Naslov
Survival of CD8 memory T cell precursors depends on NKG2D mediated PI3K signaling and Mcl-1 induction

Autori
Wensveen, Felix Martinus ; Lenartić, Maja ; Jelenčić, Vedrana ; Lemmermann, N. A. W. ; ten Brinke, Anja ; Jonjić, Stipan ; Colonna, M. ; Polić, Bojan ;

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
15th International Congress of Immunology (ICI 2013)

Mjesto i datum
Milano, Italija, 22.08.2013. - 27.08.2013

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
NKG2D; CD8 T cell memory; PI3K; Mcl1

Sažetak
Memory formation of activated CD8 T cells is the result of a specific combination of signals that promote long-term survival and inhibit differentiation into effector cells. Much is known about initial cues that drive memory formation. Which signals are essential during the intermediate stages before terminal differentiation, however, is poorly understood. We show that the activating co-receptor NKG2D controls formation of CD8 memory T cells by promoting survival of precursor cells. We demonstrate that NKG2D enhances PI3K signaling in a specific phase of memory cell commitment. This phase characterizes a transition stage from IL-2 to IL-7 dependency, during which activated cells highly rely on NKG2D-signaling for their survival. NKG2D-induced PI3K signaling is essential for the induction of pro-survival protein Mcl-1 and precursor cell survival. NKG2D-deficiency results in reduced memory cell formation and impaired protection against re-infection. Our findings show a new role for PI3K and NKG2D in an underappreciated stage of effector to memory transition that is essential for the generation of efficient long-term anti-viral protection.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA