Naslov
Antidotal efficacy of quinuclidinium oximes against soman poisoning

Autori
Lucić, Ana ; Radić, Božica ; Peraica, Maja ; Mesić, Milan ; Primožič, Ines ; Binenfeld, Zlatko

Izvornik
Archives of toxicology (0340-5761) 71 (1997), 7; 467-470

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Quinuclidinium oximes; Soman; Acetylcholinesterase reactivators

Sažetak
The efficacy of newly synthesized quinuclidinium oximes was tested in vitro and in vivo. For this purpose the inhibitory power of oximes (IC50), acute toxicity (LD50) as well as reactivating and protective capacities with respect to soman-inhibited acetylcholinesterase of human erytrocytes, were determined for each of the oximes. All oximes tested were ineffective in vitro but protected mice very efficiently (BM-1 protects against 4 LD50 of soman). The results indicate that the in vivo effectiveness of quinuclidinium oximes against soman poisoning may not be related to reactivation or protection of AChe but rather to some other mechanism of the cholinergic system.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Kliničke medicinske znanosti

POVEZANOST RADA