ࡱ> +|lA_uLg i L ( x |Xtc|vx[$bjbj @ΐΐ:TTkkkXw<kZr%"p"""..."X$X$X$X$X$X$Xe\_B$X.....$X"" =Z777."""X7."X77RJT<vV"?Nk2UXSZ0ZUI_60I_<vVvVI_V..7.....$X$X7...Z....I_.........T ]:SVEU ILI`TE U ZAGREBU FAKULTET KEMIJSKOG IN}ENJERSTVA I TEHNOLOGIJE SVEU ILI`NI DIPLOMSKI STUDIJ Vedran Regvar DIPLOMSKI RAD Zagreb, lipanj 2012. SVEU ILI`TE U ZAGREBU FAKULTET KEMIJSKOG IN}ENJERSTVA I TEHNOLOGIJE SVEU ILI`NI DIPLOMSKI STUDIJ Vedran Regvar SONOGASHIRINE REAKCIJE U PRIPRAVI NOVIH 5-ALKINILPIRIMIDINA DIPLOMSKI RAD Voditelj rada: dr. sc. Silvana Rai Mali, red.prof. lanovi ispitnog povjerenstva: dr. sc. Silvana Rai-Mali, red.prof. dr. sc. Biserka Tkal ec, V. pred dr. sc. Svjetlana Kriatafor, znan. sur. Zagreb, lipanj 2012. Zahvaljujem mentorici dr. sc. Silvani Rai Mali, red .prof., na predlo~enoj temi i svim stru nim i osobnim savjetima koji su bitno obilje~ili izradu ovog rada. Posebno zahvaljujem Andrijani Mea i, dipl. ing., na stru nom vodstvu, edukaciji, motiviranju, susretljivosti, te brojnim korisnim savjetima bez kojih izrada ovog diplomskog rada ne bi bila mogua. Zahvaljujem svim lanovima Zavoda za organsku kemiju, Fakulteta kemijskog in~enjerstva i tehnologije, na ugodnom radnom okru~enju. Takoer zahvaljujem svojim roditeljima, bratu i prijateljima koji su mi pru~ali stalnu podraku u mom akolovanju, kao i u cijelom ~ivotu. SA}ETAK RADA Cilj ovog rada je bio sintetizirati nove acikli ke i C-5 supstituirane alkinilne i bicikli ke furo[2,3-d] pirimidinske derivate s lancem poput ganciklovira [1,3-dihidroksi-2-propoksimetilni lanac], penciklovira [4-hidroksi-3-(hidroksimetil)butilni lanac] i 2,3-dihidroksipropilnim lancem na polo~aju N-1 i N-3 pirimidina kao potencijalne aktivne supstance s izra~enim i selektivnim antitumorskim djelovanjem. Navedeni spojevi, stoga, sadr~e strukturne karakteristike dviju bioloaki aktivnih skupina: C-5 supstituenata na pirimidinu i lance poznatih prolijekova, acikli kih purinskih nukleozidnih analoga. Sintezi ciljanih spojeva se pristupilo tako da je odgovarajui acikli ki lanac, uz prisustvo baze K2CO3, povezan s 5-joduracilom, C-5 supstituiranim alkinilnim derivatom uracila ili 2,4-dimetoksiuracilom. Alkinilni derivati su pripravljeni Sonogashirinom reakcijom 5-joduracila ili 5-jod-N-acikli kog derivata uracila s izabranim terminalnim alkinima pomou paladijevog katalizatora, bakrovog(I) jodida (CuI) i trietilamina. Bicikli ki furo[2,3-d] pirimidinski derivati su pripremljeni in situ intramolekularnom ciklizacijom alkinilnog derivata. Sonogashirine reakcije su, uz klasi ne na ine sinteze, provedene i primjenom mikrovalnog zra enja iz razloga ato mikrovalna organska sinteza ima niz prednosti kao ato su vee iskoriatenje, krae vrijeme i vea selektivnost reakcije. Strukture svih prireenih spojeva su potvrene spektroskopskim metodama 1H-NMR i 13C-NMR, te masenom spektrometrijom. Klju ne rije i : Sonogashirina reakcija, C-5 supstituirani alkinilni derivati uracila, acikli ki pirimidinski analozi. SUMMARY The aim of this work was to synthesize new N-acyclic C-5 alkynyl substituted and bicyclic furo[2,3-d]pyrimidine derivatives with a ganciclovir-, penciclovir-like and 2,3-dihydroxypropyl side chain as potentialy active substances with a pronounced and selective antitumor activity. Thus, new compounds contain the structural characteristics of two biologicaly important groups: both C-5 substituents and side chains of well known prodrugs, acyclic purine nucleoside derivatives. Synthesis of new pyrimidine derivatives was based on coupling reaction between 5-iodouracil, C-5 alkynyl derivatives of uracil or 2,4-dimethoxyuracil, and corresponding acyclic chain. Alkynyl compounds were prepared using Sonogashira's coupling between 5-iodouracil, or 5-iodo-N-acyclic uracil derivate, and chosen terminal alkynes, using copper(I) iodide, triethylamine and palladium complex as a catalyst. Bicyclic furo[2,3-d] pyrimidine derivatives were formed by in situ intramolecular cyclization of alkynyl derivatives. Sonogashira's reactions were carried out using both standard method and microwave methods. Organic synthesis combined with microwave irradiation turned out to be more efficient in many ways; for instance, reduced reaction time, greater reaction yield and less amount of byproduct. Structures of all synthesized compounds were confirmed by 1H-NMR and 13C-NMR spectroscopy, and mass spectrometry. Keywords : Sonogashira coupling, C-5 substituted alkynyl uracil derivatives, acyclic pyrimidine analogues SADR}AJ: UVOD 1 OPI DIO 3 NUKLEOZIDI 3 Pirimidin 5 Purin 6 ACIKLI KI ANALOZI NUKLEOZIDA 7 Aciklovir (ACV) 8 Ganciklovir (GCV) 10 Penciklovir (PCN) 12 Dihidroksipropil adenin (DHPA) 14 BICIKLI KI ANALOZI NUKLEOZIDA (BCNA) 15 SONOGASHIRINA REAKCIJA 18 SINTEZA POTPOMOGNUTA MIKROVALOVIMA 21 EKSPERIMENTALNI DIO 23 OPE NAPOMENE 23 PRIPRAVA SPOJEVA 24 PREGLED SINTETIZIRANIH SPOJEVA 29 REZULTATI I RASPRAVA 32 SINTEZE SPOJEVA 32 ANALIZA NMR SPEKTARA 38 Analiza 1H NMR spektara 38 Analiza 13C NMR spektara 42 ZAKLJU AK 45 LITERATURA 46 1.0. UVOD Ljudska civilizacija je oduvijek bila popraena bolestima koje su utjecale na razvoj i napredak cijelog ovje anstva. Kako bi se ovjek obranio od ne~eljenih patoloakih utjecaja, mnogo je vremena provedeno u tra~enju aktivnih supstanci kojima je mogue prevenirati i lije iti atetne u inke koje uzrokuje bolest. Tehnologija i znanstvena istra~ivanja su u dvadesetom stoljeu bitno doprinijela podru ju prirodnih znanosti, farmacije i medicine. Primjerice, otkrie dvostruke uzvojnice deoksiribonukleinske kiseline (DNA) predstavlja osnovu buduih otkria na podru ju biokemije i medicine. Daljnjim pojaanjavanjem njene strukture su dobivene informacije na temelju kojih je bilo mogue osmisliti druga iji pristup u dijagnostici i terapiji bolesti. Novi pristupi se prvenstveno odnose na sintezu aktivnih supstanci u lije enju malignih stanica ije je glavno obilje~je brzo razmno~avanje. Takav tip aktivnih supstanci su pirimidinski i purinski analozi koji su postali osnovne komponente u lije enju virusnih bolesti i tumora.1 Sredinom dvadesetog stoljea proveden je velikog broj istra~ivanja u nastojanju da se pronae na in kako bi se zaustavilo razmno~avanje malignih stanica. Jedan od efikasnih pristupa je bilo inhibiranje de novo sinteze DNA koristei razne sintetizirane analoge nukleozida koji su dobiveni strukturnim modifikacijama postojeih nukleozida. Kao rezultat navedenih izmjena, nukleozidni analozi su pokazali efikasno djelovanje u sprje avanju razmno~avanja malignih stanica. Njihov mehanizam djelovanja je temeljen na mogunosti ugradnje u rastui polinukleotidni lanac, ato uzrokuje prekid daljnje sinteze polinukleotida ili izmjenu funkcije novonastale nukleinske kiseline. Krajnji ishod takvih promjena u strukturi molekule DNA je smrt oboljele stanice. Njihov glavni nedostatak je bila toksi nost prema benignim stanicama, nedovoljna selektivnost kao i razmjerno mala stabilnost. Uzevai u obzir spomenute nedostatke, i dalje se provodi sinteza novih derivata aeera i heterocikli kih prstenova koji e pokazivati efikasno djelovanje bez prethodno navedenih nedostataka.2 Krajem devetnaestog stoljea dolazi do otkria novih uzro nika bolesti nazvanih virusima. Virusi su metaboli ki neaktivne estice koje nemaju stani ne dijelove i kao takve u potpunosti ovise o HYPERLINK "http://hr.wikipedia.org/wiki/Energija" \o "Energija"energiji HYPERLINK "http://hr.wikipedia.org/wiki/Stanica" \o "Stanica"stanice domaina.3 Neki virusi imaju mogunost izazivanja mutacija u stanicama domaina, na na in da DNA stanice domaina umno~avaju sa svojom DNA. Krajnja posljedica takvih promjena je rast i stvaranje tumorskih stanica i time tumorskog tkiva.4 Iz razloga ato virusi koriste metaboli ke mehanizme stanice kao na in vlastite sinteze, njihova eliminacija esto nije mogua bez eliminacije stanice domaina. Jedna od prvih aktivnih supstanci koja je pokazivala antivirusno djelovanje je aciklogvanozin, poznatiji kao aciklovir. Aciklovir je gvanozinski analog koji se koristi u lije enju herpes simpleks virusa (HSV), varicella zoster virusa (VZV), Epstein-Barr virus (EBV) i citomegalovirusa (CMV) .5 Njegovo glavno obilje~je je iznimna selektivnost uz jako malu toksi nost, te kao takav trenutno predstavlja jedan od vodeih na ina lije enja bolesti uzrokovanih prethodno navedenim virusima.6 Virusna i tumorska oboljenja se ubrajaju u vodee uzroke smrti u suvremenom svijetu, te kao takva predstavljaju velik izazov za medicinu.7 Uzevai u obzir da je te~nja za pronalaskom bioloaki aktivnih supstanci sve vea, provode se mnoga istra~ivanja novih aktivnih derivata aeera kao i novih nukleozidnih baza. Sintetski derivati su po kemijskoj strukturi jako sli ni prirodnim nukleozidima, te je iz tog razloga mogua njihova ugradnja u rastui polinukleotidni lanac. Takav mehanizam djelovanja onemoguuje daljnju sintezu polinukleotida i dolazi do smrti virusa i tumorskih stanica. Spomenuti pristup terapiji virusnih i tumorskih oboljenja predstavlja ujedno i najefikasniji na in njihova lije enja. 2.0. OPI DIO 2.1. NUKLEOZIDI Nukleozidi su glukozamini koje ini duaikova heterocikli ka baza vezana na aeer ribozu ili deoksiribozu preko N-glikozidne veze. Nukleozidne baze se dijele na purinske i pirimidinske (Slika 1.). U purinske baze se ubrajaju adenin i gvanin, dok se u pirimidinske baze ubrajaju citozin i timin. U slu aju ribonukleinske kiseline (RNA), pirimidinska baza timin je zamijenjena uracilom. Sve heterocikli ke baze imaju sposobnost postojanja u viae tautomernih oblika.8 A)  EMBED ChemDraw.Document.6.0  B)  EMBED ChemDraw.Document.6.0  Slika 1. Struktura : A) pirimidinskog prstena, B) purinskog prstena Nukleozidi se u stanici prevode u nukleotide koji predstavljaju osnovne gradivne jedinice molekula DNA i RNA. Transformacija je temeljena na djelovanju enzima kinaza, pri emu dolazi do fosforiliranja na primarnoj hidroksilnoj skupini aeera nukleozida. Adenozin trifosfat (ATP) je primjer nukleotida koji ima va~nu ulogu u opskrbljivanju stanica energijom (Slika 2.). Energija nastaje kao produkt hildrolize ATP-a u adenozin-difosfat (ADP) koji potom prelazi u adenozin-monofosfat (AMP). ATP je jedan od krajnjih produkata procesa fotofosforiliranja i stani nog disanja.8  EMBED ChemDraw.Document.6.0  Slika 2. Struktura adenozin-trifosfata (ATP) Nukleozidi i nukleotidi su pronaeni i u drugim bioloaki aktivnim komponentama. Adenozin ini osnovu struktura dvaju va~nih koenzima, nikotinamid adenin dinukleotida (NADH) i koenzima A. Nukleozide je mogue sintetizirati de novo sintezom koja se jednim dijelom provodi u jetri, ali se u veoj mjeri sintetiziraju procesom razgradnje nukleinskih kiselina koje se unose u organizam putem hrane. Nukleinske kiseline se djelovanjem enzima nukleotidaze razgrauju na nukleinske baze i aeere ribozu, odnosno deoksiribozu. Gertrude Elion i George Hitchings su pedesetih godina proalog stoljea otkrili da spoj 6-merkaptopurin ima antitumorsko djelovanje (Slika 3.). To otkrie je bila osnova za sintezu novih purinskih derivata za koje se smatralo da e takoer imati antitumorsko djelovanje. Gertrude Elion i George Hitchings su za to otkrie dobili 1988. godine Nobelovu nagradu na podru ju medicine.  EMBED ChemDraw.Document.6.0  Slika 3. Struktura 6-merkaptopurina 6-merkaptopurin se u kombinaciji sa ostalim kemoterapeuticima koristi u lije enju akutnog oblika leukemije kod oboljele djece. Taj oblik terapije se pokazao iznimno efikasnim iz razloga ato je 80% pacijenata u potpunosti izlije eno. 2.1.1. Pirimidin Pirimidin je heterocikli ki aromatski spoj kojeg ine etiri atoma ugljika i dva atoma duaika. Po prirodi je planarna molekula u kojoj je zadr~ana simetrija s obzirom na os drugog i petog ugljikovog atoma. Kemijska i fizikalna svojstva pirimidina su jako sli na svojstvima purina.9 Pirimidin je slabo bazi nog karaktera, te za razliku od piridina podlije~e reakcijama nukleofilne aromatske supstitucije. To svojstvo je posljedica duaikovih atoma koji utje u na smanjenje energije  elektrona u prstenu, ato se manifestira ote~anom elektrofilnom aromatskom supstitucijom. Time je ujedno smanjena rezonancijska stabilnost molekule ato ini reakcije adicije vjerojatnijima za razliku od reakcija supstitucije.10  EMBED ChemDraw.Document.6.0  B) EMBED ChemDraw.Document.6.0  C)  EMBED ChemDraw.Document.6.0  Slika 4. Pirimidinske baze : A) Citozin, B) Timin, C) Uracil Pirimidin je osnovna gradivna jedinica nukleozidnih baza timina, citozina i uracila (Slika 4.) Osnovna struktura pirimidina je pronaena u nekim vitaminima kao ato su tiamin (vitamin B1), riboflavin (vitamin B2) i folna kiselina (vitamin B9). Za razliku od osnovne molekule pirimidina koja ne pokazuje nikakva farmakoloaka svojstva, derivati pirimidina su se pokazali kao dobri kemoterapijski agensi.9 George Hitchings je 1948. godine otkrio da su 2,4-diaminopirimidini i 2-amino-4-hidroksipirimidini antagonisti folne kiseline. Kasnije je otkriveno da navedeni derivati pirimidina inhibiraju enzim dihidrofolat reduktazu (DHFR), to je i osnovni princip mehanizma djelovanja lijeka protiv malarije.11 Derivati pirimidina takoer pokazuju odreeno antitumorsko, protuupalno, analgetsko, antidijabetsko i antihipertenzivno djelovanje.9 2.1.2. Purin Purin je heterocikli ki aromatski spoj koji se sastoji od pet atoma ugljika i etiri atoma duaika. Detaljnijom analizom je mogue vidjeti da strukturu purina ine meusobno spojeni pirimidinski i imidazolni prsten. Purini i supstituirani purini ujedno ine najrasprostranjeniju skupinu duaikovih heterocikla u prirodi. Aromatski karakter je posljedica prisustva konjugiranih dvostrukih veza koje zna ajno doprinose stabilnosti molekule. Po prirodi su naj eae krutine bijele boje amfotermnog karaktera, koje u doticaju sa kiselinom ili lu~inom prelaze u odgovarajuu sol. Veina supstituiranih purina je slabo topiva u vodi i velikom broju organskih otapala. Purin je mogue sintetizirati u laboratoriju na viae na ina, no za razliku od nekolicine njegovih derivata, joa nije pronaen u prirodi. 12 A)  EMBED ChemDraw.Document.6.0  B)  EMBED ChemDraw.Document.6.0  Slika 5. Purinske baze : A) Adenin, B) Gvanin Purin je osnovna gradivna jedinica nukleozidnih baza adenina i gvanina (Slika 5.). Purini su ujedno i osnovne komponente velikog broja va~nih biomolekula poput ATP-a, gvanozin tri fosfata (GTP), NADH i koenzima A. Nedavno je otkriveno da imaju zna ajnu ulogu u sustavu prenoaenja ~iv anih signala. Nakon otkria 6-merkaptopurina zna ajna se pa~nja posvetila sintezi novih purinskih derivata zbog potencijalnog antitumorskog djelovanja. Mehanizam djelovanja 6-merkaptopurina je temeljen na inhibiranju nekolicine enzima koji su potrebni za sintezu adenozina i gvanozina, ato posljedi no uzrokuje prestanak rasta tumorskih stanica.12 2.2. ACIKLI KI ANALOZI NUKLEOZIDA Nukleozidni analozi su grupa spojeva ija je struktura temeljena na modifikaciji postojee duai ne baze ili aeerne skupine. S obzirom na strukturnu sli nost sa nukleozidima, nukleozidni analozi pokazuju razna bioloaka djelovanja koja su prvenstveno temeljena na metaboli kom aktiviranju analoga do difosfata/trifosfata koji inhibiraju enzim virusnu polimerazu. Takav na in djelovanja se pokazao efikasnim u lije enju tumora i virusnih bolesti.13 Acikli ki nukleozidni analozi su grupa spojeva kod kojih je na duai nu bazu vezana acikli ka skupina, te su se kao takvi pokazali efikasnima u lije enju virusnih bolesti i tumora. Jedno od glavnih obilje~ja acikli kih nukleozidnih analoga je njihova jedinstvena farmakologija ije se prednosti odnose na rjee doziranje i razmjerno visoku sigurnost i selektivnost.14 Neki od poznatijih i koriatenijih acikli kih analoga su aciklovir, penciklovir, ganciklovir, valaciklovir, famciklovir i valganciklovir.15  EMBED ChemDraw.Document.6.0  Slika 6. Struktura valaciklovira 2.2.1 Aciklovir (ACV) Aciklovir [9-(2-hidroksietoksimetil)gvanin] je nukleozidni analog molekulske formule C8H11N5O3. Struktura aciklovira je temeljena na nukleozidnoj bazi (gvanin) na koju je vezan otvoreni lanac koji zamjenjuje aeerni prsten (Slika 7.).16  EMBED ChemDraw.Document.6.0  Slika 7. Struktura aciklovira Istra~ivanje antivirusnih lijekova je po elo aezdesetih godina dvadesetog stoljea u Sjedinjenim Ameri kim Dr~avama. Schaffer H., Vince R., Bittner S. i Gurwara S. su bili prvi znanstvenici koji su uspjeli sintetizirati acikloadenozin koji je pokazivao obeavajue antivirusno djelovanje. Daljnje istra~ivanje je rezultiralo otkriem aciklovira 1974. godine, a nakon tri godine su uslijedila prva klini ka ispitivanja koja su se pokazala vrlo uspjeanima. Aciklovir je nakon nekoliko godina postao primarna terapija u lije enju herpes simpleks virusa tipa I i II. Aciklovir je takoer pokazao slabiju in vitro aktivnost prema EBV i CMV.17 Mehanizam djelovanja aciklovira je temeljen na in vivo procesu fosforiliranja koji ga prevodi u aktivni oblik. Fosforiliranje se provodi u tri stupnja koja su potaknuta djelovanjem odgovarajuih enzima. Prvi stupanj je potaknut djelovanjem virusne timidin kinaze specifi ne za HSV i VZV, ato je ujedno i razlog izuzetne selektivnosti aciklovira. Drugi i trei stupanj fosforiliranja su potaknuti djelovanjem enzima kinaze stanice domaina. Nastali aciklovir trifosfat utje e na proces izgradnje nove molekule DNA.16 Aciklovir trifosfat mo~e inhibirati sintezu virusne DNA na dva razli ita na ina. Prvi mehanizam je temeljen na kompetitivnoj inhibiciji virusne DNA polimeraze sa deoksi-gvanozin-trifosfatom, ato uzrokuje nepovratno vezanje aciklovir-trifosfata na DNA predlo~ak. Drugi mehanizam je temeljen na procesu ugradnje aciklovir-trifosfata u virusnu DNA (Slika 8).18  Slika 8. Shematski prikaz mehanizma djelovanja aciklovira S obzirom da aciklovir trifosfat ne posjeduje ribozu koja je potrebna za daljnje spajanje nukleotida, daljnji proces izgradnje novonastale molekule DNA je prekinut ato ujedno uzrokuje i njen raspad (Slika 8.). Na taj na in je onemogueno daljnje airenje virusa na zdrave stanice.16 2.2.2. Ganciklovir (GCV) Ganciklovir [9-(1,3-dihidroksi-2-propoksi-metil)gvanin] je nukleozidni analog molekulske formule C9H13N5O4. Struktura ganciklovira je temeljena na nukleozidnoj bazi (gvanin) na koju je vezan otvoreni lanac koji zamjenjuje aeerni prsten (Slika 9.).15  EMBED ChemDraw.Document.6.0  Slika 9. Struktura ganciklovira Ganciklovir se prvenstveno koristi u terapiji bolesti uzrokovanih citomegalovirusom (CMV) iz razloga ato pokazuje sto puta veu bioloaku aktivnost prema CMV od aciklovira. Iako bolesti uzrokovane CMV ne predstavljaju ~ivotnu opasnost za odrasle osobe stabilnog imuniteta, dojen ad i osobe sa oslabljenim imunitetom mogu biti u potencijalnoj ~ivotnoj opasnosti.15 Ganciklovir je takoer pokazao odreeno bioloako djelovanje na inhibiciju replikacije EBV, HSV, VZV i HHV-tip 8 virusa.18 Princip djelovanja ganciklovira je sli an mehanizmu djelovanja aciklovira koji je temeljen na in vivo procesu fosforiliranja koji se provodi u tri stupnja potaknuta djelovanjem odgovarajuih enzima. Prvi stupanj fosforiliranja je potaknut djelovanjem enzima virusne protein kinaze, fosfotransferaze UL97, specifi ne za CMV zbog koje ganciklovir ima selektivno djelovanje na oboljele stanice. Drugi i trei stupanj su potaknuti djelovanjem enzima kinaze stanice domaina. Nastali ganciklovir-trifosfat kompetitivno inhibira virusnu DNA polimerazu (Slika 10.).18  Slika 10. Shematski prikaz mehanizma djelovanja ganciklovira Ganciklovir-trifosfat kao i aciklovir-trifosfat ne posjeduje ribozu koja je potrebna za daljnje spajanje nukleotida. Time je daljnji proces izgradnje novonastale molekule DNA prekinut ato ujedno uzrokuje i njen raspad. Na taj na in je onemogueno daljnje airenje viusa na zdrave stanice.15 2.2.3. Penciklovir (PCV) Penciklovir [9-(4-hidroksi-3-hidroksimetilbut-1-il)gvanin] je nukleozidni analog molekulske formule C10H15N5O3. Struktura penciklovira je temeljena na nukleozidnoj bazi (gvanin) na koju je vezan otvoreni lanac koji zamjenjuje aeerni prsten (Slika 11.).19  EMBED ChemDraw.Document.6.0  Slika 11. Struktura penciklovira Penciklovir se prvenstveno koristi u terapiji bolesti uzrokovanih HSV-1, HSV-2 i VZV virusom. Penciklovir se isklju ivo primjenjuje lokalno jer je apsorpcija u slu aju oralne primjene jako mala. Famciklovir [diacetil ester 9-(4-hidroksi-3-hidroksimetil-but-1-il)-6-deoksigvanina] je prolijek koji se koristi kada je potrebna opa primjena penciklovira.15  EMBED ChemDraw.Document.6.0  Slika 12. Struktura famciklovira Mehanizam djelovanja je temeljen na procesu deacetiliranja i oksidacije famciklovira, prilikom ega se on prevodi u penciklovir.15 Penciklovir se u oboljeloj stanici fosforilira u penciklovir monofosfat djelovanjem virusne timidin kinaze, nakon ega slijedi prevoenje penciklovir-monofosfata u penciklovir di- i trifosfat djelovanjem stani nih kinaza. Nastali penciklovir-trifosfat inhibira virusnu DNA polimerazu ime ujedno i sprje ava daljnju sintezu DNA.18 Iako penciklovir ima manji afinitet prema virusnoj DNA polimerazi od aciklovira, njegovo vrijeme zadr~avanja u stanici je deset do dvadeset puta du~e nego ono u aciklovira.19  Slika 13. Shematski prikaz mehanizma djelovanja penciklovira 2.2.4. Dihidroksipropil adenin (DHPA) Dihidroksipropil adenin (DHPA) je nukleozidni acikli ki analog molekulske formule C8H11N5O2 kojeg su sintetizirali Eric de Clercq i Anthonin Holy sredinom sedamdesetih godina proalog stoljea. Struktura DHPA je temeljena na adeninu na kojeg je vezan acikli ki dihidroksipropilni lanac (Slika 14). Znanstveno je dokazano da DHPA ima airoko antivirusno djelovanja podjednako na DNA i RNA viruse.20  EMBED ChemDraw.Document.6.0  Slika 14. Struktura (S)-9-(2,3-dihidroksipropil)adenina Mehanizam djelovanja DHPA kao i velikog broja acikli kih analoga adenina je temeljen na inhibiranju enzima S-adenozilhomocistein (SAH) hidrolaze. Enzim SAH hidrolaza cijepa S-adenozilhomocistein (SAH) na homocistein i adenozin, pri emu je ujedno mogu daljnji metabolizam adenozina u AMP, adenin ili inozin. SAH je krajnji produkt reakcije demetoksiliranja S-adenozilmetionina (SAM) koji ima va~nu ulogu u metoksiliranju virusne mRNA. DHPA inhibira SAH hidrolazu te time onemoguava cijepanje SAH molekule i uzrokuje njeno akumuliranje, ato posljedi no inhibira i proces. Na taj na in je sprije eno metoksiliranje virusne mRNA koja je osnovna komponenta u sintezi virusne DNA.20 DHPA se zbog specifi nog na ina djelovanja svrstava u grupu SAH hidrolaza inhibitora koji se koriste u terapiji bolesti uzrokovanih herpesvirusom, retrovirusom, rabdovirusom, filuvirusom, arenavirusom, reovirusom, paramiksovirusom i poksvirusom.20 2.3. BICIKLI KI ANALOZI NUKLEOZIDA (BCNA) Bicikli ki nukleozidni analozi (BCNA) predstavljaju grupu spojeva koja ima dokazano bioloako djelovanje na sintezu varicella-zoster virusa (VZV). BCNA su po prirodi lipofilne molekule ije je glavno obilje~je mala toksi nost prema zdravim stanicama uz izrazitu selektivnost prema stanicama zahvaenima VZV. Najvei broj BCNA je temeljen na strukturi furopirimidina (Slika 15).21  EMBED ChemDraw.Document.6.0  Slika 15. Osnovna struktura furopirimidinskog analoga nukleozida Nakon ato je dokazano antivirusno djelovanje velikog broja acikli kih nukleozidnih analoga, istra~ivanja su bila usmjerena na optimiranje njihove sinteze. Jedan od na ina njihovog dobivanja je bila uporaba paladijevih kompleksa kao katalizatora, ato je rezultiralo poveanjem iskoriatenja reakcije. Uporaba paladijevih kompleksa je takoer rezultirala nastankom nepoznatog produkta molekulske mase znatno vee od one kod acikli kih analoga. Uzevai u obzir da su acikli ki analozi bili primarni cilj istra~ivanja, na nastale nepoznate produkte se nije posveivala vea pa~nja te su du~i niz godina bili smatrani kao nusprodukti paladij kataliziranih reakcija. Kasnije je raznim analiti kim metodama utvreno da se radi o novonastalim bicikli kim spojevima koji nemaju nikakvo bioloako djelovanje.22 Krajem devedesetih godina proalog stoljea su sintetizirani bicikli ki spojevi sa vezanim alifatskim lancima. Bioloakim ispitivanjima je utvreno da du~i lanac uzrokuje veu bioloako aktivnost prema VZV. Daljnim ispitivanjima je utvreno da bicikli ki analozi sa alifatskim lancima koje ini 8-10 ugljikovih atoma imaju najizra~enije antivirusno djelovanje, ak 200 puta ja e od aciklovira.23 Mehanizam nastajanja bicikli ke forme je temeljen na aktiviranju trostruke ugljik-ugljik veze djelovanjem aril-paladij-jodida koji pospjeauje njenu reaktivnost prema nukleofilu. Atom kisika sa pirimidina nukleofilno napada trostruku vezu pri emu nastaje vinil-paladij intermedijer, koji se reduktivnom eliminacijom paladija prevodi u bicikli ku formu (Slika 16.).23  EMBED ChemDraw.Document.6.0  Slika 16. Mehanizam nastajanja BCNA BCNA molekule pokazuju izrazitu selektivnost prema VZV, iako razlog takvog djelovanja jo nije razjanjen. Smatra se da je bioloko aktivnost BCNA temeljena na fosforiliranju osnovne molekule djelovanjem aktivirajueg enzima VZV timidin kinaze (VZV-TK). Osnovna molekula BCNA se fosforilira u BCNA-monofosfat (BCNA-MP), nakon ega slijedi prevoenje BCNA-MP u BCNA-difosfat (BCNA-DP).24 Istra~ivanjem je dokazano da stani na HE-NDP kinaza uzrokuje nastajanje trifosfatnog oblika veine acikli kih nukleozidnih analoga, ato nije slu aj kod BCNA. Stoga se pretpostavlja da je potencijalno nastajanje BCNA-trifosfata (BCNA-TP) mogue djelovanjem nekog drugog stani nog enzima, ili da su za antivirusno djelovanje BCNA odgovorni BCNA-MP i BCNA-DP.25 Na slici 17. je mogue vidjeti shematski prikaz pretpostavljenog mehanizma djelovanja BCNA.  Slika 17. Pretpostavljeni mehanizam djelovanja BCNA U danaanje vrijeme se provodi velik broj istra~ivanja s ciljem otkrivanja novih BCNA molekula koje bi pokazivale antivirusno djelovanje aireg spektra. Istra~ivanja su takoer usmjerena na razumijevanje njihove specifi ne selektivnosti kao i mehanizma djelovanja. Paladij katalizirane reakcije i dalje predstavljaju naju estaliji prisup sintezi BCNA.24  EMBED ChemDraw.Document.6.0  Slika 18. Strukture anti-VZV nukleozidnih analoga baziranih na furopirimidinima 2.4. SONOGASHIRINA REAKCIJA Nakon ato je u sedamdesetim godinama proalog stoljea otkriveno antivirusno djelovanje nukleozidnih analoga, velik broj istra~ivanja je bio usmjeren na na in i optimiranje njihove sinteze. Ubrzo je utvreno da reakcije potpomognute metalnim katalizatorima predstavljaju najefikasniji pristup njihovog dobivanja. Jedna od prvih sinteza je bila Mizoroki-Heck reakcija, koja je temeljena na arilaciji ili alkilaciji alkena pri temperaturama od oko 100C uz prisustvo fosfan-paladij kompleksa kao katalizatora. Kenkichi Sonogashira, Nobue Hagihara i Yasuo Tohda su 1975. godine prvi proveli paladij kataliziranu reakciju pri sobnoj temperaturi uz vee iskoriatenje. Od tada tzv. Sonogashirine reakcije predstavljaju najkoriateniji pristup sintezi novih nukleozidnih analoga.26 Sonogashirina reakcija je paladijem katalizirana reakcija alilnih i arilnih halogenida sa terminalnim alkinima uz prisustvo baze i halogene soli bakra kao ko-katalizatora.27 Naj eae upotrebljavani Pd (0) kompleksi su tris(dibenzildenaceton)dipaladij [Pd2(dba)3] i tetrakis(trifenilfosfin)paladij [(PPh3)4Pd] koji je i komercijalno najkoriateniji Pd(0) kompleks.28 Tetrakis(trifenilfosfin)paladij je po prirodi fotosenzibilan i nestabilan u atmosferskim uvjetima. Njegovi nedostatci su ote~ano uklanjanje iz smjese produkata kao i povremena slaba reaktivnost koja je posljedica velikog broja liganada. Najkoriatenije halogene soli bakra su bakar jodid (CuI) i bakar bromid (CuBr). Kao baza se naj eae koristi trietilamin (Et3N), dietilamin (Et2NH), dipropilamin (Pr2NH) i morfolin, dok se kao otapala naj eae koriste DMF, DMSO, THF i N-metilpirolidon.29 Odabir odgovarajuih kemikalija prvenstveno ovisi o prirodi supstrata i produkta, kao i o ~eljenom tijeku reakcije.26 Sonogashirinom reakcijom je mogue izravno uvesti sp2 ugljikov atom u alkine (Slika 19.).30  EMBED ChemDraw.Document.6.0  Slika 19. Sonogashirina reakcija Iako mehanizam Sonogashirinih reakcija nije u potpunosti razjaanjen, pretpostavlja se da je cijeli proces temeljen na etiri osnovna stupnja: oksidativna adicija, transmetaliranje, trans/cis izomerizacija i reduktivna eliminacija (Slika 20.). U prvom stupnju Pd (0) kompleks reagira sa arilom ili vinilom, pri emu nastaje Pd (2) intermedijer. Za oksidativnu adiciju se smatra da je najsporiji stupanj mehanizma Sonogashirinih reakcija. U drugom stupnju dolazi do transmetiliranja nastalog Pd intermedijera. Dodatkom CuI dolazi do aktivacije alkina, pri emu nastaje Cu-acetilidom koji reagira sa Pd intermedijerom. Pritom nastaje trans alkinil-Pd-R specija koja se u treem stupnju prevodi u cis formu. Cis alkinil-Pd-R specija se redukcijom u etvrtom stupnju prevodi u alkin, a Pd kompleks se regenerira. Sonogashirine reakcije sa piperidinom ili pirolidonom je mogue provesti bez prisustva CuI, ato e rezultirati nastajanjem arilalkina ili enina sa visokim iskoriatenjem.26,29  EMBED ChemDraw.Document.6.0  Slika 20. Mehanizam Sonogashirine reakcije C-5 jod supstituirani derivati pirimidina su se pokazali kao dobri sintetski intermedijeri za stvaranje nove ugljik-ugljik veze. Reakcija je temeljena na supstituciji atoma joda sa elektrofilom u polo~aju C-5.31 Sonogashirirne reakcije omoguuju sintezu nekih C-5 derivata pirimidina sa iskoriatenjem od 70% do 97%. Iako je sobna temepreatura osnovno polaziate veine Sonogashirinih reakcija, blago poveenje temperature reakcijske smjese ponekad predstavlja bolje uvjete za nastanak nove C C veze, ato ujedno podrazumijeva i vee iskoriatenje. Optimalni omjeri reaktanta Sonogashirinih reakcija za nastajanje C-5 derivata pirimidina su 2.0-2.5 ekvivalenata terminalnih alkina, 10% (PPh3)4Pd katalizatora, 20% CuI i 1.2 ekvivalenata Et3N. Otapala se dodaje u minimalnim potrebnim koli inima zbog lakaeg uklanjanja nakon provedene reakcije.29 Veina acikli kih derivata je popraena nastajanjem bicikli kih ko-produkata sa iskoriatenjem manjim od 7%, od kojih neki imaju dokazano antivirusno djelovanje protiv VZV. Sintezu bicikli kih spojeva je mogue reducirati koriatenjem veih koli ina otapala kao ato je DMF, a pospjeaiti ju je mogue koriatenjem veih koli ina bakar-jodida i trietilamina.22 SINTEZA POTPOMOGNUTA MIKROVALOVIMA Mikrovalno zra enje je elektromagnetsko zra enje valne duljine od 1 mm do 1 m, ato odgovara frekvenciji 0.3 do 300 GHz. Uzevai u obzir da se radi o elektromagnetskom zra enju, mogue ga je u svrhu jednostavnijeg razumijevanja podijeliti na elektri nu i magnetsku komponentu. Elektri na komponenta mikrovalnog zra enja je odgovorna za interakciju sa materijom, pri emu elektri no polje uzrokuje zagrijavanje dipolnom polarizacijom (rotacija dipola) ili kondukcijskim mehanizmom (ionska vodljivost), odnosno inducira polarizaciju unutar materije.32 Prva publikacija zasnovana na uporabi mikrovalnog zra enja u kemiji je objavljena 1986. godine. Prvi eksperimenti su se provodili u kunim mikrovalnim penicama kod kojih nije bilo mogue uspostaviti kontrolirane uvjete, ato je ponekad rezultiralo ne~eljenim ishodom reakcije. U danaanje vrijeme se kemijske reakcije potpomognute mikrovalovima provode u mikrovalnim reaktorima (Slika 21.). Za razliku od kunih mikrovalnih penica, mikrovalni reaktori omoguuju provoenje reakcija u potpuno kontroliranim uvjetima.33 Glavna komponenta svakog mikrovalnog reaktora je magnetron koji je ujedno i izvor mikrovalnog zra enja frekvencije 2.45 GHz. Magnetron je cijev visokog vakuuma u kojoj nastaje MW zra enje na temelju interakcije snopa elektrona i magnetskog polja. ine ga katoda negativnog potencijala, magneti te stabilni izvor elektri ne energije koji zajedno uzrokuju nastajanje MW zra enja.33  Slika 21. Shematski prikaz mikrovalnog reaktora Nastalo mikrovalno zra enje putuje valovodom do kuiata u kojem se nalazi kiveta sa uzorkom. Svaki mikrovalni reaktor joa ima deflektor i cirkulator. Deflektor osigurava konstantno mikrovalno zra enje na na in da energiju MW zra enja koja je vea od definirane pretvara u toplinsku energiju, dok cirkulator atiti magnetron i cijeli mikrovalni reaktor od reflektirajueg MW zra enja.33 Tri glavna procesa koja karakteriziraju interakciju MW zra enja sa reakcijskom smjesom ili materijalom su refleksija, transmisija i apsorpcija. Kod refleksije dolazi do odbijanja MW zra enja od povraine materijala, te je ta pojava karakteristi na za metale. Kod transmisije dolazi do prolaza MW zra enja kroz materijal bez  predaje energije samog zra enja materijalu, a sam proces je karakteristi an za nevodljive tvari (izolatore). Za razliku od prethodna dva procesa, apsorpcija uklju uje ulaz MW zra enja u materijal, te njegovu djelomi nu ili potpunu transformaciju iz jednog oblika energije u drugi. Apsorpcija MW zra enja je svojstvo materijala, ato zna i da efikasnost prijelaza jednog oblika energije u drugi prvenstveno ovisi o prirodi materijala.33 Primjena mikrovalnog zra enja u organskoj kemiji omoguuje br~e provoenje kemijskih reakcija uz vee iskoriatenje nastalog produkta. Osnovni mehanizam je temeljen na homogenom zagrijavanju reakcijske smjese ato smanjuje mogunost nastanka ne~eljenih nusprodukata, odnosno raspad nastalog produkta. 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Iz tog razloga proizlazi va~nost odabira otapala koje se koristi u mikrovalnoj sintezi. Polarna otapala dobro apsorbiraju mikrovalno zra enje, ato kao posljedicu uzrokuje njihovo zagrijavanje kao i zagrijavanje cijele reakcijske smjese. Naju estalija otapala koja se koriste u mikrovalnim sintezama su metanol, etanol, DMF, acetonitril, etil-acetat i DMSO.34 Sinteze potpomognute mikrovalovima omoguuju krae vrijeme reakcije, vee iskoriatenje, manji udio nusprodukata kao i veu selektivnost. Njihova primjena u organskoj kemiji se zbog navedenih prednosti u posljednjih dvadeset godina znatno poveala. Iako u danaanje vrijeme mikrovalna sinteza i dalje predstavlja alternativni pristup provoenju reakcija, velik broj objavljenih publikacija ukazuje na njenu va~nost u organskoj kemiji.34 3.0. EKSPERIMENTALNI DIO 3.1. OPE NAPOMENE Sva otapala su suaena i pro iaavana prema preporu enom postupku suaenja agensima i/ili destiliranjem preko molekulskih sita veli ine 3. Za praenje tijeka reakcije je koriatena metoda tankoslojne kromatografije. Tankoslojna kromatografija je provoena na plo ama 60F-254 presvu enih slojem silikagela Merck u odgovarajuem sustavu otapala. Za detekciju izoliranih komponenata je koriatena UV-svjetlost valne duljine 254 nm. Kromatografija na koloni je provedena na silikagelu (Fluka, 0.063 0.2 nm), dok su staklene kolone punjene pod utjecajem gravitacijske sile uz eluens diklormetan/metanol (CH2Cl2/MeOH) ili etil acetat (EtAc). Temperature taliata sintetiziranih spojeva su odreene na instrumentu Kofler (Reichert, Wien ) i nisu korigirane. Spektri 1H-NMR i 13C-NMR su snimljeni na spektrometru Bruker Avance 300 i 600 MHz. Svi uzorci su otopljeni u DMSO-d6 i mjereni pri 298 K u NMR cjev ici od 5mm. Kemijski pomaci () u 1H-NMR i 13C-NMR spektrima su izra~eni u ppm u odnosu prema tetrametilsilanu (TMS,  0,0 ppm), a konstante sprege (J) u hercima (Hz). Pojedina ne rezonancije su asignirane na temelju njihovih kemijskih pomaka, intenziteta signala, multipliciteta signala i konstanti sprega H-H. Maseni spektri su snimljeni na instrumentu Agilent 6410 opremljenim sa elektrosprejem i trostrukim kvadropolom (LC/MS/MS). Visokou inkovita tekuinska kromatografija (HPLC) je provedena na instrumentu Agilent 1100 sa UV detektorom koristei Zorbax C18 kolonu (2.1 x 30nm, 3.5 m). FLASH kromatografija je provedena na instrumentu Teledyne ISCO CombiFlash Rf. 3.2. PRIPRAVA SPOJEVA 1A) 5-(heks-1-inil)pirimidin-2,4-dion Reakcijska smjesa 5-joduracila (200 mg; 0.84 mmol), heksina (0.29 ml; 2.52 mmol), Et3N (0.12 ml; 1.68 mmol), CuI (15.2 mg, 0.08 mmol) i (PPh3)4Pd (78 mg, 0.08 mmol) u DMF-u (8 ml) je mijeaana na sobnoj temperaturi 24h. Napredovanje reakcije je praeno TLC-om. Nakon zavraetka reakcije otapalo je upareno uz sni~eni tlak, a nastali produkt je pro iaen kromatografijom na koloni uz slijedei eluens; CH2Cl2 i CH2Cl2:CH3OH = 40:1. Dobiven je spoj 1A (69 mg; 42.9 %). 2A) 1-alil-5-(heks-1-inil)pirimidin-2,4-dion Reakcijska smjesa 5-(heks-1-inil)pirimidin-2,4-diona (66 mg; 0.344 mmol), alil-bromida (0.03 ml; 0.35 mmol) i K2CO3 (0.12 ml; 0.31 mmol) u DMF-u (4.5 ml) je 4h zagrijavana na uljnoj kupelji (T=130 C) sa povratnim hladilom. Napredovanje reakcije je praeno TLC-om. Otapalo je upareno uz sni~eni tlak, a nastali produkt je pro iaen kromatografijom na koloni uz slijedei eluens; CH2Cl2, CH2Cl2:CH3OH = 35:1. Dobiven je spoj 2A (52.7 mg; 66.1 %) (M+ 233.3). 3A) 1-(2,3-dihidroksipropil)-5-(heks-1-inil)pirimidin-2,4-dion Metoda A : Reakcijska smjesa 1-alil-5-(heks-1-inil)pirimidin-2,4-diona (2A) (49.4 mg; 0.2127 mmol), NaClO3 (27.2 mg; 0.26 mmol), OsO4 (0.053 mg; 0.00021 mmol) u destiliranoj vodi (6 ml) je na sobnoj temperaturi mijeaana 24h. Prilikom dodavanja OsO4 reakcijska smjesa je poprimila sivu boju. Napredovanje reakcije je praeno TLC-om. Reakcijska smjesa je filtrirana preko naboranog filter papira, a potom je otapalo upareno uz sni~eni tlak. Produkt je pro iaen kromatografijom na koloni uz eluens CH2Cl2:CH3OH = 5:1. Dobiven je spoj 3A (2 mg; 3.6 %). Metoda B : Reakcijska smjesa 5-(heks-1-inil)pirimidin-2,4-diona (11 mg; 0.000049 mmol), 3-klorpropan-1,2-diola (0.01 ml, 0.11 mmol) i K2CO3 (6.8 mg; 0.049mmol) u DMF-u (5 ml) je mijeaana na sobnoj temperaturi. Nakon 72h je na temelju TLC-a vidljivo da ~eljena reakcija nije uspjela. 4A) 1-alil-5-jodpirimidin-2,4-dion Reakcijska smjesa 5-joduracila (300 mg; 1.26 mmol), K2CO3 (156.8 mg; 1.14 mmol) i alil-bromida (0.09 ml; 0.001 mmol) u DMF-u (9 ml) je mijeaana na sobnoj temperaturi 1h. Na temelju TLC-a je vidljivo da u reakcijskoj smjesi ima po etnog 5-joduracila, te je naknadno dodan alil-bromid (0.09 ml; 0.001 mmol). Reakcijska smjesa je zagrijavana na uljnoj kupelji (T=130 C) sa povratnim hladilom 24h. Napredovanje reakcije je praeno TLC-om. Otapalo je upareno uz sni~eni tlak, a nastali produkt je pro iaen kromatografijom na koloni uz eluens CH2Cl2:CH3OH = 20:1. Dobiven je spoj 4A (82.7 mg; 24.1 %). 5A) 1-(2,3-dihidroksipropil)-5-jodpirimidin-2,4-dion Reakcijska smjesa 1-alil-5-jodopirimidin-2,4-diona (4A) (70.0 mg; 0.25 mmol), NaClO3 (32.36 mg; 0.30 mmol), OsO4 (0.053 mg; 0.00025 mmol) u destiliranoj vodi (7 ml) je na sobnoj temperaturi mijeaana 24h. Napredovanje reakcije je praeno TLC-om. Otapalo je upareno uz sni~eni tlak, a nastali produkt je pro iaen kromatografijom na koloni uz eluens CH2Cl2:CH3OH = 10:1. Dobiven je spoj 5A (46 mg; 58.9 %). 8B) 3-(2,3-dihidroksipropil)-6-pentilfuro[2,3-d]pirimidin-2-on Reakcijska smjesa 1-(2,3-dihidroksipropil)-5-jodpirimidin-2,4-diona (5A) (200 mg; 0.637 mmol), 1-heptina (0.25 ml; 1.43 mmol), Et3N (0.091 ml; 0.652 mmol), CuI (15.135 mg, 0.08 mmol) i (PPh3)4Pd (59.1 mg, 0.051 mmol) u DMF-u (10 ml) je mijeaana na sobnoj temperaturi 48h. Napredovanje reakcije je praeno TLC-om. S obzirom na veliku koli inu neizregiranih reaktanta, dodana je ista koli ina Et3N, CuI i Pd(PPh3)4, a reakcijska smjesa je mijeaana na sobnoj temperaturi joa 24h. Otapalo je upareno uz sni~eni tlak, a smjesa produkata je djelomi no pro iaena kromatografijom na koloni uz eluens CH2Cl2:CH3OH = 20:1. Dobiven je spoj 8B sa popratnim ne istoama. Spoju 8B je dodan metanol, te je reakcijska smjesa filtrirana, a filtrat uparen. Filtratu je potom dodan diklormetan te je smjesa ostavljena 24h u hladnjaku. Spoj 8B se preko noi istala~io, a separacija komponenti je provedena metodom filtracije preko naboranog filter papira. Dobiven je spoj 8B (8 mg; 3.4 %). 9A) 5-(hept-1-inil)pirimidin-2,4-dion 9B) 6-pentilfuro[2,3-d]pirimidin-2-on Metoda A : Reakcijska smjesa 5-joduracila (200 mg; 0.84 mmol), heptina (0.33 ml; 2.52 mmol), Et3N (0.12 ml; 1.68 mmol ), CuI (15.2 mg; 0.08 mmol) i (PPh3)4Pd (78 mg; 0.08 mmol) u DMF-u je mijeaana na sobnoj temperaturi 24h. Napredovanje reakcije je praeno TLC-om. Otapalo je upareno uz sni~eni tlak a ostatak je pro iaen kromatografijom na koloni uz eluens CH2Cl2, a zatim CH2Cl2:CH3OH = 40:1. Dobiven je spoj 9A (46 mg; 26.6 %). Metoda B : Reakcijska smjesa 5-joduracila (500 mg; 2.1 mmol), heptina (0.83 ml; 6.3 mmol), Et3N (0.58 ml; 4.2 mmol ), CuI (40 mg; 0.21 mmol) i (PPh3)4Pd (204.75 mg; 0.21 mmol) u DMF-u je mijeaana 2h na 40 C pod utjecajem mikrovalnog zra enja (300W). Napredovanje reakcije je praeno TLC-om. Otapalo je upareno pod sni~enim tlakom, a ostatak je pro iaen kromatografijom na koloni uz po etni eluens CH2Cl2:CH3OH = 40:1, a zatim CH2Cl2:CH3OH = 20:1. Dobiveni su spojevi 9A (155 mg; 36.1 %) i 9B (17 mg; 3.9 %). 10A) 5-(hept-1-inil)-1-[4-hidroksi-3-(hidroksimetil)butil]pirimidin-2,4-dion Reakcijska smjesa 5-(hept-1-inil)pirimidin-2,4-diona (9A) (148 mg; 0.718 mmol) i K2CO3 (149 mg; 1.08 mmol) u DMF-u (9 ml) je mijeaana pola sata, a potom je dodan 1,3-diacetoksi-2-jodetilpropan (270 mg; 0.00072 mmol). Reakcijska smjesa je mijeaana 24h na sobnoj temperaturi. Napredovanje reakcije je praeno TLC-om. Otapalo je upareno pod sni~enim tlakom, a nastali produkt je pro iaen kromatografijom na koloni uz slijedei eluens; CH2Cl2, CH2Cl2:CH3OH = 10:1. Dobiven je spoj 10A (2 mg; 0.9 %). 11A) 1,3-dibenziloksi-2-klormetoksipropan Reakcijska smjesa 1,3-dibenziloksi-2-propanola (5 g; 18.37 mmol), p-formaldehida (1.25 g) i dikloretana (42 ml, 532 mmol) je 8h propuhivana plinovitim HCl-om. Potom je dodan bezvodni CaCl2. Nakon 1h je reakcijska smjesa profiltrirana, a otapalo je upareno pod sni~enim tlakom. Dobiven je spoj 11A. 12A) 2,4-diklorpirimidin Reakcijska smjesa uracila (6 g; 0.0536 mol), fosfor oksiklorida (POCl3) (107 ml; 1.15 mol) i N,N-dietilanilina (12 ml; 0.077 mol) je 1h zagrijavana na uljnoj kupelji (T=120 C) sa povratnim hladilom. Napredovanje reakcije je praeno TLC-om. Reakcijska smjesa je uparena pod sni~enim tlakom, a nastali produkt je ekstrahiran u sustavu CH2Cl2/H2O. Organski sloj je suaen nad MgSO4 koji je naknadno filtriran koriatenjem naboranog filter papira. Reakcijska smjesa je uparena pod sni~enim tlakom. Dobiven je spoj 12A koji nije pro iaavan. (M+ 150.2) 13A) 2,4-dimetoksipirimidin Reakcijska smjesa 2,4-dikloruracila (7.98 g; 0.054 mol) i natrijevog metoksida, pripremljenog otapanjem natrija (6.198 g; 0.27 mol) u metanolu (269.5 ml; 0.0084 mol), je mijeaana 20h na sobnoj temperaturi. Napredovanje reakcije je praeno TLC-om. Otapalo je upareno uz sni~eni tlak, a nastali produkt je pro iaen kromatografijom na koloni uz eluens CH2Cl2:CH3OH = 100:1. Dobiven je spoj 13A (1.3 g). 14A) 1-(1,3-dibenziloksi-2-propoksimetil)-4-metoksipirimidin-2-on Reakcijska smjesa suaenog 2,4-dimetoksiprimidina (13A) (1.2 g; 8.57 mmol) i K2CO3 (1.42 g; 0.01 mmol) otopljenog u 60 ml apsolutno suhog CH2Cl2 je 45min propuhivana sa argonom. Naknadno je dodan osuaeni 1,3-dibenziloksi-2-klormetoksipropan (11A) (3.57 g; 11.1 mmol). Reakcijska smjesa je mijeaana na sobnoj temperaturi 24h. Napredovanje reakcije je praeno TLC-om. Nakon zavraetka reakcije je K2CO3 filtriran koriatenjem naboranog filter papira, otapalo je upareno uz sni~eni tlak, a nastali produkt je pro iaen kromatografijom na koloni uz eluens CH2Cl2:CH3OH = 100:1. Dobiveni su spojevi 14A i 14B (1.27 g; 36.1 %) (M+ 411.4). 15A) 1-(1,3-dibenziloksi-2-propoksimetil)pirimidin-2,4-dion Reakcijska smjesa 1-(1,3-dibenziloksi-2-propoksimetil)-4-metoksipirimidin-2-ona (14A) (1.266g; 0.0032 mmol) i acetilklorida (AcCl) (21.67 ml; 0.304 mol) je 24h zagrijavana na uljnoj kupelji (T=63C) sa povratnim hladilom, a potom je dodano 6 ml destilirane vode. Napredovanje reakcije je praeno TLC-om. Reakcijska smjesa je pro iaavana kromatografijom na koloni uz EtAc kao eluens. Dobiven je spoj 15A (177 mg; 13.9%). 16A) 3-(2-benzoiloksietil)-1-(1,3-dibenziloksi-2-propoksimetil)-pirimidin-2,4-dion Reakcijska smjesa 1-(1,3-dibenziloksi-2-propoksimetil)pirimidin-2,4-diona (15A) (147mg; 0.3710 mmol), 2-brometil-benzoata (116.9 mg; 0.55 mmol), K2CO3 (132.14 mg; 0.96 mmol) u otapalu aceton/DMF (1:1, 5 ml) je mijeaana 24h na uljnoj kupelji (T=50 C). Napredovanje reakcije je praeno TLC-om. Nakon 24h je naknadno dodan 2-brometilbenzoat (45 mg; 0.212 mmol), a reakcijska smjesa je mijeaana 3h na uljnoj kupelji (T=50 C). K2CO3 je filtriran koriatenjem naboranog filter papira, a otapalo je upareno pod sni~enim tlakom. Nastala smjesa produkata je pro iaena FLASH kromatografijom uz CH2Cl2 i CH2Cl2:CH3OH = 100:1 kao eluens. Dobiven je spoj 16A (30 mg; 14.9 %). 17A) 3-(2-benzoiloksietil)-1-(1,3-dihidroksi-2-propoksimetil)-pirimidin-2,4-dion Reakcijska smjesa 3-(2-benzoiloksietil)-1-(1,3-dibenziloksi-2-propoksimetl)-pirimidin -2,4-diona (16A) (16.5 mg; 0.030 mmol) i istog CH2Cl2 (2 ml; 31 mmol) je mijeaana na temperaturi T =  68 C uz prethodno propuhivanje argonom. Potom je dodan BCl3 (0.133 ml; 1.52 mmol). Napredovanje reakcije je praeno TLC-om. Nakon 3h reakcija je zaustavljena dodatkom 5ml CH2Cl2/CH3OH. Otapalo je upareno uz sni~eni tlak, a nastali produkt je pro iaen kromatografijom na koloni uz EtAc kao eluens. Dobiven je spoj 17A (10.9 mg; 92.53 %) 3.3. PREGLED SINTETIZIRANIH SPOJEVA  EMBED ChemDraw.Document.6.0   EMBED ChemDraw.Document.6.0  1A 2A  EMBED ChemDraw.Document.6.0   EMBED ChemDraw.Document.6.0  3A 4A  EMBED ChemDraw.Document.6.0   EMBED ChemDraw.Document.6.0  5A 8B  EMBED ChemDraw.Document.6.0   EMBED ChemDraw.Document.6.0  9A 9B  EMBED ChemDraw.Document.6.0   EMBED ChemDraw.Document.6.0  10A 11A  EMBED ChemDraw.Document.6.0   EMBED ChemDraw.Document.6.0  12A 13A  EMBED ChemDraw.Document.6.0   EMBED ChemDraw.Document.6.0  14A 15A  EMBED ChemDraw.Document.6.0   EMBED ChemDraw.Document.6.0  16A 17A 4.0. REZULTATI I RASPRAVA 4.1. SINTEZE SPOJEVA Primjenom razli itih sintetskih puteva u viaestupnjevitim sintezama pripravljeni su spojevi iz reda C-5 supstituiranih alkinilnih pirimidina i bicikli kih furo[2,3-d]pirimidina sa odgovarajuim pobo nim lancem u polo~aju N-1 ili N-3. Sinteza C-5 alkinilnih pirimidinskih derivata i C-6 supstituiranih furo[2,3-d]pirimidin- 2-ona je provedena Sonogashirinom reakcijom 5-joduracila (5-IU) sa odgovarajuim terminalnim alkinima uz tetrakis(trifenilfosfin)paladij ((PPh3)4Pd), bakar(I)-jodid (CuI) i trietilamin (Et3N) pri sobnoj temperaturi (Shema 1).  EMBED ChemDraw.Document.6.0  1A9A, 9BR(CH2)3CH3(CH2)4CH3Shema 1. Sonogashirinom reakcijom terminalnih alkina sa 5-IU, te njihovom in situ ciklizacijom pospjeaenom Et3N i CuI sintetizirani su C-5 alkinilni pirimidinski derivati (1A, 9A) u iskoriatenju od 26.6 i 42.9 % i derivat furo[2,3-d]pirimidina (9B) u iskoriatenju od 3.9 %. Sonogashirina reakcija za spoj 9A i 9B je provedena klasi nim i mikrovalnim putem. Mikrovalna sinteza se pokazala efikasnijom zbog veeg iskoriatenja reakcije i nastajanja bicikli kog produkta. Bicikli ki furopirimidinski analog je sintetiziran in situ O-hetero-anulacijom, odnosno 5-endo-dig-elektrofilnom ciklizacijom alkinilnog derivata kataliziranom sa CuI u trietilaminu na sobnoj temperaturi. Reakcija ciklizacije uklju uje karbonilni kisik u polo~aju C-4 pirimidinskog prstena i etinsku vezu na polo~aju C-5 pirimidinskog prstena (Shema 2).  EMBED ChemDraw.Document.6.0  Shema 2. Sinteza C-5 alkinilnog pirimidinskog derivata sa vezanim 2,3-dihidroksipropilnim lancem na N-1 polo~aju (3A) je provedena na dva razli ita na ina. Prvi pristup sintezi uklju uje vezanje propenilnog supstituenta na N-1 polo~aj C-5 alkinilnog pirimidinskog derivata (1A) uz prisustvo baze (K2CO3). Nastali C-5 alkinilni pirimidinski derivat sa vezanim lancem na N-1 polo~aju (2A) se potom uz prisustvo OsO4 oksidira u spoj 3A. Drugi pristup sintezi uklju uje izravno vezanje 2,3-dihidroksipropilnog lanca na N-1 polo~aj spoja 1A uz prisustvo baze K2CO3 pomou 3-klorpropan-1,2-diola kao alkilirajueg reagensa. Prvi pristup sintezi je uspjeano proveden uz iskoriatenje 3.6 %, za razliku od drugog pristupa koji nije dao ~eljeni produkt. (Shema 3.)  EMBED ChemDraw.Document.6.0  Shema 3. Kako su oksidacijom spoja 2A uz spoj 3A (produkt oksidacije dvostruke veze) nastali i produkti oksidacije trostruke veze, primijenjen je druga iji pristup sintezi: prvo je oksidirana dvostruka veza alilnog lanca na polo~aju N-1 pirimidina, a potom je provedena Sonogashirina reakcija kako bi se priredili C-5 alkinilni i furo[2,3-d] pirimidinski derivati. 1-Alil-5-jodpirimidin (4A) pripravljen je reakcijom 3-bromprop-1-ena i 5-joduracila uz prisustvo K2CO3. Reakcija je uspjeano provedena uz iskoriatenje od 24.1 %. Nastali 1-alil-5-jodpirimidinski derivat se dodatkom OsO4 oksidira u 1-(2,3-dihidroksipropil)-5-joduracil (5A) uz iskoriatenje od 58.9 % (Shema 4).  EMBED ChemDraw.Document.6.0  Shema 4. Pokuaaj priprave C-5 alkinilnih pirimidinskih derivata (6-8A) i C-6 supstituiranih furo[2,3-d] pirimidinskih derivata (6-8B) s 2,3-dihidroksipropilnim lancem je proveden Sonogashirinom reakcijom 1-(2,3-dihidroksipropil)-5-joduracila s odgovarajuim terminalnim alkinima uz tetrakis(trifenilfosfin)paladij ((PPh3)4Pd), bakar(I)-jodid (CuI) i trietilamin (Et3N) pri sobnoj temperaturi (Shema 5). U ovim je uvjetima izoliran jedino bicikli ki furo[2,3-d] pirimidinski derivat 8B kao produkt iz reakcije s 1-heptinom. Sonogashirinim reakcijama s 1-oktin-3-olom i fenilacetilenom nisu pripravljeni ~eljeni C-5 alkinilni (6A i 7A) i C-6 supstituirani furo[2,3-d]pirimidinski derivati (6B i 7B).  Shema 5. Sinteza C-5 alkinilnog pirimidinskog derivata s dihidroksiizobutilnim lancem (10A) je temeljena na reakciji 2-acetoksimetil-4-jodbutilacetata s C-5 supstituiranim alkinilnim pirimidinskim derivatom (9A) uz prisustvo baze K2CO3 (Shema 6.). Ovim je putem pripravljen ciljani produkt s dihidroksiizobutilnim supstituentom u polo~aju N-1 pirimidina u vrlo slabom iskoriatenju.  EMBED ChemDraw.Document.6.0  Shema 6. Kloriranjem uracila u polo~ajima C-2 i C-4 je pripravljen 2,4-diklorderivat pirimidina 12A koji je potom reakcijom s natrijevim metoksidom preveden u odgovarajui 2,4-dimetoksipirimidinski analog 13A (Shema 7.). Spoj 13A je poslu~io kao supstrat za uvoenje lanca poput onog u gancikloviru reakcijom s prethodno sintetiziranim (vidi shemu 10.) 1,3-dibenziloksi-2-klormetoksipropanom (Shema 8.). Na ovaj je na in izoliran produkt s 1,3-dibenziloksi-2-propoksimetilnim lancem u polo~aju N-1 pirimidina 14A (36.1%).  EMBED ChemDraw.Document.6.0  Shema 7. Produkt 14A je potom demetoksiliran koriatenjem AcCl, pri emu je dobiven odgovarajui uracilni derivat (15A) sa iskoriatenjem reakcije 13.9 % (Shema 8.).  EMBED ChemDraw.Document.6.0  Shema 8. U sljedeem je koraku spoj 16A podvrgnut reakciji s 2-brometil-benzoatom, te je izoliran derivat uracila s 2-benzoiloksietilnim supstituentom u N-1 polo~aju pirimidina 16A uz iskoriatenje od 15 %. Benzilna zaatita odstranjena je koriatenjem BCl3, pri emu je sintetiziran spoj 17A u vrlo visokom iskoriatenju (92.3 %) (Shema 9.).  EMBED ChemDraw.Document.6.0  Shema 9. Sinteza 1,3-dibenziloksi-2-klor-metoksipropana (11A) je provedena reakcijom 1,3-dibenziloksi-2-propanola sa plinovitim HCl-om i p-formaldehidom (Shema 10).  EMBED ChemDraw.Document.6.0  Shema 10. 4.2. ANALIZA NMR SPEKTARA Analiza 1H NMR spektara Strukture spojeva su odreene na temelju kemijskih pomaka, veli ine signala i multipliciteta sprega spin  spin izmeu jezgara H-H.  EMBED ChemDraw.Document.6.0   EMBED ChemDraw.Document.6.0  EMBED ChemDraw.Document.6.0  Spektri 1H NMR za spojeve 1A i 9A pokazuju signale za protone pirimidinskog prstena (H-1, H-3, H-6), te signale za metilenske (H-3', H-4', H-5') i metilne protone (H-6') alkilnog lanca na C-5 polo~aju pirimidina. Spektri 1H-NMR za spojeve 2A i 3A pokazuju signale za protone pirimidinskog prstena (H-3, H-6), signale za protone alkinilnog lanca kao i signale za protone odgovarajueg lanca na N-1 polo~aju pirimidina. 1H-NMR za spojeve 4A i 5A pokazuje signale za protone pirimidinskog prstena (H-3, H-6), kao i signale za protone odgovarajueg lanca na N-1 (H-2'', H-3'' ili OH-2'', OH-3'') (Tablica 1.). Tablica 1. Kemijski pomaci (/ppm) i konstante sprega (J/Hz) u spektrima 1H NMR za spojeve 1A, 2A, 3A, 4A, 5A i 9A. SPOJ1A2A3A4A5A9AH-311.40 (1H,s)11.49 (1H,s)11.42 (1H,s)11.62 (1H,s)11.56 (1H, s)11.27 (1H, s)H-111.07 (1H,s)----11.11 (1H, s)H-67.88 (1H, s)7.87 (1H, s)7.75 (1H, s)8.12 (1H, s)7.52 (1H, s)7.63 (1H, s)H-3'2.62(2H, t, J=7.03)2.36(2H,t, J=6.95)2.36(2H,t, J=6.95)--2.34(2H,t, J=6.95)H-4'1.59(2H, k, J=7.07)1.46(2H,k, J=7.08)1.49(2H,k, J=7.06)--1.49(2H,k, J=7.07)H-5'-6'1.33(2H,m)1.43(2H,m)1.43(2H,m)--1.31(2H, m)CH3-6'0.96(3H,t, J=7.34)0.89(3H,t, J=7.26)0.89(3H,t, J=7.27)--0.96(3H,t, J=7.01)H-2''-5.91 (1H,m)-5.89 (1H,m)3.96 (1H, m)-H-3''-5.21 (2H,m)-5.20 (2H,m)3.39 (2H, m)-H-1''-4.28(2H,d, J=5.48)-4.29(2H,d,J=5.45)3.93; 3.43 *-OH-2''--4.99(1H,d, J=5.61)-4.96(1H,d, J=5.62)-OH-3''--4.67(1H,t, J=5.67)-4.66(1H,d, J=5.68-*3.93 (1H, dd, H1a'', J1a''2''=3.48 Hz, Jgem = 13.65 Hz); 3.43 (1H, dd, H1b'', J1b''2''=8.97 Hz, Jgem = 13.76 Hz). Analizom spektara 1H NMR je potvrena ciklizacija spoja 9B. Spektri pokazuju signale protona furo[2,3-d] pirimidinskog prstena (H-3, H-4, H-5). Uo eni su odgovarajui signali protona alifatske skupine supstituirane u polo~aju C-6. 1H-NMR spektar za spoj 8B pokazuju uz spomenute signale i signale protona 2,3-dihidroksipropilnog lanca vezanog na N-1 polo~aj pirimidinskog prstena (Tablica 2.).  EMBED ChemDraw.Document.6.0   EMBED ChemDraw.Document.6.0  Tablica 2. Kemijski pomaci (/ppm) i konstante sprega (J/Hz) u spektrima 1H NMR za spojeve 8A i 9B. SPOJH-3H-4H-5H-1'H-2'H-3'-4'CH3OH-2''OH-3''9B8.85 (1H,s)8.14 (1H, s)6.37 (1H, s)2.63 (2H, t, J=7.20)1.62 (2H, p,J=7.43)1.31 (4H, m)0.87(3H, t, J=6.69)--8B -8.30 (1H, s)6.44 (1H, s)2.65 (2H, t, J=7.24)1.63 (2H, k,J=7.24)1.36 (4H, m)0.89(3H, t, J=6.88)5.00 (1H, d)4.79 (1H, t)*8B 4.28 (1H, dd, H1a'', J1a''2''=3.12 Hz, Jgem = 12.95 Hz); 3.59 (1H, dd, H1b'', J1b''2''=8.83 Hz, Jgem = 12.95 Hz); 3.79 (1H, m, H-2''); 3.46-3.33 ( 2H, m, H-3''). 1H-NMR spektri za spoj 10A pokazuju signale za protone pirimidinskog prstena (H-3, H-6), signale protona alkinilnog lanca vezanog na C-5 polo~aj pirimidinskog prstena (H-3', H-4', H-5', H6', CH3-7'), te signale protona lanca vezanog na N-1 polo~aj pirimidinskog prstena (H-1'', H-2'', H-3'', CH2OH-3'', OH-4'') (Tablica 3.).  EMBED ChemDraw.Document.6.0  Tablica 3. Kemijski pomaci (/ppm) i konstante sprega (J/Hz) u spektrima 1H NMR za spoj 10A. SPOJH-3H-6H-3'H-4'H-5'-6'CH3-7'H-1''H-2''-3''CH2OH-3'' OH-4''10A11.40 (1H,s)7.94 (1H, s)2.36 (2H, t, J=7.06)1.56 (2H,m,)1.41-1.28 (4H, m)0.88 (3H,t, J=7.21)3.72 (2H,t, J=7.33)1.53-1.44 (3H,m)4.36 (2H,t, J=5.21) Spektri 1H NMR za spojeve 13A i 14A pokazuju signale za protone pirimidinskog prstena (H-5, H-6) kao i signale protona metoksi skupine vezane na C-2 i/ili C-4 polo~aj pirimidinskog prstena. Pored navedenih signala, 1H NMR spektar spoja 14A pokazuje signale za protone lanca vezanog na N-1 polo~aj pirimidinskog prstena (Ph, H-1'', H-3'', H-4'', H-5'') (Tablica 4.).  EMBED ChemDraw.Document.6.0  Tablica 4. Kemijski pomaci (/ppm) i konstante sprega (J/Hz) u spektrima 1H NMR za spojeve 13A i 14B. SPOJH-6H-5CH3O-4 CH3O-2PhH-1''H-3''H-4''H-5''13A8.29 (1H,d J=5.70)6.56(1H,d J=5.73)3.37 (1H, s)-----14A 7.99 (1H,d J=7.23)5.93(1H,d,J=7.22)-7.32-7.26 (10H,m)5.31 (2H, s)4.07-4.02 (1H, m)3.50-3.44 (4H, m)4.45* (4H,d) *4.45 (4H, dd, H5'', Jab=12.164 Hz, Jgem = 16.113 Hz); 1H-NMR spektri za spojeve 15A, 16A i 17A pokazuju signale za protone pirimidinskog prstena (H-5, H-6), te signale protona acikli kog lanca vezanog na N-1 polo~aj pirimidinskog prstena (Ph, H-1'', H-3'',H-4'', H-5'', OH-4''). Spoj 16A i 17A pokazuju i signale protona lanca vezanog na N-3 polo~aj pirimidinskog prstena (Bz, H-1', H-2') (Tablica 5.).  EMBED ChemDraw.Document.6.0   EMBED ChemDraw.Document.6.0   EMBED ChemDraw.Document.6.0  Tablica 5. Kemijski pomaci (/ppm) i konstante sprega (J/Hz) u spektrima 1H NMR za spojeve 15A, 16A i 17A. SPOJH-6BzH-5PhH-1''H-5''H-3''H-4''H-2'H-1'OH-4''15A7.69 (1H,d, J=7.89) -5.56 (1H, d, J=7.87)7.34 - 7.27 (10H,m)5.20 (2H,s)4.47 (4H,s)4.02- 3.96 (1H,m)3.51- 3.44 (4H,m) - - -16A 7.75 (1H,d, J=7.89)7.6-7.4 (5H,m)5.66 (1H,d J=7.83)7.36 -7.20 (10H,m)5.25 (2H,s)4.41 (4H,s)4.00-3.91 (1H,m)3.48- 3.39 (4H,m)4.18 (2H, t J=5.27)4.18 (2H, t J=5.27) -17A 7.68 (1H, d J=7.38) *5.75 (1H,d J=7.92) -5.24 (2H,s) -3.59- 3.40 (1H,m)3.49- 3.30 (4H,m)4.47 (2H, t J=5.13)4.21 (2H, t J=5.23)4.59 (2H, t J=5.49)* 7.93-7.88 (2H, Bz), 7.66-7.48 (3H, Bz). Analiza 13C NMR spektara  EMBED ChemDraw.Document.6.0   EMBED ChemDraw.Document.6.0  Spektri 13C NMR za spojeve 2A i 3A pokazuju signale atoma ugljika pirimidinskog prstena (C-2, C-4, C-5, C-6), zatim signale atoma ugljika lanca vezanog na C-5 polo~aj pirimidinskog prstena (C-1', C-2', C-3' C-4', C-5', C-6'), kao i signale atoma ugljika lanca vezanog na N-1 polo~aj pirimidinskog prstena (C-1'', C-2'', C-3''). Spektri 13C-NMR za spoj 4A pokazuju signale atome ugljika pirimidinskog prstena, te signale atoma ugljika lanca vezanog na N-1 polo~aj pirimidinskog prstena (C-1'', C-2'' i C-3''). (Tablica 6.) Tablica 6. Kemijski pomaci (/ppm) u spektrima 13C NMR za spojeve 2A, 3A i 4A. SPOJC-4C-2C-6C-5C-1''C-2''C-3''C-1'C-2'C-3'C-4'C-5'C-6'2A162.7150.2148.193.649.8133.2118.171.418.8-30.721.813.93A162.4149.2-97.251.368.863.6--63.530.221.313.44A161.5150.0118.2-49.8133.3------  EMBED ChemDraw.Document.6.0  Spektri 13C NMR za spoj 8B pokazuju signale atoma ugljika furo[2,3-d] pirimidinskog prstena (C-2, C-4, C-5, C-6, C-7, C-8), zatim signale atoma ugljika lanca vezanog na C-8 polo~aj furo[2,3-d]pirimidinskog prstena (C-1', C-2', C-3', C-4', C-5'), kao i signale atoma ugljika lanca vezanog na N-1 polo~aj pirimidinskog prstena (C-1'', C-2'', C-3'') (Tablica 7). Tablica 7. Kemijski pomaci (/ppm) u spektrima 13C NMR za spoj 8B SPOJC-4C-2C-6C-5C-7C-8C-1'C-2'C-3'C-4'C-5' 8B171.7158.1130.9106.199.953.931.026.527.822.214.3C-1''C-2''C-3''--------54.968.964.2-------- EMBED ChemDraw.Document.6.0  Spektri 13C NMR za spoj 10A pokazuju signale atoma ugljika pirimidinskog prstena (C-2, C-4, C-5, C-6), zatim signale atoma ugljika lanca vezanog na C-5 polo~aj pirimidinskog prstena (C-1', C-2', C-3', C-4', C-5', C-6', C-7'), kao i signale atoma ugljika lanca vezanog na N-1 polo~aj pirimidinskog prstena (C-1'', C-2'' C-3'', C-4'') (Tablica 8). Tablica 8. Kemijski pomaci (/ppm) u spektrima 13C NMR za spoj 10A SPOJC-4C-2C-6C-5C-1'C-2'C-3'C-4'C-5'C-6'C-7' 10A162.8150.4148.498.673.393.5 19.228.230.922.114.3C-1''C-2''C-3''C-4''-------40.628.239.858.5-------  EMBED ChemDraw.Document.6.0  Spektri 13C NMR za spojeve 13A i 14A pokazuju signale atoma ugljika pirimidinskog prstena (C-2, C-4, C-5, C-6), te signale metoksi skupina vezanih na C2 i/ili C4 polo~aj pirimidinskog prstena. Spoj 14A pokazuje signale atoma ugljika lanca vezanog na N-1 polo~aj pirimidinskog prstena (C-1', C-3', C-4', C-5') (Tablica 9). Tablica 9. Kemijski pomaci (/ppm) u spektrima 13C NMR za spojeve 13A i 14B SPOJC-4C-2C-6C-5C-1'C-3'C-4'C-5'OCH3Ph13A173.6167.7161.6104.4----57.114A171.9156.1148.995.270.378.072.777.954.2* * 128.7, 127.9, 127.5  EMBED ChemDraw.Document.6.0  Spektri 13C NMR za spoj 17A pokazuju signale atoma ugljika pirimidinskog prstena (C-2, C-4, C-5 i C-6), kao i signale atoma ugljika lanca vezanog na N-1 polo~aj pirimidinskog prstena (C-1'', C-3'', C-4''). Na N-3 polo~aj pirimidinskog prstena je takoer vezan lanac koji pokazuje odgovarajue signale atoma ugljika (C-1', C-2', C=O, C-1*, C-2* C-3*) (Tablica 10). Tablica 10. Kemijski pomaci (/ppm) u spektrima 13C NMR za spoj 17A SPOJC-4C-2C-6C-5C-1''C-3''C-4''C-1'C-2'C-1*C-2*C-3*C=O17A162.9151.8144.3101.077.581.362.240.161.4129.1129.7133.7166.1 5.0. ZAKLJU AK C-5 supstituirani alkinilni pirimidinski derivati 1A i 9A sintetizirani su Sonogashirinom reakcijom, paladijem kataliziranom reakcijom 5-joduracila i odgovarajuih terminalnih alkina, klasi nim i mikrovalnim putem. Na temelju masa pripravljenih spojeva vidljivo je da mikrovalna sinteza omoguuje vee iskoriatenje i krae vrijeme reakcije. 6-Alkilfuro[2,3-d]pirimidin-2-on (9B) je pripravljen in situ 5-endo-dig ciklizacijom 5-alkinilnog pirimidinskog derivata 9A. Kako se 2,3-dihidroksipropilni lanac nije mogao uspjeano izravno uvesti u C-5 supstitirani pirimidin uz 3-klorpropan-1,2-diol kao alkilirajui reagens, sinteza spoja 3A je uspjeano provedena u dva stupnja koja uklju uju vezanje alilnog lanca na N-1 polo~aj spoja 2A, te njegovu oksidaciju u 2,3-dihidroksipropil. Ovim su sintetskim putem, uz produkt oksidacije dvostruke veze 3A, dobiveni i produkti nastali oksidacijom trostruke veze. Sinteza C-5 supstituiranog alkinilnog pirimidinskog derivata sa dihidroksiizobutilnim lancem na polo~aju N-1 (10A) je uspjeano provedena uz 2-acetoksimetil-4-jodbutil-acetat kao alkilirajui reagens. U reakciji alkiliranja je ujedno doalo i do deacetiliranja, vjerojatno zbog bazi nih uvjeta reakcije. Spoj 14 A sintetiziran je reakcijom alkiliranja uz 11 A kao alkilirajui reagens te 2,4-dimetoksipirimidin (13A) kao supstrat za N-alkiliranje. Demetoksiliranjem spoja 14A je uspjeano pripremljen spoj 15A. 2-benzoiloksietilni supstituent je uspjeano uveden u N-1 polo~aj pirimidina reakcijom s 2-brometil-benzoatom. Debenziliranjem tako nastalog spoja 16A je uspjeano pripremljen spoj 17A. Pokuaaj uklanjanja zaatitne skupine spoja 17A proveden je u baznim uvjetima. Nastalo je viae produkata, ali koli ine su bile nedovoljne za NMR analizu. Strukture svih sintetiziranih spojeva su potvrene spektroskopskim metodama 1H-NMR i 13C-NMR te spektrometrijom masa. 6.0. LITERATURA LITERATURA Mintas, M., Rai Mali, S., Raos, N., Na ela dizajniranja lijekova, Hinus, (2000) 11 Balzarini, J., Mcgugan, C., Biochim. Biophys. Acta, 158 (2002) 287 Koonin, E.V., Senkevich, T.G., Dolja, V.V., The ancient Virus World and evolution of cells, Biol. Direct, (2006) 127 Volner, Z., Opa medicinska mikrobiologija s epidemiologijom i imunologijom, `kolska knjiga, (2000) 87 De Clercq, E., Field, H. J., Br. J. Pharmacol., 147 (2006) 153 O'Brien, J.J., Campoli-Richards, D.M., Drugs, 37 (1989) 233 Jemal, A., Bray, F., Center, M.M., Ferlay, J., Ward, E., Forman, D., CA-Cancer J. Clin., 61 (2011) 69 Gramham Solomons, T.W., Fryhle, C.B., Organic chemistry, 10th edition., John Wiley & Sons, (2010) 1133 Mishra, R., Tomar, I., IJPSDR, 2 (2011) 758 Gilchrist, T. L., Heterocyclic chemistry, Longman, New York, (1997) 357 Futterman, S., J. Biol. Chem., 228 (1957) 1031 McGRAW  HILL Concise Encyclopedia of Science and Technology, 5th edition, (2004) 1811 Galmarini, C.M., Mackey, J.R., Dumontet, C., Nature, 15 (2001) 875 Lee, W.A., Martin, C.A., Drugs,71 (2006) 254 Tyring, S.K., CRC Press, (2005) 143 Neal Nathanson et al., Viral pathogenesis and immunity, Elsevier, second edition, (2007) 244 King, D.H., J. Am. Acad. Dermatol., 18 (1988) 176 Katzung, B.G., Basic and clinical pharmacology, McGRAW  HILL, 10th edition, (2004) 1119 De Clercq, E., Am. J. Clin. Virl., 30 (2004) 115 De Clercq, E., Antiviral Res. 67 (2005) 56 Chitneni, S.K., et al., Bioorg. Medicinal Chem. Lett., 17 (2007) 3458 McGuigan, C., Balzarini, J., Antiviral Res., 71 (2006) 149 Carangio, A., et al., Antiviral Res., 12 (2011) 187 Balzarini, J., McGuigan, C., Biochim. Biophys. Acta, 1587 (2002) 287 Balzarini, J., McGuigan, C., J. Antimicrob. Chemother, 50 (2002) 5 Chinchilla, R., Najera, C., Acc. Chem. Res., 107 (2007) 874 Cho, C.S., J. Organomet. Chem., 690 (2005) 4094 Kumada, M., Pure Appl.Chem., 52 (1980) 669 Agrofoglio, L.A., et al., Chem. Rev., 103 (2003) 1875 Bandini, M., Luque, R., Budarin, V., Macquarrie, D.J., Tetrahedron, 61 (2005) 9860 Heck, R.F., J. Am. Chem. Soc., 90 (1968) 5518 Caddick, S., Fitzmaurice, R., Tetrahedron, 65 (2009) 3325 P. Lindstrm et al., Tetrahedron, 57 (2001) 9225 Loupy, A., Perreux, L., Liagre, M., Burle, K., Moneuse, M., Pure Appl. Chem., 73 (2001) 161 }IVOTOPIS Zovem se Vedran Regvar, roen sam u Zagrebu 16. studenog 1988. godine. Osnovnu akolu ure Prejca zavraio sam u Desiniu, a potom sam upisao i zavraio akolu za medicinske sestre 3 Vinogradska3 . Nakon ato sam maturirao s odli nim uspjehom, 2007. godine upisao sam Fakultet kemijskog in~enjerstva i tehnologije, smjer Primijenjena kemija. Nakon zavraetka preddiplomskog studija, 2010. godine upisao sam diplomski studij na Fakultetu kemijskog in~enjerstva i tehnologije, smjer Primijenjena kemija, modul Primijenjena organska kemija.     UVOD  PAGE \* MERGEFORMAT 2 2.0. OPI DIO  PAGE \* MERGEFORMAT 22 3.0. EKSPERIMENTALNI DIO  PAGE \* MERGEFORMAT 31 4.0. REZULTATI I RASPRAVA  PAGE \* MERGEFORMAT 44 5.0. 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B % % $$AA( : FthEMF+@D8A? @  !E˗D !E9FD: $$==_888 % % W$|B % % $$AA( : FthEMF+@D8A? @ `"E}D`"EPJD: $$==_888 % % W$ % % $$AA( : FthEMF+@D8A? @  !E9FD-E(D: $$==_888 % % W$i% % $$AA( : FthEMF+@D8A? @ 7Eտ?D-E(D: $$==_888 % % W$i|`% % $$AA( : FthEMF+@D8A? @ 6EED-E`0D: $$==_888 % % W$o< % % $$AA( : Fl`EMF+@0$BARIAL@, (EuDN   % TTs{@ B BsLPN % Fl`EMF+@0$BARIAL@, (Eձ(DN   % TTsk{z@ B BsxLPN % FthEMF+@D8A? @  !E˗DE7χD: $$==_888 % % W$}B  % % $$AA( : FthEMF+@D8A? @ E)D[ EcD: $$==_888 % % W$`u,  % % $$AA( : FthEMF+@D8A? @ [ EcD|E>D: $$==_888 % % W$`xu -% % $$AA( : FthEMF+@D8A? @  EcDvE{'CD: $$==_888 % % W$ezyu h% % $$AA( : FthEMF+@D8A? @  !E9FDE7D: $$==_888 % % W$}sS% % $$AA( : Fl`EMF+@0$BARIAL@, +ECN   % TT>M@ B BKLPN % F<0EMF+@, մ/ECH   % TT>M@ B BKLPH % Fl`EMF+@0$۫zBARIAL@, t3EC2   ( RpArial\(i0p&joD8^Ps_Dhjjh,vj jvvu&vu o j@v00| teu⡏vu5vjZ*n !Z*uv@v@vdv% TTDP@ B BNLP2% FthEMF+@D8A? @ -E(D-EC: $$==_888 % % W$Kn% % $$AA( : Fl`EMF+@0$BARIAL@, sDDO   ( RpArial\(i0p&j/D8^PsDhjjh,vj jvvu&vu o j@v00| teu⡏vu5vjZ*n !Z*uv@v@vdv% TTAJ@ B BALPO % Fh\EMF+@8,?? @ i EDUDD: $$==_888"% % W$$fGW% % $$AA( : F\PEMF+ @L@> EkD ED> EDDDUmDDDkD> EkD$$=='%  % V8%e@K@;^;S^@%  % $$AAFh\EMF+@8,?? @ ED EuD: $$==_888"% % W$cy{N % % $$AA( : F\PEMF+ @L@EDEZDpED5 E]D ED5 EDED$$==%  % V8dxktUqKUk%  % $$AAFthEMF+@D8A? @ EZD6|E¶D: $$==_888 % % W$Kz% % $$AA( : FthEMF+@D8A? @ DDDZD: $$==_888 % % W$B% % $$AA( : Fh\EMF+@8,?? @ @DDU=DuD: $$==_888"% % W$&O % % $$AA( : F\PEMF+ @L@UDDDZD DDDDUmDDDKDUDD$$==%  % V8&#-HSHo#%  % $$AAFl`EMF+@0$BARIAL@, ` EyDH   % TT`"h1@ B B`/LPH % FthEMF+@D8A? @  ED EqD: $$==_888 % % W$cg%KK+% % $$AA( : Fl`EMF+@0$BARIAL@, [D5DO   % TT ")1@ B B /LPO % F<0EMF+@, UnD5DH   % TT*"21@ B B*/LPH % FthEMF+@D8A? @ UmDDUmDqD: $$==_888 % % W$#'%SS+% % $$AA( : Fl`EMF+@0$BARIAL@, ` EUDH   % TT`h@ B B`LPH % FthEMF+@D8A? @  ED E,D: $$==_888 % % W$cgKKN% % $$AA( : Fl`EMF+@0$BARIAL@, DUDH   % TT (@ B B LPH % FthEMF+@D8A? @ UmDDUmD,D: $$==_888 % % W$#'SSN% % $$AA( : Fl`EMF+@0$BARIAL@, (E5DH   % TTs{"@ B Bs LPH % FthEMF+@D8A? @ EZDE5D: $$==_888 % % W$vz=% % $$AA( : FthEMF+@D8A? @ DZDDD: $$==_888 % % W$ % % $$AA( : Fl`EMF+@0$BARIAL@, QD5DH   % TT "@ B B  LPH % FthEMF+@D8A? @ DZDD5D: $$==_888 % % W$=% % $$AA( : FthEMF+@D8A? @ E qDEZD: $$==_888 % % W$vzr % % $$AA( : Fl`EMF+@0$BARIAL@, uD)DO   % TT@ B BLPO % FthEMF+@D8A? @ DD@kDD: $$==_888 % % W$ 4 % % $$AA( : Fl`EMF+@0$BARIAL@, VDDP   % TT@ B BLPP % FthEMF+@D8A? @ DD DD: $$==_888 % % W$E % % $$AA( : Fl`EMF+@0$BARIAL@, @rD)DO   % TT@ B BLPO % FthEMF+@D8A? @ `DDu[DD: $$==_888 % % W$ { % % $$AA( : Fl`EMF+@0$BARIAL@, DDO   % TT @ B BLPO % Fl`EMF+@0$۫zBARIAL@, 5DD-   ( RpArial\(i0p&j*D8bPs*Dhjjh,vj jvvu&vu o j@v00| teu⡏vu5vjZ*n !Z*uv@v@vdv% TT@ B BLP-% FthEMF+@D8A? @ 5DD5D@D: $$==_888 % % W$_ B_ % % $$AA( : Fl`EMF+@0$BARIAL@, D@։DO   ( RpArial\(i0p&j/D8bPsDhjjh,vj jvvu&vu o j@v00| teu⡏vu5vjZ*n !Z*uv@v@vdv% TT@ B BLPO % FthEMF+@D8A? @ =DD=D@^D: $$==_888 % % W$; U ; % % $$AA( : FthEMF+@D8A? @ œDDœD@^D: $$==_888 % % W$ U % % $$AA( : Fl`EMF+@0$BARIAL@, 8DDP   % TTv~@ B BvLPP % FthEMF+@D8A? @ aoDDk6JDD: $$==_888 % % W$  % % $$AA( : Fl`EMF+@0$BARIAL@, +UC)DO   % TTOX@ B BOLPO % FthEMF+@D8A? @ 5DD@DD: $$==_888 % % W$Zv?  % % $$AA( : Fl`EMF+@0$BARIAL@, +ԄCDP   % TT*2@ B B*LPP % FthEMF+@D8A? @ CD)CD: $$==_888 % % W$3O U % % $$AA( : Fl`EMF+@0$BARIAL@, k7DDO   % TTu~ @ B BuLPO % Fl`EMF+@0$۫zBARIAL@, GDD-   ( RpArial\(i0p&j*D8bPs*Dhjjh,vj jvvu&vu o j@v00| teu⡏vu5vjZ*n !Z*uv@v@vdv% TT@ B BLP-% FthEMF+@D8A? @ ?DD?DKD: $$==_888 % % W$x|B% % $$AA( : Fl`EMF+@0$BARIAL@, 3CDO   ( RpArial\(i0p&j/D8bPsDhjjh,vj jvvu&vu o j@v00| teu⡏vu5vjZ*n !Z*uv@v@vdv% TT)2 @ B B)LPO % Fl`EMF+@0$۫zBARIAL@, +~CD-   ( RpArial\(i0p&j*D8bPs*Dhjjh,vj jvvu&vu o j@v00| teu⡏vu5vjZ*n !Z*uv@v@vdv% TT46@ B B4LP-% FthEMF+@D8A? @ +zCD+zCKD: $$==_888 % % W$-1B% % $$AA( : Fl`EMF+@0$BARIAL@, k7D DO   ( RpArial\(i0p&j/D8bPsDhjjh,vj jvvu&vu o j@v00| teu⡏vu5vjZ*n !Z*uv@v@vdv% TTu~@ B BuLPO % FthEMF+@D8A? @ S9>f# `O͔ͥ {+H3`I9I3`f# `Pͥsx }+H7yt9tfK|# `O&͔ +!H7̒f#`O-͔ +H7Rfl# `O[ͥ\ +H3`X9X3`f;_# `P]ͥ? +H7y;9;fC# `O_ͥe# +H3`93`f&# `Pi'\ +!H71X̓1Xfjb#`O-m'e# +!H7}̓}f)#`O-os\ +H71X߅1Xf9_# `Oqse# +H7}߅}f9='# `Osͥ  +!H7y 9ff #`O-w Qqr x Rrs wyy Sst z Ttu y{{@CDIF Uuv | Vqv w{ Zt}  [}~  \~  ]u  _v  e  f  g  h  i  k  m  o  q  s  u  w  x}  z  |  ~    \ [ ^ [] ` ]_ j [i n _m p [or _qt _s Ld?2?)??" FEMF+@ VjCD0100ChemDraw 12.01gf3f  @@3 :;E<  BCD `  Zxx# ()*$$$$2$ArialTimes New Romanxg(dd'`x$$1gf3f1gf3fq&_b K+H73b^̒[^3b3f# `Nrs{b L7sJ M+H739hFhF393M# `Nts{s1 Nu&_s1 OvQJ P}3 W+H3Ƈ̟3Ƈ3(# `N~Mm X7fV Y+H73YR3Y3(# `N4J ^+H73F8hF1hFfy:X#`NH2 `01 a b01M c+H7̹fe# `O d01 j+H73`93`3 # `H l+H7y9f3#`OH n+H7333 # `H p+H7333# `H r+H73`93`3(# `Hͥ t7 v+H73`(9(3`3[# `Hͥf y+H7y~9~f># `Oͥ {+H3`93`f/# `Pͥt }+H7yp9pfx# `O& +!H7%̒%f^#`O- +H7R%%fl# `O[ͥYX +H3`T9T3`f{[# `P]ͥ; +H7y898f?# `O_ͥ +H3`!9!3`f"# `Pi'YX +!H7qT̓qTf^#`O-m' +!H7̓f%#`O-osYX +H7qT߅qTf91\# `Oqs +H7߅f9}## `OsͥK +!H7y39gf3#`O-w Qqr x Rrs wyy Sst z Ttu y{{ Uuv | Vqv w{ Zt}  [}~  \~  ]u  _v  e  f  g  h  i  k  m  o  q  s  u  w  x}  z  |  ~    \ [ ^ [] ` ]_ j [i n _m p [or _qt _s OlePres000=$_1401698501 '!mA. `WN NOle >EPRINTR&l%I'39J( EMF& nNF, EMF+@``F EMF+@ "@ @ !@ 0@?0@ #>2@DD@RDCD@0$BARIAL@H<hL?@, KEDN!b    RpArial\@TxKK,AsD8AsDPs߸DXzDxes>DT! @0v P<>XzD000v0v>=]sy !23Xdv% TT@ B BLPN % Fl`EMF+@0$BARIAL@, @EDN   % TTv~!@ B BvLPN % FthEMF+@D8A? @ u E@Du E D: $$==_888 % % W$ m% % $$AA( : FthEMF+@D8A? @ u E DaE.D: $$==_888 % % W$m X% % $$AA( : FthEMF+@D8A? @ bED1ED: $$==_888 % % W$~nC% % $$AA( : FthEMF+@D8A? @ CKE_1DVE D: $$==_888 % % W$Xv8Ym% % $$AA( : FthEMF+@D8A? @ VE DVE@2D: $$==_888 % % W$X\ m% % $$AA( : FthEMF+@D8A? @  EâD E=D: $$==_888 % % W$\aC;% % $$AA( : FthEMF+@D8A? @ VE@2DEUuD: $$==_888 % % W$X} % % $$AA( : FthEMF+@D8A? @ E@DEUuD: $$==_888 % % W$yC  % % $$AA( : FthEMF+@D8A? @ Q2E@DED: $$==_888 % % W$y 7 % % $$AA( : Fl`EMF+@0$BARIAL@, uD#DN   % TT1 9@ B B1LPN % Fl`EMF+@0$BARIAL@, uDD: $$==_888 % % W$3? % % $$AA( : FthEMF+@D8A? @ dD*D_vDD: $$==_888 % % W$#7X?J % % $$AA( : FthEMF+@D8A? @ VE@2DtDD: $$==_888 % % W$<\} % % $$AA( : Fl`EMF+@0$BARIAL@, _EuDS   % TTv~@ B BvLPS % F<0EMF+@, EuDH   % TT@ B BLPH % FthEMF+@D8A? @ EUuDEunD: $$==_888 % % W$y} r % % $$AA( : F`TEMF+@PDCDIFVjCD0100ChemDraw 12.0_38  " :;E<  BCD `  Zxx# ()*$$$$2$ArialTimes New Romanx,, g{,, d'`33 $$_38_38&4 +H73N1̒N1338# `Ns4 7f +H739393 # `Ns & f  3 $+H73[̟[3#`NH!MM %7"f &+H73[Ҝ[33# `N)f ++H7̟ _ f&#`SH        ! #& "  # *# ' $ ( ! % )!" $&& *" * ,) Ld%})??" 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CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.6.09qVjCD0100ChemDraw 12.0̟qMK/  @@3 :;E<  BCD `  Zxx# ()*l+ )}8+' EMF" nNF, EMF+@``F EMF+@ "@ @ !@ 0@?0@ #>2@DhD@+DUD@0$BARIAL@H<h?@, G E됞DN!b    RpArial\>CDp(,AsD8AsDPs߸Dxxes@DT! @0v P<@x000v0v@pf]s= !,Xdv% TTiq@ B BiLPNT % Fl`EMF+@0$BARIAL@,  E@DN   % TTIQ@ B BILPN. % Fl`EMF+@0$BARIAL@,  EDH   % TTI Q@ B BILPH % FthEMF+@D8A? @ &ED&EuD: $$==_888 % % W$lp w% % $$AA( : FthEMF+@D8A? @ &EuD&EID: $$==_888 % % W$RpwFe% % $$AA( : FthEMF+@D8A? @ 2-D>D5DuD: $$==_888 % % W$+Hbdw% % $$AA( : FthEMF+@D8A? @ 5DuD5D7D: $$==_888 % % W$+/w % % $$AA( : FthEMF+@D8A? @ +DD+DBD: $$==_888 % % W$/3NF % % $$AA( : FthEMF+@D8A? @ 5D7D5dEzD: $$==_888 % % W$+O  % % $$AA( : FthEMF+@D8A? @ Y ED5dEzD: $$==_888 % % W$Kim  % % $$AA( : FthEMF+@D8A? @ v E DcEۏD: $$==_888 % % W$KgI A % % $$AA( : Fl`EMF+@0$BARIAL@,  EhDN   % TTIQ@ B BILPN % F<0EMF+@,  EEhDH   % TTRZ@ B BRLPH % Fl`EMF+@0$۫zBARIAL@,  E@2rD2   ( RpArial\>CDp(#/oD8;ZPs_D@//h,v/ /vvu#vu^1%F /@v00| teu~-vu5v/0= !0uv@v@vdv% TT\a@ B B\LP2% FthEMF+@D8A? @ 5dEzD5dE D: $$==_888 % % W$KO 7 % % $$AA( : Fl`EMF+@0$BARIAL@, EDO   ( RpArial\>CDp(#//D8;\PsD@//h,v/ /vvu#vu^2%F /@v00| teu~-vu5v/0= !0uv@v@vdv% TT@ B BLPO# % FthEMF+@D8A? @ &ED;E>D: $$==_888 % % W$lML% % $$AA( : FthEMF+@D8A? @ DEVD E^!D: $$==_888 % % W$j t% % $$AA( : F8,EMF+@(CDIFVjCD0100ChemDraw 12.0̟qMK/  " :;E<  BCD `  Zxx# ()*$$$$2$ArialTimes New Romanx,, g{,, d'` 33 $$ ̟qMK/ ̟qMK/ +H739BB393u# `N &Z +H73̒3#`NH 7 7Z "3uZ +H73x̟qfzR #`NH2$&s+ !+H7'̒'fK/# `O            !  # #  " % "$Ld,,h)??" FEMF+@ ObjInfo#%cCONTENTS&dOlePres000}$_1401698503 .)!mA. O9NO9N%$$$$2$ArialTimes New Romanxg(dd'`\$$ ̟qMK/ ̟qMK/ +H739BB393u# `N &Z +H73̒3#`NH 7 7Z "3uZ +H73x̟qfzR #`NH2$&s+ !+H7'̒'fK/# `O            !  # #  " % "$ !mA. CS ChemDraw DrawingChemDrawOle ~EPRINT(+&CompObj~ObjInfo*,l#}9+' EMF& nNF, EMF+@``F EMF+@ "@ @ !@ 0@?0@ #>2@DhD|DUD@0$BARIAL@H<h?@, E됞DN!b    RpArial\>01p(,AsD8AsDPs߸Dxxes@DT! @0v P<@x000v0v@pf]sb!p,Xdv% TTw@ B BwLPN % F<0EMF+@, E됞DH   % TT@ B BLPH % Fl`EMF+@0$BARIAL@,  E@DN   % TTW_@ B BWLPN % Fl`EMF+@0$BARIAL@,  EDH   % TTW _@ B BWLPH % FthEMF+@D8A? @ EDEuD: $$==_888 % % W$z~ w% % $$AA( : FthEMF+@D8A? @ EuD EID: $$==_888 % % W$`~w(e% % $$AA( : FthEMF+@D8A? @ E>D?DuD: $$==_888 % % W$9VEdw% % $$AA( : FthEMF+@D8A? @ ?DuD?D7D: $$==_888 % % W$9=w % % $$AA( : FthEMF+@D8A? @ 5DD5DBD: $$==_888 % % W$=ANF % % $$AA( : FthEMF+@D8A? @ ?D7D;EzD: $$==_888 % % W$9^  % % $$AA( : FthEMF+@D8A? @ !ED;EzD: $$==_888 % % W$YwO  % % $$AA( : Fl`EMF+@0$BARIAL@, eE@iDO   % TTV_@ B BVLPO % FthEMF+@D8A? @ E.mDE D: $$==_888 % % W$W[ 7 % % $$AA( : FthEMF+@D8A? @ EmDE D: $$==_888 % % W$[` 7 % % $$AA( : Fl`EMF+@0$BARIAL@, EsEDO   % TT@ B BLPO % FthEMF+@D8A? @ EDfEiD: $$==_888 % % W$zMzK% % $$AA( : FthEMF+@D8A? @ E`D}ED: $$==_888 % % W$x U% % $$AA( : Fl`EMF+@0$BARIAL@, DDH   % TT@ B BLPH % Fl`EMF+@0$۫zBARIAL@, DUD3   ( RpArial\>01p(#/oD89Ps_D@//h,v/ /vvu#vu^1% /@v00| teu~-vu5v/@ 1b!p@ 1uv@v@vdv% TT@ B BLP3% Fl`EMF+@0$BARIAL@, DDC   ( RpArial\>01p(#/D89Ps߸D@//h,v/ /vvu#vu^2% /@v00| teu~-vu5v/@ 1b!p@ 1uv@v@vdv% TT@ B BLPC % FthEMF+@D8A? @ ?D7DYDtD: $$==_888 % % W$= + % % $$AA( : FEMF+@CDIFVjCD0100ChemDraw 12.0̟q9  " :;E<  BCD `  Zxx# ()*$$$$2$ArialTimes New Romanx,, g{,, d'`33 $$̟q9̟q9s +H73939fA(#`NHs & +H73[̒[3#`NHf 7f  3u !+H7x ̟q fx# `O & 6 #+H7%2̒%2f9# `O %+H7,e3se#`CH3              "  $  & Ld)??" FEMF+@  Interchange FormatChemDraw.Document.6.09qVjCD0100ChemDraw 12.0̟q9  @@3 :;E<  BCD `  Zxx# ()*$$$$2$ArialTimes New RomanxCONTENTS-OlePres000$_14016985040!mA. O9N@]NOle g(dd'`\$$̟q9̟q9s +H73939fA(#`NHs & +H73[̒[3#`NHf 7f  3u !+H7x ̟q fx# `O & 6 #+H7%2̒%2f9# `O %+H7,e3se#`CH3              "  $  &  !mA. CS ChemDraw DrawingChemDrawEPRINT/2CompObj~ObjInfo13CONTENTS4l9+}9+' EMF nNF, EMF+@``F EMF+@ "@ @ !@ 0@?0@ #>2@DhD+DUD@0$BARIAL@H<h?@, E됞DN!b    RpArial\>01p(,AsD8AsDPs߸Dxxes@DT! @0v P<@x000v0v@pf]s !,Xdv% TTw@ B BwLPN % F<0EMF+@, E됞DH   % TT@ B BLPH % Fl`EMF+@0$BARIAL@,  E@DN   % TTW_@ B BWLPN % Fl`EMF+@0$BARIAL@,  EDH   % TTW _@ B BWLPH % FthEMF+@D8A? @ EDEuD: $$==_888 % % W$z~ w% % $$AA( : FthEMF+@D8A? @ EuD EID: $$==_888 % % W$`~w(e% % $$AA( : FthEMF+@D8A? @ E>D?DuD: $$==_888 % % W$9VEdw% % $$AA( : FthEMF+@D8A? @ ?DuD?D7D: $$==_888 % % W$9=w % % $$AA( : FthEMF+@D8A? @ 5DD5DBD: $$==_888 % % W$=ANF % % $$AA( : FthEMF+@D8A? @ ?D7D;EzD: $$==_888 % % W$9^  % % $$AA( : FthEMF+@D8A? @ !ED;EzD: $$==_888 % % W$YwO  % % $$AA( : Fl`EMF+@0$BARIAL@, eE@iDO   % TTV_@ B BVLPO % FthEMF+@D8A? @ E.mDE D: $$==_888 % % W$W[ 7 % % $$AA( : FthEMF+@D8A? @ EmDE D: $$==_888 % % W$[` 7 % % $$AA( : Fl`EMF+@0$BARIAL@, EsEDO   % TT@ B BLPO % FthEMF+@D8A? @ EDfEiD: $$==_888 % % W$zMzK% % $$AA( : FthEMF+@D8A? @ E`D}ED: $$==_888 % % W$x U% % $$AA( : FEMF+@ CDIFVjCD0100ChemDraw 12.0̟q9  " :;E<  BCD `  Zxx# ()*$$$$2$ArialTimes New Romanx,, g{,, d'`33 $$̟q9̟q9s +H73939fA(#`NHs & +H73[̒[3#`NHf 7f 7 3u +H7x ̟q fx# `O & 6 !+H7%2̒%2f9# `O                " Ld::i)??" FEMF+@  Interchange FormatChemDraw.Document.6.09qVjCD0100ChemDraw 12.0̟q9  @@3 :;E<  BCD `  Zxx# ()*$$$$2$ArialTimes New Romanxg(dd'`\$$̟q9̟q9s +H73939fA(#`NHs & +H73[̒[3#`NHf 7f 7 3u +H7x ̟q fx# `O & 6 !+H7%2̒%2f9# `O                "  !mA. CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.6.09qVjCD0100ChemDraw 12.0{3OlePres000$_1401698505P7!mA. @]N฀NOle EPRINT69P)l%I';9J( EMFP) nNF, EMF+@``F EMF+@ "@ @ !@ 0@?0@ #>2@D@|D@RDND@0$BARIAL@H<h?@, KEDN!b    RpArial\/pJ,AsD8AsDPs߸Dxes%DT! @0v P<%000v0v%]s!,Xdv% TT@ B BLPN % Fl`EMF+@0$BARIAL@, @EDN   % TTv~!@ B BvLPN. % FthEMF+@D8A? @ u E@Du E D: $$==_888 % % W$ m% % $$AA( : FthEMF+@D8A? @ u E DaE.D: $$==_888 % % W$m X% % $$AA( : FthEMF+@D8A? @ bED1ED: $$==_888 % % W$~nC% % $$AA( : FthEMF+@D8A? @ CKE_1DVE D: $$==_888 % % W$Xv8Ym% % $$AA( : FthEMF+@D8A? @ VE DVE@2D: $$==_888 % % W$X\ m% % $$AA( : FthEMF+@D8A? @  EâD E=D: $$==_888 % % W$\aC;% % $$AA( : FthEMF+@D8A? @ VE@2DEUuD: $$==_888 % % W$X} % % $$AA( : FthEMF+@D8A? @  E?DEUuD: $$==_888 % % W$yB  % % $$AA( : FthEMF+@D8A? @ d+E?DED: $$==_888 % % W$y 7 % % $$AA( : Fl`EMF+@0$BARIAL@, uD#DN   % TT1 9@ B B1LPNn % Fl`EMF+@0$BARIAL@, uDD: $$==_888 % % W$3? % % $$AA( : FthEMF+@D8A? @ dD*D_vDD: $$==_888 % % W$#7X?J % % $$AA( : FthEMF+@D8A? @ VE@2DPDED: $$==_888 % % W$;\| % % $$AA( : Fl`EMF+@0$BARIAL@, @E|DN   % TTv~@ B BvLPNp % F<0EMF+@, E|DH   % TT@ B BLPHR % Fl`EMF+@0$۫zBARIAL@, EuD2   ( RpArial\/pJb8noD8;cPs_Dn0nh,v8n 0nvvubvu 8n@v00| teuOwvu5v8nn!nuv@v@vdv% TT@ B BLP2o% FthEMF+@D8A? @ EUuDEuD: $$==_888 % % W$y}  % % $$AA( : F`TEMF+@PDCDIFVjCD0100ChemDraw 12.0{38  " :;E<  BCD `  Zxx# ()*$$$$2$ArialTimes New Romanx,, g{,, d'`33 $${38{38&4 +H73N1̒N1338# `Ns4 7f +H739393 # `Ns & f  3 $+H73[̟[3#`NH!MM %7"f &+H73[Ҝ[33# `N)~f ++H73F{fy^+#`NH2        ! #& "  # *# ' $ ( ! % )!" $&& *" * ,) Ld%)??" FEMF+@ CompObj~ObjInfo8:CONTENTS;?OlePres000$8  @@3 :;E<  BCD `  Zxx# ()*$$$$2$ArialTimes New Romanxg(dd'`\$${38{38&4 +H73N1̒N1338# `Ns4 7f +H739393 # `Ns & f  3 $+H73[̟[3#`NH!MM %7"f &+H73[Ҝ[33# `N)~f ++H73F{fy^+#`NH2        ! #& "  # *# ' $ ( ! % )!" $&& *" * ,)  !mA. CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.6.09q_1401698506>!mA. ฀NmNOle EPRINT=@-CompObj~l &$Q=a( EMF- nNF, EMF+@``F EMF+@ "@ @ !@ 0@?0@ #>2@D@}DDND@0$BARIAL@H<h?@,  EDN!b    RpArial\/(pJ,AsD8AsDPs߸Dxes%DT! @0v P<%000v0v%]s!,Xdv% TT@ B BLPN % F<0EMF+@,  QEDH   % TT@ B BLPH % Fl`EMF+@0$BARIAL@, ` E@VDN   % TTck!@ B BcLPN % FthEMF+@D8A? @ 5pED5pEu2D: $$==_888 % % W$ w% % $$AA( : FthEMF+@D8A? @ 5pEu2D!ED: $$==_888 % % W$mwc% % $$AA( : FthEMF+@D8A? @ "EJ(DED: $$==_888 % % W$k=N$% % $$AA( : FthEMF+@D8A? @  EҶD5Du2D: $$==_888 % % W$Eccow% % $$AA( : FthEMF+@D8A? @ 5Du2D5DD: $$==_888 % % W$EI owo% % $$AA( : FthEMF+@D8A? @ E(DE²D: $$==_888 % % W$INNF% % $$AA( : FthEMF+@D8A? @ 5DD ED: $$==_888 % % W$Ejo{ % % $$AA( : FthEMF+@D8A? @ qEzD ED: $$==_888 % % W$f { % % $$AA( : Fl`EMF+@0$BARIAL@, D DN   % TT &@ B BLPN % Fl`EMF+@0$BARIAL@, DYDH   % TT&%@ B B#LPHD % Fl`EMF+@0$BARIAL@, DDN   % TT&@ B BLPN % FthEMF+@D8A? @ 5Du2DgDyD: $$==_888 % % W$(Iow % % $$AA( : FthEMF+@D8A? @ fD4DjDuD: $$==_888 % % W$  J% % $$AA( : FthEMF+@D8A? @ jDuDD.D: $$==_888 % % W$  J % % $$AA( : FthEMF+@D8A? @ DuDԐDTCD: $$==_888 % % W$$'J % % $$AA( : FthEMF+@D8A? @ 5DDrkDqD: $$==_888 % % W$(Io % % $$AA( : Fl`EMF+@0$BARIAL@,  E}DO   % TTbk@ B BbLPO % FthEMF+@D8A? @ # ED# E{D: $$==_888 % % W$cgV V % % $$AA( : FthEMF+@D8A? @  E)D E{D: $$==_888 % % W$hl  % % $$AA( : Fl`EMF+@0$BARIAL@, `$E@VDN   % TT!@ B BLPND % F<0EMF+@,  (E@VDH   % TT!@ B BLPH % Fl`EMF+@0$۫zBARIAL@, +ED2   ( RpArial\/(pJbnoD8;Ps_Dnnh,vn nvvubvu  n@v00| teuOwvu5vnȔn!Ȕnuv@v@vdv% TT$@ B B"LP2% FthEMF+@D8A? @ 5pEu2Dr#E2D: $$==_888 % % W$wd% % $$AA( : FEMF+@CDIFVjCD0100ChemDraw 12.0̟{a+N  " :;E<  BCD `  Zxx# ()*$$$$2$ArialTimes New Romanx,, g{,, d'`33 $$̟{a+N̟{a+N& +H739##39fh1#`NH& & +H73 ̒ 33# `N    &+H73F3A#`NHͷ '7 (+H73yR3y3A# `N$3 -+H7߂2 ̟{2 f# `O)&3? /+H73;̒;f+N#`NH2    ! * "  # ! $  %  )  *   + !! , % .$* 0) Ld & )??" FEMF+@ ObjInfo?ACONTENTSBOlePres000$_1401698507<IE!mA. mNЌNVjCD0100ChemDraw 12.0̟{a+N  @@3 :;E<  BCD `  Zxx# ()*$$$$2$ArialTimes New Romanxg(dd'`\$$̟{a+N̟{a+N& +H739##39fh1#`NH& & +H73 ̒ 33# `N    &+H73F3A#`NHͷ '7 (+H73yR3y3A# `N$3 -+H7߂2 ̟{2 f# `O)&3? /+H73;̒;f+N#`NH2    ! * "  # ! $  %  )  *   + !! , % .$* 0)       !"#$%&'()*+,-./01234567:=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abfijklmnopqrstuvwxyz{|}~ !mA. CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.6.09qVjCD0100ChemDraw 12.0'6ٻaMc j  @@3 :;E<  BCD `  3Ole EPRINTDG|ZCompObj~ObjInfoFH     { !"#$]&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\}_`abcdefghijklmnopqrstuvwxyz~lD AL' EMF|Z nNF, EMF+@``F EMF+@ "@ @ !@ 0@?0@ #>2@C :ED@0$BARIAL@H<hu?@, PC KDH!b    RpArial\Fllp,AsD8AsDPs߸DxesDT! @v P<00vv(]s- !I\Xdv% TT*2@ B B*LPH % F<0EMF+@, PC KDN   % TT4<@ B B4LPN % Fl`EMF+@0$BARIAL@, -D?/DN   % TTW_@ B BWLPN % FthEMF+@D8A? @ CbDClD: $$==_888 % % W$6;  % % $$AA( : FthEMF+@D8A? @ ClDODOD: $$==_888 % % W$7V C % % $$AA( : FthEMF+@D8A? @ LC:DD([D: $$==_888 % % W$;Y i % % $$AA( : FthEMF+@D8A? @ +DpDkEDDD: $$==_888 % % W$a+  % % $$AA( : FthEMF+@D8A? @ kEDDD ED UD: $$==_888 % % W$| % % $$AA( : FthEMF+@D8A? @ >D܇DÔ=DYD: $$==_888 % % W$w{ % % $$AA( : FthEMF+@D8A? @  ED UDDԬ6D: $$==_888 % % W$YrG% % $$AA( : FthEMF+@D8A? @ DԬ6DC|OD: $$==_888 % % W$=r]GI% % $$AA( : Fl`EMF+@0$BARIAL@, EyDčDN   % TT@ B BLPN % Fl`EMF+@0$BARIAL@, xDIi6DN   % TTs@ B BLPN % FthEMF+@D8A? @ kEDDDۥuDYD: $$==_888 % % W$| % % $$AA( : FthEMF+@D8A? @  D ֍DD$sD: $$==_888 % % W$ Q % % $$AA( : FthEMF+@D8A? @ D$sD9DyLD: $$==_888 % % W$ )% % $$AA( : FthEMF+@D8A? @ ZDtD5DD)QD: $$==_888 % % W$W O V% % $$AA( : FthEMF+@D8A? @ tDED ED UD: $$==_888 % % W$|| % % $$AA( : Fl`EMF+@0$BARIAL@, D:űDO   % TT@ B BLPO % FthEMF+@D8A? @ L$DRiD$%DD: $$==_888 % % W$ gX % % $$AA( : FthEMF+@D8A? @ $%DDbDeD: $$==_888 % % W$X % % $$AA( : Fl`EMF+@0$BARIAL@, 2DkDO   % TT6?@ B B6LPO % FthEMF+@D8A? @ bDeDD-D: $$==_888 % % W$6B % % $$AA( : FthEMF+@D8A? @ ?yD{cD6EdƸD: $$==_888 % % W$?` % % $$AA( : FthEMF+@D8A? @ 6EdƸD2E֨D: $$==_888 % % W$\z % % $$AA( : FthEMF+@D8A? @ 2E֨D#E&D: $$==_888 % % W$~z .% % $$AA( : Fl`EMF+@0$BARIAL@, b/E`DC   % TT@ B BLPC % F<0EMF+@, "3E`DH   % TT@ B BLPH % Fl`EMF+@0$۫zBARIAL@, 6E VD3   ( RpArial\Fllp#^.oD8nPs_DX.^.h, w^. 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CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.6.09qVjCD0100ChemDraw 12.0̬(s@@  @@3 :;E< Ole EPRINT?CompObj~ObjInfol3A;& EMF?t nNF, EMF+@``F EMF+@ "@ @ !@ 0@?0@ #>2@kDCDD@0$BARIAL@H<h?@, ]DU1DN!b    RpArial\>+p,AsD8AsDPs߸D0xes`DT! @v P<`000vv`0]s0!LXdv% TT@ B BLPN % Fl`EMF+@0$BARIAL@, ʋD.DH   % TTn}@ B B{LPH % F<0EMF+@, JD.DN   % TTn}@ B B{LPN % FthEMF+@D8A? @ DD,DpxD: $$==_888 % % W$ b % % $$AA( : FthEMF+@D8A? @ ,DpxD,D9D: $$==_888 % % W$tb bh% % $$AA( : FthEMF+@D8A? @ lD}tDlDD>D: $$==_888 % % W$w % % $$AA( : FthEMF+@D8A? @ ,D9DDD: $$==_888 % % W$`ybh8(% % $$AA( : FthEMF+@D8A? @ DDED 3D: $$==_888 % % W$`u8( '% % $$AA( : FthEMF+@D8A? @  DED DpxD: $$==_888 % % W$|  % % $$AA( : FthEMF+@D8A? @  DpxDQD+D: $$==_888 % % W$ % % $$AA( : Fl`EMF+@0$BARIAL@, : D0CO   % TT3B@ B B@LPO % FthEMF+@D8A? @ ;DAD;DPC: $$==_888 % % W$@f?#% % $$AA( : FthEMF+@D8A? @ DADDPC: $$==_888 % % W$@f_?_#% % $$AA( : Fl`EMF+@0$BARIAL@, oDLDO   % TT@ B BLPO % FthEMF+@D8A? @ DBzDDD: $$==_888 % % W$4 ]  % % $$AA( : FthEMF+@D8A? @  D}tD DTD: $$==_888 % % W$ 7 % % $$AA( : Fl`EMF+@0$BARIAL@, }DDC   % TT$[,j@ B B$hLPC % FthEMF+@D8A? @ ,D9DGDh D: $$==_888 % % W$d%ybh'c% % $$AA( : Fl`EMF+@0$BARIAL@, ,DCC   % TTGGOV@ B BGTLPC % FthEMF+@D8A? @ eDe`DjDFtC: $$==_888 % % W$+LE]*% % $$AA( : FthEMF+@D8A? @ ED)DJD8D: $$==_888 % % W$-PGaP$% % $$AA( : FthEMF+@D8A? @ %D]DED: $$==_888 % % W$0TJe/wf% % $$AA( : FthEMF+@D8A? @ DDDD: $$==_888 % % W$8 8 % % $$AA( : FthEMF+@D8A? @ DD,DD: $$==_888 % % W$8 b% % $$AA( : FthEMF+@D8A? @ ,DD,DD: $$==_888 % % W$bbh% % $$AA( : FthEMF+@D8A? @ lDBDlDD: $$==_888 % % W$h% % $$AA( : Fl`EMF+@0$BARIAL@, [4EUC(   % TTl4oC@ B BlALP(% F<0EMF+@, [EUCC   % TTp4xC@ B BpALPC % F<0EMF+@, [EUCH   % TTz4C@ B BzALPH % Fl`EMF+@0$۫zBARIAL@, [lE0C2   ( RpArial\>+p#/oD8;Ps_D//h,w/ /vvCu#vCu~'7 /@_v00| teDu/RvCu5\v/( d_v_v@_v_v@_vdv% TT:F@ B BDLP2% Fl`EMF+@0$BARIAL@, [EUC)   ( RpArial\>+p#/*D8;Ps*D//h,w/ /vvCu#vCu~'7 /@_v00| teDu/RvCu5\v/( d_v_v@_v_v@_vdv% TT4C@ B BALP)% Fl`EMF+@0$۫zBARIAL@, [OE0C3   ( RpArial\>+p#/oD8;Ps_D//h,w/ /vvCu#vCu~'7 /@_v00| teDu/RvCu5\v/( d_v_v@_v_v@_vdv% TT:F@ B BDLP3% Fl`EMF+@0$BARIAL@, [zEUCC   ( RpArial\>+p#/D8;Ps߸D//h,w/ /vvCu#vCu~'7 /@_v00| teDu/RvCu5\v/( d_v_v@_v_v@_vdv% TT4C@ B BALPC % F<0EMF+@, [:!EUCH   % TT4C@ B BALPH % Fl`EMF+@0$۫zBARIAL@, [$E0C3   ( RpArial\>+p#/oD8;Ps_D//h,w/ /vvCu#vCu~'7 /@_v00| teDu/RvCu5\v/( d_v_v@_v_v@_vdv% TT:F@ B BDLP3% FthEMF+@D8A? @ ':E C ENC: $$==_888 % % W$P<kM % % $$AA( : F EMF+@ CDIFVjCD0100ChemDraw 12.0̬(s@@  " :;E<  BCD `  3xx# ()*$$$$2$ArialTimes New Romanx,, g{,, d'`33 $$c̬(s@@`@ 1+H3Ӊd̬d3ӉB# `Nb@w" 27d?Y" 3f@J 4h?Y 5+H72\ˬU22\#`NHj@w 6r@, =+H7/̬(f0Ԯ# `Ou@w ?+H7s̬sfz# `Ow@J6 A+H7M6Z̬F6ZfNi# `Cy@;I C+H7>IU̬7IUf?|# `C@ E7@# G7@# I7@,\ KH7'\(&v`5WO@,\ (;F\! );F\? *&6`\N +@,\ ,  - . / 00\l)\3@#`(CH2)3CH3l 7`b m 8bd lxnn 9df o :fh p ;hj q <j` s >frv @jux Bdw z Dwy  F`  H  J Ly Ld44)??" FEMF+@ CONTENTS _1401698521!mA. 0NNOle EPRINTF BCD `  3xx# ()*$$$$2$ArialTimes New Romanx,, g{,, dd'`33 $$c̬(s@@`@ 1+H3Ӊd̬d3ӉB# `Nb@w" 27d?Y" 3f@J 4h?Y 5+H72\ˬU22\#`NHj@w 6r@, =+H7/̬(f0Ԯ# `Ou@w ?+H7s̬sfz# `Ow@J6 A+H7M6Z̬F6ZfNi# `Cy@;I C+H7>IU̬7IUf?|# `C@ E7@# G7@# I7@,\ KH7'\(&v`5WO@,\ (;F\! );F\? *&6`\N +@,\ ,  - . / 00\l)\3@#`(CH2)3CH3l 7`b m 8bd lxnn 9df o :fh p ;hj q <j` s >frv @jux Bdw z Dwy  F`  H  J Ly  !mA. CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.6.09ql32A;* EMFF nNF, EMF+@``F EMF+@ "@ @ !@ 0@?0@ #>2@kDCD`D@0$BARIAL@H<h?@, ]DU1DN!b    RpArial\p*,AsD8AsDPs߸DxesDT! @v P<00vv]s !RLXdv% TT@ B BLPN % Fl`EMF+@0$BARIAL@, ʋD.DH   % TTn}@ B B{LPH % F<0EMF+@, JD.DN   % TTn}@ B B{LPN % FthEMF+@D8A? @ DD,DpxD: $$==_888 % % W$ b % % $$AA( : FthEMF+@D8A? @ ,DpxD,D9D: $$==_888 % % W$tb bh% % $$AA( : FthEMF+@D8A? @ lD}tDlDD>D: $$==_888 % % W$w % % $$AA( : FthEMF+@D8A? @ ,D9DDD: $$==_888 % % W$`ybh8(% % $$AA( : FthEMF+@D8A? @ DDED 3D: $$==_888 % % W$`u8( '% % $$AA( : FthEMF+@D8A? @  DED DpxD: $$==_888 % % W$|  % % $$AA( : FthEMF+@D8A? @  DpxDQD+D: $$==_888 % % W$ % % $$AA( : Fl`EMF+@0$BARIAL@, : D0CO   % TT3B@ B B@LPO % FthEMF+@D8A? @ ;DAD;DPC: $$==_888 % % W$@f?#% % $$AA( : FthEMF+@D8A? @ DADDPC: $$==_888 % % W$@f_?_#% % $$AA( : Fl`EMF+@0$BARIAL@, oDLDO   % TT@ B BLPO % FthEMF+@D8A? @ DBzDDD: $$==_888 % % W$4 ]  % % $$AA( : FthEMF+@D8A? @  D}tD DTD: $$==_888 % % W$ 7 % % $$AA( : Fl`EMF+@0$BARIAL@, }DDC   % TT$[,j@ B B$hLPC % FthEMF+@D8A? @ ,D9DGDh D: $$==_888 % % W$d%ybh'c% % $$AA( : Fl`EMF+@0$BARIAL@, ,DCC   % TTGGOV@ B BGTLPC % FthEMF+@D8A? @ eDe`DjDFtC: $$==_888 % % W$+LE]*% % $$AA( : FthEMF+@D8A? @ ED)DJD8D: $$==_888 % % W$-PGaP$% % $$AA( : FthEMF+@D8A? @ %D]DED: $$==_888 % % W$0TJe/wf% % $$AA( : FthEMF+@D8A? @ DDDD: $$==_888 % % W$8 8 % % $$AA( : FthEMF+@D8A? @ DD,DD: $$==_888 % % W$8 b% % $$AA( : FthEMF+@D8A? @ ,DD,DD: $$==_888 % % W$bbh% % $$AA( : Fl`EMF+@0$BARIAL@, *DDO   % TT$-@ B B$LPO % F<0EMF+@, N=DDH   % TT.6@ B B.LPH % FthEMF+@D8A? @ ,DD( DD: $$==_888 % % W$$b" % % $$AA( : Fl`EMF+@0$BARIAL@, *D DO   % TT$#-2@ B B$0LPO % F<0EMF+@, N=D DH   % TT.#62@ B B.0LPH % FthEMF+@D8A? @ ,DD8D̲D: $$==_888 % % W$$)bh&m% % $$AA( : Fl`EMF+@0$BARIAL@, [4EUC(   % TTl4oC@ B BlALP(% F<0EMF+@, [EUCC   % TTp4xC@ B BpALPC % F<0EMF+@, [EUCH   % TTz4C@ B BzALPH % Fl`EMF+@0$۫zBARIAL@, [lE0C2   ( RpArial\p*0X<oD8:Ps_D<P<h,wX< P<vvCu0vCu\ X<@_v00| teDu86 vCu5\vX<@? !R@?u\v@_v@_vdv% TT:F@ B BDLP2% Fl`EMF+@0$BARIAL@, [EUC)   ( RpArial\p*0X<*D8:Ps*D<P<h,wX< P<vvCu0vCu\ X<@_v00| teDu86 vCu5\vX<@? !R@?u\v@_v@_vdv% TT4C@ B BALP)% Fl`EMF+@0$۫zBARIAL@, [OE0C3   ( RpArial\p*0X<oD8:Ps_D<P<h,wX< P<vvCu0vCu\ X<@_v00| teDu86 vCu5\vX<@? !R@?u\v@_v@_vdv% TT:F@ B BDLP3% Fl`EMF+@0$BARIAL@, [zEUCC   ( RpArial\p*0X<D8:Ps߸D<P<h,wX< P<vvCu0vCu\ X<@_v00| teDu86 vCu5\vX<@? !R@?u\v@_v@_vdv% TT4C@ B BALPC % F<0EMF+@, [:!EUCH   % TT4C@ B BALPH % Fl`EMF+@0$۫zBARIAL@, [$E0C3   ( RpArial\p*0X<oD8:Ps_D<P<h,wX< P<vvCu0vCu\ X<@_v00| teDu86 vCu5\vX<@? !R@?u\v@_v@_vdv% TT:F@ B BDLP3% FthEMF+@D8A? @ ':E C ENC: $$==_888 % % W$P<kM % % $$AA( : F EMF+@ CDIFVjCD0100ChemDraw 12.0̬(sf@  " :;E<  BCD `  3xx# ()*$$$$2$ArialTimes New Romanx,, g{,, d'`33 $$c̬(sf@`@ 5+H3Ӊd̬d3ӉB# `Nb@w" 67d?Y" 7f@J 8h?Y 9+H72\ˬU22\#`NHj@w :r@, A+H7/̬(f0Ԯ# `Ou@w C+H7s̬sfz# `Ow@J6 E+H7M6Z̬F6ZfNi# `Cy@;I G+H7>IU̬7IUf?|# `C@ I7@# K@# M7@6 O+H76 ̬6 fi#`OH@6 Q+H76 ̬6 fi#`OH@,\ SH7'\(&v`5WO@,\ ,;F\! -;F\? .&6`\N /@,\ 0  1 2 3 40\l)\3@#`(CH2)3CH3l ;`b m <bd lxnn =df o >fh p ?hj q @j` s Bfrv Djux Fdw z Hwy  J`  L  N  P  R  Ty Ld424)??" FEMF+@ CompObj~ObjInfoCONTENTS _1401698522!mA. NNVjCD0100ChemDraw 12.0̬(sf@  @@3 :;E<  BCD `  3xx# ()*$$$$2$ArialTimes New Romanx,, g{,, dd     !"#$%&'()*+,-./0123456789:;<?BCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abehijklmnopqrstuvwxyz{|}~                    6    7 ! " # $ % & ' ( ) * + , - . / 0 1 2 3 4 5 < 8 9 : ; a _ > ? @ A B C D E F G H I J K L M N O P Q R S T U V W X Y Z [ \ ] ^  b c d e f i j k l m n o p q r s t u v w x y z { | } ~  '`33 $$c̬(sf@`@ 5+H3Ӊd̬d3ӉB# `Nb@w" 67d?Y" 7f@J 8h?Y 9+H72\ˬU22\#`NHj@w :r@, A+H7/̬(f0Ԯ# `Ou@w C+H7s̬sfz# `Ow@J6 E+H7M6Z̬F6ZfNi# `Cy@;I G+H7>IU̬7IUf?|# `C@ I7@# K@# M7@6 O+H76 ̬6 fi#`OH@6 Q+H76 ̬6 fi#`OH@,\ SH7'\(&v`5WO@,\ ,;F\! -;F\? .&6`\N /@,\ 0  1 2 3 40\l)\3@#`(CH2)3CH3l ;`b m <bd lxnn =df o >fh p ?hj q @j` s Bfrv Djux Fdw z Hwy  J`  L  N  P  R  Ty  !mA. CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.6.09qOle EPRINT @'CompObj~ObjInfol))f)E% EMF@' nNF, EMF+@``F EMF+@ "@ @ !@ 0@?0@ #>2@jDClDD@0$BARIAL@H<h?@, DխD|DN!b    RpArial\Ѝp,AsD8AsDPs߸D0xesDT! @v P<000vvI]s!YLXdv% TT@ B BLPN % Fl`EMF+@0$BARIAL@, ADDH   % TTds@ B BqLPH % F<0EMF+@, DDN   % TTds@ B BqLPN % FthEMF+@D8A? @ D׀DͣDhD: $$==_888 % % W$G WH % % $$AA( : FthEMF+@D8A? @ ͣDhDͣDP*D: $$==_888 % % W$jWH W% % $$AA( : FthEMF+@D8A? @ D}{dDD.D: $$==_888 % % W$m  % % $$AA( : FthEMF+@D8A? @ ͣDP*DD D: $$==_888 % % W$VoW-% % $$AA( : FthEMF+@D8A? @ D DD #D: $$==_888 % % W$Vk-t % % $$AA( : FthEMF+@D8A? @ fD6DfDhD: $$==_888 % % W$r @ H % % $$AA( : FthEMF+@D8A? @ fDhDD+ˀD: $$==_888 % % W$ H F % % $$AA( : Fl`EMF+@0$BARIAL@, DCO   % TT)8@ B B6LPO % FthEMF+@D8A? @ D?: DDC: $$==_888 % % W$6\% % $$AA( : FthEMF+@D8A? @ sD@: DsDC: $$==_888 % % W$6\TT% % $$AA( : Fl`EMF+@0$BARIAL@, nD|DO   % TT@ B BLPO % FthEMF+@D8A? @ ecDBjDZZDɂD: $$==_888 % % W$) _ R o % % $$AA( : FthEMF+@D8A? @ fD}{dD~DD: $$==_888 % % W$  + - % % $$AA( : FthEMF+@D8A? @ DDDDHD: $$==_888 % % W$- - % % $$AA( : FthEMF+@D8A? @ DHDͣDD: $$==_888 % % W$- WH% % $$AA( : FthEMF+@D8A? @ ͣDDͣD(D: $$==_888 % % W$WHW% % $$AA( : FthEMF+@D8A? @ DBDD(D: $$==_888 % % W$ u % % $$AA( : Fl`EMF+@0$BARIAL@, =DRCI   % TT&P)_@ B B&]LPI% FthEMF+@D8A? @ ͣDP*D DnKD: $$==_888 % % W$Y&oW7% % $$AA( : FXLEMF+@H<CDIFVjCD0100ChemDraw 12.0,!r]  " :;E<  BCD `  3xx# ()*$$$$2$ArialTimes New Romanx,, g{,, d'`33 $$c,!r]`~7y +H3S7,{73Sj# `NboJt 7dQJt fB7y hQ$~ +H72SU$,N2SU$#`NHjo$~ r$7y &+H7l(7,!7f(7Q# `Ou~v (+H7lr,{re[z# `O7y *7Jt ,7Jt .7B]o 05+H72SF],?]2SF]# `Il  `b m !bd lnn "df o #fh p $hj q %j` s 'frv )ju +`  -  / 1d Ld*) *)??" FEMF+@ CONTENTS 5_1401698523!mA. N CNOle =EPRINT h-VjCD0100ChemDraw 12.0,!r]  @@3 :;E<  BCD `  3xx# ()*$$$$2$ArialTimes New Romanx,, g{,, dd'`33 $$c,!r]`~7y +H3S7,{73Sj# `NboJt 7dQJt fB7y hQ$~ +H72SU$,N2SU$#`NHjo$~ r$7y &+H7l(7,!7f(7Q# `Ou~v (+H7lr,{re[z# `O7y *7Jt ,7Jt .7B]o 05+H72SF],?]2SF]# `Il  `b m !bd lnn "df o #fh p $hj q %j` s 'frv )ju +`  -  / 1d  !mA. CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.6.09ql)6(0+( EMFh- nNF, EMF+@``F EMF+@ "@ @ !@ 0@?0@ #>2@jDC DD@0$BARIAL@H<h?@, DխD|DN!b    RpArial\ Xf0,AsD8AsDPs߸DX[xes`DT! @v P<`X[00vv`٬]s!*Xdv% TT@ B BLPN % Fl`EMF+@0$BARIAL@, ADDH   % TTds@ B BqLPH % F<0EMF+@, DDN   % TTds@ B BqLPN % FthEMF+@D8A? @ D׀DͣDhD: $$==_888 % % W$G WH % % $$AA( : FthEMF+@D8A? @ ͣDhDͣDP*D: $$==_888 % % W$jWH W% % $$AA( : FthEMF+@D8A? @ D}{dDD.D: $$==_888 % % W$m  % % $$AA( : FthEMF+@D8A? @ ͣDP*DD D: $$==_888 % % W$VoW-% % $$AA( : FthEMF+@D8A? @ D DD #D: $$==_888 % % W$Vk-t % % $$AA( : FthEMF+@D8A? @ fD6DfDhD: $$==_888 % % W$r @ H % % $$AA( : FthEMF+@D8A? @ fDhDD+ˀD: $$==_888 % % W$ H F % % $$AA( : Fl`EMF+@0$BARIAL@, DCO   % TT)8@ B B6LPO % FthEMF+@D8A? @ D?: DDC: $$==_888 % % W$6\% % $$AA( : FthEMF+@D8A? @ sD@: DsDC: $$==_888 % % W$6\TT% % $$AA( : Fl`EMF+@0$BARIAL@, nD|DO   % TT@ B BLPO % FthEMF+@D8A? @ ecDBjDZZDɂD: $$==_888 % % W$) _ R o % % $$AA( : FthEMF+@D8A? @ fD}{dD~DD: $$==_888 % % W$  + - % % $$AA( : FthEMF+@D8A? @ DDDDHD: $$==_888 % % W$- - % % $$AA( : FthEMF+@D8A? @ DHDͣDD: $$==_888 % % W$- WH% % $$AA( : FthEMF+@D8A? @ ͣDDͣD(D: $$==_888 % % W$WHW% % $$AA( : Fl`EMF+@0$BARIAL@, =DRCI   % TT&P)_@ B B&]LPI% FthEMF+@D8A? @ ͣDP*D DnKD: $$==_888 % % W$Y&oW7% % $$AA( : Fl`EMF+@0$BARIAL@, VDDO   % TT#,@ B B#LPO % F<0EMF+@, DDH   % TT-5@ B B-LPH % FthEMF+@D8A? @ ͣDD܀DHD: $$==_888 % % W$$WHF % % $$AA( : Fl`EMF+@0$BARIAL@, VD~ObjInfo@CONTENTSAa_1401698524!mA. CN`NVjCD0100ChemDraw 12.0,!rfz  @@3 :;E<  BCD `  3xx# ()*$$$$2$ArialTimes New Romanx,, g{,, dd'`33 $$c,!rfz`~7y +H3S7,{73Sj# `NboJt 7dQJt  fB7y !hQ$~ "+H72SU$,N2SU$#`NHjo$~ #r$7y *+H7l(7,!7f(7Q# `Ou~v ,+H7lr,{re[z# `O7y .7Jt 0Jt 27B]o 45+H72SF],?]2SF]# `I]o 6+H7l],]fz#`OH]o 8+H7l],]fz#`OHl $`b m %bd lnn &df o 'fh p (hj q )j` s +frv -ju /`  1  3  5d  7  9  !mA. CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.6.09qVjCD0100ChemDraw 12.0h{}(Ole cEPRINT= CCompObjd~ObjInfofl_0' EMFC nNF, EMF+@``F EMF+@ "@ @ !@ 0@?0@ #>2@D0DD@0$BARIAL@H<h?@, RDNDN!b    RpArial\p,Xx,AsD8AsDPs߸DxeshDT! @v P<h00vvhx]s!M#Xdv% TT@ B BLPN % Fl`EMF+@0$BARIAL@, " D/@DN   % TTz@ B BLPN % FthEMF+@D8A? @  DDG)DkD: $$==_888 % % W$ S f % % $$AA( : FthEMF+@D8A? @ G)DkDDY/D: $$==_888 % % W$n f % % $$AA( : FthEMF+@D8A? @ DziDDy5D: $$==_888 % % W$r^O ;% % $$AA( : FthEMF+@D8A? @ DY/DSD,D: $$==_888 % % W$cr V% % $$AA( : FthEMF+@D8A? @ SD,DDEAD: $$==_888 % % W$c~ V@ % % $$AA( : FthEMF+@D8A? @ :DK'D'D>GD: $$==_888 % % W$i w % % $$AA( : FthEMF+@D8A? @ wDWDDރD: $$==_888 % % W$  % % $$AA( : FthEMF+@D8A? @ DރDcDpD: $$==_888 % % W$ { % % $$AA( : Fl`EMF+@0$BARIAL@, ~DkDO   % TT@ B BLPO % FthEMF+@D8A? @ cDnD8D-D: $$==_888 % % W$ 0  % % $$AA( : FthEMF+@D8A? @ QDKǁDD&D: $$==_888 % % W$z Z % % $$AA( : FthEMF+@D8A? @ üDGFD&D$D: $$==_888 % % W$  % % $$AA( : FthEMF+@D8A? @ &D$D`VD.;D: $$==_888 % % W$" ;% % $$AA( : FthEMF+@D8A? @ `VD.;DlDjD: $$==_888 % % W$, ;% % $$AA( : Fl`EMF+@0$BARIAL@, ]DTDO   % TT7@@ B B7LPO % F<0EMF+@, ;pDTDH   % TTAI@ B BALPH % FthEMF+@D8A? @ `VD.;DDwD: $$==_888 % % W$9;k % % $$AA( : Fl`EMF+@0$BARIAL@, UE$DO   % TTL U@ B BLLPO % F<0EMF+@, E$DH   % TTV ^@ B BVLPH % FthEMF+@D8A? @ lDjD ED: $$==_888 % % W$(L,% % $$AA( : Fl`EMF+@0$BARIAL@, ѦD)CO   % TT5D@ B BBLPO % FthEMF+@D8A? @ SD,DSDIC: $$==_888 % % W$Cg V Q% % $$AA( : FthEMF+@D8A? @ DY/DDsC: $$==_888 % % W$KrN% % $$AA( : FthEMF+@D8A? @ DsCD72C: $$==_888 % % W$(ON% % $$AA( : FthEMF+@D8A? @ 7^DsCDԙC: $$==_888 % % W$/O % % $$AA( : FthEMF+@D8A? @ DZQCD72C: $$==_888 % % W$(< % % $$AA( : Fl`EMF+@0$BARIAL@, DN(   % TT @ B B LP(% F<0EMF+@, pDNC   % TT @ B B LPC % F<0EMF+@, DNH   % TT @ B B LPH % Fl`EMF+@0$۫zBARIAL@, pDLA2   ( RpArial\p,Xx"oD8 @Ps_D؋""h,w" ""vvCuvCuy ""@_v00| "teDuV vCu5\v")!M)u\v@_v@_vdv% TT @ B B LP2% Fl`EMF+@0$BARIAL@, DN)   ( RpArial\p,Xx"*D8 APs*D؋""h,w" #"vvCuvCuy #"@_v00| #teDuV vCu5\v")!M)u\v@_v@_vdv% TT # @ B B  LP)% Fl`EMF+@0$۫zBARIAL@, 6DLA4   ( RpArial\p,Xx"oD8 BPs_D؋""h,w" $"vvCuvCuy $"@_v00| $teDuV vCu5\v")!M)u\v@_v@_vdv% TT%*@ B B% LP4% Fl`EMF+@0$BARIAL@, DNC   ( RpArial\p,Xx"D8 CPs߸D؋""h,w" %"vvCuvCuy %"@_v00| %teDuV vCu5\v")!M)u\v@_v@_vdv% TT*2 @ B B* LPC % F<0EMF+@,  DNH   % TT4< @ B B4 LPH % Fl`EMF+@0$۫zBARIAL@, DLA3   ( RpArial\p,Xx"oD8 DPs_D؋""h,w" &"vvCuvCuy &"@_v00| &teDuV vCu5\v")!M)u\v@_v@_vdv% TT>C@ B B> LP3% FthEMF+@D8A? @ D72C3D&B: $$==_888 % % W$ - % % $$AA( : F EMF+@ CDIFVjCD0100ChemDraw 12.0h{}(  " :;E<  BCD `  3xx# ()*$$$$2$ArialTimes New Romanx,, g{,, d'`33 $$ch{}(` \┳ :+H@Ȃ@0# `Nby%qw ;7d)+T <fngLn =ha֎ >+H751e> ^>51e r# `NjQ~ ?uΓc F+H7{{};{}K;# `O\VX H7R Jh L7 N+H7PPP꩙#`OH# P+H7(D((#`OHmg.n R+H792n%9*n%-2n# `O0: T75  V YH7vL="5$ / 0 1 2v# 3}ƺ 4  5 6 7 8 95hB #`(CH2)4CH3l @`b m Abd ln stereoDjHd1lߧ(E)n Bdf o Cfh npp Dhj q Ej` v Gju I`  K  M  O  Q  Sf  Ud  W  X  Z Ld_)??" FEMF+@ CONTENTSg _1401698525!mA. ԩNNOle EPRINT :  @@3 :;E<  BCD `  3xx# ()*$$$$2$ArialTimes New Romanx,, g{,, dd'`33 $$ch{}(` \┳ :+H@Ȃ@0# `Nby%qw ;7d)+T <fngLn =ha֎ >+H751e> ^>51e r# `NjQ~ ?uΓc F+H7{{};{}K;# `O\VX H7R Jh L7 N+H7PPP꩙#`OH# P+H7(D((#`OHmg.n R+H792n%9*n%-2n# `O0: T75  V YH7vL="5$ / 0 1 2v# 3}ƺ 4  5 6 7 8 95hB #`(CH2)4CH3l @`b m Abd ln stereoDjHd1lߧ(E)n Bdf o Cfh npp Dhj q Ej` v Gju I`  K  M  O  Q  Sf  Ud  W  X  Z  !mA. CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.6.09qVjCD0100ChemDraw 12.0,0s   ؘ}x= }ю̗91+1;{JH뉃OҥV^;8ڮRilw{,ĶngNl?jЉmF$ߣvF~1c2sۮhzc&eFel9NlcDlc'*&L1YDokؘ֜I'uj9_:=>۫'ԮuEWi;NKNrkKojΉٟwb{6+pNl+g,+4b;vDr2/s֔;|SҘu'XvMh,s3'*P*QNFo=ۘ ) {1NfFc"Q Q̤a*J!*ΰij/Ddm j ? FA>?Picture 2b.6@ʷ3e&'.n.6@ʷ3e&'PNG  IHDRGsRGB pHYsod.IDATx^ xE"\I`#x @L ( *3(BB!.xJ2Q $LDEAdޞg2飺<0So W\  -i@@_\  @ @@@_%@|q  :@KN|+86RQ8Ϧ'u֝, F^$Sϥ\nE||f|أopD;zȂ#/M$ÚDg򼁖Msr'r~r`_?:V%UaM(`Iώ9p@t$]˗-!t`Mk-n&(M6+Kd*9d;G5WL)6[LFfF,qfğ<yS$G  @} u4d:⻻zMSG|W ,Axnz ən&gxY).s}n}%QҒ}B+JM RdإĹ;X칞3AYB78:;|]iə\~)|K^-ǣBPTwb+Is1bs|dΧCB<{ۑ!F6c[q;A=rOppϯP5nA3:(  ^T(*L? ""(l@_~DoU6  /?uH@7*Eė@$ QDEC nP+8KFbV^(9 Bol*85I_<9m:C =**=rXR:$i$obĐE!H TT" ėZA `W}7\ 5r/0ہ@ QEUՍ‚BKM ";w2U‚n/_>~x֭nڴ?;WE ֬U뮻jҤin͚ +r`M0 -ŋuh>RK"Sdp…}z\|9j@'X7xQO>Œ>Гqqq5jֈ3g<( i    uŗ恽2o<96@=fLB(_ )A@@KffTڹ@qf~@PW|7}BIl[nS)ڴWywȭ(N@?>i%-nnkזX )ȜjVp⅋R8oT0ͼ_\XGG|ndĘj& {QK1]]"$߃FA@ ,2[4ai=(^wwVYkiZ=SwG7$($P̖/MmѲeP(nvV*F&Mµ   -_zn"u0վCJ֦wt[h*v@BmҴ)7k}%zY/Xdau;豠FC| (K@fC\EꂹW7&ompĔH %<-vhP;$ڵkMoHnH L=tЃ={VUz711QJJӄ@+ъ~! 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CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.6.09qVjCD0100ChemDraw 12.0̛ pϐLOle EPRINT 8CompObj~ObjInfol ZT'0 EMF86 nNF, EMF+@``F EMF+@ "@ @ !@ 0@?0@ #>2@@fDB`DD@0$BARIAL@H<h?@, DDŽDN!b    RpArial\ [X,AsD8AsDPs߸Dp+xes-DT! @v P<-p+00vv-H.]s !Xdv% TT@ B BLPN % Fl`EMF+@0$BARIAL@, DYxDH   % TT@ B BLPH % Fl`EMF+@0$BARIAL@, ND+DN   % TTm|@ B BzLPN % FthEMF+@D8A? @ D'>D D$uD: $$==_888 % % W$s , % % $$AA( : FthEMF+@D8A? @  D$uD D$7D: $$==_888 % % W$s, ,L% % $$AA( : FthEMF+@D8A? @  DHqD Dq;D: $$==_888 % % W$u x% % $$AA( : FthEMF+@D8A? @  D$7DsD$D: $$==_888 % % W$_w,L % % $$AA( : FthEMF+@D8A? @ sD$DDM0D: $$==_888 % % W$_s I % % $$AA( : FthEMF+@D8A? @ sD* DɛD;7D: $$==_888 % % W$dwdo M% % $$AA( : FthEMF+@D8A? @ cD$BDcD$uD: $$==_888 % % W$z  % % $$AA( : FthEMF+@D8A? @ cD$uDCةD1D: $$==_888 % % W$ % % $$AA( : Fl`EMF+@0$BARIAL@, jDDO   % TT@ B BLPO % FthEMF+@D8A? @ CDfwD1u~D\0D: $$==_888 % % W$ & % % $$AA( : FthEMF+@D8A? @ cDHqD1zDD: $$==_888 % % W$ % % $$AA( : Fl`EMF+@0$BARIAL@, xDECO   % TT2A@ B B?LPO % FthEMF+@D8A? @ sD$D,DC: $$==_888 % % W$?c l% % $$AA( : FthEMF+@D8A? @  D$7D4DK D: $$==_888 % % W$X#w,L% % $$AA( : FthEMF+@D8A? @ 4DK DPDdC: $$==_888 % % W$3#\W% % $$AA( : FthEMF+@D8A? @ 4D] DD@sC: $$==_888 % % W$ 8[% % $$AA( : FthEMF+@D8A? @ DuCPDdC: $$==_888 % % W$3<W% % $$AA( : Fl`EMF+@0$BARIAL@, xD$B(   % TT @ B BLP(% F<0EMF+@, D$BC   % TT '@ B BLPC % F<0EMF+@, hD$BH   % TT) 1@ B B)LPH % Fl`EMF+@0$۫zBARIAL@, DVB2   ( RpArial\ [X$)oD8 6Ps_D؋))h,w) )vvCu$vCujD )@_v00| teDuJFvCu5\v)8h. !8h.u\v@_v@_vdv% TT38@ B B3LP2% Fl`EMF+@0$BARIAL@, >D$B)   ( RpArial\ [X$)*D8 7Ps*D؋))h,w) )vvCu$vCujD )@_v00| teDuJFvCu5\v)8h. !8h.u\v@_v@_vdv% TT8 ;@ B B8LP)% Fl`EMF+@0$۫zBARIAL@, DVB4   ( RpArial\ [X$)oD8 8Ps_D؋))h,w) )vvCu$vCujD )@_v00| teDuJFvCu5\v)8h. !8h.u\v@_v@_vdv% TT=B@ B B=LP4% Fl`EMF+@0$BARIAL@, D$BC   ( RpArial\ [X$)D8 9Ps߸D؋))h,w) )vvCu$vCujD )@_v00| teDuJFvCu5\v)8h. !8h.u\v@_v@_vdv% TTB J@ B BBLPC3 % F<0EMF+@, }E$BH   % TTL T@ B BLLPH % Fl`EMF+@0$۫zBARIAL@, }EVB3   ( RpArial\ [X$)oD8 :Ps_D؋))h,w) )vvCu$vCujD )@_v00| teDuJFvCu5\v)8h. !8h.u\v@_v@_vdv% TTUZ@ B BULP3% FthEMF+@D8A? @ PDdCZDAC: $$==_888 % % W$ 8W% % $$AA( : F, EMF+@  CDIFVjCD0100ChemDraw 12.0̛ pϐL  " :;E<  BCD `  3xx# ()*$$$$2$ArialTimes New Romanx,, g{,, d'`33 $$c̛ pϐL`5o 0+H7:x5פQ5פϐh #`NHbuIj 17dWIj 2fH5o 3hW"t 4+H7:x["܊QT"܊:x[U# `Nju"t 5uyt <+H7ӑpQpmQx# `Oی+ >+H79/ê'êAS/# `OC @7j( Bo EH78*-5o %n &s 's& (x5 )j( *  + , - . /̛ /L#`(CH2)4CH3l 6`b m 7bd ln stereoDjHd1lߧ(E)n 8df o 9fh npp :hj q ;j` v =ju ?f  Ad  C  D  F Ld Z )??" FEMF+@ CONTENTS _1401698527!mA. PNNOle EPRINT $K  @@3 :;E<  BCD `  3xx# ()*$$$$2$ArialTimes New Romanx,, g{,, dd'`33 $$c̛ pϐL`5o 0+H7:x5פQ5פϐh #`NHbuIj 17dWIj 2fH5o 3hW"t 4+H7:x["܊QT"܊:x[U# `Nju"t 5uyt <+H7ӑpQpmQx# `Oی+ >+H79/ê'êAS/# `OC @7j( Bo EH78*-5o %n &s 's& (x5 )j( *  + , - . /̛ /L#`(CH2)4CH3l 6`b m 7bd ln stereoDjHd1lߧ(E)n 8df o 9fh npp :hj q ;j` v =ju ?f  Ad  C  D  F  !mA. CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.6.09q                 c      0 1 ! " # $ % & ' ( ) * + , - . / 2 G 3 4 5 6 H 8 9 : ; < = > ? @ A B C D E F L I J K d b N O P Q R S T U V W X Y Z [ \ ] ^ _ ` a e f g h k l m n o p q r s t u v w x y z { | } ~  lRj A;% EMF$K nNF, EMF+@``F EMF+@ "@ @ !@ 0@?0@ #>2@kDDD@D@0$BARIAL@H<h ?@, ]DŞDN!b    RpArial\x `VVp#,AsD8AsDPs߸DXgxesDT! @v P<Xg00vv(]s~ !LXdv% TT@ B BLPN % Fl`EMF+@0$BARIAL@, ʋD_DH   % TT@ B BLPH % F<0EMF+@, JD_DN   % TT@ B BLPN % FthEMF+@D8A? @ DV2D: $$==_888 % % W$-pGQ% % $$AA( : FthEMF+@D8A? @ %DLDE8D: $$==_888 % % W$0tJ'x]% % $$AA( : Fl`EMF+@0$BARIAL@, [4ED(   % TTlSob@ B Bl`LP(% F<0EMF+@, [EDC   % TTpSxb@ B Bp`LPC % F<0EMF+@, [EDH   % TTzSb@ B Bz`LPH % Fl`EMF+@0$۫zBARIAL@, [lE A D2   ( RpArial\x `VVp#dpqoD8;rPs_Dqhqh,wpq ,hqvvCudvCuG ,pq@_v00| ,teDuΙvCu5\vpq8'q~ !8'qu\v@_v@_vdv% TTYe@ B BcLP2% Fl`EMF+@0$BARIAL@, [ED)   ( RpArial\x `VVp#dpq*D8;sPs*Dqhqh,wpq -hqvvCudvCuD -pq@_v00| -teDuΙvCu5\vpq8'q~ !8'qu\v@_v@_vdv% TTSb@ B B`LP)% Fl`EMF+@0$۫zBARIAL@, [OE A D4   ( RpArial\x `VVp#dpqoD8;tPs_Dqhqh,wpq .hqvvCudvCuG .pq@_v00| .teDuΙvCu5\vpq8'q~ !8'qu\v@_v@_vdv% TTYe@ B BcLP4% Fl`EMF+@0$BARIAL@, [zEDC   ( RpArial\x `VVp#dpqD8;uPs߸Dqhqh,wpq /hqvvCudvCuD /pq@_v00| /teDuΙvCu5\vpq8'q~ !8'qu\v@_v@_vdv% TTSb@ B B`LPC % F<0EMF+@, [:!EDH   % TTSb@ B B`LPH % Fl`EMF+@0$۫zBARIAL@, [$E A D3   ( RpArial\x `VVp#dpqoD8;vPs_Dqhqh,wpq 0hqvvCudvCuG 0pq@_v00| 0teDuΙvCu5\vpq8'q~ !8'qu\v@_v@_vdv% TTYe@ B BcLP3% FthEMF+@D8A? @ ':E&D EtPD: $$==_888 % % W$P[kl % % $$AA( : FthEMF+@D8A? @ DHDDD: $$==_888 % % W$8 8% % $$AA( : FthEMF+@D8A? @ DD,DLD: $$==_888 % % W$8b% % $$AA( : FthEMF+@D8A? @ ,DLDN7dp" ?fa @hp A+H7ltEm2lt#`NHj؎ BrC I+H7GE@9GԮ# `Ou؝w K+H7sEs9z# `Owa5 M+H7e5ZE^5Z9eh# `CyRI O+H7VIUEOIU9V|# `CC\ QH7?\(Nx\lC\ 2]\! 3]\? 4w\N 5w\l 6C\ 7  8 9 : ; <lRH\A\ӘJ@#`(CH2)4CH3ػ S7" U7ػ6 W؝6 Y7؎I [+H7IEI9|#`OHI ]7ػ\ _+H7\E\9#`OHl C`b m Dbd lxnn Edf o Ffh p Ghj q Hj` s Jfrv Ljux Ndw z Pwy  Ry  T`  V  X  Z  \  ^  ` LdSS)??" FEMF+@ CompObj~ObjInfoCONTENTSf _1401698528!mA. N3N      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFILMNOPQRSTUVWXYZ[\]^_`abcfijklmnopqrstuvwxyz{|}~VjCD0100ChemDraw 12.0E@sl@  @@3 :;E<  BCD `  3xx# ()*$$$$2$ArialTimes New Romanx,, g{,, dd'`33 $$cE@sl@`؝ =+HldEdlB# `Nb؎" >7dp" ?fa @hp A+H7ltEm2lt#`NHj؎ BrC I+H7GE@9GԮ# `Ou؝w K+H7sEs9z# `Owa5 M+H7e5ZE^5Z9eh# `CyRI O+H7VIUEOIU9V|# `CC\ QH7?\(Nx\lC\ 2]\! 3]\? 4w\N 5w\l 6C\ 7  8 9 : ; <lRH\A\ӘJ@#`(CH2)4CH3ػ S7" U7ػ6 W؝6 Y7؎I [+H7IEI9|#`OHI ]7ػ\ _+H7\E\9#`OHl C`b m Dbd lxnn Edf o Ffh p Ghj q Hj` s Jfrv Ljux Ndw z Pwy  Ry  T`  V  X  Z  \  ^  `  !mA. CS ChemDraw DrawingChemDrawOle EPRINT CompObj~ObjInfol>F6-"8 EMF  nNF, EMF+@``FEMF+@ "@ @ !@ 0@?0@ #>2@CDDD@D8A? @ ADSEY`Dm@E!b : $$==_888 % % W$yLs % % $$AA( : FthEMF+@D8A? @ Y`Dm@EADE: $$==_888 % % W$yo 7% % $$AA( : FEMF+@0$BARIAL@H<h?@, ZCDB   RpArial\x  @ p#V,AsϪD8AsϪDPsDXgxesDT! @v P<Xg00vv(]s !zLVXdv% TT>FFU@ B B>SLPB % F<0EMF+@, jCDn   % TTGFMU@ B BGSLPn% F<0EMF+@, j/CDO   % TTNFWU@ B BNSLPO % FthEMF+@D8A? @ ADSEDSE: $$==_888 % % W$XL}P% % $$AA( : Fl`EMF+@0$BARIAL@, ZCEB   % TT>F@ B B>LPB % F<0EMF+@, fCEn   % TTGM@ B BGLPn% F<0EMF+@, f/CEO   % TTNW@ B BNLPO % FthEMF+@D8A? @ ADEDE: $$==_888 % % W$X}77% % $$AA( : Fl`EMF+@0$BARIAL@, 0[Dmz EO   % TTix@ B BvLPO % FthEMF+@D8A? @ Y`Dm@EʼnDm@E: $$==_888 % % W$os  % % $$AA( : FthEMF+@D8A? @ RD E DSE: $$==_888 % % W$Ll  % % $$AA( : Fl`EMF+@0$BARIAL@, DDC   % TTFU@ B BSLPC % F<0EMF+@, DDl   % TTFU@ B BSLPl% FthEMF+@D8A? @  DSE0DSE: $$==_888 % % W$LP % % $$AA( : F\ P EMF+@L @ CDIFVjCD0100ChemDraw 12.0Lh. 2~  " :;E<  BCD `  3xx# ()*$$$$2$ArialTimes New Romanx,, g{,, d'`M33 $$Lh. 2~.\ [7.k \.-\ ^7.> `H7N;aq/.pa'.> 7+HL.:Lh.:.B# `O(. 8). 9*. :+. ;,.. <-./ =../ >/.\ ? 0 @/'1 A'.2 B() 7833 C)*4 D*+ 355 E+,6 F,- 577 G(-8 H(.L.BLh..B#`OBn.-> bH7O1*bgc-pa:.-> I+Hs2-:s^+-: 2-B `O;H- J<.- K=.. L>H/ M?b/ N@b. OAH-/ PB.-\ Q C RB:D S:AE T;< JKFF U<=G V=> FHH W>?I X?@ HJJ Y;@K Z;As2-Bs^+. 2-B#`OBn. d+H7`.ȅ`c.ȅ.# `O. f7. h+H7L.Lh.~#`Cl ]  _  a  c  e  g  i Ld>H>HT)??" FEMF+@  Interchange FormatChemDraw.Document.6.09qVjCD0100ChemDraw 12.0Lh. 2~  @@3 :;E<  BCD `  3xx# ()*$$$$2$ArialTimes New RomanxCONTENTS: _1401698529!mA. 3N0WNOle GEPRINT7 ,, g{,, dd'`O33 $$Lh. 2~.\ [7.k \.-\ ^7.> `H7P;aq/.pa'.> 7+HL.:Lh.:.B# `O(. 8). 9*. :+. ;,.. <-./ =../ >/.\ ? 0 @/'1 A'.2 B() 7833 C)*4 D*+ 355 E+,6 F,- 577 G(-8 H(.L.BLh..B#`OBn.-> bH7Q1*bgc-pa:.-> I+Hs2-:s^+-: 2-B `O;H- J<.- K=.. L>H/ M?b/ N@b. OAH-/ PB.-\ Q C RB:D S:AE T;< JKFF U<=G V=> FHH W>?I X?@ HJJ Y;@K Z;As2-Bs^+. 2-B#`OBn. d+H7`.ȅ`c.ȅ.# `O. f7. h+H7L.Lh.~#`Cl ]  _  a  c  e  g  i l@u' , EMF nNF, EMF+@``F EMF+@ "@ @ !@ 0@?0@ #>2@DD=DSD@0$BARIAL@H<h?@, DUDN!b    RpArial\.>0>,AsD8AsDPs߸DxesDT! @v P<00vv(]s!4Xdv% TT@ B BLPND % Fl`EMF+@0$BARIAL@, ޽DTDN   % TT0?@ B B=LPN % FthEMF+@D8A? @ kDDkDD: $$==_888 % % W$'] @] H% % $$AA( : FthEMF+@D8A? @ kDDD*KD: $$==_888 % % W$"6] HF% % $$AA( : FthEMF+@D8A? @ +DDD D: $$==_888 % % W$ 2 ;% % $$AA( : FthEMF+@D8A? @ HDWDhDD: $$==_888 % % W$"7GH% % $$AA( : FthEMF+@D8A? @ hDDhDD: $$==_888 % % W$'H% % $$AA( : FthEMF+@D8A? @ hDDhDBD: $$==_888 % % W$$ee% % $$AA( : FthEMF+@D8A? @ hDD3|DD: $$==_888 % % W$% % $$AA( : FthEMF+@D8A? @ 3|DDDaD: $$==_888 % % W$ % % $$AA( : FthEMF+@D8A? @ 3|D\DDD: $$==_888 % % W$ % % $$AA( : Fl`EMF+@0$BARIAL@, ˴DDC   % TT1@@ B B>LPC % F<0EMF+@, 4DDl   % TT1@@ B B>LPlD% FthEMF+@D8A? @ kDDÏDvD: $$==_888 % % W$"8] Hy `% % $$AA( : Fl`EMF+@0$BARIAL@, ޽D2@eDDZDXD@0$BARIAL@H<h?@, DUDN!b    RpArial\p0,AsD8AsDPs߸Ddxes[DT! @v P<[d00vv[`]s!$Xdv% TT@ B BLPN % Fl`EMF+@0$BARIAL@, ޽DTDN   % TT0?@ B B=LPN % FthEMF+@D8A? @ kDDkDD: $$==_888 % % W$'] @] H% % $$AA( : FthEMF+@D8A? @ kDDD*KD: $$==_888 % % W$"6] HF% % $$AA( : FthEMF+@D8A? @ +DDD D: $$==_888 % % W$ 2 ;% % $$AA( : FthEMF+@D8A? @ HDWDhDD: $$==_888 % % W$"7GH% % $$AA( : FthEMF+@D8A? @ hDDhDD: $$==_888 % % W$'H% % $$AA( : FthEMF+@D8A? @ hDDhDBD: $$==_888 % % W$$ee% % $$AA( : FthEMF+@D8A? @ hDD3|DD: $$==_888 % % W$% % $$AA( : FthEMF+@D8A? @ 3|DDDaD: $$==_888 % % W$ % % $$AA( : FthEMF+@D8A? @ 3|D\DDD: $$==_888 % % W$ % % $$AA( : Fl`EMF+@0$BARIAL@,  jDDH   % TT1@@ B B>LPH % Fl`EMF+@0$۫zBARIAL@,  yDD3   ( RpArial\p0+0oD8 )Ps_D؋00h,w0 j0vvCu+vCuMfa j0@_v00| jteDumΞrvCu5\v0(W5!(W5u\v@_v@_vdv% TT6B@ B B@LP3% Fl`EMF+@0$BARIAL@, ڀDDC   ( RpArial\p0+0D8 *Ps߸D؋00h,w0 k0vvCu+vCuMea k0@_v00| kteDumΞrvCu5\v0(W5!(W5u\v@_v@_vdv% TT1@@ B B>LPC % F<0EMF+@, ZDDO   % TT1@@ B B>LPO % FthEMF+@D8A? @ kDD=cDD: $$==_888 % % W$"7] H M% % $$AA( : Fl`EMF+@0$BARIAL@, jD E & l}7@7 EMF<H nNF, EMF+@``F EMF+@ "@ @ !@ 0@?0@ #>2@DDDD@0$BARIAL@H<h?@, ȑDDN!b    RpArial\nXfؗ,AsD8AsDPs߸DxesDT! @v P<00vv]s!4Xdv% TT @ B BLPN % Fl`EMF+@0$BARIAL@, DܥDN   % TTFU@ B BSLPN % FthEMF+@D8A? @ PDHDPDD: $$==_888 % % W$<  % % $$AA( : FthEMF+@D8A? @ PDD㶶DE: $$==_888 % % W$8L % % $$AA( : FthEMF+@D8A? @ B D EpDD: $$==_888 % % W$8L5% % $$AA( : FthEMF+@D8A? @ pDDpDlD: $$==_888 % % W$<55 % % $$AA( : FthEMF+@D8A? @ DEDDȖD: $$==_888 % % W$ 9tL% % $$AA( : FthEMF+@D8A? @ pDlDQ`DD: $$==_888 % % W$5  % % $$AA( : FthEMF+@D8A? @ Q`DD1֦D N\ Ok P\ Q> R S T  U V W  X Y  Z [  \ ]E9#`OBn H7bӘsW ^+HE9  `OI _X `v aÅ bv cX d+ e f  g h i  j k  l m  n oE9,#`OBnC {79 D |9; E };= F ~=? EGG ?A H A7 GNCL 9KN AM d ;c  c           Ld)??" FEMF+@ CompObj~ObjInfoCONTENTSK_1401698532!mA. N Nxx# ()*$$$$2$ArialTimes New Romanx,, g{,, dd'`33 $$:E2|9+,7Eܚ u+H7lEDEEDlxw# `N9Fܚ v;Y״ w+HlY?EY?lr# `N=m x7?l y7AؾX״ zK2 +H72|E2|92# `OMؠX״ H7iDӘX[ؠX״ p+HXEX9X# `O\ؑEܚ q]ؾX״ r ^ s][_ t[\XEX̦X?#`OCH3cY״ 7'l +H7+lE$l9+l# `O  7' 7 H7bӘ`\l L+HE9 `O/ M> N\ Ok P\ Q> R S T  U V W  X Y  Z [  \ ]E9#`OBn H7bӘsW ^+HE9  `OI _X `v aÅ bv cX d+ e f  g h i  j k  l m  n oE9,#`OBnC {79 D |9; E };= F ~=? EGG ?A H A7 GNCL 9KN AM d ;c  c            !mA. CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.6.09qVjCD0100ChemDraw 12.0ւf`Ole EPRINT D6CompObj~ObjInfolR /@ EMFD66 nNF, EMF+@``F EMF+@ "@ @ !@ 0@?0@ #>2@ DD DD@0$BARIAL@H<h?@, T*DDH!b    RpArial\/`pDDpF,A tD8A tDP t߸DPxet(QDT! @w P<(QP00ww(Q] t!PLXdv% TT@ B BLPH % F<0EMF+@, TDDN   % TT@ B BLPN % Fl`EMF+@0$BARIAL@, ݽDiDN   % TT1@@ B B>LPN % FthEMF+@D8A? @ kDL DkDLpD: $$==_888 % % W$'] K] S% % $$AA( : FthEMF+@D8A? @ kDLpDDwD: $$==_888 % % W$#7] SQ% % $$AA( : FthEMF+@D8A? @ FDDgDLpD: $$==_888 % % W$#7RS% % $$AA( : FthEMF+@D8A? @ gDLpDgDL0D: $$==_888 % % W$'S% % $$AA( : FthEMF+@D8A? @ gD FDgDZD: $$==_888 % % W$%e'e% % $$AA( : FthEMF+@D8A? @ gDL0D2|DLD: $$==_888 % % W$% % $$AA( : FthEMF+@D8A? @ 2|DLDDRD: $$==_888 % % W$ % % $$AA( : Fl`EMF+@0$BARIAL@,  JDLDO   % TT1@@ B B>LPO % FthEMF+@D8A? @ KDlDSDD: $$==_888 % % W$%: j y% % $$AA( : FthEMF+@D8A? @ kD FDsD!D: $$==_888 % % W$ 6] ' 7% % $$AA( : Fl`EMF+@0$BARIAL@, jDLđDO   % TT@ B BLPO % FthEMF+@D8A? @ 2DlD2DLLD: $$==_888 % % W$aa % % $$AA( : FthEMF+@D8A? @ 2\DlD2\DLLD: $$==_888 % % W$ % % $$AA( : Fl`EMF+@0$BARIAL@, D5 EO   % TTds@ B BqLPO % FthEMF+@D8A? @ D'ED E: $$==_888 % % W$VkN% % $$AA( : FthEMF+@D8A? @ D1qEpD*E: $$==_888 % % W$r>C% % $$AA( : FthEMF+@D8A? @ pD*EaD%E: $$==_888 % % W$C% % $$AA( : FthEMF+@D8A? @ pD*ED7%E: $$==_888 % % W$@C% % $$AA( : Fl`EMF+@0$BARIAL@, 8KD-2EO   % TT8A@ B B8LPO % F<0EMF+@, ]D-2EB   % TTCK@ B BCLPB % F<0EMF+@, E-2En   % TTKQ@ B BKLPn% FthEMF+@D8A? @ D7%E\Dۻ2E: $$==_888 % % W$;@% % $$AA( : Fl`EMF+@0$BARIAL@, *D2EO   % TT@ B BLPO % F<0EMF+@, =D2EB   % TT@ B BLPB % F<0EMF+@, *D2En   % TT @ B BLPn% FthEMF+@D8A? @ aD%E # `OMB T+H7̶̶> # `O6b z7  {+H7- oG# `O/ } b>G 7Ɵ>I 7\m H79IR"\m V+H~L`~ Yf`E# `Om03 W]& Xp YC Z+ݶ! [@ݘ_" \kV ]Ɵ>I ^  _ ` a  b c  d e  f g~L`~ Yf`x#`OBna\w H7 9G۵Ta\w h+H`X](`O `O/= ia\0 ja k lp m]& nʀk` o b>G p  q r s  t u  v w  x y`X](`ւ#`OBnC L79 D M9; E N;= F O=? EGG P?A H QA7 L S9KN UAM |  ~          ; LdR)??" FEMF+@ CONTENTS:_1401698533!mA. N`NOle EPRINT @  !"#$%&'()*+,-./0123456789:;<=>?@ABCDGKOSW[_cgknopqrstuvwxyz{|}~x @{@ @@3 :;E<  BCD `  3xx# ()*$$$$2$ArialTimes New Romanx,, g{,, dd'`33 $$:ւf`x7B F+H7 Q1 Q#`NH9B G;B H+H  O# `N=B I7?B J7AB KKB R+H7ււ> # `OMB T+H7̶̶> # `O6b z7  {+H7- oG# `O/ } b>G 7Ɵ>I 7\m H79IR"\m V+H~L`~ Yf`E# `Om03 W]& Xp YC Z+ݶ! [@ݘ_" \kV ]Ɵ>I ^  _ ` a  b c  d e  f g~L`~ Yf`x#`OBna\w H7 9G۵Ta\w h+H`X](`O `O/= ia\0 ja k lp m]& nʀk` o b>G p  q r s  t u  v w  x y`X](`ւ#`OBnC L79 D M9; E N;= F O=? EGG P?A H QA7 L S9KN UAM |  ~          ;  !mA. CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.6.09q !mA. CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.6.09qlURt  /@ EMF@h nNF, EMF+@``F EMF+@ "@ @ !@ 0@?0@ #>2@DD`DD@0$BARIAL@H<h?@, DDN!b    RpArial\/`F(FpF,A tD8A tDP t߸DPxet(QDT! @w P<(QP00ww(Q] t !LXdv% TT@ B BLPN` % Fl`EMF+@0$BARIAL@, ݽDiDN   % TT1@@ B B>LPN` % FthEMF+@D8A? @ kDL DkDLpD: $$==_888 % % W$'] K] S% % $$AA( : FthEMF+@D8A? @ kDLpDҼDwD: $$==_888 % % W$#7] SP% % $$AA( : FthEMF+@D8A? @ "(DDgDLpD: $$==_888 % % W$#7PS% % $$AA( : FthEMF+@D8A? @ gDLpDgDL0D: $$==_888 % % W$'S% % $$AA( : FthEMF+@D8A? @ gD FDgDZD: $$==_888 % % W$%e'e% % $$AA( : FthEMF+@D8A? @ gDL0D2|DLD: $$==_888 % % W$% % $$AA( : FthEMF+@D8A? @ 2|DLDDD: $$==_888 % % W$ % % $$AA( : Fl`EMF+@0$BARIAL@,  JDLDO   % TT1@@ B B>LPO % FthEMF+@D8A? @ KDlDBDD: $$==_888 % % W$%: j z% % $$AA( : FthEMF+@D8A? @ kD FDbDD: $$==_888 % % W$ 6] ' 7% % $$AA( : Fl`EMF+@0$BARIAL@, jDLđDO   % TT@ B BLPO % FthEMF+@D8A? @ 2DlD2DLLD: $$==_888 % % W$aa % % $$AA( : FthEMF+@D8A? @ 2\DlD2\DLLD: $$==_888 % % W$ % % $$AA( : Fl`EMF+@0$BARIAL@, D5 EO   % TTds@ B BqLPO % FthEMF+@D8A? @ D'ED E: $$==_888 % % W$VkN% % $$AA( : FthEMF+@D8A? @ D1qEpD*E: $$==_888 % % W$r>C% % $$AA( : FthEMF+@D8A? @ pD*EaD%E: $$==_888 % % W$C% % $$AA( : FthEMF+@D8A? @ pD*ED7%E: $$==_888 % % W$@C% % $$AA( : Fl`EMF+@0$BARIAL@, 8KD-2EO   % TT8A@ B B8LPO B % F<0EMF+@, ]D-2EB   % TTCK@ B BCLPB= % F<0EMF+@, E-2En   % TTKQ@ B BKLPn% FthEMF+@D8A? @ D7%E\Dۻ2E: $$==_888 % % W$;@% % $$AA( : Fl`EMF+@0$BARIAL@, *D2EO   % TT@ B BLPO % F<0EMF+@, =D2EB   % TT@ B BLPB % F<0EMF+@, *D2En   % TT @ B BLPnC% FthEMF+@D8A? @ aD%E # `OMB +H7̶̶> # `O6b 7  +H7- oG# `O/  b>G 7Ɵ>I 7\m H79IR"\m +H~L`~ Yf`E# `Om03 ]& p C +ݶ! @ݘ_" kV Ɵ>I              ~L`~ Yf`x#`OBna\w H7 9G۵Ta\w +H`X](`O `O/= a\0 a  p ]& ʀk`  b>G              `X](`ւ#`OBnB 75i 7"O H7rMWƻ5n"O a+H^"K^s"K̫"S `O"O b] c{ d e{5 f]5 gN h{5i i+H^~5e^sw5e~5m `O5i j  k l m     n  o     p  q     r s t^"S^sJ@̫"S#@CDIF`OBzC {79 D |9; E };= F ~=? EGG ?A H A7 L 9KN AM             ;  7     LdVRV)??" FEMF+@ CompObj ~ObjInfo CONTENTS _1401698534!mA. &NHNVjCD0100ChemDraw 12.0J@f`x @{@ @@3 :;E<  BCD `  3xx# ()*$$$$2$ArialTimes New Romanx,, g{,, dd'`33 $$:J@f`x7B a+H !! T# `N9B b;B c+H  O# `N=B d7?B e7AB fKB m+H7ււ> # `OMB o+H7̶̶> # `O6b 7  +H7- oG# `O/  b>G 7Ɵ>I 7\m H79IR"\m q+H~L`~ Yf`E# `Om03 r]& sp tC u+ݶ! v@ݘ_" wkV xƟ>I y  z { |  } ~      ~L`~ Yf`x#`OBna\w H7 9G۵Ta\w +H`X](`O `O/= a\0 a  p ]& ʀk`  b>G              `X](`ւ#`OBnB 75i 7"O H7rMWƻ5n"O ;+H^"K^s"K̫"S `O"O <] ={ > ?{5 @]5 AN B{5i C+H^~5e^sw5e~5m `O5i D  E F G     H  I     J  K     L M N^"S^sJ@̫"S#`OBzC g79 D h9; E i;= F j=? EGG k?A H lA7 L n9KN pAM             ;  7                               ! 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T*/74@0# `Orx +H7S{u{# `OveRQ +H73Re2Ne2NeS# `R` |TV a }VX b ~XZ c Z\ bldd \^ e ^T do`l \f m fh lwnn hj o j^ s Vrw hv ȭ|s.- +H73A|sȭȭ|s.# A> zo r<. /An atom in this label has an invalid valence.+H7oz> zo # B/S7XbG`QbG`[- ^&ChemDraw can't interpret this label.0 Alkin, CuI, Et3N fS7]Swh.T 5This label has conflicting or unassignable charges. +?j_.j_] ]    @A  :W  / 3!?[]^kb. ]7 / 5  0 !1 w .j_ ]j_  9+  l^  9+S7Ole IEPRINT `CompObjJ~ObjInfoL                        ! 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@ n(D81DSDxD: $$==_888 % % W$i]sq% % $$AA( : FthEMF+@D8?? @ 8DGDu=DGD: $$==_888 % % W$w~ % % $$AA( : F4(EMF+ @$5=DFDC@$$=='% % V0x~  % % $$AAFEMF+ @>DGDDGD@DTHDD[IDEӋD$JDLJDLDIDMDDuMDKDNDoDaMDхDkMDZDKDD9JDDIDDEHDD"FDDjdDDD6~BDхD%ADoDkWADD}uADID>3BDLJD?CDEӋDsDDDED@DݲFDDpGD>DGD$$==%  % V{   W (  " , 3 6 4 0            ( W    %  % $$AAFEMF+@D8@?@xl >DGD>DGDKDNDKDNDKDND8"DyJD8"DGD8"DxDDKD-ADKD-ADKD-AD>DGD>DGD: $$==_888 % % UPy   6 6 6        % % $$AA( : FtEMF+@D8UUBTIMES NEW ROMAN@, :Dx,DE   ( RpTimes New Roman\@e%*oD8 sPs_DȎ**h,w* *vvCu%vCuZI *@_v00| teDuzvCu5\v*P/!6P/u\v@_v@_vdv% TTwl}y@ B BwwLPE% F<0EMF+@, aDDx,Dt   % TT~ly@ B B~wLPt% FtEMF+@D8۫JBTIMES NEW ROMAN@, IDD3D3   ( RpTimes New Roman\@e%*D8 tPsDȎ**h,w* *vvCu%vCuZI *@_v00| teDuzvCu5\v*P/!6P/u\v@_v@_vdv% TTr{@ B BzLP3% FtEMF+@D8UUBTIMES NEW ROMAN@, ODx,DN   ( RpTimes New Roman\@e%*D8 uPs߸DȎ**h,w* *vvCu%vCuZI *@_v00| teDuzvCu5\v*P/!6P/u\v@_v@_vdv% TTly@ B BwLPN% F<0EMF+@, a[Dx,D,   % TTly@ B BwLP,% F<0EMF+@,  _Dx,D F<0EMF+@, dDx,DP   % TTly@ B BwLPP% F<0EMF+@, a?mDx,Dd   % TTly@ B BwLPd% F<0EMF+@, uDx,DL   % TTly@ B BwLPL% FtEMF+@D8۫JBTIMES NEW ROMAN@, aDD3D2   ( RpTimes New Roman\@e%*D8 vPsDȎ**h,w* *vvCu%vCuZI *@_v00| teDuzvCu5\v*P/!6P/u\v@_v@_vdv% TTr{@ B BzLP2% F<0EMF+@, DD3D,   % TTr{@ B BzLP,% F<0EMF+@, DD3D FtEMF+@D8UUBTIMES NEW ROMAN@, Dx,DC   ( RpTimes New Roman\@e%*ϪD8 wPsDȎ**h,w* *vvCu%vCuZI *@_v00| teDuzvCu5\v*P/!6P/u\v@_v@_vdv% TTly@ B BwLPC% F<0EMF+@, Dx,Du   % TTly@ B BwLPu% F<0EMF+@, ǏDx,DI   % TTly@ B BwLPI% Fl`EMF+@0$UUBARIAL@, ;Dp+DN   ( RpArial\@e%*D8 xPs߸DȎ**h,w* *vvCu%vCuZI *@_v00| teDuzvCu5\v*P/!6P/u\v@_v@_vdv% TTly@ B BwLPN% Fl`EMF+@0$UUBARIAL@, nDpvDN   % TT@ B BLPN% Fl`EMF+@0$UUBARIAL@, nDQDH   % TT@ B BLPH% FthEMF+@D8@? @ :D#>D:DfD: $$==_888 % % W$w4 % % $$AA( : FthEMF+@D8@? @ :DfDDDxzD: $$==_888 % % W$4 o % % $$AA( : FthEMF+@D8@? @ OD zDDfD: $$==_888 % % W$( 4 % % $$AA( : FthEMF+@D8@? @ DfDD4D: $$==_888 % % W$q4 4% % $$AA( : FthEMF+@D8@? @ DLTcDDA8D: $$==_888 % % W$sK KW% % $$AA( : FthEMF+@D8@? @ D4DDD: $$==_888 % % W$au44% % $$AA( : FthEMF+@D8@? @ DDD/D: $$==_888 % % W$ar4l% % $$AA( : Fl`EMF+@0$UUBARIAL@, ßDCO   % TT<I@ B BGLPO % FthEMF+@D8@? @ aDDaD4FC: $$==_888 % % W$HfF% % $$AA( : FthEMF+@D8@? @ aDDaD4FC: $$==_888 % % W$HfF% % $$AA( : Fl`EMF+@0$UUBARIAL@, RD}yDO   % TT@ B BLPO % FthEMF+@D8@? @ sDhDRDPD: $$==_888 % % W$0F 5 % % $$AA( : FthEMF+@D8@? @ :D%cDDzD: $$==_888 % % W$ % % $$AA( : Fl`EMF+@0$UUBARIAL@, /DDC   % TT0\7i@ B B0gLPC% FthEMF+@D8@? @ D4Dq/Dh D: $$==_888 % % W$d1u4c% % $$AA( : Fl`EMF+@0$UUBARIAL@, X>CֺCO   % TTK:SG@ B BKELPO % FthEMF+@D8@? @ CCDCC*C: $$==_888 % % W$LEPd!q% % $$AA( : FthEMF+@D8@? @ !DD!D*C: $$==_888 % % W$PETd!q% % $$AA( : FthEMF+@D8@? @ PDaFD6 |DŒC: $$==_888 % % W$I]R % % $$AA( : FthEMF+@D8@? @ SDxD6 D0C: $$==_888 % % W$Maq, % % $$AA( : FthEMF+@D8@? @ VDϪDDϪD: $$==_888 % % W$PdK % % $$AA( : Fl`EMF+@0$UUBARIAL@, DCR   % TT7D@ B BBLPR% FthEMF+@D8@? @ 6 D0CdiDC: $$==_888 % % W$@Q,  !% % $$AA( : Fl`EMF+@0$UUBARIAL@, /DCC   % TT0<7I@ B B0GLPC% FthEMF+@D8@? @ 9.DrxD9.D4C: $$==_888 % % W$2G6_DD% % $$AA( : FthEMF+@D8@? @ 9.DrxD9.D4C: $$==_888 % % W$6G:_% % $$AA( : Fl`EMF+@0$UUBARIAL@, _DuCR   % TTG%N2@ B BG0LPR% FthEMF+@D8@? @ DlCDjC: $$==_888 % % W$70HA[% % $$AA( : Fl`EMF+@0$UUBARIAL@,  DX6DC   % TTGsN@ B BG~LPC% F<0EMF+@, /EX6Du   % TTOsT@ B BO~LPu% FthEMF+@D8@? @ AD+"DWDX8D: $$==_888 % % W$7fIxyl\% % $$AA( : Fh\EMF+@8,?? @ ~DCDC: $$==_888"% % W$1:8=!d% % $$AA( : F4(EMF+ @$^DC@A@$$==% % V01:7<ii% % $$AAFh\EMF+@8,?? @ DyCDkC: $$==_888"% % W$376?BB% % $$AA( : F4(EMF+ @$DC@0A$$==% % V0385>==JJ=% % $$AAF0$EMF+@ xDq,DA1A 1A$$==%  ;UP             <>mp % $$AAF0$EMF+@ D^1DA1A1A$$==%  ;UP $ , 2 2 2| ,| $|      $<>qt % $$AAF0$EMF+@ hD 'D1A1A$$==%  ;UP             <>jm % $$AAF0$EMF+@ D 'D1A1A$$==%  ;UP      <>jm % $$AAFEMF+@D8@?@`T r-DPD iD)DAJDiD6DjD"D6{DBD͸DCD:!DrGD#DίDh%D[D8'D: $$==_888 % % UD[m 9O 3 r  % % $$AA( : FEMF+ @ZD8'DD&DLD!%DθDlDcиDDD.DDD>DrDsD]DDDr-DPDwrDfDD`DK DGDSD"D锻D&DjɻDZDDyDԻD)DtDxD0DqRDQDq!D.Dcj%DθD}&DZD8'D$$==%  % Vbk& #'+/49::976428EXn%  % $$AAFEMF+@D8@?@xl ZD8'DZD8'DcиDDcиDDcиDDفDcDr-DPD ٺDDDyDDyDDyDZD8'DZD8'D: $$==_888 % % UP`m    59=222% % $$AA( : FEMF+@D8@?@H<DCyD.CDLC3DƣCDlީCCDذCY*D8qC: $$==_888 % % U8&.=K?^% % $$AA( : FEMF+ @D0qC{DCY#D1̵CRDC~ZDU߬CDj)CD>CƮDkCD3PCDXCDClD!QCD+TCuDx;Cp;D CKD=ClUD3ChuD0CLDZC,DZC"DCDZCD<^CD0qC$$==%  % V|)21;}n`VRQPKGB<1-*.=Q%  % $$AAFEMF+@D8@?@xl D0qCD0qCƮDkCƮDkCƮDkCBD֧CDCD7]CXDI PS O K F@:. ) $ :~%  % $$AAFEMF+@D8@?@xl [ D1qC[ D1qC=DxC=DxC=DxCüD6CtD6C_DCTD CTD CTD C[ D1qC[ D1qC: $$==_888 % % UP?G ~~SSS<.  ~~% % $$AA( : FthEMF+@D8?? @ \@EED[DED: $$==_888 % % W$/|^% % $$AA( : F4(EMF+ @$[DXDDtًC@$$==% % V0/}]% % $$AAF EMF+ @ E8ED E}ED EU4FD E[6GD E$^HD# EIDEJDEu>KDEKDwEa[KDEJDEfID?E9lHD11E]GD\PE8EDGE"DD11EBDE"@DE7?DE&L?DwEk>DE}>DE??D# E@D EAD E&CD E2DD EDD E8ED$$==%  % VZykW((W%  % $$AAFEMF+@D8@?@xl E8ED E8EDEKDEKDEKD\PEGD\PE8ED\PEx[BDE>DE>DE>D E8ED E8ED: $$==_888 % % UPXxm % % $$AA( : Fh\EMF+@8,@? @  ETC ETC: $$==_888"% % W$_DkH]]% % $$AA( : F0$EMF+ @  ETC ED: $$==_888"% % W$gDk] % % $$AA( : F0$EMF+ @  ED ED: $$==_888"% % W$_k  % % $$AA( : Fh\EMF+@8,@? @ yDMD[DMD: $$==_888"% % W$i % % $$AA( : F0$EMF+ @ [DMD[D2qC: $$==_888"% % W$E v% % $$AA( : F0$EMF+ @ [D2qCyD2qC: $$==_888"% % W$EI vi v% % $$AA( : Fl`EMF+@0$UUBARIAL@, E+DN   % TTly@ B BwLPN% Fl`EMF+@0$UUBARIAL@,  &EvDN   % TT@ B BLPN% Fl`EMF+@0$UUBARIAL@,  &ELhDH   % TT@ B BLPH% FthEMF+@D8@? @ -UEP>D-UEfD: $$==_888 % % W$w%%6 % % $$AA( : FthEMF+@D8@? @ -UEfD8%EzD: $$==_888 % % W$%6  % % $$AA( : FthEMF+@D8@? @ _*EzD2EfD: $$==_888 % % W$; 6 % % $$AA( : FthEMF+@D8@? @ 2EfD2E4D: $$==_888 % % W$q6 6% % $$AA( : FthEMF+@D8@? @ {1EɁcD{1Eho8D: $$==_888 % % W$t^ ^Y% % $$AA( : FthEMF+@D8@? @ 2E4Du((ED: $$==_888 % % W$au66% % $$AA( : FthEMF+@D8@? @ u((EDkE/D: $$==_888 % % W$ar6% % $$AA( : FthEMF+@D8@? @ u((E7"DjX E4D: $$==_888 % % W$fu}5% % $$AA( : Fl`EMF+@0$UUBARIAL@, !)ECO   % TT=J@ B BHLPO % FthEMF+@D8@? @ 2E4DE< Y+H7{>090v>09R>>#`NHmbG' ZUbG' [+H7Wb'*0RbWb'*#`NHI>< \UP ]mP ^7&y~ e+H7 |^0v^$|# `O* DGe g71>< }+H7 4>80.>8$4q#?# `O D;jz 7 D/3 +H73R $2 d, $2ӑ# `R _ ! ` " a # b $ c +#%% d ' f&+ h*  ~ *   :nEJNe7V- k/An atom in this label has an invalid valence.+H7YMSMY # `N9n- l;z m+H7}wJN#`NH=n n7?V oAJ pI2 w+H7}5ֺ/ֺ5 # `OK{e y+H7~EyEJKx# `ONJ {+H}MGMh# `C2 +!H7}5/5h# `Cn! +H73Rn$`n`n$ # `R[[ +H7^[X^e#`CuC q79 D r9; E s;= F t=? EOGG u?A H vA7 J xAIL z9KO |?N  N O   N ,A,A !  pSQ VѢ 7"  P-P- 7"  W8R+ dXnTV.. +H7Y.4+S.4+Y.0# `NVn.. Xz B +H7} ?w ? d E#`NHZnW 7\VW ^J B fF{i 7h0˸_ jc3sG +H7]6sD0sD@L @ CDIF/w6J# `OrzRK +H7S}R+wR+}^# `Ov˸k +H73R˘h8˘hXn# `R` TV a VX b XZ c Z\ bldd \^ e ^T do`l \f m fh lwnn hj o j^ s Vrw hv /YȭY RȭY ]ȭ j&ChemDraw can't interpret this label.C    Et3N, PdL2, CuI_o;_Z i    DPaG]L`    ! t D,q7    ! P1bG D;bG    ! ^9^bG     4xx   " <ȭ5ȭ   " <     :  / :  : W ' $79;=?AKN( @+ + !\Zbo; i7 / 5  0 !1 w o;_ Z_  6 a 6 |!\E $Qo 7 / 5   0 1 ! t aG DP z DP  `]L ]L `Q!2 j-q 7 / 5   0 1 ! P q D, _G!D,  7 `y7 G/N!1oFm 7 / 5   0 1 !  bG1 bGSwE  bG D; z D; bGSwE!ZbG^a9 7 / 5  0 !1 w 9^ bG^  ; D v D ;6Ld  )??" FEMF+@ CONTENTS 6_1401698537!mA. ǰNpVNOle MEPRINT) xVjCD0100ChemDraw 12.08^#`Xn  @@3 :;E<  BCD `  (33xx# ()*$$$$2$ArialTimes New Romanx,, g{,, dd'`33 $$ d,^Rӑy>< Y+H7{>090v>09R>>#`NHmbG' ZUbG' [+H7Wb'*0RbWb'*#`NHI>< \UP ]mP ^7&y~ e+H7 |^0v^$|# `O* DGe g71>< }+H7 4>80.>8$4q#?# `O D;jz 7 D/3 +H73R $2 d, $2ӑ# `R _ ! ` " a # b $ c +#%% d ' f&+ h*  ~ *   :nEJNe7V- k/An atom in this label has an invalid valence.+H7YMSMY # `N9n- l;z m+H7}wJN#`NH=n n7?V oAJ pI2 w+H7}5ֺ/ֺ5 # `OK{e y+H7~EyEJKx# `ONJ {+H}MGMh# `C2 +!H7}5/5h# `Cn! +H73Rn$`n`n$ # `R[[ +H7^[X^e#`CuC q79 D r9; E s;= F t=? EOGG u?A H vA7 J xAIL z9KO |?N  N O   N ,A,A !  pSQ VѢ 7"  P-P- 7"  W8R+ dXnTV.. +H7Y.4+S.4+Y.0# `NVn.. Xz B +H7} ?w ? d E#`NHZnW 7\VW ^J B fF{i 7h0˸_ jc3sG +H7]6sD0sD/w6J# `OrzRK +H7S}R+wR+}^# `Ov˸k +H73R˘h8˘hXn# `R` TV a VX b XZ c Z\ bldd \^ e ^T do`l \f m fh lwnn hj o j^ s Vrw hv /YȭY RȭY ]ȭ j&ChemDraw can't interpret this label.C    Et3N, PdL2, CuI_o;_Z i    DPaG]L`    ! t D,q7    ! P1bG D;bG    ! ^9^bG     4xx   " <ȭ5ȭ   " <     :  / :  : W ' $79;=?AKN( @+ + !\Zbo; i7 / 5  0 !1 w o;_ Z_  6 a 6 |!\E $Qo 7 / 5   0 1 ! t aG DP z DP  `]L ]L `Q!2 j-q 7 / 5   0 1 ! P q D, `G!D,  7 `y7 G/N!1oFm 7 / 5   0 1 !  bG1 bGSwE  bG D; z D; bGSwE!ZbG^a9 7 / 5  0 !1 w 9^ bG^  ; D v D ;6   lKq !@$A EMFx8 nNF, EMF+@``F EMF+@ "@ @ !@ 0@?0@ #>2@BC3EE@0$UUBARIAL@H<h?@, CDN!b    RpArial\(gUDEpI,AsD8AsDPs߸D@Nxesx=DT! @v P<x=@N00vvx=]s !DLXdv% TT@G@ B B@LPN% Fl`EMF+@0$UUBARIAL@, CUٍDH   % TT@G@ B B@LPH% Fl`EMF+@0$UUBARIAL@, j4CBDH   % TT{#@ B BLPH% F<0EMF+@, dCBDN   % TT${+@ B B$LPN% FthEMF+@D8@? @ ^CWވDZD}D: $$==_888 % % W$Ga  % % $$AA( : FthEMF+@D8@? @ ZD}DZDKD: $$==_888 % % W$]a  % % $$AA( : FthEMF+@D8@? @ ZDczDZDwQOD: $$==_888 % % W$Y^ C% % $$AA( : FthEMF+@D8@? @ ZDKDtC2D: $$==_888 % % W$Bpa : % % $$AA( : FthEMF+@D8@? @ tC2D C]FD: $$==_888 % % W$,pF: % % $$AA( : FthEMF+@D8@? @ j|C2UDj|C}D: $$==_888 % % W$&* % % $$AA( : FthEMF+@D8@? @ j|C}DpCÈD: $$==_888 % % W$&@  % % $$AA( : Fl`EMF+@0$UUBARIAL@, CCO   % TT?KGX@ B B?VLPO % FthEMF+@D8@? @ tC4DtCr D: $$==_888 % % W$@VDu2% % $$AA( : FthEMF+@D8@? @ tC4DtCr D: $$==_888 % % W$DVHuY2Y% % $$AA( : Fl`EMF+@0$UUBARIAL@, EUBDO   % TT@ B BLPOu % FthEMF+@D8@? @ 5HCDB1^D: $$==_888 % % W$,2 ' % % $$AA( : FthEMF+@D8@? @ j|CczDBŇD: $$==_888 % % W$*  % % $$AA( : Fl`EMF+@0$UUBARIAL@, $;DT *DC   % TTwk~x@ B BwvLPC% FthEMF+@D8@? @ ZDKD|9D{7D: $$==_888 % % W$]sx _O% % $$AA( : Fl`EMF+@0$UUBARIAL@, D[fDT DC   % TT[h@ B BfLPC% FthEMF+@D8@? @ :FD(DSaDID: $$==_888 % % W$|`n% % $$AA( : FthEMF+@D8@? @ :ID .DSdD{D: $$==_888 % % W$~cq O% % $$AA( : FthEMF+@D8@? @ :LD.S3DSgD,#D: $$==_888 % % W$ft$%9 % % $$AA( : Fl`EMF+@0$UUBARIAL@, BDRC(   % TTLY@ B BWLP(% F<0EMF+@, DRCC   % TTLY@ B BWLPC% F<0EMF+@, DRCH   % TTLY@ B BWLPH% Fl`EMF+@0$۫JBARIAL@, 2DTeD2   ( RpArial\(gUDEpIoD8\ CPs_Dh,w >vvCuvCuw r >@_v00| >teDuqvCu5\v !Du\v@_v@_vdv% TTQZ@ B BYLP2% Fl`EMF+@0$UUBARIAL@, 2pDRC)   ( RpArial\(gUDEpI*D8] CPs*Dh,w ?vvCuvCut r ?@_v00| ?teDuqvCu5\v !Du\v@_v@_vdv% TTLY@ B BWLP)% Fl`EMF+@0$۫JBARIAL@, 2DTeD3   ( RpArial\(gUDEpIoD8^ CPs_Dh,w @vvCuvCuw r @@_v00| @teDuqvCu5\v !Du\v@_v@_vdv% TTQZ@ B BYLP3 % Fl`EMF+@0$UUBARIAL@, ܢDRCC   ( RpArial\(gUDEpID8_ CPs߸Dh,w AvvCuvCut r A@_v00| AteDuqvCu5\v !Du\v@_v@_vdv% TTLY@ B BWLPC% F<0EMF+@, 2DRCH   % TTLY@ B BWLPH% Fl`EMF+@0$۫JBARIAL@, DTeD3   ( RpArial\(gUDEpIoD8` CPs_Dh,w BvvCuvCuw r B@_v00| BteDuqvCu5\v !Du\v@_v@_vdv% TTQZ@ B BYLP3% FthEMF+@D8@? @ ڇtD D3SDD: $$==_888 % % W$Sa  I% % $$AA( : FthEMF+@D8?? @ DoDʗBDoD: $$==_888 % % W${  % % $$AA( : F4(EMF+ @$WBD:oD,D@$$=='% % V0{     % % $$AAFEMF+ @  DpDfD_pDDfqDiDmrD˻D6@sDnDgtDDjuDqD vDDevDDs=vDGʵD.uD+ D!uDhSDHtDܶD?rD DW*qDDpD D4oDܶDmDhSD3kD+ DHjDGʵD7.jDD}iDDiDqDiDDPjDnDkD˻D lDiDnDDoDfDoD DpD$$==%  % V t W .              | g ^ V R P S [ e r .~ W t  %  % $$AAFEMF+@D8@?@xl DpD DpDDevDDevDDevDDrDDpDD=mDDiDDiDDiD DpD DpD: $$==_888 % % UP        v P P P   % % $$AA( : FtEMF+@D8BTIMES NEW ROMAN@, WoDU5XDK   ( RpTimes New Roman\(gUDEpID8d CPs߸Dh,w CvvCuvCut r C@_v00| CteDuqvCu5\v !Du\v@_v@_vdv% TT@ B BLPK: % FtEMF+@D8pBTIMES NEW ROMAN@, u}D`D2   ( RpTimes New Roman\(gUDEpID8e CPsDh,w DvvCuvCuw r D@_v00| DteDuqvCu5\v !Du\v@_v@_vdv% TT@ B BLP2% FtEMF+@D8BTIMES NEW ROMAN@, :DU5XDC   ( RpTimes New Roman\(gUDEpIϪD8f CPsDh,w EvvCuvCut r E@_v00| EteDuqvCu5\v !Du\v@_v@_vdv% TT@ B BLPC % F<0EMF+@, SDU5XDO   % TT@ B BLPO % FtEMF+@D8pBTIMES NEW ROMAN@, 僐D`D3   ( RpTimes New Roman\(gUDEpID8g CPsDh,w FvvCuvCuw r F@_v00| FteDuqvCu5\v !Du\v@_v@_vdv% TT@ B BLP3% Fl`EMF+@0$UUBARIAL@, MDqDB   ( RpArial\(gUDEpIϪD8h CPsDh,w GvvCuvCut r G@_v00| GteDuqvCu5\v !Du\v@_v@_vdv% TT@ B BLPB% F<0EMF+@, vXDqDr   % TT@ B BLPr% FthEMF+@D8@? @ c`D2#|DuDTD: $$==_888 % % W$ % % $$AA( : FthEMF+@D8@? @ uDTDDzD: $$==_888 % % W$ B % % $$AA( : FthEMF+@D8@? @ DzD?DTD: $$==_888 % % W$B % % $$AA( : FthEMF+@D8@? @ D$DDp&D: $$==_888 % % W$B @ / % % $$AA( : Fl`EMF+@0$UUBARIAL@, DDN   % TT+2@ B B+LPN% Fl`EMF+@0$UUBARIAL@,  VDBDH   % TT{@ B BLPHs% F<0EMF+@, bSDBDN   % TT{@ B BLPN% FthEMF+@D8@? @ D|ЈDOE}D: $$==_888 % % W$3MJ  % % $$AA( : FthEMF+@D8@? @ OE}DOEKD: $$==_888 % % W$IM  % % $$AA( : FthEMF+@D8@? @ ,DczD,DwQOD: $$==_888 % % W$EIl lC% % $$AA( : FthEMF+@D8@? @ OEKDD2D: $$==_888 % % W$-pM  % % $$AA( : FthEMF+@D8@? @ D2DD]FD: $$==_888 % % W$p1 % % $$AA( : FthEMF+@D8@? @  RD2UD RD}D: $$==_888 % % W$22 % % $$AA( : FthEMF+@D8@? @  RD}D"DDD: $$==_888 % % W$+2  % % $$AA( : Fl`EMF+@0$UUBARIAL@, GDCO   % TT+K3X@ B B+VLPO % FthEMF+@D8@? @ xD4DxD D: $$==_888 % % W$+V/u2% % $$AA( : FthEMF+@D8@? @ xD4DxD D: $$==_888 % % W$/V3u 2 % % $$AA( : Fl`EMF+@0$UUBARIAL@, (jDDO   % TT@ B BLPO % FthEMF+@D8@? @  DDB[D tD: $$==_888 % % W$Q2  % % $$AA( : FthEMF+@D8@? @  RDczDBDڇD: $$==_888 % % W$2  % % $$AA( : Fl`EMF+@0$UUBARIAL@,  ET *DC   % TTbkix@ B BbvLPC% FthEMF+@D8@? @ OEKD! E{7D: $$==_888 % % W$Isc O% % $$AA( : Fl`EMF+@0$UUBARIAL@, vET DC   % TT~[h@ B B~fLPC% FthEMF+@D8@? @ n E(D6EtED: $$==_888 % % W$h`}n% % $$AA( : FthEMF+@D8@? @ .E .DEwD: $$==_888 % % W$icqO% % $$AA( : FthEMF+@D8@? @ E.S3DöE#D: $$==_888 % % W$kft%% % $$AA( : FthEMF+@D8@? @ DTDDUmD: $$==_888 % % W$-1  % % $$AA( : FthEMF+@D8@? @ DUmDOEUD: $$==_888 % % W$-M  % % $$AA( : FthEMF+@D8@? @ OEUDOEUD: $$==_888 % % W$IM  % % $$AA( : FthEMF+@D8@? @ .DD.DUD: $$==_888 % % W$EIlCl % % $$AA( : Fl`EMF+@0$UUBARIAL@, n!ERC(   % TTLY@ B BWLP(% F<0EMF+@, b"ERCC   % TTLY@ B BWLPCq% F<0EMF+@, na%ERCH   % TTLY@ B BWLPH% Fl`EMF+@0$۫JBARIAL@, `(ETeD2   ( RpArial\(gUDEpIoD8 CPs_Dh,w HvvCuvCuw r H@_v00| HteDuqvCu5\v !Du\v@_v@_vdv% TTQZ@ B BYLP2% Fl`EMF+@0$UUBARIAL@, *ERC)   ( RpArial\(gUDEpI*D8 CPs*Dh,w IvvCuvCut r I@_v00| IteDuqvCu5\v !Du\v@_v@_vdv% TTLY@ B BWLP)% Fl`EMF+@0$۫JBARIAL@, ny+ETeD3   ( RpArial\(gUDEpIoD8 CPs_Dh,w JvvCuvCuw r J@_v00| JteDuqvCu5\v !Du\v@_v@_vdv% TTQZ@ B BYLP3% Fl`EMF+@0$UUBARIAL@, n1-ERCC   ( RpArial\(gUDEpID8 CPs߸Dh,w KvvCuvCut r K@_v00| KteDuqvCu5\v !Du\v@_v@_vdv% TTLY@ B BWLPC% F<0EMF+@, 00ERCH   % TTLY@ B BWLPH% Fl`EMF+@0$۫JBARIAL@, .3ETeD3   ( RpArial\(gUDEpIoD8 CPs_Dh,w LvvCuvCuw r L@_v00| LteDuqvCu5\v !Du\v@_v@_vdv% TTQZ@ B BYLP3% FthEMF+@D8@? @ EdHD ED: $$==_888 % % W$SaqI% % $$AA( : FthEMF+@D8?? @ DdMDDUMD: $$==_888 % % W$!%00 % % $$AA( : F4(EMF+ @$[DU-D@D@\DSD@\DeD+DDD'DDJDDqDwDDgDsDuDDDDiDIDljDDDDj^D$$==%  % V((2{/p'S*{|&=S]lq|r{oh^F*<S5p2{%  % $$AAFEMF+@D8@?@xl Dj^DDj^D[DwD[DwD[DwDU]DdmDDdmDu,DdmDqDwDqDwDqDwDDj^DDj^D: $$==_888 % % UP)* 2{2{{{{2Nr{r{r{2{2{% % $$AA( : FtEMF+@D8BTIMES NEW ROMAN@, DDO   ( RpTimes New Roman\(gUDEpID8 CPs߸Dh,w MvvCuvCut r M@_v00| MteDuqvCu5\v !Du\v@_v@_vdv% TT @ B BLPO % F<0EMF+@, DDs   % TT@ B BLPs% F<0EMF+@, DDO   % TT@ B BLPOg % FtEMF+@D8pBTIMES NEW ROMAN@, DXD4   ( RpTimes New Roman\(gUDEpID8 CPsDh,w NvvCuvCuw r N@_v00| NteDuqvCu5\v !Du\v@_v@_vdv% TT!@ B BLP4% Fl`EMF+@0$UUBARIAL@, DEN   ( RpArial\(gUDEpID8 CPs߸Dh,w OvvCuvCut r O@_v00| OteDuqvCu5\v !Du\v@_v@_vdv% TT+l2y@ B B+wLPN% Fl`EMF+@0$UUBARIAL@,  VD DH   % TT<I@ B BGLPHm% F<0EMF+@, bSD DN   % TT<I@ B BGLPN% FthEMF+@D8@? @ gD,EOE E: $$==_888 % % W$2aMrH-% % $$AA( : FthEMF+@D8@? @ OE EOETD: $$==_888 % % W$IAMe--% % $$AA( : FthEMF+@D8@? @ ,D E,DHD: $$==_888 % % W$ECIcl lP% % $$AA( : FthEMF+@D8@? @ OETDDU D: $$==_888 % % W$-1ME--% % $$AA( : FthEMF+@D8@? @ DU DD/D: $$==_888 % % W$11B-% % $$AA( : FthEMF+@D8@? @  RDE RD E: $$==_888 % % W$Ge22-% % $$AA( : FthEMF+@D8@? @  RD E"\DE: $$==_888 % % W$a+q2-% % $$AA( : Fl`EMF+@0$UUBARIAL@, GDDO   % TT+ 3@ B B+LPO % FthEMF+@D8@? @ xD DxDTD: $$==_888 % % W$+/6>% % $$AA( : FthEMF+@D8@? @ xD DxDTD: $$==_888 % % W$/36 > % % $$AA( : Fl`EMF+@0$UUBARIAL@, (jDUEO   % TTly@ B BwLPO % FthEMF+@D8@? @  D5 EDE: $$==_888 % % W$bsQ>% % $$AA( : FthEMF+@D8@? @  RD ED2E: $$==_888 % % W$_p2 % % $$AA( : Fl`EMF+@0$UUBARIAL@,  EDC   % TTb,i9@ B Bb7LPC% FthEMF+@D8@? @ OETD! E]D: $$==_888 % % W$I4cE-\% % $$AA( : Fl`EMF+@0$UUBARIAL@, vE&DC   % TT~)@ B B~'LPC% FthEMF+@D8@? @ n EaD4EDD: $$==_888 % % W$h }.'% % $$AA( : FthEMF+@D8@? @ .E|DED: $$==_888 % % W$i$2\% % $$AA( : FthEMF+@D8@? @ EIDEwD: $$==_888 % % W$k'52% % $$AA( : FthEMF+@D8@? @ D\EDE: $$==_888 % % W$-w1-% % $$AA( : FthEMF+@D8@? @ DEOE#E: $$==_888 % % W$-M--% % $$AA( : FthEMF+@D8@? @ OE#EOEF0E: $$==_888 % % W$IM--% % $$AA( : Fl`EMF+@0$UUBARIAL@, 4 EUSEO   % TTbj@ B BbLPO % F<0EMF+@, ߼ EUSEH   % TTjq@ B BjLPH% FthEMF+@D8@? @ OE#EV EHE: $$==_888 % % W$Ic-^% % $$AA( : Fl`EMF+@0$UUBARIAL@, 4 EUS4EO   % TTbj@ B BbLPO % F<0EMF+@, ߼ EUS4EH   % TTjq@ B BjLPHs% FthEMF+@D8@? @ OEF0E EcV5E: $$==_888 % % W$Ic-% % $$AA( : Fl`EMF+@0$UUBARIAL@, n!EUMD(   % TT @ B BLP(% F<0EMF+@, b"EUMDC   % TT @ B BLPC% F<0EMF+@, na%EUMDH   % TT @ B BLPH % Fl`EMF+@0$۫JBARIAL@, `(ED2   ( RpArial\(gUDEpIoD8 CPs_Dh,w PvvCuvCuw r P@_v00| PteDuqvCu5\v !Du\v@_v@_vdv% TT@ B BLP2% Fl`EMF+@0$UUBARIAL@, *EUMD)   ( RpArial\(gUDEpI*D8 CPs*Dh,w QvvCuvCut r Q@_v00| QteDuqvCu5\v !Du\v@_v@_vdv% TT @ B BLP)% Fl`EMF+@0$۫JBARIAL@, ny+ED3   ( RpArial\(gUDEpIoD8 CPs_Dh,w RvvCuvCuw r R@_v00| RteDuqvCu5\v !Du\v@_v@_vdv% TT@ B BLP3% Fl`EMF+@0$UUBARIAL@, n1-EUMDC   ( RpArial\(gUDEpID8 CPs߸Dh,w SvvCuvCut r S@_v00| SteDuqvCu5\v !Du\v@_v@_vdv% TT @ B BLPC% F<0EMF+@, 00EUMDH   % TT @ B BLPHT% Fl`EMF+@0$۫JBARIAL@, .3ED3   ( RpArial\(gUDEpIoD8 CPs_Dh,w TvvCuvCuw r T@_v00| TteDuqvCu5\v !Du\v@_v@_vdv% TT@ B BLP3% FthEMF+@D8@? @ E|0D ErD: $$==_888 % % W$"tV% % $$AA( : FthEMF+@D8?? @ DoD(DN܋D: $$==_888 % % W$j6I) % % $$AA( : FD8EMF+ @4(DD(DN DU)DNlDD_D$$==%  % V,k6U-  H%  % $$AAFEMF+ @DUDzDO D9DMDsD>DkD@DJcDDjDDb\D2DDDDD~DDD/DDDbD ID0D{˹DD7D^DκDDIDD?D DOD9DVDv^DYD DD¡DҽD_aDDEpDDЦDD\ݿDPDBD0D߫D8DDUD$$==%  % V0?}sY5 yidcb_]XSL9.  , P9zRhw}%  % $$AAFEMF+@D8@?@xl DUDDUDDDDDDD=D`D7D^D1D[DYD DDYD DDYD DDDUDDUD: $$==_888 % % UP.A }}ddd`L8}}% % $$AA( : FtEMF+@D8BTIMES NEW ROMAN@, {DDK   ( RpTimes New Roman\(gUDEpID8 CPs߸Dh,w UvvCuvCut r U@_v00| UteDuqvCu5\v !Du\v@_v@_vdv% TT@ B BLPK % FtEMF+@D8pBTIMES NEW ROMAN@, :)DwD2   ( RpTimes New Roman\(gUDEpID8 CPsDh,w VvvCuvCuw r V@_v00| VteDuqvCu5\v !Du\v@_v@_vdv% TT@ B BLP2% FtEMF+@D8BTIMES NEW ROMAN@, :DDC   ( RpTimes New Roman\(gUDEpIϪD8 CPsDh,w WvvCuvCut r W@_v00| WteDuqvCu5\v !Du\v@_v@_vdv% TT@ B BLPC % F<0EMF+@, 哏DDO   % TT@ B BLPO % FtEMF+@D8pBTIMES NEW ROMAN@, ÖDwD3   ( RpTimes New Roman\(gUDEpID8 CPsDh,w XvvCuvCuw r X@_v00| XteDuqvCu5\v !Du\v@_v@_vdv% TT@ B BLP3% Fl`EMF+@0$UUBARIAL@,  DuDC   ( RpArial\(gUDEpID8 CPs߸Dh,w YvvCuvCut r Y@_v00| YteDuqvCu5\v !Du\v@_v@_vdv% TTZa@ B BZLPC% F<0EMF+@, ^DuDl   % TTab@ B BaLPl% FthEMF+@D8@? @  DD DD: $$==_888 % % W$[_/% % $$AA( : FthEMF+@D8@? @  DD)=D\D: $$==_888 % % W$[{% % $$AA( : FthEMF+@D8@? @ )=D\DHCiDD: $$==_888 % % W$wM % % $$AA( : Fl`EMF+@0$UUBARIAL@, DDO   % TT@ B BLPO % F<0EMF+@, 4|DDH   % TT@ B BLPH % FthEMF+@D8@? @ HCiDD%*DD: $$==_888 % % W$ M  % % $$AA( : Fl`EMF+@0$UUBARIAL@, ~s7DDO   % TTu&}3@ B Bu1LPO % F<0EMF+@, )^DDDH   % TT}&3@ B B}1LPH,% FthEMF+@D8@? @ )=D\D)=D/D: $$==_888 % % W$w {)m% % $$AA( : FthEMF+@D8@? @ DKDDxD: $$==_888 % % W$)  h% % $$AA( : FthEMF+@D8@? @ DxDDD: $$==_888 % % W$ h L% % $$AA( : FthEMF+@D8@? @ ˗DDDgD: $$==_888 % % W$  4% % $$AA( : FtEMF+@D8BTIMES NEW ROMAN@, {CpD1   ( RpTimes New Roman\(gUDEpID8 CPs(sh,w ZvvCuvCut r Z@_v00| ZteDuqvCu5\v !Du\v@_v@_vdv% TT(/@ B B(LP1% F<0EMF+@, CpDA   % TT0;@ B B0LPA| % FtEMF+@D8BTIMES NEW ROMAN@, ED2   % TTW^@ B BWLP2 % F<0EMF+@, : EDA   % TT_j@ B B_LPA, % FtEMF+@D8BTIMES NEW ROMAN@, D(E3   % TT$@ B BLP3 % F<0EMF+@, #D(EA   % TT%0@ B B%LPA, % Fh.\.EMF+@ CDIFVjCD0100ChemDraw 12.0:efaT[  " :;E<  BCD `  (33xx# ()*$$$$2$ArialTimes New Romanx,, g{,, d'`33 $$c:e_D`م3 +H77070_5#`NHby}G 7da}G fU3 haN +H7d.!^Ůd.!#`NHjyN r=3 +H72@/:/@*6# `Ouم +H72ӈee # `OwUY\ +H72XYYRYYXY_# `CyI5rq +H72L5nF5nL5Rt# `C=; H7 :Enjg=; uR; uR; Qkg; =;n      2sA;9CD#`(CH2)3CH3l `b m bd lxnn df o fh p hj q j` s frv jux dw z wy  y iurrU3lhv /An atom in this label has an invalid valence.H73duoJEw`93fa +Hi^3d^fjd# `C:3r$L +H ,wuoJsRquoJEwP# `O;3rhv +HuHs3pHsfv|y `O<3f1 +Hi3dfjD# `O=3r +H3u3p3u`# `K>3l +H3o3j3o`# `K? 9:@ 9;A ;<B <=LpuriurrU#/  K2CO3,ub=p xvi #+H7zvj,ubzvj#`Br R~ 7 x.t 7 = 7     :O̶T[م~  +H^# `NyF  7aF U~ a+ +H7d+^+d+#`NHy+ =~ +H72@^:^@ CDIF@:# `OمO +H72ӈO̶O̶# `OU  +H72X/ R/ X# `CI! +H72LFL$# `Cٝ~  7٩F "7F $7=x6 &H7 :g%f=x6 uRxB uRxZ Qkgxf =x         2sAx!5;x!59CT[#`(CH2)3CH3                   !  #  % ' ̌|@C )H7CϬ3vEC L+HC3ӹ#`OsFC +HCC3ӡv `OGC +HCϬCϬ3ӹv `OHC +HCC3v `OIC +HCC3ӹv `OJ EFK EGL EHM EI|̌|@# OsO43O̶faT[3s~ 3+H3S33S^# `N3s F 472sF 53s~ 62s+ 7+H72S+2+2S+#`NH3s + 83s~ ?+H7l^3^f:# `O3sO A+H7lO̶3O̶f# `O3s  C+H7l/ 3/ f# `C3s! E+H7l3f$# `C3s.~ G73s:F I3sRF K73s.  M+H7l1 3+ f1#`OH3s^  O+H7la 3[ fa#`OH3sx6 QH7g8%f3sx6 *<xB +<xZ ,xf -3sx .  / 0 1 2 x!533x!53T[#`(CH2)3CH3  9   :     ;   <   =  >@@4CDIF  @ B D  F  H  J  L  N  P  R YuxǓh| T/An atom in this label has an invalid valence.H7uOř$R +HxuO8uOrugW# `Ǒh| +H9܀x܀x2S@# `Ǒ1 +H9II2S # `O ̌ +H::# `K!̌ +H::# `Ǩg V+H9dd2S3;k# `C" # $ %  euxYuxU#/  K2CO3*jCe)jeF U+H7CjCK#`Cl+jeF W7-jz.[ Y/jVo [71j2 ]+H72j2e#`OH3jz.[ _+H7zXjzXd#`OH, X)+ . Z+- 0 \-/ 2 ^/1 4 `-3 W@3@_V@ a7X@ b7Y cLThis isolated bond is probably not intended to have chemical significance.VX _]fb\ d7^? e7_ fLThis isolated bond is probably not intended to have chemical significance.\^ Yk9̌9, g&ChemDraw can't interpret this label.1Aly̎yٜ h&ChemDraw can't interpret this label.2AnMBP i&ChemDraw can't interpret this label.3A@sH@sH]    3CٗC (   \s2j%P S     c*W]     c     !(oH]@vH 7 / 5  0 !1 w H@s H]@s  f& Df& f&!ٗk3 (7 / 5  0 !1 w C3 Cٗ  GgP$ VgP$ Gj!݅P2z S7 / 5  0 !1 w s2\ Pj%  2, v, 2DLdMM)??" FEMF+@ CompObjN~ObjInfoPCONTENTS ._1401698538/!mA. ?NNcN !mA. CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.6.09q !mA. CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.6.09qVjCD0100ChemDraw 12.0:efaT[  @@3 :;E<  BCD `  (33xx# ()*$$$$2$ArialTimes New Romanx,, g{,, dd'`33 $$c:e_D`م3 +H77070_5#`NHby}G 7da}G fU3 haN +H7d.!^Ůd.!#`NHjyN r=3 +H72@/:/@*6# `Ouم +H72ӈee # `OwUY\ +H72XYYRYYXY_# `CyI5rq +H72L5nF5nL5Rt# `C=; H7 :Enjg=; uR; uR; Qkg; =;n      2sA;9CD#`(CH2)3CH3l `b m bd lxnn df o fh p hj q j` s frv jux dw z wy  y iurrU3lhv /An atom in this label has an invalid valence.H73duoJEw`93fa +Hi^3d^fjd# `C:3r$L +H ,wuoJsRquoJEwP# `O;3rhv +HuHs3pHsfv|y `O<3f1 +Hi3dfjD# `O=3r +H3u3p3u`# `K>3l +H3o3j3o`# `K? 9:@ 9;A ;<B <=LpuriurrU#/  K2CO3,ub=p xvi #+H7zvj,ubzvj#`Br R~ 7 x.t 7 = 7     :O̶T[م~  +H^# `NyF  7aF U~ a+ +H7d+^+d+#`NHy+ =~ +H72@^:^@:# `OمO +H72ӈO̶O̶# `OU  +H72X/ R/ X# `CI! +H72LFL$# `Cٝ~  7٩F "7F $7=x6 &H7 :g%f=x6 uRxB uRxZ Qkgxf =x         2sAx!5;x!59CT[#`(CH2)3CH3                   !  #  % ' ̌|@C )H7CϬ3vEC L+HC3ӹ#`OsFC +HCC3ӡv `OGC +HCϬCϬ3ӹv `OHC +HCC3v `OIC +HCC3ӹv `OJ EFK EGL EHM EI|̌|@# OsO43O̶faT[3s~ 3+H3S33S^# `N3s F 472sF 53s~ 62s+ 7+H72S+2+2S+#`NH3s + 83s~ ?+H7l^3^f:# `O3sO A+H7lO̶3O̶f# `O3s  C+H7l/ 3/ f# `C3s! E+H7l3f$# `C3s.~ G73s:F I3sRF K73s.  M+H7l1 3+ f1#`OH3s^  O+H7la 3[ fa#`OH3sx6 QH7g8%f3sx6 *<xB +<xZ ,xf -3sx .  / 0 1 2 x!533x!53T[#`(CH2)3CH3  9   :     ;   <   =  >  @ B D  F  H  J  L  N  P  R YuxǓh| T/An atom in this label has an invalid valence.H7uOř$R +HxuO8uOrugW# `Ǒh| +H9܀x܀x2S@# `Ǒ1 +H9II2S # `O ̌ +H::# `K!̌ +H::# `Ǩg V+H9dd2S3;k# `C" # $ %  euxYuxU#/  K2CO3*jCe)jeF U+H7CjCK#`Cl+jeF W7-jz.[ Y/jVo [71j2 ]+H72j2e#`OH3jz.[ _+H7zXjzXd#`OH, X)+ . Z+- 0 \-/ 2 ^/1 4 `-3 W@3@_V@ a7X@ b7Y cLThis isolated bond is probably not intended to have chemical significance.VX _]fb\ d7^? e7_ fLThis isolated bond is probably not intended to have chemical significance.\^ Yk9̌9, g&ChemDraw can't interpret this label.1Aly̎yٜ h&ChemDraw can't interpret this label.2AnMBP i&ChemDraw can't interpret this label.3A@sH@sH]    3CٗC (   \s2j%P S     c*W]        !(oH]@vH 7 / 5  0 !1 w H@s H]@s  f& Df& f&!ٗk3 (7 / 5  0 !1 w C3 Cٗ  GgP$ VgP$ Gj!݅P2z S7 / 5  0 !1 w s2\ Pj%  2, v, 2D              y h           ! 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" )qs\+ks\s|#/  K2CO3>{CܨDD 5+H7$CdC$E# `ID\ 7|h 7|Հ DՌ 7Dդ H7O*x$Dդ +H>d)X `O% հ &դ +HH `O' (DՌ  ) ($* $%+ %&, %'@CDIF>dܨ#`OCOCH3>~Ռ 7>~դ H7Prz)X.>~դ +H׬>{qƁ `O/|հ 0Dդ +H>d)X `O1| 2>~Ռ  3 2.4 ./5 /06 /1׬>{>sܨ#`OCOCH3              k?#W}k +HkҌ(k(kҌ# `Nl} 7le kY ke? +H7khkckh#`NHk}? kA +H7Dk?E # `Ok#w +H7#Wk#WV# `OlY/ +H7\,lW,]z2# `ClMpcD +H7PpAlKpAQpCG# `ClAL,Y H7Q%>_=kL,lAL,Y HVL,e HVL,} $kL, $kL, lAL,A       ELWl?LWlRG}#`(CH2)4CH3k 7k? 7k? k#w 7k#w +H7#Wk#WVJ#`OHk 7l +H7l#`OH                                        9@9L9Y, &ChemDraw can't interpret this label.9A: ̌ _ &ChemDraw can't interpret this label.10AJRu9euN     ST  J c !RrNgx9e 7 / 5  0 !1 w 9eu Nu  GL$ M(L$ GDLdR>R)??" FEMF+@ CompObjV~ObjInfo XCONTENTS_1401698540 !mA. NN !mA. CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.6.09q !mA. CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.6.09qVjCD0100ChemDraw 12.0k?%}  @@3 :;E<  BCD `  (33xx# ()*$$$$2$ArialTimes New Romanx,, g{,, dd'`D33 $$c?%dD`ފ0 +H7--d3#`NHb~}E 7df}E fZ0 hf +H7icni#`NHj~ rB0 +H7)E-?-E3# `OuފE +H7)؍%%Y # `OwZYiZ +H7)]YWWYW]YI]# `CyN52o +H7)Q5RlK5RlQ5r# `CB H7E?E.hlB lW lW Hpl Hpl Bk       )xF{@{>HD#`(CH2)4CH3l `b m bd lxnn df o fh p hj q j` s frv jux dw z wy  y \+ks\s|^nCv /An atom in this label has an invalid valence.H7F~eەJxa^hfa +H)Xkf^~ef^qkfd# `C^tL +HjxەJнrەJxP `O^tCv +H)XwCos~qCosqwvy `O^hX +H)Xk8~e8qkRk# `O^t +H>w ~q >wa# `K^n +H>q ~k >qa# `K   ! " )qs\+ks\s|#/  K2CO3>{CܨDD 5+H7$CdC$E# `ID\ 7|h 7|Հ DՌ 7Dդ H7G*x$Dդ +H>d)X `O% հ &դ +HH `O' (DՌ  ) ($* $%+ %&, %'>dܨ#`OCOCH3>~Ռ 7>~դ H7Hrz)X.>~դ +H׬>{qƁ `O/|հ 0Dդ +H>d)X `O1| 2>~Ռ  3 2.4 ./5 /06 /1׬>{>sܨ#`OCOCH3              k?#W}k +HkҌ(k(kҌ# `Nl} 7le kY ke? +H7khkckh#`NHk}? kA +H7Dk?E # `Ok#w +H7#Wk#WV# `OlY/ +H7\,lW,]z2# `ClMpcD +H7PpAlKpAQpCG# `ClAL,Y H7I%>_=kL,lAL,Y HVL,e HVL,} $kL, $kL, lAL,A       ELWl?LWlRG}#`(CH2)4CH3k 7k? 7k? k#w 7k#w +H7#Wk#WVJ#`OHk 7l +H7l#`OH                                        9@9L9Y, &ChemDraw can't interpret this label.9A: ̌ _ &ChemDraw can't interpret this label.10ABJu9euN     KL  B c !JrNgx9e 7 / 5  0 !1 w 9eu Nu  GL$ M(L$ GDOle YEPRINT .̘CompObjZ~ObjInfo\lwBP3, EMF̘a nNF, EMF+@``F EMF+@ "@ @ !@ 0@?0@ #>2@BDE^D@0$UUBARIAL@H<h:?@,  DlDN!b    RpArial\p,A tD8A tDP t߸DxetXDT! @w P<X00wwXB] t !LXdv% TT@ B BLPN=% Fl`EMF+@0$UUBARIAL@, DDN   % TT%@ B B#LPN% FthEMF+@D8@? @ DTDDUD: $$==_888 % % W$ L % % $$AA( : FthEMF+@D8@? @ DUDߘDD: $$==_888 % % W$  3 % % $$AA( : FthEMF+@D8@? @ D1D_DD: $$==_888 % % W$  R % % $$AA( : FthEMF+@D8@? @ D{D:DUD: $$==_888 % % W$  O% % $$AA( : FthEMF+@D8@? @ :DUD:DUD: $$==_888 % % W$OO% % $$AA( : FthEMF+@D8@? @ :D1D:DD: $$==_888 % % W$% % $$AA( : FthEMF+@D8@? @ :DUDCDUmD: $$==_888 % % W$O % % $$AA( : FthEMF+@D8@? @ CDUmD.\DW^D: $$==_888 % % W$ 3 % % $$AA( : FthEMF+@D8@? @ CD$D.܍DsD: $$==_888 % % W$ 4R % % $$AA( : Fl`EMF+@0$UUBARIAL@, VDDC   % TT%@ B B#LPC% F<0EMF+@, bDDl   % TT%@ B B#LPl% FthEMF+@D8@? @ DUD`iDD: $$==_888 % % W$  T % % $$AA( : Fl`EMF+@0$UUBARIAL@, DDC   % TT@ B BLPCD% F<0EMF+@, DDl   % TT@ B BLPl% FthEMF+@D8@? @ CDUmDCDT9D: $$==_888 % % W$ O % % $$AA( : Fl`EMF+@0$UUBARIAL@, 4C˵DH   % TT#@ B BLPH@% F<0EMF+@, adC˵DN   % TT$+@ B B$LPN% Fl`EMF+@0$UUBARIAL@,  CKDN   % TT@G$@ B B@"LPN=% Fl`EMF+@0$UUBARIAL@,  CU9DH   % TT@ G-@ B B@+LPH% FthEMF+@D8@? @ CUͭDE.C/D: $$==_888 % % W$,F; % % $$AA( : FthEMF+@D8@? @ |CTD|CUMD: $$==_888 % % W$&*@% % $$AA( : FthEMF+@D8@? @ |CUMDC#D: $$==_888 % % W$& @% % $$AA( : FthEMF+@D8@? @ CW>DmDUMD: $$==_888 % % W$G a% % $$AA( : FthEMF+@D8@? @ mDUMDmDUMD: $$==_888 % % W$]a% % $$AA( : FthEMF+@D8@? @ mDDmDD: $$==_888 % % W$Z^% % $$AA( : FthEMF+@D8@? @ mDUMDCUͭD: $$==_888 % % W$Ba; % % $$AA( : Fl`EMF+@0$UUBARIAL@, ECfDO   % TT@H@ B B@LPO= % FthEMF+@D8@? @ C DCTD: $$==_888 % % W$@D B % % $$AA( : FthEMF+@D8@? @ C DCTD: $$==_888 % % W$DHZ ZB % % $$AA( : Fl`EMF+@0$UUBARIAL@, 3fVBfDO   % TT$@ B B"LPO % FthEMF+@D8@? @ [lC +DDB D: $$==_888 % % W$ ,$% % $$AA( : FthEMF+@D8@? @ |CDDB:D: $$==_888 % % W$ *% % $$AA( : FthEMF+@D8?? @ \9rDUDg[#DUD: $$==_888 % % W$g % % $$AA( : F4(EMF+ @$g#DU]D;C@$$=='% % V0g  % % $$AAFEMF+ @ -DUD5DD9D2KD89D6Du{D`DyDwDD}CsDuDnpDCD[oDD}oDD+oDDWpDPDopDPDqDDWrD+UD\yrDUDWrD@DqDүDopDDWpD#0D+oDD}oDD[oDʇDnpDǫD}CsD DyDwDːDu{D*D89DTD9DwJD5DXD-DUD$$==%  % V  c :                        : c   %  % $$AAFEMF+@D8@?@xl -DUD-DUD[oDD[oDD[oDD\yrD-D\yrDUD\yrD^D[oDʇD[oDʇD[oDʇD-DUD-DUD: $$==_888 % % UP             % % $$AA( : FtEMF+@D8BTIMES NEW ROMAN@, h0DкDP   ( RpTimes New Roman\p,`58oD88P t_D48X58h,/w`58 X58vvJu,vJuf0/ `58@Lw00| teKu͞EvJu5Iw`58t !tuIw@Lw@Lwdv% TTqw@ B BqLPP;% F<0EMF+@, ;DкDO   % TTx@ B BxLPO? % F<0EMF+@, FJDкDC   % TT@ B BLPC % F<0EMF+@, hWDкDl   % TT@ B BLPl% FtEMF+@D8pBTIMES NEW ROMAN@,  ]DU-D3   ( RpTimes New Roman\p,`58D88P tD48X58h,/w`58 X58vvJu,vJue0/ `58@Lw00| teKu͞EvJu5Iw`58t !tuIw@Lw@Lwdv% TT@ B BLP3% FthEMF+@D8?? @ 0DUD DUD: $$==_888 % % W$%8% % $$AA( : F4(EMF+ @$DU]DC@$$==% % V0$==% % $$AAF$EMF+ @ 6%DUDDD81D2KD0D6D_DD3   ( RpArial\p,`58oD88 P t_D48X58h,/w`58 X58vvJu,vJue0/ `58@Lw00| teKu͞EvJu5Iw`58t !tuIw@Lw@Lwdv% TT&@ B B%LP3% Fl`EMF+@0$UUBARIAL@, >DDC   ( RpArial\p,`58D88P t߸D48X58h,/w`58 X58vvJu,vJuf0/ `58@Lw00| teKu͞EvJu5Iw`58t !tuIw@Lw@Lwdv% TT%@ B B#LPC% F<0EMF+@, DDO   % TT&%@ B B#LPO % FthEMF+@D8@? @ $DUD~D| D: $$==_888 % % W$% @s% % $$AA( : Fl`EMF+@0$UUBARIAL@, 0EDO   % TTU]@ B BULPO5 % F<0EMF+@, EDC   % TT^e@ B B^LPC% F<0EMF+@,  EDH   % TTel@ B BeLPH% Fl`EMF+@0$۫JBARIAL@, 0ED3   ( RpArial\p,`58oD88P t_D48X58h,/w`58 X58vvJu,vJue0/ `58@Lw00| teKu͞EvJu5Iw`58t !tuIw@Lw@Lwdv% TTmp@ B BmLP3u% FthEMF+@D8@? @ &EUmD&ET9D: $$==_888 % % W$W\ O % % $$AA( : FtEMF+@D8BTIMES NEW ROMAN@, D D1   ( RpTimes New Roman\p,`58D88P t( t48X58h,/w`58 X58vvJu,vJuf0/ `58@Lw00| teKu͞EvJu5Iw`58t !tuIw@Lw@Lwdv% TT$6@ B B3LP1<% F<0EMF+@, D D2   % TT$6@ B B3LP2% F<0EMF+@, +D DA   % TT$6@ B B3LPA % FtEMF+@D8BTIMES NEW ROMAN@, ED1   % TTQ%X7@ B BQ4LP1<% F<0EMF+@, ED3   % TTY%`7@ B BY4LP3<% F<0EMF+@,  EDA   % TTa%l7@ B Ba4LPA< % FtEMF+@D8BTIMES NEW ROMAN@, ϓCDU   % TT//:A@ B B/>LPU % F<0EMF+@, ڷCDr   % TT:/@A@ B B:>LPrra% F<0EMF+@, CDa   % TTA/HA@ B BA>LPa)% F<0EMF+@, CDc   % TTI/OA@ B BI>LPc'% F<0EMF+@, SCDi   % TTP/SA@ B BP>LPi% F<0EMF+@, bDDl   % TTU/XA@ B BU>LPl=% FEMF+@ CDIFVjCD0100ChemDraw 12.0nY @{@ " :;E<  BCD `  (33xx# ()*$$$$2$ArialTimes New Romanx,, g{,, d'`33 $$:3gfu73s} |+H73S˝3˝3S]# `N93s} };2sF ~+H72Sf2f2S&# `N=3s 7?3s 7A3sF K3sm +H7ln3gfn#`ClM3sF +H7lf3ff#`ClC 79 D 9; CLEE ;= F =? EGG ?A H A7 GNCL 9K N AM Yn_OHV٦N 3 XٲrW +H7r7!rr7!#`NHZrW \N 3 +H7N@0N@0_N6#`NH^*G 7`ٲ*G 7hَN 3 +H72ӑN0N036# `Oj +H72nnɡ # `Ob VX c XZ d Z\ e \^ f ^` egg `V i Vhk Zjr(2T[˽mq2W H728•2$t2W d+Hb2T2TbZ# `P2W e+H(|2dT2dT•eZ# `O2? f+H(|2d@28•2d@#`Cl2W g+H(|2T2T•2$\#`Cl2o h+H(|2l2l•2$t#`Cl i j k l(ܻ2T(2T[˽m# POCl3wY}pv̌e H7̬"eť m +Hl.̬"e.#`Nǎe n+Hee̬eʻ `ǑA o p qe}Y}p# NaOCH3|˝P{32Ĺ H732ĭfe32ĭ a32 b+H232fe#@ CDIF`OH cL˝˝P#% CH3OH3 33~3s} 3s +H73S33S# `N3s 3s} +H73S̝3̝3S]# `N3sF 73sF 73s H7g3s3s r+Hl3fF `O3s s3s t  u vl 3 33 #`OCH33s} H7?J3s} w+Hl]3]f `O3s x3s} y  z {l]3]33]#`OCH3 ~          ~    ~  _ &ChemDraw can't interpret this label.12A &ChemDraw can't interpret this label.13A@y#Ly#Y2SC &ChemDraw can't interpret this label.Uracilپ2~پJN    پ]پ}      Y :  r :   w |!JNp2~ 7 / 5  0 !1 w 2~پ JNپ  3s o3s  A!}p] 7 / 5  0 !1 w ]پ }پ  =3s ,p3s =ĉCLd vB n)??" FEMF+@ CONTENTS}_1401698541!mA. N0SNOle ]EPRINTLW VjCD0100ChemDraw 12.0nY @{@ @@3 :;E<  BCD `  (33xx# ()*$$$$2$ArialTimes New Romanx,, g{,, dd'`33 $$:3gfu73s} y+H73S˝3˝3S]# `N93s} z;2sF {+H72Sf2f2S&# `N=3s |7?3s }7A3sF ~K3sm +H7ln3gfn#`ClM3sF +H7lf3ff#`ClC 79 D 9; CLEE ;= F =? EGG ?A H A7 GNCL 9K N AM Yn_OHV٦N 3 XٲrW +H7r7!rr7!#`NHZrW \N 3 +H7N@0N@0_N6#`NH^*G 7`ٲ*G 7hَN 3 +H72ӑN0N036# `Oj +H72nnɡ # `Ob VX c XZ d Z\ e \^ f ^` egg `V i Vhk Zjr(2T[˽mq2W H728•2$t2W a+Hb2T2TbZ# `P2W b+H(|2dT2dT•eZ# `O2? c+H(|2d@28•2d@#`Cl2W d+H(|2T2T•2$\#`Cl2o e+H(|2l2l•2$t#`Cl f g h i(ܻ2T(2T[˽m# POCl3wY}pv̌e H7̬"eť j +Hl.̬"e.#`Nǎe k+Hee̬eʻ `ǑA l m ne}Y}p# NaOCH3|˝P{32Ĺ H732ĭfe32ĭ :32 ;+H232fe#`OH <L˝˝P#% CH3OH3 33~3s} 3s +H73S33S# `N3s 3s} +H73S̝3̝3S]# `N3sF 73sF 73s H7g3s3s o+Hl3fF `O3s p3s q  r sl 3 33 #`OCH33s} H7?J3s} t+Hl]3]f `O3s u3s} v  w xl]3]33]#`OCH3 ~          ~    ~  _ &ChemDraw can't interpret this label.12A &ChemDraw can't interpret this label.13A@y#Ly#Y2SC &ChemDraw can't interpret this label.Uracilپ2~پJN    پ]پ}      Y :  r :   w |!JNp2~ 7 / 5  0 !1 w 2~پ JNپ  3s o3s  A!}p] 7 / 5  0 !1 w ]پ }پ  =3s ,p3s =ĉClFar^\ | V0 EMFL nNF, EMF+@``F EMF+@ "@ @ !@ 0@?0@ #>2@CD[E D@0$UUBARIAL@H<h?@, ^ E&eDN!b    RpArial@j~ f5@f5p#A tDA tD t߸D8et'DT! @Lw Լ'ww'xb] tT!dv% TTx@ B BxLPN% Fl`EMF+@0$UUBARIAL@, EzDN   % TT@ B BLPN% FthEMF+@D8@? 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@ >D'yD>DD: $$==_888 % % W$x|  % % $$AA( : FthEMF+@D8@? @ >DD`D^D: $$==_888 % % W$x X % % $$AA( : FthEMF+@D8@? @ DD^,DcDBD: $$==_888 % % W${m  # % % $$AA( : FthEMF+@D8@? @ "sDʚDDD: $$==_888 % % W$ [  % % $$AA( : FthEMF+@D8@? @ DDDoD: $$==_888 % % W$  % % $$AA( : FthEMF+@D8@? @ D^,DD[FsD: $$==_888 % % W$ m % % $$AA( : FthEMF+@D8@? @ DoDjDVD: $$==_888 % % W$ U % % $$AA( : FthEMF+@D8@? @ jDVDGDٕjD: $$==_888 % % W$}U [ % % $$AA( : FthEMF+@D8@? @ jD*]DJDoD: $$==_888 % % W$U  % % $$AA( : Fl`EMF+@0$UUBARIAL@, zCDH   % TTFM@ B BFLPHE% Fl`EMF+@0$۫JBARIAL@, IpCpD3   ( RpArial@j~ f5@f5p# 2oDRo t_D/2(,/w2 2pvvJu vJuop 2@Lw< 4eKuvJu5Iw2ئT!ئuIw@Lw@Lwdv% TTNQ@ B BNLP3a% Fl`EMF+@0$UUBARIAL@, %DDC   ( RpArial@j~ f5@f5p# 2DRp t߸D/2(,/w2 2pvvJu vJuop 2@Lw< 4eKuvJu5Iw2ئT!ئuIw@Lw@Lwdv% TTRY@ B BRLPC% F<0EMF+@,  DDO   % TTZb@ B BZLPOS % FthEMF+@D8@? @ >DDrDD: $$==_888 % % W$a| 0a % % $$AA( : Fl`EMF+@0$UUBARIAL@, fcD6DO   % TTbo@ B BmLPO/ % F<0EMF+@, }pD6DC   % TTbo@ B BmLPCe% F<0EMF+@, w|D6DH   % TTbo@ B BmLPHo% Fl`EMF+@0$۫JBARIAL@, 39D #D3   ( RpArial@j~ f5@f5p# 2oDRr t_D/2(,/w2 2pvvJu vJuop 2@Lw< 4eKuvJu5Iw2ئT!ئuIw@Lw@Lwdv% TTgp@ B BoLP3% FthEMF+@D8@? @ jDVDjDg.D: $$==_888 % % W$mU U % % $$AA( : FthEMF+@D8?? @ DׁDDׁD: $$==_888 % % W$=\ \ % % $$AA( : F4(EMF+ @$ݐDwDLD@$$=='% % V0< T f f T T % % $$AAFEMF+ @ED Ec DDeDDDqDzD&DpD%DsD"DD1DQ DoDDۯDfkDDD:D`DkDoDDDkDZD:DCʀDDwDۯD*~DoD}DBD^n}D1DvD}D"Dp}D%D2J~D&DxVDqDEDDހDDdD EÁDED$$==%  % V9J] ` ng Eq }        s h ] R F 0 '     $ / ; EH nR Z ] %  % $$AAFEMF+@D8@?@xl EDED1DQ D1DQ D1DQ DDUHDDDD6yD1DvD}D1DvD}D1DvD}DEDED: $$==_888 % % UP7K ] ]    y ] @    ] ] % % $$AA( : Fl`EMF+@0$UUBARIAL@, BDEΐDB   % TT>K@ B BILPB% F<0EMF+@, }EΐDn   % TT>K@ B BILPn% F<0EMF+@, EΐDO   % TT>K@ B BILPO % FthEMF+@D8@? @ oEDbEND: $$==_888 % % W$#AZJP% % $$AA( : FthEMF+@D8@? @ _Eo@D'(ED: $$==_888 % % W$x pJ% % $$AA( : Fl`EMF+@0$UUBARIAL@, @gEDDO   % TTPX@ B BPLPO % FthEMF+@D8@? @ 'p^EDgEqD: $$==_888 % % W$7Q#J$ % % $$AA( : FthEMF+@D8@? @ !iE|DhED: $$==_888 % % W$RVF%;%S% % $$AA( : FthEMF+@D8@? @ hEDo]ED: $$==_888 % % W$6V';%Sz#J% % $$AA( : FthEMF+@D8@? @ hEDґsED: $$==_888 % % W$Rq(;%S&\% % $$AA( : Fl`EMF+@0$UUBARIAL@, lEtDB   % TT]?cL@ B B]JLPB% F<0EMF+@, LkoEtDn   % TTd?iL@ B BdJLPn% F<0EMF+@, qEtDO   % TTj?rL@ B BjJLPO % FthEMF+@D8@? @ ґsEDOsE2D: $$==_888 % % W$l$qB&\&% % $$AA( : Fl`EMF+@0$UUBARIAL@, >WEΐDB   % TT&>,K@ B B&ILPB% F<0EMF+@, YEΐDn   % TT->2K@ B B-ILPn% F<0EMF+@, \EΐDO   % TT3>;K@ B B3ILPO % FthEMF+@D8@? @ o]ED]END: $$==_888 % % W$5#:Az#Jp#% % $$AA( : FthEMF+@D8@? @ p^ED'p^ED: $$==_888 % % W$7;# #J% % $$AA( : F,4 4EMF+@ CDIFVjCD0100ChemDraw 12.0kqKO4H @{@ " :;E<  BCD `  (33xx# ()*$$$$2$ArialTimes New Romanx,, g{,, d'`V33 $$:kqK?N\7kQr7 <+H7k1uWkqoWk1u # `N9kQ7 =;kQ1 >+Hk1/kq/k14# `N=kQF ?7?kQrF @7AkQf1 AKkQ?n H+H7K?Nkq?Ndr # `OMkQN1 JH7WA7j55kQN1 +HKQ.kqK.dQ*5# `O6kQB7 7kQf1  8 759 56KQ.kqK.kSC#`OCH3ҫŔ1 7?HF +H769HB_HBR{0I# `OP>ԞE (ߗ0 7+V'Z 7ߩY H7X_UI ߩY +HVUUEp]# `Olm C$X <-X Il = G%v; f1n +V'Z              x\}L\#`OBnl0 H7Y\l1,HYl0 +H{l1,;l1,Al3# `Oi:|#D A#/ ;. 7H&C <-X C$X ;D (ߗ0              tl93S#l93#`OBnC B79 D C9; E D;= F E=? 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(                tlӜl#`OBnI ~ J  K  L  KMM  N  O P                   Z,(sOR,{Y`[vث /An atom in this label has an invalid valence.H7a`{mNӭ`[p 2+HTs/`{m/ns# `C`[|F 3+H:NzNӭ `O`[|ث 4+HT`{yn `O`[p 5+HTs`{mnsŴ `O`[|nj 6+H`;nj`{ynj`;# `K`[vnj 7+H`;ynj`{snj`;y# `K 8 9 : ;@CDIFyOR,(sOR,{#/  K2CO3\O\O\8q &ChemDraw can't interpret this label.13A^tO3ƁO3xH &ChemDraw can't interpret this label.14A_tOƁO &ChemDraw can't interpret this label.15ASb|b|O f   Tc7~{7~U v    de  : S Z f :  T !bxObb f7 / 5  0 !1 w b| O|  ?  ?RF6!cvzUn8{ v7 / 5  0 !1 w {7~ U7~  1 ]51 LdGcr^Gc,)??" FEMF+@ CompObj^~ObjInfo`CONTENTS3_1401698542 #!mA. }wNvN !mA. CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.6.09q !mA. CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.6.09q      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVuZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~VjCD0100ChemDraw 12.0kqKO4H @{@ @@3 :;E<  BCD `  (33xx# ()*$$$$2$ArialTimes New Romanx,, g{,, dd'`G33 $$:kqK?N\7kQr7 7+H7k1uWkqoWk1u # `N9kQ7 8;kQ1 9+Hk1/kq/k14# `N=kQF :7?kQrF ;7AkQf1 <KkQ?n C+H7K?Nkq?Ndr # `OMkQN1 EH7HA7j55kQN1  +HKQ.kqK.dQ*5# `O6kQB7  7kQf1   8 759 56KQ.kqK.kSC#`OCH3ҫŔ1 7?HF +H769HB_HBR{0I# `OP>ԞE (ߗ0 7+V'Z 7ߩY H7I_UI ߩY +HVUUEp]# `Olm C$X <-X Il = G%v; f1n +V'Z              x\}L\#`OBnl0 H7J\l1,HYl0 +H{l1,;l1,Al3# `Oi:|#D A#/ ;. 7H&C <-X C$X ;D (ߗ0              tl93S#l93#`OBnC =79 D >9; E ?;= F @=? 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Մb!Y(A׀H9Q 7 / 5  0 !1 w 9QE E  f f f?  = !"#$%&'()*+,-./0123456789:;<l@ABCDmFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijknopqrsvwxyz{|}~l2l?M EMFGj nNF, EMF+@``F EMF+@ "@ @ !@ 0@?0@ #>2@~DeDpE@D@0$BARIAL@H<h ?@, ;DSfDB!b    RpArial\(gU()H)pIV,AsϪD8AsϪDPsD@Nxesx=DT! @v P<x=@N00vvx=]s!LVXdv% TT@ B BLPB % F<0EMF+@, d(DSfDn   % TT@ B BLPn% F<0EMF+@, dDSfDO   % TT@ B BLPO % FthEMF+@D8A? @ cDkqDb1D0qD: $$==_888 % % W$ % % % $$AA( : Fl`EMF+@0$BARIAL@, M(D)JDB   % TT@ B BLPB % F<0EMF+@, D)JDn   % TT@ B BLPn% F<0EMF+@, ݍD)JDO   % TT@ B BLPO % FthEMF+@D8A? @ D)֮DDD: $$==_888 % % W$ $ % % $$AA( : FthEMF+@D8A? @ b1D0qDD4֓D: $$==_888 % % W$% e % % $$AA( : FthEMF+@D8A? @ DDD4֓D: $$==_888 % % W$$ e % % $$AA( : Fl`EMF+@0$BARIAL@, TDUDO   % TT"@ B BLPO % F<0EMF+@, DUDH   % TT#+@ B B#LPH % FthEMF+@D8A? @ D4֓D`DD: $$==_888 % % W$e q % % $$AA( : FthEMF+@D8?? @ UE(D;D(D: $$==_888 % % W$:t#  % % $$AA( : F4(EMF+ @$DDʪCA$$=='% % V0;s  ( (  % % $$AAFEMF+ @ E8DXE5cDuEՕD05E*vDE.DVEdDEpD3EYDE%DEf DETƘD,Eo[DZEӗDqE7D`EɎDEDE D`EO֓DqE'(DZEDEDEgDDEr*D3EWDȆDVErDE91D05EDuE╔DXEk DE8D$$==%  % Vo= 0    c /, 5 9 7 1 )    # #        / c    0 = %  % $$AAFEMF+@D8A?@xl E8DE8DE%DE%DE%DUEDUE8DUEqDEr*DEr*DEr*DE8DE8D: $$==_888 % % UPn = = 9 9 9 % % %    = = % % $$AA( : Fl`EMF+@0$BARIAL@, E,ifDB   % TTu}@ B BuLPB % F<0EMF+@, 4mE,ifDn   % TT~@ B B~LPn% F<0EMF+@, 4QE,ifDO   % TT@ B BLPO % FthEMF+@D8A? @ 41E,qD)E,qD: $$==_888 % % W$ ) % % $$AA( : Fl`EMF+@0$BARIAL@, ETDB   % TTu}@ B BuLPB % F<0EMF+@, 4mETDn   % TT~@ B B~LPn% F<0EMF+@, 4QETDO   % TT@ B BLPO % FthEMF+@D8A? @ 41ED)ED: $$==_888 % % W$ ) % % $$AA( : FthEMF+@D8A? @ )E,qD1EГD: $$==_888 % % W$) i % % $$AA( : FthEMF+@D8A? @ )ED1EГD: $$==_888 % % W$) i % % $$AA( : Fl`EMF+@0$BARIAL@, X?EDDO   % TT@ B BLPO % FthEMF+@D8A? @ 1EГD4>EГD: $$==_888 % % W$i v % % $$AA( : FtEMF+@D8BTIMES NEW ROMAN@, #D؆DH   ( RpTimes New Roman\(gU()H)pI$D8Ps߸D!$h,w$ L$vvCuvCut r L$@_v00| LteDuqvCu5\v$!u\v@_v@_vdv% TTEP@ B BELPH % F<0EMF+@, UE؆DC   % TTPZ@ B BPLPC % F<0EMF+@, E؆Dl   % TT[^@ B B[LPl% FtEMF+@D8BTIMES NEW ROMAN@, #DDP   % TTEM@ B BELPP % F<0EMF+@, EDF   % TTNV@ B BNLPF % F<0EMF+@, UEDA   % TTWb@ B BWLPA % FthEMF+@D8A? @ BE̎D1IE,qD: $$==_888 % % W$%e ) % % $$AA( : Fl`EMF+@0$BARIAL@, VE,ifDC   ( RpArial\(gU()H)pI$D8Ps߸D!$h,w$ M$vvCuvCut r M$@_v00| MteDuqvCu5\v$!u\v@_v@_vdv% TT&.@ B B&LPC % F<0EMF+@, ZE,ifDl   % TT/1@ B B/LPl% FthEMF+@D8A? @ 1IE,qD'VE,qD: $$==_888 % % W$&) <" % % $$AA( : FEMF+@ CDIFVjCD0100ChemDraw 12.0~Np{Z  " :;E<  BCD `  3xx# ()*$$$$2$ArialTimes New Romanx,, g{,, d'`33 $$~Np{;s H7,o'~"%CڮVs n+H~w2~Np2w# `OW,͍_ oXsP pYs2 qZc# r[2 s\ çP t]׍} u^s v _ w^V` xV]a yWX fgbb zXYc {YZ bdd |Z[e }[\ dff ~W\g W]~w~Np|w#`OBns 7ק H7:"&l"H9Ȯiק +H D ; `OjP^ k çP l2 m" nʮ1 o/O p| q:  r qis ipt jk yzuu klv lm uww mnx no wyy joz jpD{;#`OBn: 7 [  +H7)c)&#`OH           Xp?ZsJ( H7z6o,M KsJ( +Hwb$Xpb${w",# `O׍A KsJ sJ A  ç8 oͧ8 A zsJF   ! "  '(## $  #%% &  %'' ( w2,Xp?{w2,#`OBn?sJF 7@;J( H7,,C K*;J( +Hb$Ob$", `O+A ,rͧJ - çJ .A /08 08 1A 2JF  3 2*4 *15 +, :;66 ,-@CDIF7 -. 688 ./9 /0 8:: +0; +12,O?2,#`OBnB;JF 7C(JU D(Js +H7boSbo"w# `OOsJ 7QsJ +H7wXp{wZ#`ClE ? F @B G ?C H BC I CD P DO R OQ LfffK3I +H7?fff#HClM3  /An atom in this label has an invalid valence.PFA@9#@9         L M!%99# 7 / 5  0 !1 w 9#@ 9@  f֙ f f֙ Ld2U)??" FEMF+@ CompObjf~ObjInfo "hCONTENTS _1401698544)%!mA. *NJ%N !mA. CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.6.09qVjCD0100ChemDraw 12.02<GZ <  @@3 :;E<  BCD `  VjCD0100ChemDraw 12.0~Np{Z  @@3 :;E<  BCD `  3xx# ()*$$$$2$ArialTimes New Romanx,, g{,, dd'`33 $$~Np{;s nH7,o'~"%CڮVs +H~w2~Np2w# `OW,͍_ XsP Ys2 Zc# [2  \ çP  ]׍}  ^s   _  ^V` V]a WX fgbb XYc YZ bdd Z[e [\ dff W\g W]~w~Np|w#`OBns o7ק qH7:"&l"H9Ȯiק +H D ; `OjP^ k çP l2 m" nʮ1 o/O p|  q: ! r "qis #ipt $jk yzuu %klv &lm uww 'mnx (no wyy )joz *jpD{;#`OBn: r7 [ t w+H7)c)&#`OH p  s  u  v  x  Xp?ZsJ( H7z6o,M KsJ( z+Hwb$Xpb${w",# `O׍A {KsJ |sJ }A ~ ç8 oͧ8 A zsJF   ! "  '(## $  #%% &  %'' ( w2,Xp?{w2,#`OBn?sJF 7@;J( H7,,C K*;J( +Hb$Ob$", `O+A ,rͧJ - çJ .A /08 08 1A 2JF  3 2*4 *15 +, :;66 ,-7 -. 688 ./9 /0 8:: +0; +12,O?2,#`OBnB;JF 7C(JU D(Js +H7boSbo"w# `OOsJ 7QsJ +H7wXp{wZ#`ClE ? F @B G ?C H BC I CD P DO R OQ LfffK3I +H7?fff#HClM3  /An atom in this label has an invalid valence.PFA}@9#@9 y       } L M!%99# y7 / 5  0 !1 w 9#@ 9@  f֙ f f֙ Ole iEPRINT$'HJCompObjj~ObjInfo&(llxM09 S* EMFHJ nNF, EMF+@``F EMF+@ "@ @ !@ 0@?0@ #>2@7DCDD@0$۫jBARIAL@H<h?@, SD1DH!b    RpArial\H `! p,,AtD8AtDPt߸D?xet DT! @w P< ?00ww 0T]tU!,Xdv% TTp{@ B ByLPH% F<0EMF+@, 7]D1DN   % TTp{@ B ByLPN% Fl`EMF+@0$۫jBARIAL@, ŁDrDN   % TT@ B BLPN% Fl`EMF+@0$۫jBARIAL@, ŁD~DH   % TT@ B BLPH% FthEMF+@D8@? @ bDOADbDdD: $$==_888 % % W$y  % % $$AA( : FthEMF+@D8@? @ bDdDiD!vD: $$==_888 % % W$ > % % $$AA( : FthEMF+@D8@? @ ID;vDmVDdD: $$==_888 % % W$  % % $$AA( : FthEMF+@D8@? @ mVDdDmVD9D: $$==_888 % % W$t  `% % $$AA( : FthEMF+@D8@? @ mDaDmD"5ە <@@!w00| 8vv vv v+>5ە >@@!w00| >te v -v v5w@pϧU!pϧuw@!w@!wdv% TT-Y0_@ B B-_LP1% FthEMF+@D8@? @ D@(DmDI+D: $$==_888 % % W$[&g`VF% % $$AA( : FtEMF+@D8۫:BTIMES NEW ROMAN@, D iD1   ( RpTimes New Roman\H `! p,@D8.':PtD8h,w@ ?8vv vv v+=5ە ?@@!w00| ?te v -v v5w@pϧU!pϧuw@!w@!wdv% TT@ B BLP1% FtEMF+@D8۫:BTIMES NEW ROMAN@, hDZD2   % TT@ B BLP2% FtEMF+@D8۫:BTIMES NEW ROMAN@, hD7D3   % TTv}@ B B|LP3% FtEMF+@D8۫:BTIMES NEW ROMAN@, Dj'D4   % TTkr@ B BqLP4% FtEMF+@D8۫:BTIMES NEW ROMAN@, bD8D5   % TTw~@ B B}LP5% FtEMF+@D8۫:BTIMES NEW ROMAN@, bD]D6   % TT@ B BLP6% FtEMF+@D8۫:BTIMES NEW ROMAN@, DD1   % TT^e@ B BdLP1% F<0EMF+@, DD'   % TT^e@ B BdLP'% FtEMF+@D8۫:BTIMES NEW ROMAN@, :DD2   % TT_f@ B BeLP2% F<0EMF+@, %DD'   % TT_f@ B BeLP'% FtEMF+@D8۫:BTIMES NEW ROMAN@, DD3   % TT _f@ B B eLP3% F<0EMF+@, DD'   % TT_f@ B BeLP' % FtEMF+@D8BTIMES NEW ROMAN@, sD`vD1   ( RpTimes New Roman\H `! p,@D8.(:Pt(t8h,w@ @8vv vv v+=5ە @@@!w00| @te v -v v5w@pϧU!pϧuw@!w@!wdv% TT@ B BLP1% F<0EMF+@, UD`vDA   % TT@ B BLPA % F<0EMF+@, U)D`vD,   % TT@ B BLP,% F<0EMF+@, äD`vD F<0EMF+@, ^D`vD9   % TT@ B BLP9% F<0EMF+@, D`vDA   % TT@ B BLPA % F, EMF+@  CDIFVjCD0100ChemDraw 12.02<GZ <  " :;E<  BCD `  ff3xx# ()*$$$$2$ArialTimes New Romanx,, g{,, d'`333 $$2<GZ<X9l $+H7Y[9moYVSeY[9mo#`NHm9l %Yx &+H7z|u|ơ#`NHmH '7 XH ( YN )> 0+H7,A\|2<\|9A`Á# `Osw] 2+H74zGZtGZzk_# `OYN{x 47YN{x 67YN{x 8+H7P{2K{hX{#`CH2C< :+H73RYF<YA<eG<#`R1 *  +  ,  -   .   /   1  3 5   7  9  ;  fto|foo|vl< <&ChemDraw can't interpret this label. p1"3no3io̬oҢr =&ChemDraw can't interpret this label. p2$fF]ofFXo^Ңr >&ChemDraw can't interpret this label. p3&ffUo|ffPo|Vl< ?&ChemDraw can't interpret this label. p4(]mXmef_9i @&ChemDraw can't interpret this label. p5* om jmp9i A&ChemDraw can't interpret this label. p6+lKm<lFm<eM9 B&ChemDraw can't interpret this label.p1'-3K93F9̌Mv C&ChemDraw can't interpret this label.p2'.3K3F̌Ml\ D&ChemDraw can't interpret this label.p3'1yYvy ߬ E&ChemDraw can't interpret this label.1A, 9ALdxN0xN`)??" FEMF+@ CONTENTSm _1401698545+!mA. J%NHNOle EPRINT*-EMff3xx# ()*$$$$2$ArialTimes New Romanx,, g{,, dd'`b33 $$2<GZ<X9l $+H7Y[9moYVSeY[9mo#`NHm9l %Yx &+H7z|u|ơ#`NHmH '7 XH ( YN )> 0+H7,A\|2<\|9A`Á# `Osw] 2+H74zGZtGZzk_# `OYN{x 47YN{x 67YN{x 8+H7P{2K{hX{#`CH2C< :+H73RYF<YA<eG<#`R1 *  +  ,  -   .   /   1  3 5   7  9  ;  fto|foo|vl< <&ChemDraw can't interpret this label. p1"3no3io̬oҢr =&ChemDraw can't interpret this label. p2$fF]ofFXo^Ңr >&ChemDraw can't interpret this label. p3&ffUo|ffPo|Vl< ?&ChemDraw can't interpret this label. p4(]mXmef_9i @&ChemDraw can't interpret this label. p5* om jmp9i A&ChemDraw can't interpret this label. p6+lKm<lFm<eM9 B&ChemDraw can't interpret this label.p1'-3K93F9̌Mv C&ChemDraw can't interpret this label.p2'.3K3F̌Ml\ D&ChemDraw can't interpret this label.p3'1yYvy ߬ E&ChemDraw can't interpret this label.1A, 9A !mA. CS ChemDraw DrawingChemDrawlZZy/JI0 EMFM nNF, EMF+@``F EMF+@ "@ @ !@ 0@?0@ #>2@pE DD5V @!w00| te v -v v5wpϧk!"pϧuw@!w@!wdv% TT @ B B LP2 % FthEMF+@D8@? @ 8EU]DAEU]D: $$==_888 % % W$% % $$AA( : Fl`EMF+@0$۫jBARIAL@, _KEgDR   ( RpArial\H `!(Hp,D8H Pt߸D(xh,w xvv vv v+=5V @!w00| te v -v v5wpϧk!"pϧuw@!w@!wdv% TT @ B B LPR% F<0EMF+@, +NEgD'   % TT@ B BLP'% FthEMF+@D8@? @ vAEE TD7JEտD: $$==_888 % % W$ n Q% % $$AA( : FtEMF+@D8۫:BTIMES NEW ROMAN@, yIEUED1   ( RpTimes New Roman\H `!(Hp,D8J PtD(xh,w xvv vv v+=5V @!w00| te v -v v5wpϧk!"pϧuw@!w@!wdv% TT-4@ B B3LP1% FtEMF+@D8۫:BTIMES NEW ROMAN@, xEU)D2   % TTw$z+@ B Bw*LP2% FtEMF+@D8۫:BTIMES NEW ROMAN@, xEUD3   % TTwz@ B BwLP3% FtEMF+@D8۫:BTIMES NEW ROMAN@, yIEUuD4   % TT @ B B LP4% FtEMF+@D8۫:BTIMES NEW ROMAN@, y ET5D5   % TT@ B BLP5% FtEMF+@D8۫:BTIMES NEW ROMAN@, y EUAD6   % TT&-@ B B,LP6% FtEMF+@D8۫:BTIMES NEW ROMAN@, y,ETD1   % TT@ B BLP1% F<0EMF+@, n.ETD'   % TT@ B BLP'% FtEMF+@D8۫:BTIMES NEW ROMAN@, x7EUD2   % TT@ B BLP2% F<0EMF+@, Ό8EUD'   % TT@ B BLP'% FtEMF+@D8۫:BTIMES NEW ROMAN@, y@EUD3   % TT@ B BLP3% F<0EMF+@, dBEUD'   % TT@ B BLP'% FtEMF+@D8BTIMES NEW ROMAN@, "EE2   ( RpTimes New Roman\H `!(Hp,D8K Pt(t(xh,w xvv vv v+=5V @!w00| te v -v v5wpϧk!"pϧuw@!w@!wdv% TTKY@ B BWLP2% F<0EMF+@, j%EEA   % TTKY@ B BWLPA % F<0EMF+@, *)EE,   % TTKY@ B BWLP,% F<0EMF+@, x*EE F<0EMF+@, U+EE3   % TTKY@ B BWLP3% F<0EMF+@, `.EEA   % TTKY@ B BWLPA % Fl`EMF+@0$۫jBARIAL@, ?EER   ( RpArial\H `!(Hp,D8L Pt߸D(xh,w xvv vv v+=5V @!w00| te v -v v5wpϧk!"pϧuw@!w@!wdv% TTNY@ B BWLPR% F<0EMF+@, EE'   % TTNY@ B BWLP' % F<0EMF+@, mEE'   % TTNY@ B BWLP'% FthEMF+@D8@? @ XE7DXEE: $$==_888 % % W$;Q% % $$AA( : F EMF+@ CDIFVjCD0100ChemDraw 12.02'̌%  " :;E<  BCD `  ff3xx# ()*$$$$2$ArialTimes New Romanx,, g{,, d'`33 $$_2'%`9 &+H7Y9MY3Y9M#`NHa9 'bY( (+Ht&t&Ɓ+# `Nc(; )7d(; *eY( +f( 2+H7,<&2<&9`+# `Ogs 4+H74''k # `OhY{XM 67iY{Xb 87jY{Xw :+H7{t2ӽ{th{|#`CH2kٵ< <+H73RY<̆Y<̆Y%#`R'lY( H+H73R<&<&`-#`R''o ,`a p -ab q .bc r /cd qwss 0de t 1e` u 3efv 5agw 7dh x 9hi y ;ij z =jk { Ibl ~fO&fO&l) >&ChemDraw can't interpret this label. p133̬҂ ?&ChemDraw can't interpret this label. p2fFfF҂ @&ChemDraw can't interpret this label. p3ffO&ffO&l) A&ChemDraw can't interpret this label. p4m|4m|4ef9I7 B&ChemDraw can't interpret this label. p5 m|4 m|49I7 C&ChemDraw can't interpret this label. p6lmLlmLe9O D&ChemDraw can't interpret this label.p1'39_39_̌Vc E&ChemDraw can't interpret this label.p2'3or3ořl&ChemDraw can't interpret this label. p133̬҂ ?&ChemDraw can't interpret this label. p2fFfF҂ @&ChemDraw can't interpret this label. p3ffO&ffO&l) A&ChemDraw can't interpret this label. p4m|4m|4ef9I7 B&ChemDraw can't interpret this label. p5 m|4 m|49I7 C&ChemDraw can't interpret this label. p6lmLlmLe9O D&ChemDraw can't interpret this label.p1'39_39_̌Vc E&ChemDraw can't interpret this label.p2'3or3ořlRQvĞLCkM1"3eĖӹt2Zx!$W2tFم78zѭS;UڱoiU1O_σ#u]k{tˈZ4t\%׌k('5}nt}nv啌^\i {,ZUA=g% :MKe k~J[m![?-u/\z-t_Pѵv=7|Z!t_nr۟%&od@?XH=}_@}ŹOgWe;(?'W_Ö J[fm![هyRlY-b˵ʾ?1%&8B@uVYßKk8'0Ma`OSUWoހFyi\qv ̾D=[ik',ԙIA;8g{ V y.Pq`:/x.s@bv\˲*5's*Fswk\ (g:>^q\@9JԹ㚾uJٹ g2@(Uⳓ{?Ie~ }.0d-ES |( FxR}ʖyB/\} mGs }.N);LFE u {Ie, ߸Öʖ4_l)JgO(@z ir_,Qn\geƕs~I }[I9~mI_}.0;0sF>ǭPX`1Es#~B50!ຜ,ʏ˦ ?wtlnICFmo( Jb)"D",;CC!xۊxwPjRXJ̺|>b9^CQB( '!YD07h(l\YC1"" |/!^,WކL@%.+BkJ 64rp_;SrGŶ?:}1tԳԣe6k866$T$n9uhlΓ'VN}MؠAh@%Z"Jhhy"@'IB66KĞ ԡty'!GwVءbK,n«Vc7%I^\!Qk)r,a]X GN (å:6Pywߦhiu6vQ Kɥ2ą*eeyH}}[[>F.YԨKBsI.œV.|lX*M ߹Vtn,/HmO.F~[ml -g8 b6ΘkGnX# 9c`mEJk/n]go+up, kZ" l:# rۀkI*kIu/Rz^VkpU#ۦ6Иoxcsd"/mSV7c\.J;%RN~]{,KMhY>~]lw1q|C׵bAlyEiK#Nx8>I~9wxu^?Xd KIsCfErQJʲ#uΞf^/2PPgum5,&)OI&EM,3o6)$eRv{l3[R^T?M-{&JIyIQTpI2WR8Jˀ$%[R*s }~ nr3g͹]QK*kICQH*CFPd"Bʋݠ)I̞lc@EZR7 /٦<)ZB:ZSbٚZz]T]/٦#IOlhmQqq gQguW#q'*)%5EpcKeH Iy]Q޹3ղN<')o({ꭔ➮$堢h,,0u|luRS&5r͐6aE]+%U[?Jox1:"I̞lcT֒*%۔g~|tSٚZzԣT]/٦{#$w 9ڜUo鲷3Sd! }kXOjs^5[5%[D^77S(p%_m4>5[5|$B/6!KЊ|OEHU"piauZ@SDϖKQsG>GMq6 ~}~7 C@pUqeR:,q䙕s6Uo[(m' qbgRFR(J?&)vIP ) Ōi*)CŸD M S_O7 ኲ-󤴲(Ou>))ܲrr ET ZReoRIH1=%I̞#ekbk1~HQ+J*kI^m3e? >p:):ٚZzъZIRYKlS)6P61eWղ5(1yL+]Ky2.;H>@R)²E{M+:$VgtN_!n6iXF?{hrl+7ҥ5M}i8sl Ha W2Yl1eJ-瓞To{wmu5ӳ {bؼ2SRURS뗋+T&)%4}%ũ(3HDEqX짆LRg~&.^Klsڲ5[d?u$Jy6噲8Ĕ]Wf+v*tET֒*%۔gʦ ML7jTZITc)c53=uW Y9 3se)KO Lϖ ۇ;UiSDe#s"f,JFF2r"0K''r.VNmpb_V}7pt`| q`9Aed!,\,RJbW,% IdXFxH`X*Q$Js],C$+x,qӎ,玏HP:o)Fb{)6jgW?h12X9d'/oM+I}}y[:rȯ/S,[]C9[Q*O$YRQ[  7umH +af`YkE[G@ޙx$iv:OQSql8Vq^- A?d!2]).%B?fzVg%P8FíKn5H,9Os8|"yh ˢ<M*zVgeW]?B]Q.|zףnz J8VΓe[;9=vbg]͙Оq9.QguVsQ拟'-{٩Er=F,5O'G]qi4pFޯ 703ե|F}AR__I# u< ||y}Rc.: 6G/Y>[$CJxCwAvQUat\PAHP 1BHpAv @JqBI1`BX b(("l&PQ@ E=^ߌ%f7/37zGK(jCu+ Ԧ@* ]sC9ɫ@j#EQd!9˷ BQ(/\Iq(|%nSH]ᶭN Ǡ^NNH9 ]+=eomfQy#`gq]iaJJRǠEZZnWtRIS,?-U(kʻI]}nRz-i%Q2Pc}`.*ZPR._;9 RԚ4_0 2R u{n !qη`[;HTj@HE^ԩ XF֚Ss.\j4hRouBZ,@KQ%N![$\EH^v nw`sh攒g1)I(kP~? 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@ 8EU]DAEU]D: $$==_888 % % W$% % $$AA( : Fl`EMF+@0$۫jBARIAL@, _KEgDR   ( RpArial\H `!(Hp,D8H Pt߸D(xh,w xvv vv v+=5V @!w00| te v -v v5wpϧk!"pϧuw@!w@!wdv% TT @ B B LPR% F<0EMF+@, +NEgD'   % TT@ B BLP'% FthEMF+@D8@? @ vAEE TD7JEտD: $$==_888 % % W$ n Q% % $$AA( : FtEMF+@D8۫:BTIMES NEW ROMAN@, yIEUED1   ( RpTimes New Roman\H `!(Hp,D8J PtD(xh,w xvv vv v+=5V @!w00| te v -v v5wpϧk!"pϧuw@!w@!wdv% TT-4@ B B3LP1% FtEMF+@D8۫:BTIMES NEW ROMAN@, xEU)D2   % TTw$z+@ B Bw*LP2% FtEMF+@D8۫:BTIMES NEW ROMAN@, xEUD3   % TTwz@ B BwLP3% FtEMF+@D8۫:BTIMES NEW ROMAN@, yIEUuD4   % TT @ B B LP4% FtEMF+@D8۫:BTIMES NEW ROMAN@, y ET5D5   % TT@ B BLP5% FtEMF+@D8۫:BTIMES NEW ROMAN@, y EUAD6   % TT&-@ B B,LP6% FtEMF+@D8۫:BTIMES NEW ROMAN@, y,ETD1   % TT@ B BLP1% F<0EMF+@, n.ETD'   % TT@ B BLP'% FtEMF+@D8۫:BTIMES NEW ROMAN@, x7EUD2   % TT@ B BLP2% F<0EMF+@, Ό8EUD'   % TT@ B BLP'% FtEMF+@D8۫:BTIMES NEW ROMAN@, y@EUD3   % TT@ B BLP3% F<0EMF+@, dBEUD'   % TT@ B BLP'% FtEMF+@D8BTIMES NEW ROMAN@, "EE2   ( RpTimes New Roman\H `!(Hp,D8K Pt(t(xh,w xvv vv v+=5V @!w00| te v -v v5wpϧk!"pϧuw@!w@!wdv% TTKY@ B BWLP2% F<0EMF+@, j%EEA   % TTKY@ B BWLPA % F<0EMF+@, *)EE,   % TTKY@ B BWLP,% F<0EMF+@, x*EE F<0EMF+@, U+EE3   % TTKY@ B BWLP3% F<0EMF+@, `.EEA   % TTKY@ B BWLPA % Fl`EMF+@0$۫jBARIAL@, ?EER   ( RpArial\H `!(Hp,D8L Pt߸D(xh,w xvv vv v+=5V @!w00| te v -v v5wpϧk!"pϧuw@!w@!wdv% TTNY@ B BWLPR% F<0EMF+@, EE'   % TTNY@ B BWLP' % F<0EMF+@, mEE'   % TTNY@ B BWLP'% FthEMF+@D8@? 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@ xEBDxEjfD: $$==_888 % % W$qzu,,0 % % $$AA( : FthEMF+@D8@? @ xEjfD|EwD: $$==_888 % % W$q,0 ^ % % $$AA( : FthEMF+@D8@? @ lEwD7#EjfD: $$==_888 % % W$ 40 % % $$AA( : FthEMF+@D8@? @ 7#EjfD7#E:D: $$==_888 % % W$u40 4p% % $$AA( : FthEMF+@D8@? @ 7"EbcD7"E=D: $$==_888 % % W$w % % $$AA( : FthEMF+@D8@? @ 7#E:DXzE$D: $$==_888 % % W$gy4p% % $$AA( : FthEMF+@D8@? @ XzE$DE926D: $$==_888 % % W$vgv{B% % $$AA( : Fl`EMF+@0$۫jBARIAL@,  E/CO   % TTNY@ B BWLPOP% FthEMF+@D8@? @ XE%DXEb D: $$==_888 % % W$Wl% % $$AA( : FthEMF+@D8@? @ XE%DXEb D: $$==_888 % % W$Wl% % $$AA( : Fl`EMF+@0$۫jBARIAL@, LErDO   % TTZ`@ B BZLPOl% FthEMF+@D8@? @ kEgDj E xD: $$==_888 % % W$avC> / % % $$AA( : FthEMF+@D8@? @ xEmcD9 E tD: $$==_888 % % W$_u,  % % $$AA( : Fl`EMF+@0$۫jBARIAL@, ,EDI   % TTcn@ B BlLPI % FthEMF+@D8@? @ 7#E:D &,En'D: $$==_888 % % W$iy4p% % $$AA( : FtEMF+@D8۫:BTIMES NEW ROMAN@, yEjD1   ( RpTimes New Roman\E@(Hp"&D89PtD%&h,w& 3&vv vv v;pB 3&@!w00| 3te vh4v v5w&89&~!x89&uw@!w@!wdv% TT@ B BLP1% FtEMF+@D8۫:BTIMES NEW ROMAN@, xEb\D2   % TTwz@ B BwLP2% FtEMF+@D8۫:BTIMES NEW ROMAN@, xEb9D3   % TTwwz~@ B Bw}LP3% FtEMF+@D8۫:BTIMES NEW ROMAN@, yE(D4   % TTls@ B BrLP4% FtEMF+@D8۫:BTIMES NEW ROMAN@, yy Ez:D5   % TTx@ B B~LP5% FtEMF+@D8۫:BTIMES NEW ROMAN@, yy E^D6   % TT@ B BLP6% FtEMF+@D8BTIMES NEW ROMAN@, #E`D4   ( RpTimes New Roman\E@(Hp"&D89Pt(t%&h,w& 4&vv vv v;pB 4&@!w00| 4te vh4v v5w&89&~!x89&uw@!w@!wdv% TT@ B BLP4% F<0EMF+@, d&E`DA   % TT@ B BLPA % Fl`EMF+@0$۫jBARIAL@,  EDR   ( RpArial\E@(Hp"&D89Pt߸D%&h,w& 5&vv vv v;pB 5&@!w00| 5te vh4v v5w&89&~!x89&uw@!w@!wdv% TT@ B BLPR% F<0EMF+@, ED'   % TT@ B BLP'% F<0EMF+@, m\ED'   % TT@ B BLP'% FthEMF+@D8@? @ XzE?DXzEUD: $$==_888 % % W$d } % % $$AA( : F4 ( EMF+@$  CDIFVjCD0100ChemDraw 12.02<̌M  " :;E<  BCD `  ff3xx# ()*$$$$2$ArialTimes New Romanx,, g{,, d'`33 $$22<M3Y9i +H7\9W\9#`NH4n9i 5y( +H{&v&{!+# `N6n:  77Y: !8O( "9Y?( )+H7A%2<%A`C+# `O:3x ++H74zuzk- # `O;O{L -5+H7Q{KL{KQM# `I( 6+H73R%%`-#`R''? #34 @ $45 A %56 B &67 AGCC '78 D (83 E *89F ,4:G .7;  75 Kfu%fp%?wl( /&ChemDraw can't interpret this label. p1L3nV3iVlp" 0&ChemDraw can't interpret this label. p2Mf^VfYV_" 1&ChemDraw can't interpret this label. p3Nf&V%f&Q%Wl( 2&ChemDraw can't interpret this label. p4Ǒ^m4̌Ym4e&`96 3&ChemDraw can't interpret this label. p5Pom4jm4yq96 4&ChemDraw can't interpret this label. p6Ty:نy:̬̌F 5&ChemDraw can't interpret this label.4ALdZOZOct)??" FEMF+@ CompObj~ObjInfohjCONTENTS _1401698556ewm!mA. }NPѠNM  @@3 :;E<  BCD `  ff3xx# ()*$$$$2$ArialTimes New Romanx,, g{,, dd'`33 $$22<M3Y9i +H7\9W\9#`NH4n9i 5y( +H{&v&{!+# `N6n:  77Y: !8O( "9Y?( )+H7A%2<%A`C+# `O:3x ++H74zuzk- # `O;O{L -5+H7Q{KL{KQM# `I( 6+H73R%%`-#`R''? #34 @ $45 A %56 B &67 AGCC '78 D (83 E *89F ,4:G .7;  75 Kfu%fp%?wl( /&ChemDraw can't interpret this label. p1L3nV3iVlp" 0&ChemDraw can't interpret this label. p2Mf^VfYV_" 1&ChemDraw can't interpret this label. p3Nf&V%f&Q%Wl( 2&ChemDraw can't interpret this label. p4Ǒ^m4̌Ym4e&`96 3&ChemDraw can't interpret this label. p5Pom4jm4yq96 4&ChemDraw can't interpret this label. p6Ty:نy:̬̌F 5&ChemDraw can't interpret this label.4AOle EPRINTloMACompObj~ObjInfonp !mA. CS ChemDraw DrawingChemDraw Interchange FormatChemDraw.Document.6.09qVjCD0100ChemDraw 12.0RUٻ Y  @@3 :;E<  BCD `  ff3xx# ()*l.h)1 EMFAe nNF, EMF+@``F EMF+@ "@ @ !@ 0@?0@ #>2@DDDkD@0$۫jBARIAL@H<h ?@, ODDN!b    RpArial\^0WPW,AsD8AsDPs߸DP xes_DT! @Du P<_P 00DuDu_]s !\Xdv% TT"@ B B LPN% Fl`EMF+@0$۫jBARIAL@, ADDN   % TTAL@ B BJLPN% FthEMF+@D8@? @ DDD[D: $$==_888 % % W$ B% % $$AA( : Fl`EMF+@0$۫jBARIAL@, #DDO   % TTAL@ B BJLPO% FthEMF+@D8@? @ >D9D!DD: $$==_888 % % W$8HW ]% % $$AA( : FthEMF+@D8@? @ DAVDѥDD: $$==_888 % % W$5Ep< /% % $$AA( : FthEMF+@D8@? @ D  @ c Eb X5ͺ 6&ChemDraw can't interpret this label. p1gTgT%"3! 7&ChemDraw can't interpret this label. p2[gt[gtX3A 8&ChemDraw can't interpret this label. p3NNX 9&ChemDraw can't interpret this label. p4-!-!Ɨ :&ChemDraw can't interpret this label. p5HHh ;&ChemDraw can't interpret this label. p6L A&ChemDraw can't interpret this label.8B`KK>ڱ B&ChemDraw can't interpret this label. p7aοκrhc C&ChemDraw can't interpret this label. p8Ld-ha)??" FEMF+@ CONTENTS _1401698557s!mA. N:NOle  EPRINTru(e    !"#$%&')*+-./013$$$$2$ArialTimes New Romanx,, g{,, dd'`h33 $$RUٻ Y $+H7##f0# `N %[ &+H[S[S'`# `N '7 ([ )n[w 0+H7%[[!# `Ow 2+H7%"ٻٻ.?"# `Ov 47_, <RբQ ?+H73R91RURURUY#`R'b [ D+H73R [[ #`R'' *  +  ,  -  .  /  1  3 5  =  >  @ c Eb X5ͺ 6&ChemDraw can't interpret this label. p1gTgT%"3! 7&ChemDraw can't interpret this label. p2[gt[gtX3A 8&ChemDraw can't interpret this label. p3NNX 9&ChemDraw can't interpret this label. p4-!-!Ɨ :&ChemDraw can't interpret this label. p5HHh ;&ChemDraw can't interpret this label. p6L A&ChemDraw can't interpret this label.8B`KK>ڱ B&ChemDraw can't interpret this label. p7aοκrhc C&ChemDraw can't interpret this label. p8 !mA. 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EGG T?A H UA7 GNCL W9KN YAM d [;c r&| 5 o f+H7?r،r?# `No gr$ h+H78>8# `Ne i7 e j7?S$ ks rH77ԬӺ|{lUs \+H?3Ӻ?ӺL# `OVc=R ]Wo@ ^ X _WUY `UV?3? #`OCH3~$ tH78 sAþ~$ a+Hrf<r&{< # `Oso b?S$ c  d erfTr&|T?;#`OCH3 l  m  n  o  p  q  s  u )hhOhεo v&ChemDraw can't interpret this label. l1b4949hg w&ChemDraw can't interpret this label. l2949h_49Ŧg x&ChemDraw can't interpret this label. l3yfhf4 y&ChemDraw can't interpret this label. l46ΒΒF z&ChemDraw can't interpret this label. l5Β5<ΒF {&ChemDraw can't interpret this label. l6iϹGG5\4YJ |&ChemDraw can't interpret this label. l1i9595΂< }&ChemDraw can't interpret this label. l29 9ho΂< ~&ChemDraw can't interpret this label. l3"hGIhGhJ &ChemDraw can't interpret this label. l46h|Uh|U/X &ChemDraw can't interpret this label. l5ih|Uh|U5L/X &ChemDraw can't interpret this label. l66h6Εq &ChemDraw can't interpret this label.13Au =15 =1BC &ChemDraw can't interpret this label.14AlMC IC, EMF nNF, EMF+@``F EMF+@ "@ @ !@ 0@?0@ #>2@ DCD@D@0$UUBARIAL@H<h@?@, aE09JDN!b    RpArial\xaط??pM,A tD8A tDP t߸Dp~"xet"DT! @w P<"p~"00ww""] t!TLXdv% TT@ B BLPN% Fl`EMF+@0$UUBARIAL@, 5"EDN   % TT@ B BLPNA% FthEMF+@D8@? 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@ DGDMDnjD: $$==_888 % % W$ < o< % % $$AA( : FthEMF+@D8@? @ DF}DMDPD: $$==_888 % % W$  o % % $$AA( : FthEMF+@D8@? @ MDnjDDGD: $$==_888 % % W$o< +< % % $$AA( : FthEMF+@D8@? @ DGDDND: $$==_888 % % W$+< +<% % $$AA( : FthEMF+@D8@? @ DG}DDRD: $$==_888 % % W$  _% % $$AA( : FthEMF+@D8@? @ DNDMD5D: $$==_888 % % W$r+<o<% % $$AA( : FthEMF+@D8@? @ MD5DDND: $$==_888 % % W$ro< <% % $$AA( : FthEMF+@D8@? @ MD|9EuD: $$==_888 % % W$% % $$AA( : Fl`EMF+@0$UUBARIAL@, ܜ7E9DO   % TT1>@ B B<LPO % F<0EMF+@, :E9DH   % TT1>@ B B<LPH% FthEMF+@D8@? @ y>9EuD=9ED: $$==_888 % % W$5(% % $$AA( : Fl`EMF+@0$UUBARIAL@, L!E DO   % TT1>@ B B<LPO % F<0EMF+@, 0%E DH   % TT1>@ B B<LPH% FthEMF+@D8@? @ #ErD#EKD: $$==_888 % % W$4%%'% % $$AA( : FEMF+*@$?ZZ<?(3B@D8UUBTIMES NEW ROMAN@, ExD1   ( Rp Times New Roman\xaط??pMf(sD87"P tD0s sh,/w(s P svvJufvJu!7 P(s@Lw00| PteKu*vJu5Iw(s@u!T@uuIw@Lw@Lwdv% TT@ B BLP1% FxEMF+*@$??*@$?ZZ<?ݻ{5B@, Ļ!EڤD'   % TT@ B BLP'% FxEMF+*@$??*@$?ZZ<?һK6B@, gv"EVD'   % TT@ B BLP'% FEMF+*@$??@D8UUBTIMES NEW ROMAN@, )E^D3   ( RpTimes New Roman\xaط??pMf(sD87"P tD0s sh,/w(s Q svvJufvJu!7 Q(s@Lw00| QteKu*vJu5Iw(s@u!T@uuIw@Lw@Lwdv% TT @ B BLP3% F<0EMF+@, +E^D'   % TT @ B BLP'% F<0EMF+@, ,E^D'   % TT @ B BLP'% FEMF+*@$?=?{p@ʵB@D8UUBTIMES NEW ROMAN@,  ED4   ( RpTimes New Roman\xaط??pMf(sD87"P tD0s sh,/w(s R svvJufvJu!7 R(s@Lw00| RteKu*vJu5Iw(s@u!T@uuIw@Lw@Lwdv% TT @ B BLP4% FxEMF+*@$??*@$?=?=p$B@, "ErnD'   % TT @ B BLP'% FxEMF+*@$??*@$?=?'p[B@, #EkaD'   % TT @ B BLP'% FEMF+*@$??@0$UUBARIAL@, D,DC   ( RpArial\xaط??pMf(sD87"P t߸D0s sh,/w(s S svvJufvJu!7 S(s@Lw00| SteKu*vJu5Iw(s@u!T@uuIw@Lw@Lwdv% TT+m2z@ B B+xLPC% Fl`EMF+@0$UUBARIAL@, D;DO   % TT+v3@ B B+LPO % FthEMF+@D8@? 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V&ChemDraw can't interpret this label. 2j *"c *.m . W&ChemDraw can't interpret this label. 3Uc׺8\׺8e׺< X&ChemDraw can't interpret this label. 4V#bjqTEHcqTEVlqTI Y&ChemDraw can't interpret this label. 5W{ Et E} I Z&ChemDraw can't interpret this label. 6=]o]; [&ChemDraw can't interpret this label.17A}T rM V9_ h&ChemDraw can't interpret this label.@CDIF1'`tYc i&ChemDraw can't interpret this label.3*UR]K 0U j&ChemDraw can't interpret this label.2*{]hV#yV_ k&ChemDraw can't interpret this label.1*}?b2g2r]9 w&ChemDraw can't interpret this label.1''H-Fi-F{L x&ChemDraw can't interpret this label.3'' 4D4O; y&ChemDraw can't interpret this label.4''_fX&.b9 &ChemDraw can't interpret this label.2'}bFǯE2L &ChemDraw can't interpret this label.2''LdOCO)??" FEMF+@ CompObj~ObjInfoCONTENTSy1Table_VjCD0100ChemDraw 12.0E<|l @{@ @@3 :;E<  BCD `  (33xx# ()*$$$$2$ArialTimes New Romanx,, g{,, dd'`33 $$E<b|lideT% E+HiDhT"ibT"iDhTg(# `Nid}T% Fid0P: G+HiD0p7i0p7iD00=# `Nid} O H7ide O I7idY0P: Jidx Q+H7^x ix w# `OidA0P: S+H7^D007i>007wDcc=# `Om%{Cɤ \7n% ]7o%{Z ^7p%cZ _q%W `7r%cCɤ a7 N l+H7K ͫK?3Q# `O 0N m{m: o7%c q7Uc s+H76U`U`|l#`OH{: u+H76{6B#`OH%W# z/An atom in this label has an invalid valence.HZCETCa w#`CO%?# |+H7BE<)9B 7# `O%c ~7%W  7id0P: 7M K N L O M P N OQQ O R P S RT Tw bmn |xx cno y dop xzz epq { fqr z|| grm  n  p  r  t  v  {p  }          #b>!8H{>!8V>!< U&ChemDraw can't interpret this label. 1{qT*tqT*}qT. V&ChemDraw can't interpret this label. 2j *"c *.m . W&ChemDraw can't interpret this label. 3Uc׺8\׺8e׺< X&ChemDraw can't interpret this label. 4V#bjqTEHcqTEVlqTI Y&ChemDraw can't interpret this label. 5W{ Et E} I Z&ChemDraw can't interpret this label. 6=]o]; [&ChemDraw can't interpret this label.17A}T rM V9_ h&ChemDraw can't interpret this label.1'`tYc i&ChemDraw can't interpret this label.3*UR]K 0U j&ChemDraw can't interpret this label.2*{]hV#yV_ k&ChemDraw can't interpret this label.1*}?b2g2r]9 w&ChemDraw can't interpret this label.1''H-Fi-F{L x&ChemDraw can't interpret this label.3'' 4D4O; y&ChemDraw can't interpret this label.4''_fX&.b9 &ChemDraw can't interpret this label.2'}bFǯE2L &ChemDraw can't interpret this label.2''Vd ` txK0%000044 lapxKyt$8T$$If!v h55#5555555 5 5 V5 d#v#v##v#v#v#v#v#v#v #v #v V#v d:V l4 ```````````` txKKKKKKKKKKKK0%+55#5555555 5 5 V5 d/ /  / apxKKKKKKKKKKKKyt$8Tkdg $$IfTl4  Fi { }P!$ #Vd ```````````` txKKKKKKKKKKKK0%000044 lapxKKKKKKKKKKKKyt$8T$$If!v h55#5555555 5 5 V5 d#v#v##v#v#v#v#v#v#v #v #v V#v d:V l4 ` txK0%+55#5555555 5 5 V5 d/ / /  / apxKyt$8Tkd $$IfTl4  Fi { }P!$ #Vd ` txK0%000044 lapxKyt$8T+Dd R ; S A:@?"?@"0%Tʶ~$Ra= @=Y0%Tʶ~$R(eXi 'x] tTչg^y@̐H€(yAD 1Q*I H@h=ZR/޺{-Zo .ZoJr"wZEU}}23&1dϿ!hBV M;hR4 X  ϙ&D4 xɏHpL d Lwtܨx yxngwtʖU8-kX[X-ߕ-7ێlzxБ)7r?Y6l*ƕiW_fLgTf[,p| $XW1@_Jyù?FY@}R'=VN!DcrCCn( {=((W9r@myJb(FD{kqn%æYVr,s zPOccj`z[^sʿ}O]@٣*u!}7e>煴{B? yWꥑ{7|s/qϐ`^?Ѵ3yoae\}m vobk1|JS1AI+?{L|czt+sC'j1|6hsEȫ*hU'z˲uH̟sLg[ JM'\ 5ןCSx;jo}GЀІ #g\w ݟk g*蹊f\BZxa}ݶ'דsՎ =l:b&s'1\de\o F]=WbI۫߶}&t'c;ms6Tϔŋg;[,;"bųWm/O1SQzeQ<N[N;X?Cg+yM{o΅$ve# ^.Ţb}zod#m'Zp~6^#D0@N׮^6zմ Q6nknu22c@lEb+G WkR>I?]i>|}VGy|qj(IKn'SF5~ -{fݍ~ga|Ypx;ʳB<r#6E1zFc?c$:Ƴ`ahEria: f1k+8ƻW<4~nT|S[ ŋ<%b CK|V}O~WKZg6 9w=cG ΏZ_]\"|b.ː׉yO^5Xo?`2{a)RlhkdDlJyJnuG>\#PNـ9l>輟= o ęÆSCs8sTa|?p.J?,xɏH|N1;!|V8e[) iQ$ӷS-cm!/[zӷBVɡBdc.֭,qݚ3T]u37_ Fnq?t3j}" 9B>N}gM%=}qTɏK _?{dbo\l?#ۯG>8Rz N@[ k {kK?.u֖l˖.laY"P|%^*HdK.=]ؘ݆ld _U|7tOIwu|k ?P~wZ󂪴k>G/G~ q|-iyiדƵ뎡Fʾk<=RУsO;.w}YSuqFy8\+44S@nwp'q'["?ozLi<"ZyD 2.xɏHܻf ?+8R[WeB]ْ5'| ~Y<5>l}ي>hN|pD=|iu1ѢMٿ7s3IorHd9q{{|΅Nʷ>{ ^}u8HԀ=Y{d=#Gϵ> W{jeQF?ě.@͑j/~*W(G!H)]l[0Dl~֩Wq% EC:p?4`']bm.m6|XeK2}{'J[B^"t׷N-?lak ybNICϕ?;NYr8^閒([Ӈ^<%8;G汶-oѷGNJ{?>= Le-^8~J^0lB-n0DlI*N9y{K whZV&o icSttdjB|Sp:R=ryAL#o:33QlƱhtD&fMd xnC!p#q•Sg%81lXB|T43!,߀41D2? 3r5:ܿܢvE.~5Mmdh%-Y;Uֽ*.Em4jsI*;9`m=b⣪W+9K @*6i壥,1T؈{\Ҷ$T"S/BK *tb>^@w+;|3b;*E*G?ȋ/ ,é88 r$$If!v h5{5u5555555 5 5 5 #v{#vu#v#v#v#v#v#v#v #v #v :V l ```````````` txKKKKKKKKKKKK0&5{5u5555555 5 5 / / apxKKKKKKKKKKKKyt$8Tkd$% $$IfTl  ,/ 6FGI=1 P#`&{u ```````````` txKKKKKKKKKKKK0&000044 lapxKKKKKKKKKKKKyt$8T$$If!v h5{5u5555555 5 5 5 #v{#vu#v#v#v#v#v#v#v #v #v :V l4 ` txK0&+5{5u5555555 5 5 / /  / / apxKyt$8TkdG+ $$IfTl4  ,/ 6FGI=1 P#`&`{u ` txK0&000044 lapxKyt$8T$$If!v h5{5u5555555 5 5 5 #v{#vu#v#v#v#v#v#v#v #v #v :V l4 ` txK0&+5{5u5555555 5 5 / /  / apxKyt$8Tkd1 $$IfTl4  ,/ 6FGI=1 P#`& {u ` txK0&000044 lapxKyt$8T$$If!v h5{5u5555555 5 5 5 #v{#vu#v#v#v#v#v#v#v #v #v :V l4 ` txK0&+5{5u5555555 5 5 / / /  / apxKyt$8Tkd7 $$IfTl4  ,/ 6FGI=1 P#`& {u ` txK0&000044 lapxKyt$8TDd jR < S A;@?"?A" z4Oז)C> @= z4Oז)e!\"cx] tU־ Ia$,YMTCаGL2j EPpFe#ȢʦfuUI6MKLo[zݯޫD & WZ G&tD:nĽd_!of@b Nŷq:,>Q'uA\&;]˶_~h&ξZSqW.[\<)~8vb}G)IqazSNp]Hz[,2L*(T ".G&QH 4YDuu5 I׍ZT(bê;A&hL%zcvOk(qeZw' ~VV]Owpc; I;Zcjct=41I^$Cw]$rG&B ʼHQ7?شrjoE6xrJCEb{SӐRq c 4" 4 1K㸮K̿_?zlUW}pq׫P:@ԙSg7dMܾpw{ g>#;@.\S̾uVǢV $AvFc). < rUQ Ցb8)MنGuy{(OP{b&W73#VtZoCxDț68B51.v+前aJ7ZZgаv= 7U\zZuÍkcUZ6qo5>f5quflC:\߻8l~Xo{mj]`69q%.6XU9]kty˜&ƿ9ұakm3&Ιl\.jNs > `0&f\32:kMOp]\Yu 9dW4x*[u%뛟l<-?K麮^ }sy_ گ͗2ȇjg [sLVLf@cGԋ%`YLV8{CީSėкV6 };e愞^N="Mڰ ʗB>a•E:f/A5iú 'ӽ;MA}_y{_5~}nXs_CwPDEw::4,7Pg UokNx吏6H|;V;a&u91<{.kp>pc>1w 11>@1q#S&)=q 51d8}msK/A~흼G` _kMT[k |ŵ%ؔ_jhsvNܩ,[8Kod  k,75~ڮIܟwO] |D =,[6c91x:ceͣC5&UGš{,՟-JX`n#hz%l|0G'oV0b}ߌږ\ Wyuan0&{@_` KޘUaY1詰!z&GPrn&iknjXF<_V<5|2OcHƉX3O% io-{ђo}"l|kGo7&7mqMc^ퟫ'_ƯcbmY15]:+׬ S(פ8s5wG] k~SS'~r wD="cj2)3}SHoo |GEH)+yM!cnO:1Nw qy3}|fgnwmC}b $זzAϝjW D@c#O_lB] ~4l6>>B/>~S*Bگ}!= ss /.FR.e ,OmdkgKVؼ:2p$uD w`DƩ>D1 rs#uoF$NWC߈tֻs]޿H8ûs׸~wN ջ3c8'/QX2>zwUB.b16EoAܻoP~::~qr0xp_xFGu :<>vԊϷȆQ@u ?>p58xo|PH|epv|(J\Z#_BA'}gli d~kxh:P>,`j׎s/maxㅡZ;vM@]A\?+o)Gd |>w: Z76q?2kKuw?*>+qj#<:PÚCxW9M[rkGTCOi)VY{]f<̒G.&?>t'،dx8Yn`~A.š`гBFQCjzу6d҃f^=(@Ñz>bCr5afͨrB2*T dž  ]P*(%y6iq5H%];RF! 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