Pregled bibliografske jedinice broj: 692932
New insights into the role of chronic inflammation and cytokines in the etiopathogenesis of gastroenteropancreatic neuroendocrine tumors
New insights into the role of chronic inflammation and cytokines in the etiopathogenesis of gastroenteropancreatic neuroendocrine tumors // Neuroendocrinology, 99 (2014), 2; 75-84 doi:10.1159/000362339 (međunarodna recenzija, pregledni rad, znanstveni)
CROSBI ID: 692932 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
New insights into the role of chronic inflammation and cytokines in the etiopathogenesis of gastroenteropancreatic neuroendocrine tumors
Autori
Cigrovski Berković, Maja ; Čačev, Tamara ; Catela Ivković, Tina ; Zjačić-Rotkvić, Vanja ; Kapitanović, Sanja
Izvornik
Neuroendocrinology (0028-3835) 99
(2014), 2;
75-84
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
GEP-NET ; inflammation ; cytokines ; tumorigenesis
Sažetak
Although previously considered rare, recent epidemiological studies have revealed that the incidence (3.6/100, 000) and prevalence (35/100, 000) of gastroenteropancreatic neuroendocrine tumours (GEP-NETs) has increased over the past few decades. Despite the progress in the understanding of GEP-NETs molecular biology, there is still little advance in the early diagnosis due to lack of specific tumour markers. As the tumours are mostly detected in their late stage, they are not well controlled by either biotherapy or conventional chemotherapy, and thus represent a significant clinical issue. Chronic inflammation has been implicated in the development of GEP-NETs. This review presents recent findings that link pro- inflammatory cytokines to molecular basis of GEP- NETs tumorigenesis, leading to a more personalized approach to disease management and therapy.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
MZOS-098-0982464-2508 - Molekularna genetika i farmakogenetika gastrointestinalnih tumora (Kapitanović, Sanja, MZOS ) ( CroRIS)
MZOS-134-1342428-0491 - Neuroendokrini tumori probavnog sustava i gušterače (Cigrovski Berković, Maja, MZOS ) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb,
KBC "Sestre Milosrdnice"
Profili:
Sanja Kapitanović
(autor)
Vanja Zjačić-Rotkvić
(autor)
Tamara Čačev
(autor)
Maja Cigrovski Berković
(autor)
Tina Catela Ivković
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE