Naslov
Formulating lecithin-based microemulsions using rhamnolipid biosurfactant

Autori
Miočić, Sandra ; Ferderber, Kristina ; Filipović-Grčić, jelena

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts / Lovrić, Jasmina ; Pepić, Ivan, Filipović-Grčić, Jelena ; Mrhar, Aleš - Zagreb : Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, 2012, 130-130

ISBN
978-953-6256-69-3

Skup
The 9th Central European Symposium on Pharmaceutical Technology

Mjesto i datum
Dubrovnik, Hrvatska, 20.09.2012. - 22.09.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
microemulsions; lecithin; rhamnolipid; biosurfactant

Sažetak
According to the results surfactant mixtures composed of rhamnolipid and lecithin in ratio 1.5:1 were able to produce microemulsions for all four types of oil, with ratio of surfactant mixture to oil phase fixed at 1:1. Amount of water phase in microemulsion systems ranged from 10 to 20 %w/w depending on the employed oil phase. The microemulsion existence areas were defined through construction of pseudoternary phase diagrams with four different oils, water and surfactant mixture, and with or without sodium chloride. Microemulsion systems were characterized by polarized optical microscopy and viscosity measurements. For oils MCT and PPG-15 two regions were identified in sodium chloride-free phase diagrams ; a microemulsion phase and liquid crystalline phase. Addition of sodium chloride to these systems prevented formation of liquid crystalline phase and enabled incorporation of higher amount of water into the microemulsion system. It is assumed that addition of electrolyte directly affects carboxylate groups of rhamnolipids by shielding their negative charge and thus making rhamnolipids more hydrophobic, which affects their interaction with other microemulsion constituents. According to the results microemulsions with rhamnolipid-lecithin surfactant mixture were successfully formed with range of different oils by adjusting hydrophilicity and lipophilicity balance of the microemulsion system.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

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