Naslov
Expression and prognostic value of the Ki-67 in Wilms' tumor : experience with 48 cases

Autori
Jurić, Ivo ; Pogorelić, Zenon ; Kuzmić Prusac, Ivana ; Biočić, Mihovil ; Jakovljević, Gordana ; Stepan, Jasminka ; Župančić, Božidar ; Čulić, Srđana ; Krušlin, Božo

Izvornik
Pediatric surgery international (0179-0358) 26 (2010), 5; 487-493

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Wilms’ tumor ; Nephroblastoma ; Ki-67 ; Societe’ International d’Oncologie Pediatrique protocol (SIOP) ; Surgery

Sažetak
Ki-67, tumor proliferation marker, is an important prognostic factor in a variety of cancers. In the present study, we investigated the expression and the prognostic value of Ki- 67 in nephroblastoma. Ki-67 expressions were investigated by immunohistochemistry on paraffin-embedded material in 48 children operated on because of nephroblastoma. Patients were treated according to SIOP protocol. The mean follow-up period was 5.4 years. A proliferation index was obtained by immunohistochemistry using anti-Ki-67 anti- body. The mean Ki-67 proliferation index in the blastemal type was 12.3%, and in the epithelial type, 21.4%. In the anaplastic type, Ki-67 proliferation index was: in the blastemal component 20%, in the stromal 21%, and in the epithelial 31%. In the mixed tumor type, Ki-67 proliferation index was assessed as: in the blastemal component 10%, in the epithelial 33% and in the stromal 31.5%. Proliferation index for the epithelium was significantly higher than those found for the blastema (P = 0.001). A correlation between Ki- 67 and tumor stage found proliferation index significantly higher in stages I and II (P = 0.002). The results support the conclusion that Ki-67 is a relevant marker for assessing the proliferative activity and tumor cell dynamics of nephroblastoma, but it may not be a good clinical prognostic marker.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA