bulum, Tomislav ; Prkačin, Ingrid ; Blaslov, Kristina ; Zibar, Karin ; Duvnjak, Lea
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Nephrology Dialysis Transplantation 2014 ; 29 (Suppl. 3): iii426-iii427.
/ - , 2014
Skup
51st ERA-EDTA Congress
Mjesto i datum
Amsterdam, Nizozemska, 31.05.2014. - 03.06.2014
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
type 1 diabetes; retinopathy; renal function
Sažetak
It is assumed that retinopathy and nephropathy, as most important microvascular complications in diabetes, occurs at the same time and that retinovascular pathology reflects renal disease. However, several studies demonstrated that albuminuria is not a risk factor for diabetic retinopathy and that retinopathy might be present already in normoalbuminuric state in type 1 diabetic patients (T1DM). The aim of this study was to evaluate the prevalence and predictors of nonproliferative (NPR) and proliferative/laser- treated retinopathy (PR) in normoalbuminuric T1DM.Study included 333 (198 without retinopathy, 114 with NPR and 21 with PR) normoalbuminuric T1DM with normal or mildly decreased renal function (estimated glomerular filtration rate (eGFR) > 60 ml min-1 1.73m-2) and before any interventions with statins, ACE inhibitors or angiotensin II receptor blockers. Patients without retinopathy compared to those with NPR and PR were younger (31 vs 39 vs 45 years, p<0.001), had longer duration of diabetes (7 vs 18 vs 23 years, p<0.001), lower hemoglobin A1c (7.2±1.5 vs 7.8±1.6 vs 7.8±1.4%, p=0.003), lower total cholesterol (4.8±0.9 vs 5.0±0.9 vs 5.6±1.0 ol/L, p=0.02), lower LDL cholesterol (2.7±0.7 vs 2.8±0.7 vs 3.1±0.9 mmol/L, p=0.03), lower heart rate (HR) (70 vs 78 vs 85 beats/min, p<0.001) and higher eGFR (104 vs 94 vs 81 ml/min). Stratifying clinical and metabolic characteristics of patients for degree of eGFR, trends across quartiles for age (43±9 vs 23±4 years, p<0.001), duration of diabetes (17±10 vs 9±6 years, p<0.001), hemoglobin A1c (7.1±1.2 vs 8.4±1.9%, p=0.002), total cholesterol (5.1±0.7 vs 4.6±0.7 mmol/L, p=0.02), and LDL cholesterol (2.9±0.7 vs 2.4±0.7 mmol/L, p=0.006) were statistically significant. Retinopathy might be present already in normoalbuminuric state in T1DM. Age, duration of diabetes, hemoglobin A1c, total and LDL cholesterol are major risk factors associated with progression of retinopathy and renal disease.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Ustanove:
Klinika za dijabetes, endokrinologiju i bolesti metabolizma Vuk Vrhovac,
Medicinski fakultet, Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE