Pregled bibliografske jedinice broj: 690309
Method of detection of amino acid sequence and/or identification of peptides and proteins, by use of a new derivatization reagent and synthesis of 5-formyl-benzene-1, 3-disulphonicacid as derivatization reagent
Method of detection of amino acid sequence and/or identification of peptides and proteins, by use of a new derivatization reagent and synthesis of 5-formyl-benzene-1, 3-disulphonicacid as derivatization reagent
(2012)
CROSBI ID: 690309 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Method of detection of amino acid sequence and/or identification of peptides and proteins, by use of a new derivatization reagent and synthesis of 5-formyl-benzene-1, 3-disulphonicacid as derivatization reagent
Autori
Cindrić, Mario ; Hameršak, Zdenko ; Dodig, Ivana
Broj patenta
WO 2012/156764 A1
Godina
2012
Datum patenta
22.11.2012.
Sažetak
Present invention refers to a novel and improved method of derivatization and detection of amino acid sequence and/or identification of proteins, peptides by a new derivatization compound. Precisely, the method discloses a novel approach to derivatization of peptides or proteins by compounds comprising two or more sulfonyl groups and analysis of derivatized analytes in negative mode of operation of mass spectrometer. This method allows unambiguous analysis of amino acid sequence of long-chain peptides/proteins. Also, the invention discloses a novel synthesis procedure of 5-formyl-benzene-l, 3-disulphonic acid as derivatization compound.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
098-0000000-3454 - Proteomska analiza tkiva u bolesnika s karcinomom prostate (Cindrić, Mario, MZOS ) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb
