Naslov
Lethal toxicity following standard dose of 5-FU in patients carrying DPYD c.1905+1G>A mutation

Autori
Božina, Nada ; Goršić, Irma ; Pejnović, Lana ; Badžek, Saša ; Pleština, Stjepko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Pharmacogenomics and Theranostics in practice / - , 2013

Skup
EUROMEDLAB Milano 2013 - Post-Congress Satellite Meetings Florence: Pharmacogenomics and Theranostics in practice

Mjesto i datum
Firenca, Italija, 24.05.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
DPYD; 5-FU; toxicity

Sažetak
Dihydropyrimidine dehydrogenase (DPD) is the key enzyme in the detoxification of 5-fluorouracil (5-FU). Patients with DPD deficiency are at increased risk of severe toxicity from 5-FU. UGT1A1 is important for the irinotecan pharmacokinetic. DPYD c.1905+1AA mutation is known to result in DPD deficiency which is the cause of severe adverse and sometimes lethal reactions to 5-FU. UGT1A1 is also important for the irinotecan pharmacokinetic. The genotyping of cancer patients for DPYD and irinotecan gene variants prior to administration of 5-FU would be desirable for identification of increased risk of severe toxicity.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA