Naslov
CD34+ and CFU-GM content during peripheral blood CD34+ selection for autologous transplantation

Autori
Batinić, Drago ; Petrovečki, Mladen ; Nemet, Damir ; Golubić, Branka ; Užarević, Banka ; Perović, Edi ; Bojanić, Ines ; Mrsić, Mirando ; Bogdanić, Vinko ; Pisk, Mirta ; Labar, Boris

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Bone Marrow Transpl / Goldman, J. - Basingstoke : New York (NY) : Stockton Press, 1999, 196-196

Skup
25th Annual Meeting of the European Group for Blood and Marrow Transplantation

Mjesto i datum
Hamburg, Njemačka, 22.03.1999. - 24.03.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
CD34+; CFU-GM; positive selection

Sažetak
The aim of the study was to analyze the relationship between the CD34+ and CFU-GM content in leucocyte products during CD34+ selection (Ceprate, CellPro) in patients undergoing autologous transplantation. A total of 37 patients were analyzed, including 12 pts. With non-Hodgkin lymphoma, 11 with breast carcinoma, 10 with multiple myeloma, 3 with Mb. Hodgkin and 1 pt. with ovarian cancer. Mobilization protocol consisted of cyclophosphamide, BEAM or VIP-protocol, all in combination with G-CSF. Leukaphereses contained a median of 6.95x10E6 CD34+/kg b.w. (2-7-40.6) and 20.1x10E4 CFU-GM/kg b.w. (1.1-117.8) (r=0.412, p<0.05). The median CD34+ purity in selected product was 83% (28-96), whereas the calculated yields of CD34+ cells and CFU-GM with regard to apheresis product were 36.2% (2-7-82.2) and 15.1% (3.4-49.6), respectively. Although CD34 and CFU-GM were significantly correlated, no correlation was Found between the extent of CD34+ and CFU-GM decrease (r=0.057), indicating a different rate of specific cell loss during the CD34+ selection.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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