Naslov
Genotyping of CYP2D6 in Parkinson's Disease

Autori
Štefanović, Mario ; Topić, Elizabeta ; Ivanišević, Ana-Maria ; Relja, Maja ; Koršić, Marta

Izvornik
Clinical chemistry and laboratory medicine (1434-6621) 38 (2000), 9; 929-934

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Parkinson's Disease; CYP2D6; clinical oscilation

Sažetak
Parkinson's disease is characterized by progressive degeneration of DA neurons. Cytochrome P450 enzyme is one of the most investigated and highly polymorphic isoforms, which metabolizes many drugs and is also involved in the metabolism of dopamine. Using allele-specific multiplex PCR, we genetyped 186 subjects for CYP2D6 *3, *4, *6, *7, and +( alleles in order to esrtimate allelic, genotyping and predicted phenotype frequencies in the control and patient groups, and to investigate the possible statistical differences between PD disease patients (n=41) and healthy controls (n=145). PD patients were further divided into two subroups according to H&Y staging of the disease (HY).The preliminary results of this study showed that only the prevalence of CYP2D6 *4 allele differed significantly between the PD patients and control groups.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

Napomena
Rad je kao poster prezentiran na skupu 1st Alps-Adria meeting on human genetics, održanom od 14.-15.04.2000.g., Brijuni, Hrvatska ; objavljen u Knjizi sažetaka ; Ljiljana Zergollern (ur.) ; Zagreb : Hrvatsko društvo za humanu genetiku, 2000. ; str. 53-54.

POVEZANOST RADA