Naslov
Uloga farmakogenomike u farmakoterapiji - Od funkcijske genomike do racionalne terapije
(Role of pharmacogenomics in pharmacotherapy - From functional genomics to rational therapy)

Autori
Božina, Nada

Izvornik
Pharmaca : hrvatski časopis za farmakoterapiju (0031-6857) 42 (2004), 2; 71-86

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, ostalo

Ključne riječi
drug transporters; metabolic enzymes; pharmacogenomic; receptors

Sažetak
Genetic polymorphisms in drug-metabolizing enzymes, transporters, receptors, and other drug targets have been linked to interindividual differences in the efficacy and toxicity of many medications. Pharmacogenomic studies are rapidly elucidating the inherited nature of these differences in drug disposition and effects, thereby enhancing drug discovery and providing a stronger scientific basis for optimizing drug therapy on the basis of each patient's genetic predisposition. Besides interindividual, the existence of marked interracial and interethnic differences have been documented. Because most drug effects are determined by the interplay of several gene products that influence the pharmacokinetics and pharmacodynamics of drugs, including inherited differences in drug targets (e.g., receptors) and drug disposition (e.g., metabolizing enzymes and transporters), polygenic determinants of effects have become increasingly important in pharmacogenomics. Ethnic diversity implies that ethnic origin has relevance in pharmacogenetic studies, and must be considered in pharmacotherapy. Pharmacogenomics has become increasingly important in healthcare. The identification and functional analysis of human genes have considerably improved the study of disease processes and the development and rational use of drugs. They have become a useful tool for physicians to make reliable assessments of an individual's risk of developing a particular disease and to explain interindividual variation in therapeutic effectiveness and toxicity of drugs.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Farmacija

POVEZANOST RADA