Naslov
Arylsulphatase A(ASA) in human brain during ageing

Autori
Radeljak, Sanja ; Mihaljević-Peleš Alma

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Psychiatria Danubina / Hofmann, Gustav ; Sartorius, Norman - Zagreb : Medicinska naklada, 1998, 177-177.

Skup
18th Danube symposium of psychiatry

Mjesto i datum
Zagreb, Hrvatska, 04.06.1998. - 06.06.1998

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
ASA; human brain; ageing

Sažetak
A relationship between arylsulphatase A(ASA) deficiency and various neuropsychiatric disorders has been indicated. However, very little is known about regional distribution and ASA activity in human brain during ageing. Thus, we measured ASA activity in different brain regions(prefrontal, parietal, temporal, occipital, cerebellar, hypoccampal and insular cortex, sensorymotor cortex, talamus and amigdala) of healthx persons, using para-nitro.catechol(p-NCS) as an in vitro substrate. In the "younger" group(age 15-30), ASA activity was highest in cerebellar and lowest in sensorymotor cortex. There was no correlation between ASA activity and in any of the region and age. In the "older" group(30-80 years), ASA activity was decreased in occipital(by 10%) and cerebellar(by 30%)cortex, and stable in in fronatal cortex and other region irrespective of age. Our results suggest that ASA activity in selected brain regions declines during ageing. Since ASA defficiency is related to demyelinization process and ASA pseudodefficiency has high rate among general population, one could assume that the age-related decline in ASA activity might contribute to onset of demyelinization-associated neuropsychiatric disorders on elderly.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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